PATIENT STRATIFICATION. 15 year A N N I V E R S A R Y. The Life Sciences Knowledge Management Company

Transcription

1 PATIENT STRATIFICATION Treat the Individual with the Knowledge of All BIOMAX 15 year A N N I V E R S A R Y The Life Sciences Knowledge Management Company

2 Patient Stratification Tailoring treatment of the individual using the knowledge of all Patient stratification involves the use of biomarkers, genetic profiles, research data and clinical information to create subsets within a patient population allowing patients to be grouped in terms of a therapeutic response. Stratification reaches beyond current statistical patient evaluation methods and epidemiological predictions to integrate and bring thousands of clinical data points and intrinsic and extrinsic parameters to the patient evaluation process. The result is better decision making on behalf of the individual patient as well as the healthcare delivery organization a true win-win situation. Biomax enables patient stratification by providing a computational and conceptual infrastructure as well as solution building for the integration and analysis of diverse data to elicit usable patient knowledge. Benefits include the following: Improvement of patient care and quality of life Reduction of costs, unnecessary treatments and patient discomfort Development of novel approaches to business management and risk reduction Genetics Biology Biochemistry Medicine Lifestyle Behavior Sociology etc. Prognosis Prophylaxis Diagnosis Therapy Systems Medicine Improving patient care by understanding the intrinsic biology of disease Systems medicine is the holistic approach to a patient s care. It incorporates evidence-based medicine with the interactions between all components of health, disease, human genetics, environment and behavior. Not only does a systems approach improve therapeutic outcomes for individual patients, it leads to significant reductions in both healthcare delivery and clinical management costs. By deciphering the functional and regulatory networks underlying the behavior of complex biological systems and combining them with clinical data, Biomax is helping organizations succeed in bringing personalized medicine to their operations. Most importantly, Biomax enables, in a few hours or days, information to be extracted, fine-tuned and ultimately realized as knowledge in the clinical environment. Biomax creates value for clients by eliminating software coding, reducing implementation time and providing a means to bring critical insights to patient stratification. The impact of being able to exploit clinical knowledge effectively using state-of-the-art technology cannot be overestimated. This applies to both improved patient care and better management of treatment costs. Prof. Wouters, Chairman Board of Directors, CIRO+ Biomax has worked independently and in partnership with public and private organizations for several years to develop computational and mathematical tools for disease-specific, systems-wide approaches. Current project examples follow: SYNERGY Modeling and simulation environment for systems medicine using Chronic Obstructive Pulmonary Disease (COPD) as a use case AirPROM Airway Disease PRedicting Outcomes through Patient-Specific Computational Modeling MeDALL Mechanisms of the Development of ALLergy SysCLAD Systems prediction of Chronic Lung Allograph Dysfunction BIOBRIDGE Integrative Genomics and Chronic Disease Phenotypes: Modeling and Simulation Tools for Clinicians STATegra User-driven development of statistical methods for experimental planning, data gathering and integrative analysis of next-generation sequencing, proteomics and metabolomics data

