600 tonnes 11.2 M 100% of CO2 emissions offset. allocated to protecting the environment. green electric energy in Spain Goals.

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1 600 tonnes 11.2 M of CO2 emissions offset allocated to protecting the environment This pillar contributes towards achieving the following Sustainable Development Goals: 100% green electric energy in Spain ESTEVE, in accordance with the principles of sustainable development, carries out its activities respecting people and the environment, taking into consideration the risks and environmental impacts, and using the best practices and technologies available to prevent contamination. To this end it promotes and participates in voluntary initiatives beyond those required by environmental legislation Goals 2018 Goals Implement Phase II of the Clean Industry Certification Programme promoted by the Mexico s Ministry for the Environment, PROFEPA, for Sintenovo Reduce CO2 emissions to achieve a reduction of 6% in the next three years, contributing to SDG (13.2) in the fight against climate change Resilience to climate change P erform an energy efficiency audit in the Sintenovo plant SUSTAINABILITY REPORT 90% In progress

2 Company profile ı Responsible business ı Health and well-being ı Employment and human development ı Environment ESTEVE promotes environmental improvements through the ISO Management Systems implemented in all its production plants, which undergo internal and external audits every year. This environment management covers the whole life cycle of the products and processes, from R&D, to the manufacturing of active ingredients, to the manufacture and marketing of pharmaceutical products. Life-cycle management Analysing the life cycle provides a quantitative overview of the environmental impacts of each product from its design to its elimination, including production, transport, use and maintenance, as well as knowing the environmental footprint of the organisation. In 2017 the new sustainability assessment model for suppliers was defined and the new pilot program to begin to assess them will begin in Optimising consumption The optimisation of resources and the responsible management of consumption is one of the main focal points of ESTEVE s environmental actions. Consumption of key resources have evolved as follows: Raw materials consumption Water consumption Electricity consumption Gas consumption tn m 3 GJoules GJoules +4% +5% +4% +11% 21,321 24,686 25, , , , , , , , , , The variations in consumption are basically due to the variety of the portfolio of products manufactured. With regard to raw materials, it should be noted that 3% is reinvested into the in-house processes, which represents 849 tonnes of solvents being reused in the chemical business. In 2017 the consumption of electricity from the grid at the production centres in Spain originated from renewable energy sources. It should be noted that, of ESTEVE s total water consumption, 93% comes from the municipal supply and 7% from underground water, with 7% of the volume being reused. [GRI 103-1, GRI 103-2, GRI 103-3, GRI 302-1, GRI 302-4, GRI 303-1, GRI 303-3] 47

3 Combating climate change and other emissions As part of ESTEVE's commitment to combating climate change, it has been a part of the United Nations Caring for Climate programme since Our actions are aligned with the Sustainable Development Goals (SDG), to reduce CO 2 emissions, incorporating renewable energies, implementing improvements to our installations and promoting sustainable behaviours. Highlights of 2017 Adhesion to the Voluntary Accords programme for the reduction of greenhouse gases promoted by the Catalan Department for Climate Change of the Catalan government. Entry in the carbon footprint register, offsetting and projects to absorb carbon dioxide of the Ministry of Agriculture, Food and Environment. Incorporation of the CO 2 emissions associated with waste treatment, which account for 40% of all emissions in 2017, and those associated with workers commuting in Mexico. The 2017 actions under our campaign to fight climate change Suma tu gesto, resta CO 2 (Add your gesture, take away CO2) are: Green energy: renewal, for the fifth consecutive year, of the purchase of renewable electricity for 100% of the production centres in Spain. Offsetting of 600 tonnes of CO 2 through a project for the construction and maintenance of small hydroelectric power plants in China. This project also represents social benefits through cooperation in the development of the most vulnerable rural populations. Monitoring projects to optimise consumption identified in the energy audits of our highestconsuming facilities in Spain. In particular, at the production centre in Martorelles (Spain), where there is a specific energy optimisation working group, the total carbon footprint in 2017 went down 5% from the previous year, and for the Chemicals business production centre in Banyeres del Penedès (Spain) the reduction was 9% in tonnes of CO 2 compared to Expansion of the scope of the annual ESTEVE Greenhouse Gasses (GHG) inventory, including in the 2017 figures emissions derived from processing waste in Spain and Mexico and emissions derived from the commuting of Sintenovo workers (Mexico). The overall 2017 carbon footprint result, calculated according to the Greenhouse Gas Protocol (GHG Protocol), increased by 11%, mainly due to the addition of waste treatment in scope 3, increased consumption, and emissions from the company fleet and/or leasing reflected in scope 1, as shown in the graph: CO 2 emissions Spain and Mexico 28,549 tn CO 2 [GRI 103-1, GRI 103-2, GRI 103-3, GRI 305-1, GRI 305-2, GRI 305-3, GRI 305-4, GRI 305-5] 23 14,629 3,117 10,803 31,005 tn CO 2 16,997 1,916 12,091 34,443 tn CO ,738 2,084 13, Scope 1: Direct emissions by ESTEVE in Spain and Mexico (including emissions from the leased vehicle fleet). Scope 2: ESTEVE s indirect emissions resulting from electricity consumption in Spain and Mexico. Scope 3: Transport and distribution of electricity + business trips + worker commuting + waste in Spain and Mexico. Intensity: greenhouse gas emissions in tonnes CO 2 -eq for scopes 1 and 2, divided by turnover in millions of dollars. Scope 1 Scope 2 Scope 3 Intensity SUSTAINABILITY REPORT

