For further information, please contact your Neogen Corporation representative.

Transcription

1 Kit SDS Cover Sheet Product Name: Alert for Histamine Item No(s): 9515, 9515B This is a test kit that is comprised of several individual components, listed below, each of which may have its own Safety Data Sheet (SDS). If a component does not have a Safety Data Sheet included, the item falls under Hazard Communication [191.12(b)(6)], Articles, and does not require a Safety Data Sheet. Kit Components: 1. Control 2. Enzyme-HRP Conjugate 3. Sample Extract Diluent Buffer 4. Wash Buffer 5. K-Blue Advanced TMB Substrate Change in substrate beginning with lot. no.: 6. Red Stop Solution Antibody-Coated Microwells and Mixing Wells 9515B For further information, please contact your Neogen Corporation representative. 62 Lesher Pl Lansing, MI (517) SDS 9515, 9515B. Alert for Histamine October 218

2 SAFETY DATA SHEET according to 29 CFR and GHS Alert Histamine 5 ppm Control SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier date Page 1/6 Product name Alert Histamine 5 ppm Control Product code For Kits 9515, 9515B 1.2. Relevant identified uses of the substance or mixture and uses advised against Product Use Description [SU3] Industrial uses: Uses of substances as such or in preparations at industrial sites; [PC21] Laboratory chemicals; Intended for laboratory use only Details of the supplier of the safety data sheet Company Address Web Neogen Corporation 62 Lesher Place Lansing MI USA Telephone / Emergency telephone number Emergency telephone number Further information regulatorysupport@neogen.com Hotline(s): Medical: United States ( ), International ( ). Spill/CHEMTREC: United States ( ), International ( ). SECTION 2: Hazards identification 2.2. Label elements Hazard Statements No Significant Hazard SECTION 3: Composition/information on ingredients 3.2. Mixtures EC 1272/28 Chemical Name Index No. CAS No. EC No. REACH Registration Number Conc. (%w/w) Classification Histamine dihydrochloride % Skin Irrit. 2: H315; Skin Sens. 1: H317; Eye Irrit. 2: H319; Resp. Sens. 1: H334; STOT SE 3: H335;

3 2/6 Description Alert Histamine 5 ppm Control date No components need to be disclosed according to the applicable regulations. SECTION 4: First aid measures 4.1. Description of first aid measures Inhalation Eye contact Skin contact Ingestion No irritation expected. Move the exposed person to fresh air. Rinse immediately with plenty of water. Contact lenses should be removed. No irritation expected. Rinse immediately with plenty of water Most important symptoms and effects, both acute and delayed Inhalation Eye contact Skin contact Ingestion SECTION 5: Firefighting measures 5.1. Extinguishing media 5.2. Special hazards arising from the substance or mixture DO NOT INDUCE VOMITING unless advised to do so by a doctor. Never give anything by mouth to an unconscious person. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. If you feel unwell, seek medical advice (show the label where possible). Use extinguishing media appropriate to the surrounding fire conditions Advice for firefighters This product is not flammable. Use extinguishing media appropriate to the surrounding fire conditions. Wear suitable respiratory equipment when necessary. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures 6.2. Environmental precautions 6.3. Methods and material for containment and cleaning up 6.4. Reference to other sections SECTION 7: Handling and storage 7.1. Precautions for safe handling Adopt best Manual Handling considerations when handling, carrying and dispensing. Ensure adequate ventilation of the working area. Prevent further spillage if safe. Clean spillage area thoroughly with plenty of water. Absorb spillage to prevent material damage. Clean spillage area thoroughly with plenty of water. Do not flush into surface water. See section 2, 8 & 13 for further information Conditions for safe storage, including any incompatibilities Adopt best Manual Handling considerations when handling, carrying and dispensing. Avoid contact with eyes. Do not eat, drink or smoke in areas where this product is used or stored. Ensure adequate ventilation of the working area. Keep refrigerated. Keep container tightly closed. Keep only in the original container.

4 3/6 Alert Histamine 5 ppm Control date 7.3. Specific end use(s) See Section 1.2 for further information. SECTION 8: Exposure controls/personal protection 8.2. Exposure controls Appropriate engineering controls Individual protection measures Eye / face protection Skin protection - Hand protection Respiratory protection Occupational exposure controls Ensure adequate ventilation of the working area. Use as appropriate:. Protective clothing. Use as appropriate:. Suitable eye protection. Use as appropriate:. Chemical resistant gloves. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from food, drink and animal feed and/ or feed products. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties State Liquid Color Clear Odor No data available Odour threshold No data available ph No data available Melting point No data available Freezing Point No data available Boiling point No data available Flash point No data available Evaporation rate No data available Flammability limits Not applicable. Vapor pressure No data available Vapor density No data available Relative density No data available Partition coefficient No data available Autoignition temperature No data available 9.2. Other information Viscosity No data available Explosive properties Not applicable. Oxidising properties No data available VOC (Volatile organic compounds) Solubility No data available SECTION 1: Stability and reactivity 1.1. Reactivity No data available

5 4/6 Alert Histamine 5 ppm Control date 1.1. Reactivity Stable under normal conditions Chemical stability Stable under normal conditions Possibility of hazardous reactions 1.4. Conditions to avoid Keep away from heat Incompatible materials 1.6. Hazardous decomposition products Carbon oxides. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity Skin corrosion/irritation Serious eye damage/irritation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard Repeated or prolonged exposure Mixtures Toxicological information No irritation expected. No irritation expected. Not found to be a potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs, Volumes Not listed in the National Toxicology Program (NTP) 13th Report on Carcinogens. Not listed in the OSHA standard Carcinogens. Avoid prolonged or repeated exposure. Caution - substance not yet fully tested. No data available SECTION 12: Ecological information Toxicity No data available Persistence and degradability No data is available on this product Bioaccumulative potential No data is available on this product.

