The Centre of New Pharmaceutical and Health Technologies SANTAKA valley: research orientation towards entrepreneurship promotion

Transcription

1 The Centre of New Pharmaceutical and Health Technologies SANTAKA valley: research orientation towards entrepreneurship promotion

2 HIGHER EDUCATION REFORM IN LITHUANIA The integration of Education and Research Institutions Research orientation towards international quality Competitive research funding Strengthening of the links between research and business

3 STRUCTURE Faculty of Medicine Faculty of Odontology Institute of Cardiology Institute of Endocrinology Faculty of Veterinary Veterinary institute Faculty of Pharmacy Institute of Behavioral Medicine Faculty of Animal Husbandry Technology Institute of Animal Science Faculty of Nursing Faculty of Public Health Institute of Neurosciences Small Animal Clinic of Dr. L.Kriaučeliūnas Large Animal Clinic

4 FUNCTIONING MECHANISMS OF LIVING TISSUES Influence of lifestyle and environmental factors to health Cardiology Endocrinology Pulmonology and immunology Comparative anatomy of cardiac neural plexus Research of influence of cardiac neural plexus for the discovery and treatment arrhythmias Development of regeneration modules of cardiac structures Research of physiological physical properties Morphology Immunology Epidemiology Reproduction NUTRITION AND BIOTECHNOLOGY PUBLIC HEALTH SCIENCES Oncology Gastroenterology Neuroscience An experimental model of colitis and its relationship with intestinal inflammatory diseases Livestock welfare Zoohygiene and ecology Pharmacology Rehabilitation and nursing Research of structural tissue remodeling Livestock breading and genetics CLINICAL RESEARCH Emergency medicine The health oh woman and child Ophthalmology Oral and maxillofacial pathology Infectology Elaboration of novel medications and search for their market Effects of Gingko biloba extract on rat heart function Development of model of intracranial hypertension Development of functional products for improvement of organism system activities Feedstuff and nutrition Communicable diseases Noncommunicable diseases Feedstuff quality and nutrition protection Development of functional products LIVESTOCK WELLNESS AND FEEDSTOCK QUALITY

5 Average Citations per Item : 2.82 h-index : 22 Research orientation towards international quality Biomedical Sciences Published Items of ISI WOS Citations in Each Year Sum of the Times Cited : 2539 Sum of Times Cited without self-citations : 2281

6 COMPETITIVE RESEARCH FUNDING LUHS international research projects and research projects supported by Research Council of Lithuania (RCL), in Group of projects 6FP 7FP COST EUREKA Others RCL Total Number of projects

7 NUMBER OF PhD STUDENTS IN LITHUANIAN UNIVERSITY OF HEALTH SCIENCES Code Area of Science Number of PhD Students B Biology 20 02B Biophysics 3 06B Medicine B Odontology 17 08B Pharmacy 17 09B Public Health 32 10B Nursing 22 02A Veterinary medicine 36 03A Zootechnics 22 Total 284

8 Strengthening the links between research and business Establishment of the Centre of Innovation and Business between Kaunas University of Technology, LEI and Lithuanian University of Health Sciences Open access Centres of the Valleys The development of applied research

9 Integrated Science, Studies and Business Centre (valley) of SANTAKA Medical Academy, LUHS 15.3 million Kaunas University of Technology 9.8 million building sector 5.5 million scientific equipment 34.5 million Lithuanian Energy Institute 6.5 million Financed by EU structural funds

10 The main task of the Santaka RPHTC: To create the development of science and business cooperation in the pharmaceutical and health technologies sectors. This objective contributes to the Integrated Science, Studies and Business Center (Valley) Santaka objective establishing a valley in the area of private and public research, creation of knowledge intensive firms and the provision of knowledge-intensive services.

