4.0 PAS-X NEWS PHARMA. DIGITAL. CONNECTED. PHARMA CONTENTS

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1 Dear customers, Recently a biotech manufacturer approached us asking whether we could help them increase productivity. We analyzed their batch tree data and found recurring patterns to better understand yield variations. The results were used to pinpoint critical process phases and identify optimization potential. This is a good example of how our new Enterprise Manufacturing Intelligence (EMI) solutions help reveal previously indecipherable insights into the inner workings of pharmaceutical processes to provide actionable decision-making intelligence. Whether it s EMI, Big Data, Plug & Produce, Smart Devices or Software as a CONTENTS KRKA, SLOVENIA 2 CHUGAI PHARMACEUTICAL, JAPAN 2 B. BRAUN, GERMANY 3 Service, there are various concepts en route to the pharma factory of the future. However, pharma and biotech manufacturers can only gain sustainable competitive advantages if these concepts are well-integrated to ensure seamless data exchange. That s where we come in. Together with the Medipak Systems companies and other partners, we develop integrated solutions for Pharma 4.0. With our manufacturing IT solutions and services based on our PAS-X MES, we support smart networking throughout the entire value chain of pharma production. At this year s User Group Meeting, our customers once again benefit from our PAS-X Classes. These courses have been tremendously well-received, and we have got excellent feedback that they help our customers realizing maximum value from PAS-X. Two awards offer further evidence that we re on the right track. Werum was honored with the Frost & Sullivan Global Technology Leadership Award and, for the second consecutive year, with the Asian Manufacturing Award. We are extremely grateful for the recognition, and offer special thanks to the many customers and partners who continue to be a fundamental part of our success. We look forward to working with you towards Pharma 4.0! Yours sincerely Rüdiger Schlierenkämper CEO Werum IT Solutions GmbH ASTRAZENECA, USA 3 DESITIN ARZNEIMITTEL, GERMANY 4 HERMES ARZNEIMITTEL, GERMANY 4 TRACK & TRACE SERIALIZATION 5 PHARMA. DIGITAL. CONNECTED. ENTERPRISE MANUFACTURING INTELLIGENCE (EMI) 5 PHARMA ENDORSED SERVICE PARTNERS 8 INTERVIEW: NEW DIGITAL SERVICES 9 WERUM ASIA 10 ASIAN MANUFACTURING AWARD AND FROST & SULLIVAN AWARD 11 PAS-X AS A SERVICE PHARMA PHARMA-MANUFACTURING.BLOG 12 Read more on pages 6+7

2 PHARMA. DIGITAL. CONNECTED. KRKA, SLOVENIA ANNIVERSARY: KRKA AND WERUM CELEBRATE 20 YEARS OF SUCCESSFUL COLLABORATION Werum s PAS-X is Krka s standard MES / Implementation in 12 manufacturing sites in different European countries A reason to be proud of: Krka and Werum collaborate to improve the pharmaceutical production at Krka facilities already for 20 years. Krka is a leading international generic pharmaceutical manufacturer with headquarters in Novo mesto, Slovenia. The collaboration started in the 1990s with the first project covering a PAS- X 1.4 system for the tableting plant in Novo mesto. Later on, it was extended with W&D for the plant Notol in Novo mesto. In parallel, the go-live preparations in the fully automated plant Notol-1 began. With the switch to SAP in 2004, PAS-X was migrated to V2 and rolled out in plants outside Slovenia. An important milestone for Krka and Werum was the start of the V3 program with a pilot implementation in 2013 in the Croatian plant. Notol-2 was built and successfully taken into operation in In the next big step, Krka will migrate the Notol-1 plant to V3. Since the PAS-X V1 implementation 20 years ago, PAS-X became our standard MES system and is being used today in about 12 sites in Slovenia, Croatia, Russia, Poland, and Germany, says Sebastijan Kos at Krka, d. d., Novo mesto. We have been able to establish a reliable and personal partnership with Werum, which we value very much. We are very pleased that Krka places their confidence in us, says Hendrik Harms, Project Manager at Werum IT Solutions GmbH. Krka is one of our long-standing customers with a complete MES footprint. With 1,800 users, 850 terminals and 200 connected SCADA systems, Novo mesto represents the largest PAS-X installation worldwide. CHUGAI PHARMACEUTICAL, JAPAN CHUGAI TO DEPLOY WERUM S PAS-X MES FOR BIOPHARMACEUTICAL PRODUCTION IN JAPAN New plant in Tokyo designed for production of cutting-edge biotech APIs / Werum s PAS-X MES chosen for its standard product approach and pre-configured content packages Chugai Pharmaceutical Co., Ltd., a member of the Roche Group, has chosen Werum s PAS-X MES for a greenfield project at their Ukima site in the north of Tokyo. Chugai is one of Japan s leading research-based pharmaceutical companies specialized in prescription drugs with strengths