Echo. for Regulated Environments. Echo Acoustic Liquid Handling for Regulated Laboratories BROCHURE

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1 Acoustic Liquid Handling for Regulated Laboratories THE REVOLUTIONARY ACOUSTIC LIQUID TRANSFER TECHNOLOGY for Regulated Environments BROCHURE Version 1.1 MARCH 2018 LABCYTE INC. 170 Rose Orchard Way San Jose, CA USA Toll-free: Fax: LABCYTE INC. All rights reserved.

2 BROCHURE ECHO LIQUID HANDLERS FOR REGULATED ENVIRONMENTS ECHO ENABLES REGULATORY COMPLIANCE Echo Advantages Enable Regulatory Compliance Re-imagine Your Science and Research Bioassay development and deployment is highly challenging. Complex workflows and stringent success criteria require you to use liquid handling solutions that offer both the flexibility to meet your unique workflow needs and the exceptional reproducibility your work demands. Using an innovative non-contact dispensing technology, Labcyte Liquid Handlers deliver the utmost flexibility with any-well to any-well transfer and unparalleled accuracy and precision, even when working with nanoliter transfer volumes. Design of Experiments (DOE), pooling large numbers of assay components and sample randomization, commonly challenging for standard automated liquid handlers, are not only possible on the Echo Liquid Handler, but are straightforward. Combined with the added benefit of cost reductions through assay miniaturization and the elimination of pipette tips, Echo Liquid Handlers are transforming how researchers approach their science. Revolutionary Echo Acoustic Liquid Handling Technology Echo acoustic liquid handling technology uses sound energy to provide highly accurate, fully automated, non-contact dispensing of fluids. Dynamic Fluid Analysis technology from Labcyte enables the Echo system to determine fluid composition, fluid height, and the power needed to eject a precise volume of fluid into the destination well. This analysis happens in milliseconds, enabling precise and accurate transfer of nanoliter (nl) droplets into an inverted microplate. Larger volume transfers are achieved by rapidly transferring several hundred droplets per second. Transfers can be made from any well to any well, allowing for miniaturization and automation of complex assays to dramatically reduce reagent costs and save precious samples. 2

3 ECHO WORKFLOW ADVANTAGE Echo Workflow Advantage Traditional Serial Dilution Transfer same volume of decreasing concentrations Echo Direct Dilution Transfer decreasing volumes of same concentration 10 µl 3.16 µl 3.16 µl 3.16 µl 75 nl 25 nl 7.5 nl 2.5 nl Different volumes of the same stock solution are transferred DIRECTLY to the assay plate to generate the same final concentrations Stock Solution 10 mm 1.0 mm mm 0.1 mm 31.6 µm Transfer 1.5 µl of each dilution to assay plate for total assay volume of 20 µl Stock Solution 10 mm 75 µm 23.7 µm 7.5 µm 2.37 µm 75 µm 25 µm 7.5 µm 2.5 µm DMSO % in Assay = 0.75% when Diluent is 10% DMSO DMSO % in Assay = 0.75% After Backfill to 75 nl Total DMSO MAXIMIZE Lab Resources INCREASE Data Quality ACCELERATE Productivity AUTOMATE Complex Assays COMPLY with Regulations Miniaturize assays Conserve sample and reagent Eliminate tip costs Reduce workflow steps Minimize assay reruns Eliminate pipetting variances Eliminate sample loss on tips No cross-contamination No bio-active leachates from tips Design, test, and optimize assays rapidly Easily create multiple reagent combinations in one plate Transfer multiple fluid types and concentrations from a single plate Transfers with low CV and high accuracy Transfer multiple reagents combinations quickly Transfer any-well to any-well Enable compliance with 21CFR Part 11 Plug into your existing IT infrastructure Seamless integration with Echo application software User permissions management through Microsoft Windows Active Directory Echo protocol versioning and approval 3

4 BROCHURE ECHO LIQUID HANDLERS FOR REGULATED ENVIRONMENTS ECHO LIQUID HANDERS Liquid Handlers for Regulated Environments 525R for higher volume transfer 550R for medium throughput 555R for high throughput TRANSFER VOLUME 25 nl 5 μl 2.5 nl 2 μl 2.5 nl 2 μl GENOMICS CELL-BASED ASSAYS BIOCHEMICAL ASSAYS PROTEOMICS 4