11 The Centre of new pharmaceutical and health technologies SANTAKOS valley 2010 February 2011 October 2010 August 2012 September

12 CONSTRUCTION STAGES VS VISUALIZATION The Centre of new pharmaceutical and health technologies SANTAKOS valley LABORATORY COMPLEX

13 CONSTRUCTION STAGES VS VISUALIZATION Establishment of the Centre of new pharmaceutical and health technologies SANTAKA valley AUDITORIUM COMPLEX

14 Structure of the Center of New Pharmaceutical and Health Technologies SANTAKA LABORATORIES 1. Laboratory of Fitopharmacy; 2. Laboratory of Preclinical drug investigation; 3. Laboratory of Medical target histopathological research; 4. Laboratory of Drug metabolism and pharmacological regulation of pathological processes; 5. Laboratory of Pharmaceutical technologies; DEPARTMENTS 6. Department of Pharmaceutical Technology Social Pharmacy; 7. Department of Clinical Pharmacy; 8. Department of Pharmacognosy 9. Department of Pharmaceutical Chemistry 10. Department of Analytical and Toxicological Chemistry

15 The Advanced Pharmaceutical and Health Technology Center 1. Investigation of natural biologically active compounds and phytodrugs 2. Tissue engineering tissue engineering of heart valves and cartilage 3. Preclinical study of drugs 4. Investigation of pharmaceutical targets in tissues, personalized medicine 5. Investigation of proteins and peptids: technologies for extraction, purification 6. Pharmaceutical technologies: investigation of drug carriers 7. Synthesis and analysis of biologically active compounds

16 Joint projects of Faculty of Pharmacy and Ltd companies in 2012 Aconitum Ltd development and validation of methods for quantitative analysis of drug substances of herbal origin Biok laboratorija Ltd research and evaluation of UV-filter characteristics of excipients in skin care products Medicata Ltd qualitative and quantitative characterization of bee venom, development of products containing bee venom and biopharmaceutical evaluation Orivas Ltd analysis and assessment of scientific/technical documentation of pharmaceutical preparations

17 Pharmaceutical company Aconitum Ltd Cooperation in the area of optimization of analytical methods for quality assessment of new products Quality of pharmaceutical preparations confirms emphasis on patient safety Modern analytical methods are highly specific thus are accepted as objectives for science based pharmaceutics

18 GINKOBIL 80 mg Cooperation achievements: Modern stability indicating high performace liquid chromatography (HPLC) analytical procedure introduced for qualitative and quantitative determiantion of terpenolactones High performace liquid chromatography method introduced for determination of flavonoid solubility and stability Also quality control methods introduced for the following products: VENOSAN BILBERIN LIVOSIL

19 Cosmetic products company Biok laboratorija Ltd Cooperation to develop product technologies and quality control methods: Development of optimal semisolid formulation, containing substances of natural origin Quality evaluation of product experimental batches applying modern analytical approaches

20 Development of skin protection products and efficacy assessment Evaluation of protective characteristics of natural origin substances: Search and evaluation of UV filters Research of protection mechanisms of natural origin substances Quality evaluation of experimental formulations

21 Manufacturer of pharmaceuticals and food supplements Medicata Filia Ltd Research of bee vital activity products: Qualitative and quantitative characterization of propolis Formulation and quality evaluation of propolis containing products Efficacy testing of propolis containing preparations in vitro

22 Manufacturer of pharmaceuticals and food supplements Medicata Filia Ltd Bee venom possibilities for new product development: Qualitative and quantitative characterization of bee venom Development and evaluation of products containing bee venom Biopharmaceutical evaluation of experimental formulations containing bee venom

23 Pharmaceutical company Orivas Ltd Expert analysis and assessment of scientific and technical information of pharmaceutical preparations: Participation in development of new and innovative products Expertise of registration documentation Scientific and professional consultations

24 LABORATORY OF PRECLINICAL DRUG EXAMINATION Preclinical testing of new compounds Optinis mepingas C2-60-AD C2-60-VD 15 Cellular electrophysiology Tissue engineering

25 Laboratory of Preclinical Drug Examination (Research themes) Service for drug examination, target identification and toxicity testing on: Ionotropic receptors, such as Ca2+, Na+, K+, Cl- and other ion channels in isolated cardiac myocytes, cultured neurons and cell lines; Metabotropic, ion channel related receptors, such as adrenergic, muscarinic, glutamatergic and other receptors, in acutely isolated cells, cell cultures and smooth and cardiac muscle preparations; Intercellular homotypic and heterotypic gap junctions channels formed of various connexins expressed in HeLa cells, stem cells, cardiac myocytes and cultured neurons; Experimental animal, Langendorf-perfused heart and cardiac muscle preparation in control and experimentally induced pathological conditions.