6 5/6 Alert Histamine 5 ppm Control date Partition coefficient Alert Histamine 5 ppm Control No data available Mobility in soil No data is available on this product Results of PBT and vpvb assessment No data is available on this product Other adverse effects Caution - substance not yet fully tested. SECTION 13: Disposal considerations Waste treatment methods Dispose of in compliance with all. local and national regulations. Disposal methods Dispose of in compliance with all. local and national regulations. Disposal of packaging Dispose of in compliance with all. local and national regulations. SECTION 14: Transport information UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards Special precautions for user Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture Regulations Hazard Communication Standard: 29 Code of Federal Regulations : Occupational Safety and Health Standards: Z: Toxic and Hazardous Substances: Hazard Communication. All chemicals in this product are TSCA listed or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory. TSCA - United States Toxic Substances Control Act Section 8(b) Inventory.

7 6/6 Alert Histamine 5 ppm Control Safety, health and environmental regulations/legislation specific for the substance or mixture US State Regulations: New Jersey Right-to-Know Hazardous Substance List: This material contains no reportable components Pennsylvania Right-to-Know Hazardous Substance List: This material contains no reportable components. date Rhode Island Right-to-Know Hazardous Substance List:. This material contains no reportable components. SECTION 16: Other information Other information California Prop 65:. WARNING: Reproductive effects - Text of Hazard Statements in Section 3 Further information Skin Irrit. 2: H315 - Causes skin irritation. Skin Sens. 1: H317 - May cause an allergic skin reaction. Eye Irrit. 2: H319 - Causes serious eye irritation. Resp. Sens. 1: H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled. STOT SE 3: H335 - May cause respiratory irritation. DISCLAIMER: The information and recommendations set forth herein ("Information") are presented in good faith and believed to be correct as of the date issued. No representation is made regarding the completeness or accuracy of the Information. Further, because of the many factors that affect the use of this product, the Information is supplied upon the condition that the person(s) receiving it will make their own determination regarding its suitability for their own unique purpose(s), prior to use. Except as expressly stated herein, NO WARRANTIES, GUARANTEES, OR REPRESENTATIONS OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, COURSE OF PERFORMANCE, USAGE OF TRADE, OR RESULTS TO BE OBTAINED BY USE OF THIS PRODUCT are made with respect to this product or use of this product. The product covered is furnished "as is" and only subject to the warranties herein provided, no liability is assumed resulting from the use of this product.

8 SAFETY DATA SHEET according to 29 CFR and GHS Page 1/7 Alert Histamine-HRP Conjugate SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier date Product name Product code Alert Histamine-HRP Conjugate For Kits 9515, 9515B 1.2. Relevant identified uses of the substance or mixture and uses advised against Product Use Description [SU3] Industrial uses: Uses of substances as such or in preparations at industrial sites; [PC21] Laboratory chemicals; Intended for laboratory use only Details of the supplier of the safety data sheet Company Address Web Neogen Corporation 62 Lesher Place Lansing MI USA Telephone / Emergency telephone number Emergency telephone number Further information Hotline(s): Medical: United States ( ), International ( ). Spill/CHEMTREC: United States ( ), International ( ). SECTION 2: Hazards identification 2.2. Label elements Hazard Statements No Significant Hazard SECTION 3: Composition/information on ingredients 3.2. Mixtures

9 Alert Histamine-HRP Conjugate date Page 2/ Mixtures EC 1272/28 Chemical Name Index No. CAS No. EC No. REACH Registration Conc. Classification Number (%w/w) Acetic acid % (Acetic acid) Flam. Liq. 3: H226; Skin Corr. 1A: H314; Sodium periodate Ox. Sol. 1: H271; Skin Corr. 1C: H314; Eye Dam. 1: H318; STOT RE 1: H372; Aquatic Acute 1: H4; Sodium borohydride Water-react. 1: H26; Acute Tox. 3: H31; Skin Corr. 1B: H314; Eye Dam. 1: H318; Repr. 1B: H36; Description SECTION 4: First aid measures 4.1. Description of first aid measures Inhalation Eye contact Skin contact Ingestion No components need to be disclosed according to the applicable regulations. No irritation expected. Move the exposed person to fresh air. Rinse immediately with plenty of water. Contact lenses should be removed. No irritation expected. Rinse immediately with plenty of water Most important symptoms and effects, both acute and delayed Inhalation Eye contact Skin contact Ingestion SECTION 5: Firefighting measures 5.1. Extinguishing media 5.2. Special hazards arising from the substance or mixture DO NOT INDUCE VOMITING unless advised to do so by a doctor. Never give anything by mouth to an unconscious person. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. If you feel unwell, seek medical advice (show the label where possible). Use extinguishing media appropriate to the surrounding fire conditions Advice for firefighters This product is not flammable. Use extinguishing media appropriate to the surrounding fire conditions. Wear suitable respiratory equipment when necessary. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures 6.2. Environmental precautions 6.3. Methods and material for containment and cleaning up Adopt best Manual Handling considerations when handling, carrying and dispensing. Ensure adequate ventilation of the working area. Prevent further spillage if safe. Clean spillage area thoroughly with plenty of water. Absorb spillage to prevent material damage. Clean spillage area thoroughly with plenty of water. Do not flush into surface water.

