Safety Data Sheet - Version 5.0 Preparation Date 7/20/2016 Latest Revision Date (If Revised) SDS Expiry Date 7/19/2019

Transcription

1 Safety Data Sheet - Version 5.0 Preparation Date 7/20/2016 Latest Revision Date (If Revised) SDS Expiry Date 7/19/ IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product Identifier Chemical Name Vitamin B12 Catalogue # V Relevant Identified Uses of the Substance or Mixture and Uses Advised Against Product Uses To be used only for scientific research and development. Not for use in humans or animals. 1.3 Details of the Supplier of the Safety Data Sheet Company Toronto Research Chemicals 2 Brisbane Road Toronto, ON M3J 2J8 CANADA Telephone FAX orders@trc-canada.com 1.4 Emergency Telephone Number Emergency# between (GMT-5) 2. HAZARDS IDENTIFICATION WHMIS Classification (Canada) Not WHMIS controlled. WHMIS Symbols (Canada) 2.1/2.2 Classification of the Substance or Mixture and Label Elements GHS Hazards Classification (According to EU Regulation 1272/2008 and US OSHA ) Not a hazardous substance by GHS. EU Classification (According to EU Regulation 67/548/EEC) Not a hazardous substance by this Classification. EU Risk and Safety Statements (According to EU Regulation 67/548/EEC) Hazard Statements Hazard Codes Risk Codes and Phrases Not a hazardous substance by this Classification. Safety Precaution Codes and Phrases GHS Hazards Identification (According to EU Regulation 1272/2008 and US OSHA ) Signal Word GHS Hazard Statements Not a hazardous substance according to GHS. Toronto Research Chemicals - V Page 1

2 GHS Precautionary Statements 2.3 Unclassified Hazards/Hazards Not Otherwise Classified. 3. COMPOSITION/INFORMATION ON INGREDIENTS 3.1 Substances Molecular Formula: C 63 H 88 CoN 14 O 14 P Molecular Weight: CAS Registry #: EC#: Synonyms 5,6-Dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-1H-benzimidazole Monoester Cobinamide Cyanide Inner Salt; 5,6- Dimethylbenzimidazolyl Cyanocobamide; 5,6-Dimethylbenzimidazolyl-Co-cyanocobamide; Anacobin; Antipernicin; Apikobal; B-Twelve; B-Twelve Ora; Bedodeka; Bedoz; Behepan; Berubi; Berubigen; Dobetin; Docemine; Docibin; Poyamin; Rebramin; Redamina; Vitarubin; Vitral; 3.2 Mixtures Not a mixture. 4. FIRST AID MEASURES 4.1 Description of First Aid Measures General Advice If medical attention is required, show this safety data sheet to the doctor. If Inhaled If inhaled, move person to fresh air. If not breathing, give artificial respiration and consult a physician. In Case of Skin Contact Wash affected area with soap and water. Consult a physician if any exposure symptoms are observed. In Case of Eye Contact Immediately rinse eyes with plenty of water for at least 15 minutes. Consult a physician. If Swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Do NOT induce vomiting unless advised to do so by a physician or Poison Control Center. Seek medical attention. 4.2 Most Important Symptoms and Effects, Both Acute and Delayed The most important known symptoms and effects are described in the labeling (see section 2.2) and/or section Indication of any Immediate Medical Attention and Special Treatment Needed. 5. FIREFIGHTING MEASURES 5.1 Extinguishing Media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special Hazards Arising from the Substance or Mixture Carbon oxides, Nitrogen oxides, Phosphorous oxides, Cobalt oxides 5.3 Advice for Firefighters Wear self contained breathing apparatus for fire fighting if necessary. 5.4 Further Information. 6. ACCIDENTAL RELEASE MEASURES Toronto Research Chemicals - V Page 2

3 7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage conditions: -20 C Freezer 7.3 Specific End Uses For scientific research and development only. Not for use in humans or animals. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1 Control Parameters Contains no components with established occupational exposure limits. 8.2 Exposure Controls Appropriate Engineering Controls A laboratory fumehood or other appropriate form of local exhaust ventilation should be used to avoid exposure. Personal Protective Equipment All recommendations below are advisory in nature and a risk assessment should be performed by the employer/end user prior to use of this product. The type of protective equipment must be selected based on the amount and concentration of the dangerous material being used in the workplace. Eye/Face Protection Safety goggles or face shield. All equipment should have been tested and approved under appropriate standards, such as NIOSH (US), CSA (Canada), or EN 166 (EU). Skin Protection Gloves should be used when handling this material. Gloves are to be inspected prior to use. Contaminated gloves are to be removed using proper glove removal technique so that the outer surface of the glove does not contact bare skin. Dispose of contaminated gloves after use in compliance with good laboratory practices and local requirements. Gloves used for incidental exposures (splash protection) should be designated as chemical resistant by EU standard EN 374 with the resistance codes corresponding to the anticipated use of the material. Unrated gloves are not recommended. Suggested gloves: AnsellPro Sol-Vex nitrile gloves style , 15 mil thickness. Penetration time has not been determined. Gloves used for prolonged direct exposure (immersion) should be designated chemical resistant as per EN 734 with the resistance codes corresponding to the anticipated use of the material. Suggested gloves: AnsellPro Viton/Butyl gloves style , 4/8 mil thickness. Penetration time has not been determined. These recommendations may not apply if the material is mixed with any other chemical, or dissolved into a solution. A risk assessment must be performed to ensure the gloves will still offer acceptable protection. Body Protection Fire resistant (Nomex) lab coat or coveralls. Respiratory Protection Recommended respirators are NIOSH-approved N100 or CEN-approved FFP3 particulate respirators. These are to be only used as a backup to local exhaust ventilation or other engineering controls. If the respirator is the only means of protection, a full-face supplied air respirator must be used. Toronto Research Chemicals - V Page 3