26 current (pa) current (pa) INVESTIGATION OF PHARMACEUTICAL TARGETS IN TISSUES, PERSONALIZED MEDICINE 2000 ext 0.9Mg, 1.8Ca Mg, 1.8Ca TRPM7 current difference current potential (mv) potential (mv) Patch-clamp recording system for the TRPM7 current registration in the isolated heart cells TRP; Laboratory of Membrane biophysics

27 PERSONALISED MEDICINE Treatment of inflammatory bowel diseases with Azathioprine (AZA) Treatment with antiaggregants and anticoagulants

28 Regression model for warfarin dosage during initiation (A) and during long-term treatment (B) (A) R 2 for the model 4 th step, R 2 =0.386 Variable B p Constant < (B) R 2 for the model 4 th step,r 2 =0.508 Variable B p Age (years) < Constant < Weight (kg) < Age (years) < Serum creatinine level (μmol/l) INR Amiodarone Ambroxol β 2 agonists Spironolaktone CYP2C9* < CYP2C9* < VKORC1 (G 1639A) A < CYP4F2 A1347A < Weight (kg) TTH FT INR Amiodarone Ca channel blockers CYP2C9* CYP2C9* < VKORC1 (G 1639A) A < VKORC1 (G3730A)* The influence of CYP2C19 G681A genotype on antiplatelet effect of clopidogrel in patients` treated for 2 weeks with clopidogrel Genotype n % Platelet aggregation after induction with ADP mean±sd (% agr ) CYP2C19 *1/* ±15.67 CYP2C19 *1/* ±24.05 CYP2C19 *2/* The total: ±19.71

29 AUTOMATIC DETECTION OF VOICE PATHOLOGY EARLY DIAGNOSTICS- SUCCESSFUL TREATMENT

30 AUTOMATIC DETECTION OF PATHOLOGICAL VOICES A major goal in this project is to create a tool which will allow automatic detection of a pathological voice. The ultimate expected benefit of the project is improvement of screening and early diagnostics of laryngeal diseases (including laryngeal carcinoma) and better treatment and recovery results. Elaborated tool for automatic voice pathology detection and screening of laryngeal diseases should have a world wide commercial potential. Partners: Department of Electrical and Control Equipment, Kaunas University of Technology, Kaunas, Lithuania; Intelligent Systems Laboratory, Halmstad University, Halmstad, Sweden

31 Joint applied research projects with Kaunas University of Technology No. Project title LUHS department Funding (thousand Lt.) 1 Application of transcranial ultrasound in diagnosis of neurodegenerative diseases Dept. Neurology 323,80 2 Pathological voice Dept. Ear, nose and throat diseases 3 "Eureka" E! 4452 EDFAS " Assessment system of distributed intelligence functional status for the elderly and disabled" Dept. Geriatrics 250,00 4 ITEA2 GUARANTEE Guardian angel for the extended home environment ITEA Dept. Geriatrics 250,00 5 Non-invasive expert system for the diagnosis of intraocular tumors IN Lab. Ophtalmology 6 Eurostars E!4846 SKINMONITOR " Diagnosis of skin cancer using information and communication technologies " Dept. Skin and Venerology diseases 515,20 7 Animal nutrition and development of the technology for improved biological value of meat, milk and eggs Institute of Animal sciences 146,08 8 Clinical and physical aspects of brachytherapy of head and neck tumors Dept. Oncology 63 9 Hybrids of garden plants - a new source of anthocyanins IN Lab. Biochemistry 892,7

32 Thank you for your attention