10 3/7 Alert Histamine-HRP Conjugate date 6.4. Reference to other sections See section 2, 8 & 13 for further information. SECTION 7: Handling and storage 7.1. Precautions for safe handling 7.2. Conditions for safe storage, including any incompatibilities 7.3. Specific end use(s) Adopt best Manual Handling considerations when handling, carrying and dispensing. Avoid contact with eyes. Do not eat, drink or smoke in areas where this product is used or stored. Ensure adequate ventilation of the working area. Keep refrigerated. Keep container tightly closed. Keep only in the original container. See Section 1.2 for further information. SECTION 8: Exposure controls/personal protection 8.2. Exposure controls Appropriate engineering controls Individual protection measures Eye / face protection Skin protection - Hand protection Respiratory protection Occupational exposure controls Ensure adequate ventilation of the working area. Use as appropriate:. Protective clothing. Use as appropriate:. Suitable eye protection. Use as appropriate:. Chemical resistant gloves. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from food, drink and animal feed and/ or feed products. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties

11 4/ Information on basic physical and chemical properties State Liquid Color Amber Odor Odorless Odour threshold No data available ph No data available Melting point No data available Freezing Point No data available Boiling point No data available Flash point No data available Evaporation rate No data available Flammability limits Not applicable. Vapor pressure No data available Vapor density No data available Relative density No data available Partition coefficient No data available Autoignition temperature No data available 9.2. Other information Viscosity No data available Explosive properties Not applicable. Oxidising properties No data available VOC (Volatile organic compounds) Solubility Miscible in water SECTION 1: Stability and reactivity 1.1. Reactivity 1.2. Chemical stability 1.3. Possibility of hazardous reactions 1.4. Conditions to avoid 1.5. Incompatible materials No data available 1.6. Hazardous decomposition products Alert Histamine-HRP Conjugate Stable under normal conditions. Stable under normal conditions. Keep away from heat. Carbon oxides. SECTION 11: Toxicological information Information on toxicological effects date Acute toxicity Skin corrosion/irritation Serious eye damage/irritation No irritation expected. No irritation expected.

12 5/7 Alert Histamine-HRP Conjugate date Information on toxicological effects Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard Repeated or prolonged exposure Mixtures Toxicological information Not found to be a potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs, Volumes Not listed in the National Toxicology Program (NTP) 13th Report on Carcinogens. Not listed in the OSHA standard Carcinogens. Avoid prolonged or repeated exposure. Caution - substance not yet fully tested. No data available SECTION 12: Ecological information Toxicity No data available Persistence and degradability No data is available on this product Bioaccumulative potential Partition coefficient No data is available on this product. Alert Histamine-HRP Conjugate No data available Mobility in soil No data is available on this product Results of PBT and vpvb assessment No data is available on this product Other adverse effects Caution - substance not yet fully tested. SECTION 13: Disposal considerations Waste treatment methods Dispose of in compliance with all. local and national regulations. Disposal methods Dispose of in compliance with all. local and national regulations. Disposal of packaging Dispose of in compliance with all. local and national regulations.

13 6/7 Alert Histamine-HRP Conjugate SECTION 14: Transport information UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards Special precautions for user Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture date Regulations Hazard Communication Standard: 29 Code of Federal Regulations : Occupational Safety and Health Standards: Z: Toxic and Hazardous Substances: Hazard Communication. SECTION 16: Other information Other information All chemicals in this product are TSCA listed or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory. TSCA - United States Toxic Substances Control Act Section 8(b) Inventory. US State Regulations: New Jersey Right-to-Know Hazardous Substance List: This material contains no reportable components Pennsylvania Right-to-Know Hazardous Substance List: This material contains no reportable components. Rhode Island Right-to-Know Hazardous Substance List:. This material contains no reportable components. California Prop 65:. WARNING: Reproductive effects - Text of Hazard Statements in Section 3 Flam. Liq. 3: H226 - Flammable liquid and vapour. Skin Corr. 1A: H314 - Causes severe skin burns and eye damage. Ox. Sol. 1: H271 - May cause fire or explosion; strong oxidiser. Skin Corr. 1C: H314 - Causes severe skin burns and eye damage. Eye Dam. 1: H318 - Causes serious eye damage. STOT RE 1: H372 - Causes damage to organs through prolonged or repeated exposure. Aquatic Acute 1: H4 - Very toxic to aquatic life.