4 Company profile ı Responsible business ı Health and well-being ı Employment and human development ı Environment The production plants are equipped with systems to treat the emissions from the production processes such as scrubbers, a Regenerative Thermal Oxidation (RTO) plant in Celrà (Girona) and cryogenic plants in Celrà and Banyeres del Penedès (Tarragona). At the production centres of the chemicals business in Spain, balances of solvents are carried out in compliance with the legislation governing the emission of volatile organic compounds, and this is reported at a European level in the PRTR Register (European Pollutants Release and Transfer Register). In particular, the mass emissions of nitrogen oxides (NOx), sulphur oxides (SOx), non-methane volatile organic compounds (NMVOC), emissions of carbon monoxide (CO), dichloromethane (DCM), chlorine and inorganic compounds such as HCl and particulate matter emissions (PM10) are recorded. The equivalent emissions associated with the use of these gases and heating and/or cooling equipment that use substances that damage the ozone layer have been quantified within Scope 1 of the GHG emissions and are not very significant in terms of ESTEVE s total emissions. Effluent and waste management ESTEVE performs careful management of the environmental types of waste and wastewater. The Company has wastewater treatment plants at its Chemicals production plants in Spain and China and all production centres have control systems to ensure the quality of the discharged waste water is appropriate and remains below the contamination limits parameters established by law. In 2017 there were no significant spillages or discharges (24) that could have affected the quality of the water. All wastewater is discharged into the public sewerage system of the zone in question. In 2017 a total of 367,540 m 3 of waste water was discharged into the sewerage system, 78% of the total volume. The volume of waste depends on the quantity and type of products manufactured, and total waste generation increased by 7% compared to the previous year of The management, treatment and destination of this waste depends on its characteristics (composition, degree of hazard, origin, etc.) Waste Destination/treatment of waste 2017 tonnes 1,531 24,741 1,783 26,344 Recovery: 651 tonnes 2% Other type of external management: 240 tonnes 1% Landfill: 5,022 tonnes 18% Recycling: 1,385 tonnes 5% Re-used: 12,568 tonnes 45% Incinerated: 8,247 tonnes 29% Composted: 14 tonnes 0% Tonnes of non-hazardous Tonnes of hazardous waste Continual efforts are made to minimise the waste generated at source, which centres on: Optimising the reuse of solvents during production process stages. Optimising the management of solvent waste with a significant impact on the environment and costs in the chemicals business. Improving the separation and recycling of waste. Reducing the environmental impact of packaging and containers for pharmaceutical products within ESTEVE s Business Prevention Plan, as a member of SIGRE and ECOEMBES SIGRE. [GRI 103-1, GRI 103-2, GRI 103-3, GRI 305-6, GRI 305-7, GRI 306-1, GRI 306-2, GRI 306-3] (24) Significant spillage: Accidental discharge that has happened at ESTEVE Centres, which involves an impact on health and/or the environment and which triggers any of the scenarios in the Emergency Plan. 49

5 Conservation of biodiversity ESTEVE is committed to caring for and protecting the spaces surrounding our plants and the countries where we operate, which is why we collaborate in partnership with non-governmental organisations. Additionally, to promote the circular economy and responsible consumption, ESTEVE promotes the reuse of disused assets and goods to give them a second life. Outstanding programmes Bosques Terapéuticos (Therapeutic Forests) Collaborating with Collaborating since 2017 results Sèlvans Association forests selected 3 forests implemented 25 guides trained 27 beneficiaries of the therapeutic itineraries Cumulative results 2017 was the first year of project implementation Small hydraulic power plants in China ECODES tonnes of CO 2 offset 3,128 tonnes of CO 2 offset Reactiva, reuse of disused resources Resource Bank Foundation donation 2 social entities 740 kilos of material donated 740 euros saved on purchases 74 kilos of CO 2 saved 19 donations 21 social entities 11,135 kilos of material donated 25,250 euros saved on purchases 1,200 kilos of CO 2 saved Bosques Terapéuticos (Therapeutic Forests) As part of its commitment to health and preserving the biodiversity surrounding our work centres, ESTEVE has been partnering with Sèlvans, formerly the Natura Foundation, for more than 10 years. We have been supporting the Bosques Terapéuticos (Therapeutic Forests) project in the province of Girona (Spain) since This project has three goals: Highlights of 2017 The Bosques Terapéuticos (Therapeutic Forests) programme promoted by the Sèlvans Association, which has a three-fold objective: to preserve mature forests, to create new jobs and to promote health. Promote the well-being and active health of people (patients and local communities). Protect and preserve the biodiversity of old forests. Create new jobs by training therapeutic guides to lead the itineraries. Therapeutic itineraries are carried out in these forests which consist of walking through the forest (slow walk) while doing a series of guided sensorial exercises in order to achieve well-being and improve health. With this project ESTEVE is promoting health, healthy habits and the environment. [GRI 103-1, GRI 103-2, GRI 103-3, GRI 413-1] SUSTAINABILITY REPORT