4 9. PHYSICAL AND CHEMICAL PROPERTIES 9.1 Information on Basic Physical and Chemical Properties A) Appearance B) Odour Dark Red Solid C) Odour Threshold D) ph E) Melting Point/Freezing Point F) Initial Boiling Point/Boiling Range >133 C (dec.) G) Flash point H) Evaporation Rate I) Flammability (Solid/Gas) J) Upper/Lower Flammability/Explosive Limits K) Vapour Pressure L) Vapour Density M) Relative Density N) Solubility O) Partition Coefficient: n-octanol/water DMSO (Slightly), Water (Slightly) P) Auto-Ignition Temperature Q) Decomposition Temperature R) Viscosity S) Explosive Properties T) Oxidizing Properties 9.2 Other Information no data available 10. STABILITY AND REACTIVITY 10.1 Reactivity Chemical Stability Decomposes on exposure to light. Stable under recommended storage conditions Possibility of Hazardous Reactions Conditions to Avoid Incompatible Materials Strong mineral acids Hazardous Decomposition Products In the event of fire: See section 5. Other decomposition products:. 11. TOXICOLOGICAL INFORMATION 11.1 Information on Toxicological Effects A) Acute Toxicity Oral LD50: Mouse - > 5,000 mg/kg Dermal LD50:. B) Skin Corrosion/Irritation C) Serious Eye Damage/Irritation D) Respiratory or Skin Sensitization E) Germ Cell Mutagenicity F) Carcinogenicity Inhalation LC50:. Toronto Research Chemicals - V Page 4

5 G) Reproductive Toxicity/Teratogenicity H) Single Target Organ Toxicity - Single Exposure I) Single Target Organ Toxicity - Repeated Exposure J) Aspiration Hazard K) Potential Health Effects and Routes of Exposure Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion May be harmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. L) Signs and Symptoms of Exposure The most important known symptoms and effects are described in the labeling (see section 2.2) and/or section 11. To the best of our knowledge, the chemical, physical, and toxicological properties of this material have not been thoroughly investigated. M) Additional Information RTECS: GG ECOLOGICAL INFORMATION 12.1 Toxicity Persistance and Degradability Bioaccumulative Potential Chasmichthys gulosus - 3 d Bioconcentration factor (BCF): Mobility in Soil Results of PBT and vpvb Assessment Other Adverse Effects. 13. DISPOSAL CONSIDERATIONS 13.1 Waste Treatment Methods A) Product Product may be burned in an incinerator equipped with afterburner and scrubber. Excess and expired materials are to be offered to a licensed hazardous material disposal company. Ensure that all Federal and Local regulations regarding the disposal and destruction of this material are followed. B) Contaminated Packaging Dispose of as above. C) Other Considerations Product is not to be disposed of in sanitary sewers, storm sewers, or landfills. 14. TRANSPORT INFORMATION 14.1 UN Number DOT (US): N/A IATA: N/A IMDG: N/A ADR/RID: N/A 14.2 UN Proper Shipping Name DOT (US)/IATA: Not dangerous goods IMDG/ARD/RID: Not dangerous goods Toronto Research Chemicals - V Page 5

6 14.3 Transport Hazard Class(es) DOT (US): N/A IATA: N/A IMDG: N/A ADR/RID: N/A 14.4 Packing Group DOT (US): N/A IATA: N/A IMDG: N/A ADR/RID: N/A 14.5 Environmental Hazards DOT (US): IATA: IMDG: ADR/RID: 14.6 Special Precautions for User 15. REGULATORY INFORMATION This safety data sheet complies with the requirements of WHMIS (Canada), OSHA (US), and EU Regulation EC No. 1907/2006 (European Union) Safety, Health and Environmental Regulations/Legislation Specific for the Substance or Mixture A) Canada DSL/NDSL Status: This product or a component of this product is registered on the Canadian DSL/NDSL. B) United States TSCA Status: This product or a component is listed on the US EPA TSCA. C) European Union ECHA Status: This product is not registered with the EU ECHA Chemical Safety Assessment 16. OTHER INFORMATION 16.1 Revision History Original Publication Date: 7/20/ List of Abbreviations LD50 Median lethal dose of a substance required to kill 50% of a test population. LC50 Medial lethal concentration of a substance required to kill 50% of a test population. LDLo Lowest known lethal dose TDLo Lowest known toxic dose IARC International Agency for Research on Cancer NTP National Toxicology Program RTECS Registry of Toxic Effects of Chemical Substances 16.3 Further Information Copyright Toronto Research Chemicals Inc. Copies may be made for internal use only. The above information is believed to be correct to the best of our knowledge, but is to be only used as a guide. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Please take all due care when handling this product. Toronto Research Chemicals - V Page 6