14 7/7 Alert Histamine-HRP Conjugate date Other information Further information Water-react. 1: H26 - In contact with water releases flammable gases which may ignite spontaneously. Acute Tox. 3: H31 - Toxic if swallowed. Skin Corr. 1B: H314 - Causes severe skin burns and eye damage. Repr. 1B: H36 - May damage fertility or the unborn child. DISCLAIMER: The information and recommendations set forth herein ("Information") are presented in good faith and believed to be correct as of the date issued. No representation is made regarding the completeness or accuracy of the Information. Further, because of the many factors that affect the use of this product, the Information is supplied upon the condition that the person(s) receiving it will make their own determination regarding its suitability for their own unique purpose(s), prior to use. Except as expressly stated herein, NO WARRANTIES, GUARANTEES, OR REPRESENTATIONS OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, COURSE OF PERFORMANCE, USAGE OF TRADE, OR RESULTS TO BE OBTAINED BY USE OF THIS PRODUCT are made with respect to this product or use of this product. The product covered is furnished "as is" and only subject to the warranties herein provided, no liability is assumed resulting from the use of this product.

15 SAFETY DATA SHEET according to 29 CFR and GHS Phosphate Buffered Saline, Foil Pouch SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier date Page 1/6 Product name Product code 114 Phosphate Buffered Saline, Foil Pouch 1.2. Relevant identified uses of the substance or mixture and uses advised against Product Use Description [SU3] Industrial uses: Uses of substances as such or in preparations at industrial sites; [PC19] Intermediate; Intended for laboratory use only Details of the supplier of the safety data sheet Company Address Web Neogen Corporation 62 Lesher Place Lansing MI USA Telephone / Emergency telephone number Emergency telephone number Further information Hotline(s): Medical: United States ( ), International ( ). Spill/CHEMTREC: United States ( ), International ( ). SECTION 2: Hazards identification 2.2. Label elements Hazard Statements No Significant Hazard SECTION 3: Composition/information on ingredients 3.2. Mixtures EC 1272/28 Chemical Name Index No. CAS No. EC No. REACH Registration Number Conc. (%w/w) Classification Potassium chloride % Skin Irrit. 2: H315; Eye Irrit. 2: H319; STOT SE 3: H335; Description No components need to be disclosed according to the applicable regulations.

16 2/6 Phosphate Buffered Saline, Foil Pouch date SECTION 4: First aid measures 4.1. Description of first aid measures Inhalation Eye contact Skin contact Ingestion No irritation expected. Move the exposed person to fresh air. Rinse immediately with plenty of water. Contact lenses should be removed. No irritation expected. Rinse immediately with plenty of water Most important symptoms and effects, both acute and delayed Inhalation Eye contact Skin contact Ingestion SECTION 5: Firefighting measures 5.1. Extinguishing media 5.2. Special hazards arising from the substance or mixture DO NOT INDUCE VOMITING unless advised to do so by a doctor. Never give anything by mouth to an unconscious person. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. If you feel unwell, seek medical advice (show the label where possible). Use extinguishing media appropriate to the surrounding fire conditions Advice for firefighters This product is not flammable. Use extinguishing media appropriate to the surrounding fire conditions. Wear suitable respiratory equipment when necessary. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures 6.2. Environmental precautions 6.3. Methods and material for containment and cleaning up 6.4. Reference to other sections SECTION 7: Handling and storage 7.1. Precautions for safe handling Adopt best Manual Handling considerations when handling, carrying and dispensing. Ensure adequate ventilation of the working area. Prevent further spillage if safe. Clean spillage area thoroughly with plenty of water. Absorb spillage to prevent material damage. Clean spillage area thoroughly with plenty of water. Do not flush into surface water. See section 2, 8 & 13 for further information Conditions for safe storage, including any incompatibilities 7.3. Specific end use(s) Adopt best Manual Handling considerations when handling, carrying and dispensing. Avoid contact with eyes. Do not eat, drink or smoke in areas where this product is used or stored. Ensure adequate ventilation of the working area. Keep refrigerated. Keep container tightly closed. Keep only in the original container. See Section 1.2 for further information.

17 3/6 SECTION 8: Exposure controls/personal protection 8.2. Exposure controls Phosphate Buffered Saline, Foil Pouch date Appropriate engineering controls Individual protection measures Eye / face protection Skin protection - Hand protection Respiratory protection Occupational exposure controls Ensure adequate ventilation of the working area. Use as appropriate:. Protective clothing. Use as appropriate:. Suitable eye protection. Use as appropriate:. Chemical resistant gloves. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from food, drink and animal feed and/ or feed products. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties State Powder Color White Odor Odorless/Slight Odour threshold No data available ph 7.4 Melting point No data available Freezing Point No data available Boiling point No data available Flash point No data available Flammability limits No data available Vapor pressure No data available Vapor density No data available Relative density No data available Partition coefficient No data available Autoignition temperature No data available 9.2. Other information Explosive properties No data available Oxidising properties No data available VOC (Volatile organic compounds) Solubility Soluble in water SECTION 1: Stability and reactivity 1.1. Reactivity 1.2. Chemical stability No data available Stable under normal conditions. Stable under normal conditions.

18 4/ Possibility of hazardous reactions 1.4. Conditions to avoid Keep away from heat Incompatible materials 1.6. Hazardous decomposition products Carbon oxides. SECTION 11: Toxicological information Information on toxicological effects Phosphate Buffered Saline, Foil Pouch date Acute toxicity Skin corrosion/irritation Serious eye damage/irritation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard Repeated or prolonged exposure Mixtures Toxicological information No irritation expected. No irritation expected. Not found to be a potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs, Volumes Not listed in the National Toxicology Program (NTP) 13th Report on Carcinogens. Not listed in the OSHA standard Carcinogens. Avoid prolonged or repeated exposure. Caution - substance not yet fully tested. No data available SECTION 12: Ecological information Toxicity No data available Persistence and degradability No data is available on this product Bioaccumulative potential Partition coefficient No data is available on this product. Phosphate Buffered Saline, Foil No data available Pouch Mobility in soil No data is available on this product.