3 Biomax Health Informatics Solutions for effective management of clinical knowledge Biomax provides both conceptual and computational infrastructure for an evidence-based and diseasecentric approach to healthcare delivery. Biomax solutions are highly flexible and provide integrated knowledge management using the versatile BioXM platform for patient stratification and targeted therapy. Biomax Health Informatics enables clinicians to comprehensively evaluate clinical activity and use this knowledge for better patient care, therapeutic and business management decisions. Biomax Health Informatics Applying semantic integration to clinical data to achieve patient stratification and personalized medicine Case Study Chronic Obstructive Pulmonary Disease (COPD) Objectives Enable granular patient stratification scheme Move away from standard therapeutic approaches Improve individual patient therapy outcomes Reduce costs and improve risk management Clinical data Biomax is enabling organizations to achieve the following: Profile patients against all previously treated patients Predict therapeutic outcome based on holistic assessment Deliver full transparency on any clinical activity Compare Biomax Health Informatics Traditional Software Development Recruit, interview and hire a team of developers Write code Adaptable Biomax Health Informatics No new hires required No need to write code Methods Using a customized Biomax solution, clinical data was semantically integrated and transformed into practical information and insights. Data consisted of 6,000 parameters per COPD patient, which was collected on thousands of patients over six years. Results The resulting patient map confidently identifies parameters for therapy outcome predictions. A better understanding of the disease and effect of treatment was established. Transparency on patient care and resource allocation was achieved. Biomax Health Informatics Long development time of months to years Inflexible to changing requirements and rapid data growth Fully configurable by user within a few weeks or by Biomax as a service Evolving requirements built into the design (reconfigure on-the-fly ); unlimited scalability Costs of patient care through more efficient treatment and management were reduced. Therapeutic outcomes Requires large project groups as domain experts along with local IT expertise Results (hence success) become visible only at the end of a (long) project Download and configure life science data repositories Uncertain outcome Long-term maintenance costs may increase significantly over the course of a project Solution building process driven by lean teams or domain experts; does not require local IT expertise Fast turnaround times with first results becoming available immediately Life science data repositories included and pre-configured Proven technology and guaranteed outcome Proven low maintenance cost over time and high ROI COPD is a huge and growing burden for public health worldwide.in Europe, an annual cost of treatment of approximately 20 billion euros. The CIRO+ Data Center allows for the first time a better understanding of patient outcome based on systematic pre- and post-assessment data of more than 3,000 patients over the past 6 years with up to 6,000 clinical data points captured for each patient. Patient stratification Prof. Wouters, Chairman Board of Directors, CIRO+

4 BioXM Knowledge Management Ready-to-go software platform provides fast and flexible solution building BioXM Knowledge Management A graphical representation Step 1: Design the data model Biomax Health Informatics solutions are built using the BioXM Knowledge Management Environment. This ready-to-go software platform transforms complex and diverse data into usable information and knowledge by allowing practitioners and business analysts to address specific questions without cost-intensive and timeconsuming programming projects. Flexible BioXM technology drives knowledge management toward your specific needs such as: Expand knowledge semantically integrate any data from any source seamlessly Step 3: Query and refine results Refine decision making connect the dots explaining biomedical systems Diverse data Create new hypotheses visualize novel relationships between data networks Applications using the BioXM platform with virtually limitless possibilities Keep repositories of scientific data such as experimental results, a corporate gene index, a phenotype catalog, a patient register or a compound database. Step 2: Import the specific information Keep track of ongoing projects with one click to generate table reports and overview graphs. Generate networks from multiple sources in one step and find previously undetected links in the data. Identify biomarker candidates based on automated literature analysis and compare the results to experimental results in the same software platform. Connect clinical data and statistical analyses. Organize, review, compare, annotate and modify biological pathways originating from different sources. Classify biological functions using ontologies specific to focused scientific areas. Easily integrate external statistical packages (R, BioConductor), bioinformatics tools, chemoinformatic algorithms, Web services and more. Step 4: Deploy Web apps to end-users See more details about each step by visiting: /agile

5 robert-koch-str planegg germany tel.: fax.: info@biomax.com About Biomax Biomax Informatics AG is a leading provider of customized bioinformatics solutions. The company s flagship product, the BioXM Knowledge Management Environment, is a powerful decision-support tool enabling measurable productivity increases in biomedical R&D and clinical practice. The easy-to-use and highly configurable software allows domain experts, rather than programmers, to create, structure and visualize complex scientific models. The product is supplemented with sequence analysis, data integration, and text-mining software modules and domain-specific biomedical content solutions, for example in oncology. Biomax creates value for clients by eliminating the coding process, slashing the implementation time of complex projects, and helping users to harness the information overload and distill critical insights from data. The Biomax worldwide customer community includes companies and research organizations that are successful in the areas of drug discovery, diagnostics, fine chemicals, food production and plant production. BIOMAX 15 year A N N I V E R S A R Y Biomax and BioXM are registered trademarks of Biomax Informatics AG in Germany and other countries. Viscovery is a registered trademark of Viscovery Software GmbH. Registered names, trademarks, etc., used in this document, even when not specifically marked as such, are not to be considered unprotected by law. PATSTRBRO1304