in biotechnology products. The new plant is designed to produce cutting-edge biopharmaceuticals APIs using cell cultivation USP/DSP production processes. Together with its partner in Japan, Chiyoda System Technologies Corporation, Werum will deliver a full-scope PAS-X MES, including standardized level 2 and level 4 interfaces. Customizations will be reduced to an absolute minimum. Chugai opted for PAS-X due to its standard product approach and Werum s experience in the biopharmaceutical industries. After conducting thorough research through reference visits at several pharma companies sites in the US and visiting the PAS-X UGM several times, we are convinced that PAS-X is the best answer to the needs of our new Ukima plant, says a representative of Chugai Pharmaceutical Co., Ltd. In particular the innovative content specifically aiming at biopharmaceutical production processes and developed together with other PAS- X customers was a decisive factor. 2 WERUM

3 B. BRAUN, GERMANY B. BRAUN S FIRST PAS-X V3 PROJECT SUCCESSFULLY IMPLEMENTED Upgrade to PAS-X at plant A in Melsungen / Integration of ERP and DCS / Extension to full-scope MES and roll-out to other German sites planned B. Braun Melsungen AG B. Braun updated their PAS-X system from PAS-X V2 to V3 in plant A at their HQs in Melsungen. B. Braun is one of the world s leading healthcare providers. In plant A, the company produces anesthesia i.e. tranquilizers and hypnotics for all surgical processes. In order to meet the global demand, it was necessary to extend and automate the weighing process. A Fit/Gap analysis showed that many of our required functions are included in the latest PAS-X version, says Mike Werner, Engineer for Control Systems, B. Braun Melsungen AG. As an adjustment of our old system would have resulted in higher costs, the decision for an upgrade to PAS-X was quickly taken. The upgrade is B. Braun s first project. The new version is implemented close-to-standard. PAS-X is fully integrated with SAP ERP on Level 4 and with Simatic Batch DCS on Level 2. For the future, B. Braun plans to extend their PAS-X system to a functionally complete MES and to roll-out to further sites in Melsungen and Berlin. ASTRAZENECA, USA ASTRAZENECA SUCCESSFULLY DIGITIZES MANUFAC- TURING PROCESSES WITH GLOBAL STANDARD MES CORE SYSTEM Deployment of AZ s standard MES on the basis of Werum s PAS-X / Single software version for all sites / Standardized business processes and enhanced data integrity The leading biopharmaceutical manufacturer AstraZeneca had a diversified MES landscape: from paper-based execution to various legacy systems. In order to harmonize, the company opted for Werum as its preferred MES supplier. We conducted a feasibility study with the conclusion that PAS-X was the best fit for our requirements, says Rod Hoffman, Senior Manufacturing Business Analyst, AstraZeneca. But without central coordination and a core program, our deployments were not standardized from an IT or business process perspective. The goal is to use a common technology platform alongside guidelines to help drive standardization across the network. AZ aims at a single software version in all manufacturing sites, reducing development effort, rollout times and maintenance costs. The PAS-X system from the Mount Vernon plant served as a template to leverage the ERP interface to the North American SAP instance. After the successful first standard MES core go-live in Mount Vernon the go-lives of Frederick and Newark soon followed. WERUM 3

4 PHARMA. DIGITAL. CONNECTED. DESITIN, GERMANY LEADING PRODUCER OF ANTI-EPILEPTICS INTRODUCES PAS-X TRACK & TRACE Fast implementation out of the box at Desitin s plant in Hamburg, Germany / Regional and mid-sized pharma manufacturer benefits from comprehensive product-based functionality Desitin Arzneimittel implements Werum s PAS-X Track & Trace as level 3 solution at its plant in Hamburg, Germany. The company is a regional, mid-sized pharmaceutical manufacturer with leading positions in the treatment of neurological and psychiatric illnesses especially epilepsy and Parkinson s syndrome. Desitin required a lean, powerful and easy to implement track-and-trace solution to comply with the anti-counterfeiting requirements of its various international target markets. These include all EU countries. We opted for Werum s PAS-X Track & Trace solution as the connector between the shop floor and the serialization level because it meets all of our requirements, says D. Weniger, Head of Process Department and Project Lead of FMD Project, Desitin Arzneimittel GmbH. It is a proven serialization and aggregation solution that is already used successfully by many pharma and biotech manufacturers around the globe. Werum s PAS-X Track & Trace solution is installed out of the box thus ensuring a short