19 5/6 Phosphate Buffered Saline, Foil Pouch Results of PBT and vpvb assessment No data is available on this product Other adverse effects Caution - substance not yet fully tested. SECTION 13: Disposal considerations Waste treatment methods Dispose of in compliance with all. local and national regulations. Disposal methods Dispose of in compliance with all. local and national regulations. Disposal of packaging Dispose of in compliance with all. local and national regulations. SECTION 14: Transport information UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards Special precautions for user Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture date Regulations Hazard Communication Standard: 29 Code of Federal Regulations : Occupational Safety and Health Standards: Z: Toxic and Hazardous Substances: Hazard Communication. All chemicals in this product are TSCA listed or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory. TSCA - United States Toxic Substances Control Act Section 8(b) Inventory. US State Regulations: New Jersey Right-to-Know Hazardous Substance List: This material contains no reportable components Pennsylvania Right-to-Know Hazardous Substance List: This material contains no reportable components.

20 6/6 Phosphate Buffered Saline, Foil Pouch Safety, health and environmental regulations/legislation specific for the substance or mixture SECTION 16: Other information Other information Rhode Island Right-to-Know Hazardous Substance List:. This material contains no reportable components. date Text of Hazard Statements in Section 3 Further information Skin Irrit. 2: H315 - Causes skin irritation. Eye Irrit. 2: H319 - Causes serious eye irritation. STOT SE 3: H335 - May cause respiratory irritation. DISCLAIMER: The information and recommendations set forth herein ("Information") are presented in good faith and believed to be correct as of the date issued. No representation is made regarding the completeness or accuracy of the Information. Further, because of the many factors that affect the use of this product, the Information is supplied upon the condition that the person(s) receiving it will make their own determination regarding its suitability for their own unique purpose(s), prior to use. Except as expressly stated herein, NO WARRANTIES, GUARANTEES, OR REPRESENTATIONS OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, COURSE OF PERFORMANCE, USAGE OF TRADE, OR RESULTS TO BE OBTAINED BY USE OF THIS PRODUCT are made with respect to this product or use of this product. The product covered is furnished "as is" and only subject to the warranties herein provided, no liability is assumed resulting from the use of this product.

21 SAFETY DATA SHEET according to 29 CFR and GHS Page 1/6 Wash Buffer, 25X SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier date Product name Wash Buffer, 25X Product code 24218, Relevant identified uses of the substance or mixture and uses advised against Product Use Description [SU3] Industrial uses: Uses of substances as such or in preparations at industrial sites; [PC21] Laboratory chemicals; Intended for laboratory use only Details of the supplier of the safety data sheet Company Address Web Neogen Corporation 62 Lesher Place Lansing MI USA Telephone / Emergency telephone number Emergency telephone number Further information Hotline(s): Medical: United States ( ), International ( ). Spill/CHEMTREC: United States ( ), International ( ). SECTION 2: Hazards identification 2.2. Label elements Hazard Statements No Significant Hazard SECTION 3: Composition/information on ingredients Description SECTION 4: First aid measures 4.1. Description of first aid measures No components need to be disclosed according to the applicable regulations. Inhalation No irritation expected. Move the exposed person to fresh air. Eye contact Rinse immediately with plenty of water. Contact lenses should be removed. Skin contact No irritation expected. Rinse immediately with plenty of water

22 2/6 Wash Buffer, 25X date Description of first aid measures Ingestion 4.2. Most important symptoms and effects, both acute and delayed Inhalation Eye contact Skin contact Ingestion SECTION 5: Firefighting measures 5.1. Extinguishing media 5.2. Special hazards arising from the substance or mixture DO NOT INDUCE VOMITING unless advised to do so by a doctor. Never give anything by mouth to an unconscious person. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. No irritation expected. Seek medical attention if irritation or symptoms persist. If you feel unwell, seek medical advice (show the label where possible). Use extinguishing media appropriate to the surrounding fire conditions Advice for firefighters This product is not flammable. Use extinguishing media appropriate to the surrounding fire conditions. Wear suitable respiratory equipment when necessary. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures 6.2. Environmental precautions 6.3. Methods and material for containment and cleaning up 6.4. Reference to other sections SECTION 7: Handling and storage 7.1. Precautions for safe handling Adopt best Manual Handling considerations when handling, carrying and dispensing. Ensure adequate ventilation of the working area. Prevent further spillage if safe. Clean spillage area thoroughly with plenty of water. Absorb spillage to prevent material damage. Clean spillage area thoroughly with plenty of water. Do not flush into surface water. See section 2, 8 & 13 for further information Conditions for safe storage, including any incompatibilities 7.3. Specific end use(s) Adopt best Manual Handling considerations when handling, carrying and dispensing. Avoid contact with eyes. Do not eat, drink or smoke in areas where this product is used or stored. Ensure adequate ventilation of the working area. Keep refrigerated. Keep container tightly closed. Keep only in the original container. See Section 1.2 for further information. SECTION 8: Exposure controls/personal protection 8.2. Exposure controls