5 ECHO SOFTWARE APPLICATIONS Software Applications Quick and Reliable Liquid Handling Task Management Application Software streamlines liquid handling protocol creation for common applications and processes. Each Echo application is designed around a specific liquid handling workflow and uses a combination of wizards and graphical interfaces to facilitate the creation of plate formats, liquid transfer routines, and output files greatly simplifying assay development and running. Researchers can rapidly create and test protocols off-line using built-in simulators to validate every transfer before running live on the Echo Liquid Handler saving time and valuable reagents. Cherry Pick Combination Screen Dose-Response Plate Reformat Enable Ultimate Transfer Flexibility Simplify Complex Combination Screening Layouts Tighten Response Curves with Direct Dilution Rapid Assay Plate Assembly Uses information in pick lists to transfer from any source well to any destination well A graphical interface to visually combine dose-response curves, controls, and single concentration transfers Simplifies protocol creation for dose response using direct dilution with a wizard-based interface Design custom layouts used to assemble assays or reformat and replicate screening libraries 5

6 BROCHURE ECHO LIQUID HANDLERS FOR REGULATED ENVIRONMENTS ECHO 21CFR11 COMPLIANCE MANAGER 21CFR11 Compliance Manager Manage and Track Users and Electronic Records Associated with Echo Liquid Handler 21CFR11 Compliance Manager (ECM) locks down and tracks all Echo Liquid Handler usage, protocol changes and Echo log file outputs using state-of-art security algorithms. Using advanced checksum verification, the software detects any data tampering assuring data integrity and peaceof-mind. Use of common user and database management tools minimizes Information Technology infrastructure needs. ECM offers five user access profiles to actively control and track: User access utilizing Microsoft Windows Active Directory and AD-LDS Data organization including SQL database creation, backup and restoration Protocol creation, changes and approvals Echo run log file access and output Seamlessly integrating with your favorite Echo Liquid Handler applications, assay development and production analyst teams enjoy the full functionality of the Echo Liquid Handler with the appropriate oversight necessary to meet regulatory tracking and auditing requirements. Define User Roles Roles Guest User PowerUser Approver Admin View APPROVED protocols and run reports Run APPROVED protocols Create, edit, and run DRAFT protocols Edit APPROVED protocols Override approval requests Archive or delete project data Disable OBSOLETE protocols from running 6

7 ECHO 21CFR11 COMPLIANCE MANAGER WORKFLOW Echo Compliance Manager Workflow 21CRF11 Compliance Manager (ECM) Software SQL Server DB Client Computer Dose-Response (EDR) Software Plate Reformat (EPR) Software Combination Screen (ECS) Software Server API Server For more information, visit Labcyte Service and Support Timely service and preventive maintenance are essential for optimal instrument performance and data quality. Labcyte offers a range of service contract options for the Echo Liquid Handler fit every lab s needs and budget, including those specifically tailored to the needs of regulated laboratories. Each regulated instrument includes software and instrument IQ/OQ documentation and training to get your lab personnel up to speed as quickly as possible. Labcyte provides global field service and applications support with local personnel in the United States, United Kingdom, continental Europe, Australia, and Asia. Our application scientists have extensive experience with a broad variety of workflows and provide support and training on all Labcyte products to help you maximize the utility of the Echo Liquid Handler and Access Laboratory Workstations. 7

8 LABCYTE INC. 170 Rose Orchard Way San Jose, CA USA Toll-free: Fax: SALES North America Europe info-europe@labcyte.com Japan info-japan@labcyte.com Asia info-us@labcyte.com Other info-us@labcyte.com All product names and brands are properties of their respective owners LABCYTE INC. All rights reserved. Labcyte,, MicroClime, the Labcyte logo, Access, Tempo, and Dynamic Fluid Analysis are registered trademarks or trademarks of Labcyte Inc., in the U.S. and/or other countries. FOR RESEARCH USE ONLY. Not for use in diagnostic procedures. BRH-ECRE-1.1 MAR 2018