implementation time and safeguarding future upgrades. Initially the system covers two packaging lines and will be extended in It integrates the SAP ERP and SAP ATTP at level 4 with the OCS at the shop floor level. HERMES ARZNEIMITTEL, GERMANY EUROPE S LARGEST MANUFACTURER OF EFFERVESCENT TABLETS OPTS FOR WERUM S PAS-X Werum s combined software and pharma expertise as decisive factor / Implementation of PAS-X Track & Trace in plants in Germany and Austria The pharma company Hermes Arzneimittel has opted for Werum s PAS-X. At its production sites in Wolfratshausen, Germany, and Wolfsberg, Austria, the company will initially implement PAS-X Track & Trace in packaging. Hermes Arzneimittel a leading, mediumsized pharma company is Europe s largest manufacturer of effervescent tablets and other OTC products. In addition to their own products, Hermes Arzneimittel manufactures on behalf of other pharma companies. As contract manufacturer, the company has to fulfill not only strict requirements of regulatory authorities, but also the requirements of its pharma customers. This includes connecting to different level 4 customer systems to exchange serial numbers. PAS-X Track & Trace will serve as central platform for the flexible integration of level 4 customer systems. Werum s software covers the labeling requirements of all target countries and offers comprehensive product-based functionality out of the box. In search of a strong supplier, we soon came across Werum, says Frank Hemmers, Head of IT, Hermes Arzneimittel GmbH. It s software and pharma expertise convinced us a combination that cannot be taken for granted in the Track & Trace area. 4 WERUM

5 TRACK & TRACE SERIALIZATION BENEFITS OF MES SYSTEMS AS LEVEL 3 TRACK & TRACE SOLUTIONS According to the ANSI/ISA S95 standard, an efficient Track & Trace solution should integrate level 4 with the packaging equipment and line controllers on shop floor level 2 via standard interfaces. Level 4 comprises the ERP for the administration of material master data as well as the Central Repository which is typically responsible for the generation and randomization of serial numbers. In some scenarios no level 4 repository might be required, so that the level 3 Track & Trace solution should also be able to generate serial numbers and act as a long term archive for these numbers at least at site level. To benefit from the advantages of comprehensive production control and documentation including equipment management the Track & Trace solution can also be directly integrated into an MES on level 3. The serialization solution should be integrated into an MES to benefit from the advantages of comprehensive production control and documentation. Jürgen Laskowski, Director Track & Trace, Werum IT Solutions GmbH LEVEL 4 LEVEL 0-2 LEVEL 3 ERP System MES Solution Track & Trace Solution Line Controller & Packaging Equipment Central Repository Level 3: Benefits of a Track & Trace and MES integration Seamless integration of Electronic Batch Records (EBR) and serialization order Batch Record Reports (BRR) include serialization data Only one graphical user interface for the operator Fully automated stock creation Central maintenance of material master data ENTERPRISE MANUFACTURING INTELLIGENCE (EMI) NEW: WERUM S EMI SOLUTIONS Start gaining a deeper understanding of your manufacturing processes With the use of Werum s EMI solutions, production data in pharma and biotech facilities will be leveraged to support better decision-making and to gain deeper insights. Data from a variety of sources will be accessed and evaluated using state-of-the-art algorithms and visualizations. Intelligent data analysis of your manufacturing facility allows a wide range of applications from simple reports to investigative analyses and even real-time process interaction. The benefits The management can make sound decisions, the process stability and efficiency will be improved, and consequently the product quality and productivity will be increased. Improved product quality and productivity Processes can be monitored / adjusted almost in real-time Qualitative assessments for ongoing process auditing Reduced costs for creating standard reports and faster A facility is a treasure chest full of data. Our EMI solutions give you the key to it. Dirk Heche, Senior Head of Business Development EMI, Werum IT Solutions GmbH troubleshooting (e.g. root cause analysis) WERUM 5

6 4.0 PHARMA PHARMA 4.0 SHAPING THE FUTURE WITH PAS-X MES Together with partners, Werum is working on pharma manufacturing of the future Systems, equipment, and personnel have become increasingly interconnected in the digital economy, offering new opportunities for the pharma and biotech industries. Together with our fellow Medipak Systems companies and other partners, including key organizations within ISPE, Werum IT Solutions is shaping the pharma manufacturing concepts of the future. We provide innovative solutions that apply groundbreaking Pharma 4.0 technologies into pharmaceutical and biotech production environments. To achieve this, we combine our process and software expertise with our partners machine and plant operations know-how. The goal is clear: generate sustainable competitive advantages for you, our customers in the pharma and biotech industries. Start your digital transformation today! Pharma 4.0 solutions: Plug & Produce Vertical integration our standardized interfaces between MES, automation and control systems is a fundamental prerequisite for implementing various Pharma 4.0 solutions. Enterprise Manufacturing Intelligence (EMI) We translate your production data into usable information for decision-making and improved processes. Werum s manufacturing IT solutions for pharmaceutical and biopharmaceutical manufacturers are the basis to continuously improve production performance and pave the way for the Industrial Internet of Things. Smart Devices We connect intelligent, mobile, and networked equipment making available the right information at the right time and place. Tonya M. Fowler Director of Americas, Europe, and Africa Best Practices, Frost & Sullivan 6 WERUM

7 ENABLING PHARMA 4.0 WERUM S NEW VENDOR-INDEPENDENT PLUG & PRODUCE SOLUTION SIMPLIFIES EQUIPMENT INTEGRATION IN PHARMA PRODUCTION Simple integration of equipment into the production network / New standardized message-based interface / Reduced integration workload of up to 75% Vertical integration is a prerequisite for the implementation of many Industrie 4.0 solutions. To enable a fully connected pharma production, Werum offers a new Plug & Produce solution on the basis of PAS-X. Message-based interface Werum s new Plug & Produce solution allows a fast and easy integration of machines and automation systems into a pharmaceutical production environment previously a highly complex and timeconsuming task. This is possible because the machine on the shop floor and our PAS-X MES communicate directly via Werum s new standardized messagedbased interface, explains Klaus Sauermann, Senior Head of Business Development at Werum IT Solutions GmbH. Our Plug & Produce concept ensures that PAS-X and a new machine or automation system speak the same language. Open vendor-independent interface What makes Werum s Plug & Produce solution unique is that it is an open, completely vendor-independent solution: Pharmaceutical manufacturers can use it with any smart equipment such as filter integrity testers and analytical test devices as well as with DCS or SCADA systems. Together with partners, vendors, pharma companies and organizations like ISPE, Werum is collaborating to establish a message-based interface as an open industry standard, which will be included in Werum s PAS-X MES software. Reduced integration workload Drug manufacturers benefit from a significantly lower engineering, configuration and qualification workload. The installation is less prone to errors and project run times are highly reduced. Compared to before, the workload for integrating a new machine into the production environment can be cut by up to 75 percent, says Klaus Sauermann. In other words, the workload will be merely a quarter of what it used to be! Pilot implementation at GE Healthcare GE Healthcare is among the first customers who will implement Werum s Plug & Produce solution. At their manufacturing site in Uppsala, Sweden, the life science company will use the new approach to integrate the automation and equipment level to Werum s PAS-X MES for the production of a chromatography medium. The machine and PAS-X communicate directly via our new standardized messaged-based interface significantly reducing integration workload. Klaus Sauermann, Senior Head of Business Development, Werum IT Solutions GmbH Watch our video and learn more about the smart way to connect a new machine to the production network of your pharma factory! WERUM 7

8 PHARMA. DIGITAL. CONNECTED. MES IMPLEMENTATION SUPPORT IN EUROPE AND USA ÅF INDUSTRY, EIS AND ON/OFF CERTIFIED AS NEW PAS-X ENDORSED SERVICE PARTNER New partnership agreements signed / Pharma and biotech manufacturers in Europe and USA benefit from additional local PAS-X MES expertise during on-site implementation Werum IT Solutions further expands its PAS-X Service Partner network in Europe and America. The world s leading supplier of manufacturing execution systems (MES) signed partnership agreements with leading engineering and consulting companies. As certified PAS-X Endorsed Service Partners, ÅF Industry and the on/off Group will support Werum customers during the on-site-implementation of Werum s PAS-X MES in Europe. EIS will deliver support in Europe and the US. The new PAS-X