23 3/6 Wash Buffer, 25X date Exposure controls Appropriate engineering controls Individual protection measures Eye / face protection Skin protection - Hand protection Respiratory protection Occupational exposure controls Ensure adequate ventilation of the working area. Use as appropriate:. Protective clothing. Use as appropriate:. Suitable eye protection. Use as appropriate:. Chemical resistant gloves. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from food, drink and animal feed and/ or feed products. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties State Liquid Color No data available Odor No data available Vapor pressure No data available Vapor density No data available Relative density No data available Fat Solubility No data available Partition coefficient No data available Autoignition temperature No data available 9.2. Other information Viscosity No data available Explosive properties No data available Oxidising properties No data available Flash point No data available Freezing Point No data available Boiling point No data available Evaporation rate No data available Odour threshold No data available ph No data available Melting point Not applicable. Flammability limits Not applicable. Solubility Soluble in water Conductivity No data available Surface tension No data available Gas group No data available Benzene Content No data available Lead content No data available VOC (Volatile organic compounds) No data available

24 4/6 Wash Buffer, 25X date SECTION 1: Stability and reactivity 1.1. Reactivity Stable under normal conditions Chemical stability Stable under normal conditions Possibility of hazardous reactions 1.4. Conditions to avoid Keep away from heat Incompatible materials 1.6. Hazardous decomposition products Carbon oxides. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity Skin corrosion/irritation Serious eye damage/irritation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard Repeated or prolonged exposure Mixtures Toxicological information No irritation expected. No irritation expected. Not found to be a potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs, Volumes Not listed in the National Toxicology Program (NTP) 13th Report on Carcinogens. Not listed in the OSHA standard Carcinogens. Avoid prolonged or repeated exposure. Caution - substance not yet fully tested. No data available SECTION 12: Ecological information Toxicity No data available Persistence and degradability No data is available on this product Bioaccumulative potential No data is available on this product

25 5/6 Wash Buffer, 25X date Partition coefficient Wash Buffer, 25X No data available Mobility in soil No data is available on this product Results of PBT and vpvb assessment No data is available on this product Other adverse effects Caution - substance not yet fully tested. SECTION 13: Disposal considerations Waste treatment methods Dispose of in compliance with all. local and national regulations. Disposal methods Dispose of in compliance with all. local and national regulations. Disposal of packaging Dispose of in compliance with all. local and national regulations. SECTION 14: Transport information UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards Special precautions for user Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture Regulations Hazard Communication Standard: 29 Code of Federal Regulations : Occupational Safety and Health Standards: Z: Toxic and Hazardous Substances: Hazard Communication. All chemicals in this product are TSCA listed or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory. TSCA - United States Toxic Substances Control Act Section 8(b) Inventory

26 6/6 Wash Buffer, 25X Safety, health and environmental regulations/legislation specific for the substance or mixture US State Regulations: New Jersey Right-to-Know Hazardous Substance List: This material contains no reportable components Pennsylvania Right-to-Know Hazardous Substance List: This material contains no reportable components. date Rhode Island Right-to-Know Hazardous Substance List:. This material contains no reportable components. SECTION 16: Other information Further information California Prop 65:. WARNING: Reproductive effects - DISCLAIMER: The information and recommendations set forth herein ("Information") are presented in good faith and believed to be correct as of the date issued. No representation is made regarding the completeness or accuracy of the Information. Further, because of the many factors that affect the use of this product, the Information is supplied upon the condition that the person(s) receiving it will make their own determination regarding its suitability for their own unique purpose(s), prior to use. Except as expressly stated herein, NO WARRANTIES, GUARANTEES, OR REPRESENTATIONS OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, COURSE OF PERFORMANCE, USAGE OF TRADE, OR RESULTS TO BE OBTAINED BY USE OF THIS PRODUCT are made with respect to this product or use of this product. The product covered is furnished "as is" and only subject to the warranties herein provided, no liability is assumed resulting from the use of this product

27 SAFETY DATA SHEET according to 29 CFR and GHS Page 1/7 K-Blue Advanced TMB Substrate SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier date Product name Product code K-Blue Advanced TMB Substrate , , , , , L, 31921, W, W Relevant identified uses of the substance or mixture and uses advised against Description Substrate Solution Details of the supplier of the safety data sheet Company Address Web Neogen Corporation 62 Lesher Place Lansing MI USA Telephone / Emergency telephone number Emergency telephone number Further information Manufactured By: Hotline(s): SECTION 2: Hazards identification 2.2. Label elements regulatorysupport@neogen.com Neogen Corporation 944 Nandino Blvd. Lexington, KY U.S.A. Hazard Statements No Significant Hazard 2.3. Other hazards Medical: United States ( ), International ( ). Spill/CHEMTREC: United States ( ), International ( ). Other hazards No data is available on this product. SECTION 3: Composition/information on ingredients 3.2. Mixtures

