Accelerating Fish Growth

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1 Accelerating Fish Growth Nissim Chen Ph.D., M.B.A., Founder & CEO September

2 Legal Disclaimer IMPORTANT NOTICE This presentation has been prepared by AquiNovo Ltd. (the Company ) solely for informational purposes. The information contained herein has been prepared to assist prospective investors in making their own evaluation of the Company and does not purport to be complete or to contain all of the information a prospective or existing investor may desire. In all cases, interested parties should conduct their own investigation and analysis of the Company and the data set forth in this information. The Company has prepared this presentation based on information available to it, including information derived from public sources that have not been independently verified. The Company makes no representation or warranty as to the accuracy or completeness of this information and shall not have any liability for any representations (expressed or implied) regarding information contained in, or for any errors omissions in, this presentation. This presentation includes certain statements and estimates provided by the Company with respect to the projected future performance of the Company. Such statements, estimates and projections reflect various assumptions by management concerning possible anticipated results, which assumptions may or may not be correct. No representations are made as to the accuracy of such statements, estimates or projections. This presentation may contain statements that are not historical facts, referred to as forward looking statements. The Company s actual future results may differ materially from those suggested by such statements. No assurance can be given that future events will occur or that projections will be achieved. Past performance is not a reliable indication of future performance. This presentation is not, and nothing in it should be construed as, an offer, invitation or recommendation in respect of the Company s securities, or an offer to sell, or a solicitation of an offer to buy, the Company s securities in any jurisdiction. Neither this presentation nor anything in it shall form the basis of any contract or commitment. Prospective investors should not construe the contents of this presentation as business, legal, tax, investment or other advice. Each prospective investor should make his, her or its own inquiries and consult his, her or its own advisors as to the appropriateness and desirability of an investment in the Company and as to business, legal, tax and related matters concerning an investment in the Company. An investment in the Company shall be allowed only to such number and category of investors in accordance with applicable laws and regulations and pursuant to a predetermined process. Accordingly, detailed information in connection with the investment shall be revealed and delivered only to a limited number of qualifying investors as provided by law. 2

3 The Company Established in October 2015; portfolio company of The Trendlines Group Seed funding from the Trendlines Group, including direct investment, government grant and in-kind support 25 m 2 fish lab for fish growth experiments located in Rehovot, Israel Broodstock tanks Nursery tanks Growth tanks 3

4 The Need and AquiNovo s Solution Aquaculture production is rapidly expanding as marine sources are being depleted and fish consumption increases AquiNovo s technology provides a non-gmo, non-hormonal, easy-to-use solution for accelerating fish growth AquiNovo s products will increase farm revenues by shortening time to market and increasing fish yield with same infrastructure 4

5 AquiNovo s Technology Proprietary short peptides Bind key reproductive hormone receptor Inhibits sexual maturation 5 Administered via feed Control AquiNovo material

6 The Opportunity Relevant biological systems exist in most fin fish; a market potential of over 50 million tonne (2014 market) Estimated addressable market potential for first two products ranges from US$180 million in 1 st year of sales to around US$400 million in 4 th year of sales Carp 28 M Tilapia 5.3 M Catfish 3.9 M 1st Product 8.5 million metric tons projected at year of launch Salmonids Marine 3.4 M 2.4 M 2nd Product 6.4 million metric tons projected at year of launch 6

7 Go To Market AquiNovo will manufacture and sell its materials to fish feed producers for incorporation into feeds; end-users - hatcheries and fish farms First two products will be developed with strategic partners Launch of tilapia product projected to 3 years after investment Launch of salmon product ~4 years after investment 7

8 IP & Regulatory Composition of matter and method claims Patent applications filed in national phase in target markets Very positive international search report Initial discussions with regulatory authorities suggest feed additive status 8

9 Risk Mitigation Starts Early in the Development Process Main Risks Regulatory designation Safety for humans Mitigation Method and Timing Initial regulatory mapping in Israel, China and Norway suggest potential for feed additive status. Initial experiments show fast disappearance of peptide in fish blood. Additional studies of peptide stability in fish organs and metabolite profile are planned. Accordingly, feeding period with peptide will be set to ensure zero peptide amount in fish prior to harvest and eliminate concern for human safety. Commercial-scale production Development of commercial scale production process (Liquid Phase System) during

10 Round A Funding Tilapia strategic partner Advanced discussions Inclusive of cash investment Raising additional funds Use of proceeds Complete development of tilapia product Enhance development of salmon project 10

11 AquiNovo s Team Nissim Chen; Founder & CEO. Ph.D., MBA. >15 years experience in technology commercialization and international business development in the biotech and ag-bio industries; formerly VP BD at FuturaGene Group, Director BD at Ramot - Tel Aviv University technology transfer company; Ph.D., Hebrew University of Jerusalem; MBA., Tel Aviv University Freddy Shaviv, Head of Production, Expert manager with long proven track record in strategic planning, production and operations in the pharmaceutical and chemical industries. Formerly CEO ChemAgis and Agis Industries. Serve as board member of various biotech firms. MSc Mechanical Engineering, BSc Chemical Engineering Alexander Tsimanis; Senior Chemist. Ph.D. 30 years of leading academic research and senior R&D positions in the biotech industry; vast experience with peptides; Ph.D. chemistry & molecular biology, Latvian Academy of Sciences Nardy Lampl; MolecularBiologist. Ph.D. (Weizmann Institute of Science); over 20 years of molecular biology research in several fields Raanan Katz; Marine Biologist, B.A. (Ruppin Academic Center) experience in fish farming 11

12 Inventors & Expert Advisors Prof. Berta Levavi-Sivan Inventor & Senior Advisor, Fish Reproduction Professor at Hebrew University. A world renowned specialist of aquaculture. B.Sc. in Life Science, M.Sc. Zoology, Ph.D. in Zoology from Tel Aviv University. Research focused on the endocrine axis that leads to fish reproduction, and introduction of new species to Israeli aquaculture. 91 publications and 2 patents. Prof. Chaim Gilon Inventor & Senior Advisor, Peptide Chemistry Professor Emeritus at the Faculty of Science, Hebrew University. A world renowned expert in Organic Chemistry. Co-founder and consultant to several biotech companies. Research focused on molecular mechanism of memory, conversion of bioactive peptides into drugs and signal transduction therapy. 270 peer reviewed publications and 40 patents. 12

13 Thank You AquiNovo: Increasing Aquaculture Yields Contact Dr. Nissim Chen, CEO 13