Endorsed Service Partners will e.g. provide resources for MBR design, system configuration, installation, and the integration of automation systems and equipment. PAS-X Endorsed Service Partners meet all requirements of Werum s PAS-X Service Partner Program. The main objective is to offer the same quality and competence of services to Werum customers all over the world through reliable, experienced and certified partners. The Service Partners need to have comprehensive PAS-X knowledge, participate at PAS-X trainings on a regular basis, possess experience in the regulated industry and use a quality management system. The certification has to be renewed on a regular basis. MES IMPLEMENTATION SUPPORT IN CHINA NEOTRIDENT CERTIFIED AS PAS-X ENDORSED SERVICE PARTNER LOCAL Werum IT Solutions and Chinese-based Neotrident sign partnership in China / Customers benefit from additional resources during PAS-X MES implementation Good news for pharma and biotech manufacturers in China: Werum IT Solutions further expands its PAS-X Service Partner network. The world s leading supplier of manufacturing execution systems (MES) signed a partnership agreement with Neotrident. Based in Beijing with several local offices in China, Neotrident is a leading IT solutions provider to the Chinese life science industry. As a certified PAS-X Endorsed Service Partner Local, Neotrident will support Werum customers in the People s Republic of China during the on-site implementation of Werum s PAS-X MES. For instance, Neotrident will provide resources for project management, MBR design, system configuration, installation, training and the integration of automation and equipment. We selected Neotrident among many candidates based on long-time experience in the life sciences industry and because of their complementary capabilities in terms of ISA-Level 3 systems says Olivier Néron, Senior Vice President China Operations at Werum IT Solutions. Lingxiao Cao, CEO of Neotrident: Neotridents s long experience in offering IT solutions to the pharmaceutical market makes us a stable and reliable partner for Werum and its customers during the implementation of PAS-X MES. With our deep understanding of the daily operations in the industry we can perform the transition from a paper-based to a digital-based quality control system more efficiently and in high quality. 8 WERUM

9 INTERVIEW NEW DIGITAL SERVICES FOR WERUM CUSTOMERS Interview with Torsten Isenberg, Senior Director Services, and Jürgen Geidies, Director Head of Services at Werum IT Solutions Werum has developed new digital services for its customers. What s the objective? Torsten Isenberg: We want to provide best possible support to our customers as they move toward the fully networked and smart pharmaceutical production, known as Pharma 4.0. For this, we are developing new digital services with two overarching goals. First, these services aim to simplify even further the processes between us and our customers. Second, the innovative digital PAS-X services help optimize our customers production processes. Can you name a few examples? Jürgen Geidies: Yes. We have, for example, improved our Incident Management System. Here, the user interface has been redesigned and the processing of tickets has been optimized. We have expanded the search function and, moving forward, also will offer an FAQ section to our customers. We will launch a web-based selfservice portal for our customers and partners offering product information, databases, troubleshooting, and downloads of software and documents. Jürgen Geidies, Director Head of Services, Werum IT Solutions GmbH Is it also possible to connect Werum s Incident Management System to the customer s system? Jürgen Geidies: Yes, that is also possible. For this, we provide a universal interface that customers can use to integrate our Incident Management System into their systems. Thanks to the process digitization, data can be easily and transparently exchanged between a customer s service desk and our system. What further innovations are planned? Torsten Isenberg: As part of the next phase, we will be introducing a web-based self-service portal providing, for example, current product information, databases for knowhow and configuration management, troubleshooting, and a download area for software and documents. The self-service features will be complemented by numerous contact options, such as chat and callback services. The portal will offer customized content not only to customers, but also to service and sales partners, PFU members and UGM participants. The networked factory is not limited to networking equipment personal relationships to the people at our customers are very important to us. Torsten Isenberg, Senior Director Services, Werum IT Solutions GmbH Can you tell us more about new PAS-X services? Jürgen Geidies: Our customers can, for example, use our new service for preventive maintenance of their PAS-X systems. Our PAS-X monitoring tool offers complete monitoring of the PAS-X system s stability and performance in real time. It combines well-placed sensors with powerful functions that process incoming data streams into actionable information. PAS-X Monitoring recommends necessary maintenance work before MES performance decreases preempting performance drop-off. This ensures PAS-X system efficiency while simultaneously relieving pressure on personnel. What is Werum s vision for the future? Torsten Isenberg: Together with our customers, we want to realize the pharma factory of the future. As far as the networked factory is concerned, this is by no means limited to networking equipment. Personal relationships and the connection to the people at our customers are very important to us. Join in! Get in touch with us online, by telephone or at one of our events. WERUM 9

10 PHARMA. DIGITAL. CONNECTED. WERUM ASIA WERUM INDIA SUPPORT CENTRE OF EXCELLENCE (WISE) Cooperation with Werum s Indian lead partner Sarla Technologies / Operational base within India to meet the expectations from the Indian market Werum IT Solutions completes the setup of the Werum India Support Centre of Excellence (WISE). WISE is a formation together with our lead partner Sarla Technologies to provide an operational base within India. A joint team of both Werum and Sarla resources meets the large demand and expectations from the Indian market. From our base in Mumbai we are very excited and active to further build up our local presence to the benefit of our existing and new clients: Werum is very focused to be part of Make in India! with a large team also based in India. Benefits Own Werum India key experts for project management, application architects and engineers (pre-duringpost deployment) Partner networked, experienced and qualified resources Already setup physical locations in Mumbai and Bangalore Strong integration with client side teams and efforts, directly plugged into Werum s global resources Managed completely under a single point of contact to Werum, no delegation of responsibility Able to provide both core PAS-X services and non-core MES services such as client side PM, infrastructure and hardware, CSV, L2 and L4 integration works WERUM ASIA LOCAL MES TEAM IN INDIA STRENGHTENED WITH NEW COUNTRY MANAGER Rajesh Vedak appointed as India Country Manager at Werum IT Solutions Ltd., Thailand / Werum customers benefit from local pharma industry expertise Werum strengthens its MES team in Asia by bringing in a new experienced pharma industry expert: Rajesh Vedak supports pharmaceutical and biopharmaceutical manufacturers in the region from Werum s Asia hub location as India Country Manager. Supported by the team at Werum s Asia Pacific HQs in Bangkok, Thailand, he will ensure a close connection to local customers delivering unrivaled customer satisfaction through Werum s best-in-class MES solutions. With our new County Manager who is located in the same region as the facilities of our customers, we will be able to offer our PAS-X MES product and implementation services in India even faster and more efficiently, says Lars Hornung, Senior Director Global Sales, Werum IT Solutions GmbH. With Rajesh Vedak we were able to recruit a local expert with almost 20 years of pharma industry experience, adds David Margetts, Managing Director, Werum IT Solutions Ltd., Thailand. This will enable us to serve our customers in India even better than in the past. Rajesh Vedak worked in different sales, business management and development positions at Rockwell Automation and at Merck Millipore. Most recently, he worked as Sales Lead Life Sciences in the Indian market. 10 WERUM

11 AWARDS WERUM IT SOLUTIONS HONORED WITH AWARDS FOR TECHNOLOGY LEADERSHIP AND BEST PHARMA SOLUTIONS Awards recognize Werum s best-in-class Manufacturing IT solutions Werum is very proud to have won several prestigious awards in 2017 again. We thank our clients and partners who are the fundamental part of our success and helped make these great achievements happen. Frost & Sullivan Global Technology Leadership Award 2017 Based on its analysis of the industrial automation solutions market for the pharmaceutical and biotechnology sectors, Frost & Sullivan recognizes Werum IT Solutions with the 2017 Global Technology Leadership Award. As the most functional, comprehensive MES on the 2017 GLOBAL INDUSTRIAL AUTOMATION SOLUTIONS FOR PHARMA & BIOTECH TECHNOLOGY LEADERSHIP AWARD market, Werum s PAS-X enhances the operational efficiency of pharmaceutical and biotechnology manufacturers businesses, increases their productivity, and aids in regulatory compliance. For its focus on leveraging technology to drive customer value, we