28 K-Blue Advanced TMB Substrate date Page 2/ Mixtures EC 1272/28 Chemical Name Index No. CAS No. EC No. REACH Registration Conc. Classification Number (%w/w) 2-Pyrrolidinone Eye Irrit. 2: H319; Urea hydrogen peroxide Ox. Sol. 3: H272; Skin Corr. 1B: H314; Eye Dam. 1: H318; Further information SECTION 4: First aid measures 4.1. Description of first aid measures Inhalation Eye contact Skin contact Ingestion The exact percentage (concentration) of composition has been withheld as a trade secret. Move the exposed person to fresh air. Rinse immediately with plenty of water for 15 minutes holding the eyelids open. Contact lenses should be removed. Remove contaminated clothing. Wash off immediately with plenty of soap and water. DO NOT INDUCE VOMITING Most important symptoms and effects, both acute and delayed Inhalation Eye contact Skin contact Ingestion May cause irritation to respiratory system. May cause irritation to eyes. May cause irritation to skin. Ingestion may cause nausea and vomiting Indication of any immediate medical attention and special treatment needed Inhalation Eye contact Skin contact Ingestion SECTION 5: Firefighting measures 5.1. Extinguishing media If you feel unwell, seek medical advice (show the label where possible). Immediate medical attention is required Special hazards arising from the substance or mixture 5.3. Advice for firefighters SECTION 6: Accidental release measures Seek medical attention if irritation or symptoms persist. If you feel unwell, seek medical advice (show the label where possible). Use extinguishing media appropriate to the surrounding fire conditions. Burning produces irritating, toxic and obnoxious fumes. Wear suitable respiratory equipment when necessary Personal precautions, protective equipment and emergency procedures 6.2. Environmental precautions 6.3. Methods and material for containment and cleaning up Ensure adequate ventilation of the working area. Avoid contact with skin and eyes. Wash hands after handling the product. Do not allow product to enter drains. Prevent further spillage if safe. Absorb with inert, absorbent material. Transfer to suitable, labelled containers for disposal. Clean

29 3/7 K-Blue Advanced TMB Substrate 6.3. Methods and material for containment and cleaning up spillage area thoroughly with plenty of water Reference to other sections See section 2, 8 & 13 for further information. SECTION 7: Handling and storage 7.1. Precautions for safe handling date Conditions for safe storage, including any incompatibilities 7.3. Specific end use(s) Adopt best Manual Handling considerations when handling, carrying and dispensing. Avoid contact with eyes and skin. Ensure adequate ventilation of the working area. Keep containers tightly closed. Keep in a cool, dry, well ventilated area. Store in correctly labelled containers. See section 1.2 for further information. SECTION 8: Exposure controls/personal protection 8.1. Control parameters 8.2. Exposure controls Occupational exposure controls. Appropriate engineering controls Individual protection measures Eye / face protection Skin protection - Hand protection Skin protection - Other Respiratory protection Occupational exposure controls Ensure adequate ventilation of the working area. Wear suitable protective clothing. Wear:. Approved safety goggles. Wear:. Chemical resistant gloves. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from food, drink and animal feed and/ or feed products. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties

30 4/ Information on basic physical and chemical properties State Liquid Color Clear/Light blue Odor Characteristic ph Melting point No data available Freezing Point No data available Boiling point No data available Flash point No data available Evaporation rate No data available Flammability limits No data available Vapor pressure No data available Vapor density No data available Relative density No data available Fat Solubility No data available Partition coefficient No data available Autoignition temperature No data available 9.2. Other information Viscosity No data available Oxidising properties No data available Odour threshold No data available Solubility No data available Conductivity No data available Surface tension No data available Gas group No data available Benzene Content No data available Lead content No data available VOC (Volatile organic compounds) SECTION 1: Stability and reactivity 1.1. Reactivity 1.2. Chemical stability 1.3. Possibility of hazardous reactions 1.4. Conditions to avoid 1.5. Incompatible materials K-Blue Advanced TMB Substrate No data available 1.6. Hazardous decomposition products Stable under normal conditions. SECTION 11: Toxicological information Burning produces irritating, toxic and obnoxious fumes. date

31 5/ Information on toxicological effects Acute toxicity Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard Repeated or prolonged exposure Toxicological information SECTION 12: Ecological information Toxicity Persistence and degradability Bioaccumulative potential K-Blue Advanced TMB Substrate May cause irritation to skin. May cause irritation to eyes. date Not listed in the National Toxicology Program (NTP) 13th Report on Carcinogens. Not listed in the OSHA standard Carcinogens. Not found to be a potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs, Volumes Avoid prolonged or repeated exposure. No data available No data available Partition coefficient K-Blue Advanced TMB No data available Substrate Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Dispose of in compliance with all local and national regulations. Disposal methods Contact a licensed waste disposal company

32 6/7 Disposal of packaging K-Blue Advanced TMB Substrate 1 date Do NOT reuse empty containers. Empty containers can be sent for disposal or recycling. SECTION 14: Transport information UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards Special precautions for user Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code Not applicable. SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture Regulations Hazard Communication Standard: 29 Code of Federal Regulations : Occupational Safety and Health Standards: Z: Toxic and Hazardous Substances: Hazard Communication Chemical safety assessment SECTION 16: Other information Other information All chemicals in this product are TSCA listed or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory. TSCA - United States Toxic Substances Control Act Section 8(b) Inventory. US State Regulations: New Jersey Right-to-Know Hazardous Substance List: 2-Pyrrolidinone: Y Pennsylvania Right-to-Know Hazardous Substance List: 2-Pyrrolidinone: Y, 1,2, Ethanediamine, N,N'-bis)-2-aminoethyl):Y. Massachusetts Right-to-Know Hazardous Substance List: 2-Pyrrolidinone: Y. No data is available on this product. Text of Hazard Statements in Section 3 This document differs from the previous version in the following areas:. 1 - Product code. Eye Irrit. 2: H319 - Causes serious eye irritation. Ox. Sol. 3: H272 - May intensify fire; oxidiser

