SAFETY DATA SHEET Page 1 of 6

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1 Revised: 9/11/18 NAME: PAPAVERINE HYDROCHLORIDE SAFETY DATA SHEET Page 1 of 6 Humco Holding Group, Inc Alumax Dr Texarkana TX USA cs@humco.com 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION Product Name: Papaverine Hydrochloride Synonyms: Papaverini hydrochloridum Recommended Use: No relevant information available. Manufacturer / Supplier: Humco Holding Group, Inc Alumax Dr Texarkana TX USA cs@humco.com 24-Hour Emergency Number (CHEMTREC) USA International All non-emergency calls should be directed to Customer Service at SDS NO Hour Emergency Number (CHEMTREC) USA International All non-emergency calls should be directed to Customer Service at HAZARD IDENTIFICATION Pictogram: GHS06 Classification: Acute Tox. 3 Signal Word: Hazard Statements: Danger H301 Toxic if swallowed 3. COMPOSITION / INGREDIENTS CHEMICAL NAME PAPAVERINE HYDROCHLORIDE PAPAVERINI HYDROCHLORIDUM CAS# The exact percentage has been withheld as a trade secret

2 Page 2 of 6 4. FIRST-AID MEASURES ROUTE COMMON SYMPTOMS FIRST AID Inhalation Not determined In case of unconsciousness place patient stably in side position for transportation. Ingestion Not determined Seek medical treatment Do not induce vomiting; immediately call for medical help Skin Not determined Seek immediate medical advice. Immediately wash with water and soap and rinse thoroughly. Eyes Not determined Rinse opened eye for several minutes under running water. Consult a doctor 5. FIRE-FIGHTING MEASURES Flash Point: Auto Ignition: Extinguishing Media: Products of Combustion: Fire Fighting Equipment and Procedures: Not Applicable CO2, extinguishing powder, or water spray. Fight larger fires with water spray or alcohol resistant foam. Nitrogen oxides (NOx) Carbon monoxide (CO) Hydrogen chloride (HCl) Wear fully protective suit 6. ACCIDENTAL RELEASE MEASURES Personal Precautions: Environmental Precautions: Method of Containment & Clean-Up: Not required Damp down dust with water spray Do not allow to enter sewers/surface or ground water Ensure adequate ventilation 7. HANDLING AND STORAGE Handling: Storage: Thorough dedusting Store in cool, dry conditions in well-sealed receptacles.

3 Page 3 of 6 8. EXPOSURE CONTROLS AND PERSONAL PROTECTION Engineering Controls: Personal Protective Equipment (PPE) Eye/Face Protection: Skin Protection: Respiratory Protection General Hygiene Considerations: No further relevant information. Protective work clothing. Not required Protective gloves Suitable respiratory protective device recommended Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance: Crystalline, White Upper/Lower Flammability: Not Applicable Odor: Odorless Vapor 795 C (1,463 F): Odor Threshold: Vapor Density: Not Applicable ph: Density at 20 C (68 F): Melting point /Freezing Point: Boiling point/range: 280 C(536 F) (Zersetzung) 1,453 C (2,615 F) Solubilities: Partition coefficient: n-octanol/water: Slightly soluble in water Flash point Not Applicable Auto-ignition temperature Evaporation rate Not Applicable Decomposition Temperature: Flammability: Product is not flammable Viscosity >180 C (>536 F) Not Applicable

4 Page 4 of STABILITY AND REACTIVITY Reactivity: Chemical Stability: Possibility of Hazardous reactions: Conditions to Avoid: Incompatible materials: Hazardous Decomposition Products: Reacts with strong oxidizing agents Carbon monoxide and carbon dioxide Nitrogen oxides (NOx) Hydrogen chloride (HCl) 11. TOXICOLOGICAL INFORMATION Acute toxicity: Skin irritation: Eye contact damage: Respiratory damage: Ingestion overdose: Delayed, immediate, or chronic effects from short- and long-term exposure LD50 Oral: Dermal: Symptoms associated with exposure: Based on available data, the classification criteria are not met. Based on available data, the classification criteria are not met. 68 mg/kg (rat) Carcinogenicity: OSHA: NTP: IARC: Substance is not listed. Substance is not listed. Substance is not listed.

5 Page 5 of ECOLOGICAL INFORMATION Acute or chronic aquatic toxicity: Chemical degradation: Biodegradation: Bioaccumulation potential Adsorption studies or leaching studies: Other adverse effects Water hazard class 1: slightly hazardous for water 13. DISPOSAL CONSIDERATIONS Dispose in accordance with federal, state and local laws and regulations. Avoid release into environment. Must not be disposed of together with household garbage. Do not allow product to reach sewage system. 14. TRANSPORT INFORMATION DOT Hazard Classification: UN number: UN proper shipping name: Transport hazard class(es): Packing group number: Environmental hazards: Special precautions: UN1544 Alkaloids, solid, n.o.s. (Papaverine Hydrochloride) 6.1 Toxic substances III Not Applicable Warning: Toxic substances REGULATORY INFORMATION

6 Page 6 of OTHER INFORMATION The information in this SDS is considered current and reliable. However, the data is provided without any warranty, expressed or implied, regarding its correctness or accuracy. Since the conditions for use, handling, storage and disposal are beyond Humco s control, it is the responsibility of the user to determine safe conditions for use and to assume liability for loss, damage, or expenses arising from improper use. No warranty expressed or implied regarding the product described herein will be created by or inferred from any statement or omission. Various agencies may have specific regulations concerning the transportation, handling, storage, use or disposal of this product which may not be reflected in the SDS. The user should review these regulations to ensure full compliance.