are pleased to present Werum with the Global Technology Leadership Award. Tonya M. Fowler, Director of Americas, Europe, and Africa, Best Practices, Frost & Sullivan Asian Manufacturing Award Best Pharma Solutions Provider 2017 For the second time after 2016, Werum IT Solutions has been presented the Asian Manufacturing Award in the Best Pharma Solutions Provider category. With this award, the jury of experts honors the technological development, product innovation and expert service of Werum s Manufacturing IT solutions in the pharma and biotech industry across Asia. To receive the AMA award again from our customers is a fantastic achievement reward for our entire team. We would like to thank all of our customers, partners and employees for their valued contributions. David Margetts, Managing Director, Werum IT Solutions Ltd., Thailand David Margetts, Managing Director at Werum IT Solutions Ltd., Thailand, says: During the last year, we have steadily strengthened our MES hub in Asia with new local offices and teams. To receive the AMA award again from our customers is a fantastic achievement reward for our entire team and headquarters. We would like to thank all of our customers, partners and employees for their valued contributions this award further motivates us towards even greater success. With its flagship product PAS-X, Werum is the world s leading supplier of MES and manufacturing IT solutions dedicated to the pharmaceutical and biopharmaceutical industries, says Tonya M. Fowler, Director of Americas, Europe, and Africa, Best Practices, Frost & Sullivan. The company supports enterprise manufacturing intelligence, an advanced integration of the automation layer, and superior interfacing technologies, in line with the Industrial Internet of Things and Industrie 4.0 trends. WERUM 11

12 NEW: WERUM S PAS-X AS A SERVICE Start the digitization of your manufacturing facility with a small solution and scale up easily as your business grows Do you have a pharma or biotech facility which would benefit from digitized manufacturing processes to ensure regulatory compliance, increase manufacturing performance and leverage technology for innovation but you do not have an MES system yet? PAS-X as a Service is the easiest and fastest way to benefit from the best MES avai lable Benjamin Pieritz, Senior Vice President Operations, Werum IT Solutions America, Inc. Maybe you have no high-grade IT infrastructure in place or you are just starting the commercialization of your products and cannot justify Capital Expansion to your board. You do not want to burden yourself with hiring, training and maintaining personnel that takes care of right-sizing your hardware and software systems for the digitization of your factory. Or you have a growing business that needs the ability to scale up fast. Werum s new PAS-X as a Service might be your answer! With the best-in-class MES for the pharma and biotech industry available as a service: You pay as you go with subscription based pricing! You do not need to worry about the infrastructure for your MES system. You let the IT experts do the job of managing the platform, giving you more time to concentrate on your core competencies! You can seamlessly scale up your MES anytime your business scales up! You can use the same MES throughout your enterprise independently of facility size, thereby standardizing your processes. NEW: Digital channel for experts to exchange ideas on current solutions and forward-looking topics affecting pharmaceutical and biotech manufacturing The new blog will allow pharmaceutical and biotech professionals to share opinions and ideas concerning such wideranging topics such as Digitization, Industrie 4.0, Plug & Produce and Big Data. Other frequent topics will be those relevant to generic drugs, reducing time to market, and regulatory requirements. As the market leader in pharma MES, Werum brings heft to the blogspace: Werum is an expert in pharmaceutical and biotech processes, and our managers and consultants are familiar with complicated industry challenges and dedicated best practices, says Karl Hoffmann, Senior Director Marketing & Business Development at Werum. The new blog is a platform to expand upon thought leadership to help shape and improve the future of pharma manufacturing. Visitors can easily post comments without logging in, and Werum also is inviting guest bloggers to share their experience with the industry (the company will provide guest writers with login data). To contribute, please communications@werum.com. Werum IT Solutions GmbH Wulf-Werum-Str Lüneburg, Germany T info@werum.com Werum IT Solutions America, Inc. 5 Sylvan Way Parsippany, NJ 07054, USA T info@werum-america.com Werum IT Solutions Ltd Liberty Square Building, 287 Silom Rd. Silom, Bangkok 10500, Thailand T info@werum-asia.com