33 7/7 K-Blue Advanced TMB Substrate date Other information Further information Skin Corr. 1B: H314 - Causes severe skin burns and eye damage. Eye Dam. 1: H318 - Causes serious eye damage. DISCLAIMER: The information and recommendations set forth herein ("Information") are presented in good faith and believed to be correct as of the date issued. No representation is made regarding the completeness or accuracy of the Information. Further, because of the many factors that affect the use of this product, the Information is supplied upon the condition that the person(s) receiving it will make their own determination regarding its suitability for their own unique purpose(s), prior to use. Except as expressly stated herein, NO WARRANTIES, GUARANTEES, OR REPRESENTATIONS OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, COURSE OF PERFORMANCE, USAGE OF TRADE, OR RESULTS TO BE OBTAINED BY USE OF THIS PRODUCT are made with respect to this product or use of this product. The product covered is furnished "as is" and only subject to the warranties herein provided, no liability is assumed resulting from the use of this product

34 SAFETY DATA SHEET according to 29 CFR and GHS Page 1/7 Red Stop Solution SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier date Product name Product code Red Stop Solution 31474, 31475, 31476, 31471, 31473, 3121, 31XXX Relevant identified uses of the substance or mixture and uses advised against Description Aqueous Stop Solution Details of the supplier of the safety data sheet Company Address Web Neogen Corporation 62 Lesher Place Lansing MI USA Telephone / Emergency telephone number Emergency telephone number Further information Manufactured By: Hotline(s): SECTION 2: Hazards identification 2.1. Classification of the substance or mixture regulatorysupport@neogen.com Neogen Corporation 944 Nandino Blvd. Lexington, KY U.S.A Classification - GHS 2.2. Label elements Hazard Statements No Significant Hazard 2.3. Other hazards Medical: United States ( ), International ( ). Spill/CHEMTREC: United States ( ), International ( ). Other hazards No data is available on this product. SECTION 3: Composition/information on ingredients 3.2. Mixtures

35 Red Stop Solution date Page 2/ Mixtures EC 1272/28 Chemical Name Index No. CAS No. EC No. REACH Registration Number Conc. (%w/w) Classification Sodium fluoride % Acute Tox. 3: H31; Skin Corr. 1C: H314; Eye Irrit. 2: H319; Aquatic Acute 3: H42; Further information SECTION 4: First aid measures 4.1. Description of first aid measures Inhalation Eye contact Skin contact Ingestion The exact percentage (concentration) of composition has been withheld as a trade secret. Move the exposed person to fresh air. Rinse immediately with plenty of water for 15 minutes holding the eyelids open. Contact lenses should be removed. Remove contaminated clothing. Wash off immediately with plenty of soap and water. DO NOT INDUCE VOMITING Most important symptoms and effects, both acute and delayed Inhalation Eye contact Skin contact Ingestion May cause irritation to respiratory system. May cause irritation to eyes. May cause irritation to skin. Ingestion may cause nausea and vomiting Indication of any immediate medical attention and special treatment needed Inhalation Eye contact Skin contact Ingestion SECTION 5: Firefighting measures 5.1. Extinguishing media If you feel unwell, seek medical advice (show the label where possible). Seek medical attention Special hazards arising from the substance or mixture 5.3. Advice for firefighters SECTION 6: Accidental release measures Seek medical attention if irritation or symptoms persist. If you feel unwell, seek medical advice (show the label where possible). Use extinguishing media appropriate to the surrounding fire conditions. Burning produces irritating, toxic and obnoxious fumes. Wear suitable respiratory equipment when necessary Personal precautions, protective equipment and emergency procedures 6.2. Environmental precautions 6.3. Methods and material for containment and cleaning up Ensure adequate ventilation of the working area. Avoid contact with skin and eyes. Wash hands after handling the product. Do not allow product to enter drains. Prevent further spillage if safe. Absorb with inert, absorbent material. Transfer to suitable, labelled containers for disposal. Clean spillage area thoroughly with plenty of water

36 3/7 Red Stop Solution date Reference to other sections See section 2, 8 & 13 for further information. SECTION 7: Handling and storage 7.1. Precautions for safe handling 7.2. Conditions for safe storage, including any incompatibilities 7.3. Specific end use(s) Adopt best Manual Handling considerations when handling, carrying and dispensing. Avoid contact with eyes and skin. Ensure adequate ventilation of the working area. Keep containers tightly closed. Keep in a cool, dry, well ventilated area. Store in correctly labelled containers. See section 1.2 for further information. SECTION 8: Exposure controls/personal protection 8.1. Control parameters 8.2. Exposure controls Occupational exposure controls. Appropriate engineering controls Individual protection measures Eye / face protection Skin protection - Hand protection Skin protection - Other Respiratory protection Occupational exposure controls Ensure adequate ventilation of the working area. Wear suitable protective clothing. Wear:. Approved safety goggles. Wear:. Chemical resistant gloves. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from food, drink and animal feed and/ or feed products. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties