advanced IRMS inlets Isoprime

Transcription

1 advanced IRMS inlets Isoprime

2 Working together... Isoprime has a comprehensive range of inlet systems suitable for the IsoPrime mass spectrometer. They allow a broad range of sample types to be analysed to a level of precision to suit your requirements. Naturally, both Dual Inlet (DI) and Continuous Flow (CF) needs are catered for in our product line. Our inlets are designed to carefully combine high sample throughput, high precision and day-to-day reliability. Imagine the extra sensitivity of a very low memory ion source that delivers exceptional ion production, a detector system with up to ten long-life Faraday collectors and a high stability head amplifier together providing stable and precise results. Then consider the power of IonVantage software designed for ease of use and speed of sample analysis. Now, add the ability to switch instantly between class-leading inlets capable of multielemental CHNS analysis, headspace gas analysis, compound specific isotope analysis and ultra high precision analysis of carbonates and waters. It s easy to see why the Isoprime series works together like no other, giving you the very best solutions in the field of stable isotope mass spectrometry.

3 ...as no other Dual Inlet Constructed to high specifications, Isoprime s Dual Inlet ensures high precision measurements for small sample sizes, or gases such as SO 2, without memory effects. The Dual Inlet contains two stepper-motor driven high compression ratio bellows and fourteen low dead volume valves. The inter-valve connections are machined from a single block of metal and the complete inlet may be baked to 90 o C. The bellows on the reference side measures 100mL to allow long automated runs and the Dual Inlet design allows for minimum possible dead volume. For the highest precision requirements, Isoprime has a range of Dual Inlet Systems. These enable very small samples to be analysed precisely and accurately. Continuous Flow Whenever you need a Continuous Flow (CF) sample preparation and management system, Isoprime is the ideal choice, with an extensive range of CF inlets incorporating class-leading technologies. With an electrostatic filter fitted as standard, the IsoPrime is fully equipped for C, H, N, O and S isotope measurements. Rapid analysis of a large quantity of samples can be achieved easily, with autosamplers and diluters available to make the process more efficient. C, H, N, O and S can be sampled quickly and precisely, using gas, liquid or solid samples, whilst maintaining high precision. Instant switching between Dual Inlet - Continuous Flow modes MS/Inlet/Sample management & control with IonVantage software Multiple inlet connection Easy-fit plug and play inlet connectivity

4 Elemental Analysis Isoprime is an Elementar company, sharing research and development expertise for C, H, N, O and S, ensuring that the world s most advanced elemental analysis solution is achieved through the combination of the vario MICRO cube and vario EL cube, together with an IsoPrime mass spectrometer. The vario elemental analyser series is the result of 100 years expertise, coupled with state of the art micro electronics and mechanics. In addition, Elementar have a tradition of long term oriented technical support ensuring that your EA-IRMS is well supported for years to come. vario MICRO cube vario MICRO cube is optimized for micro samples and uses an innovative columnar gas separation with Thermal Programmed Desorption (TPD). It combines simplicity of chromatographic methods with large concentration capacity and baseline peak separation of purge and trap techniques. This is the the basis for simultaneous C, N, S-IRMS analysis even for high carbon and very low sulfur concentrations. The vario EA series uses columnar gas separation and Thermal Programmed Desorption (TPD) to feed gas into its thermal conductivity sensor (TCD), which is impervious to oxygen intrusion. The instruments have in common an absolute blank free ball valve sample injection (patented) in connection with a 120 position autosampler. The combustion furnace operates up to 1200 o C with 10 years warranty and can also be used at 1350 o C for O and H pyrolysis applications. Electronic mass flow control serves for stable calibration over many months. Very large detection range from ppm to 100% concentration with large range thermoconductivity (TCD) and NDIR option. The special gas separation serves also for large absolute dynamic ranges of absolute element content and ratios and software supporting 21 CFR Part 11 is available.

5 vario EL cube Optimized for the widest range of sample weights from < 1mg up to even 100mg of organic or 1g soil samples, the vario EL cube is the ultimate in elemental analysis. Its unique gas separation at 3 specific temperature controlled absorber columns serve for micro and macro analysis in one instrument without compromises. In addition to simultaneous CNS-IRMS, the vario EL cube can be configured for CHNS-IRMS analysis (Elementar patent) in connection with an IsoPrime. These multiple element capabilities are even possible with high carbon, low nitrogen and sulfur samples. Options available Oxygen analysis with TCD and IR detection Sulfur IR photometer kit Chlorine analysis Capsule technique for liquids Automatic liquid injector Hydrogen-IRMS analysis, low temperature* High temperature pyrolysis for H and O-IRMS analysis *vario EL cube only

6 Gas & Liquid Chromatography Inlets GC-IRMS Isoprime s GC-IRMS facilitates compound specific isotope analysis for applications such as environmental science, geosciences, food authentication or biomedical sciences. The GC interface and selected options can enable on-line measurement of δ 13 C, δ 15 N, δ 18 O and δd of organic compounds separated by capillary chromatography. The GC-IRMS precisely analyses samples sizes down to 1.0nmol with GC combustion and 20nmol for GC pyrolysis achieved through efficient separation and combusition or pyrolysis, without isotopic fractionation. The Isoprime GC V Interface is designed around Agilent Technologies, Inc., GC separation technology. The standard GC combustion and pyrolysis package comes with an Agilent 7890 gas chromatograph with a split/splitless injector, DB-5 capillary column and flame ionization detector (FID) detector, Isoprime Limited s GC V microbore oxidation/pyrolysis furnace and interface heater. The interface has a maximum temperature of 1500 o C and can be used for both combustion and pyrolysis applications. Water can be removed either by a membrane dryer or a cryogenic trap. Gas flow is regulated throughout the entire interface. Heart-splitting switches eluent between the GC V interface and FID to allow only compounds of interest to be analysed on the IsoPrime. Reference gas is automatically pulsed into the IsoPrime and timings are fully adjustable to optimize placement of the gas pulses for your sample chromatography. Parameters can be saved in the software and recalled when a specific sample or standard type is analysed again to be able to save time and effort in the laboratory. The GC-IRMS package can be fully automated by addition of an autosampler. For compound specific nitrogen isotope analysis the configuration includes a reduction furnace, fixing kit and cryogenic trap for removing CO 2 and H 2 O. Autosampler Split/Splitless injector Programmable temperature vaporiser (PTV) injector On-column injector

7 GC-IRMS continued The standard configuration for δd analysis includes ChromeHD for low temperature analysis of δd (1050 o C). The powerful continuous flow data processing (CFDP) package within IonVantage has numerous methods available for sample peak integration and background correction. Previously analysed samples can be reprocessed whilst another sample is running. LiquiFace The LiquiFace is the Liquid Chromatography (LC) inlet for compound specific isotope analysis for aqueous solvent separations such as sugars, amino acids and organic compounds. A peristaltic pump is used to deliver reagents to the LiquiFace. Eluent from the Ion Chromatograph (IC) mixes with these reagents, is heated and the resultant CO 2 is separated using a gas separation unit and δ 13 C of the separated compound is analysed. The Liquiface can also be used for underivatised samples, not suitable for GC analysis. With Isoprime s Liquid Chromatography you can perform other techniques which until now, have been impossible.

8 Dual Inlet Dual Micro-Inlet When it comes to the most demanding of IRMS requirements, dual-inlet capability is essential. Simultaneous multiple comparison of sample and reference gases can be achieved via a dual inlet system and it is particularly useful in geoscience, hydrology and environmental applications. With its unique modular design and monobloc changeover valve construction, Isoprime s compact Dual Micro-inlet system delivers the ultimate performance in dual inlet IRMS. Featuring stepper-motor driven high compression ratio bellows and 14 low dead volume valves, it represents the most advanced high performance dual inlet system available.

9 Automated Dual Inlet Systems Three systems are available for fully automated dual inlet analysis of multiple samples. They include an autosampler allowing for unattended operation. AquaPrep AquaPrep is for the high precision analysis of 18 O and D/H of waters. MultiCarb MultiCarb is for the high precision analysis of 13 C and 18 O of small size carbonates. It includes a bakeable on-line water trap using a bespoke cryoprobe and fully acid resistant needle design. It is especially efficient for extremely small samples MultiPrep Combines the capabilities of the AquaPrep and MultiCarb in one system. New developments in MultiPrep technology have delivered a reliable and robust solution to high precision carbonate analysis. Redesigned cold fingers give dependable trapping of the smallest samples whilst enhanced scripting control handles sample gas quickly to give unparalleled results. New DI-Data Processing compiles data into summary graphs and tables allowing the performance to be tracked and making dating analysis much quicker for the user.

10 Head Space Gas Analysis MultiFlow CF IRMS The MultiFlow Continuous Flow IRMS inlet series is available in three options for a broad spectrum of applications including geology, enviromental, food authentication and medical sciences. The incorporation of innovative Direct Injection technology allows more flexibility in sample introduction, whilst Heartcutting ensures that only pure gas is introduced into the mass spectrometer. The inclusion of an autosampler enables high throughput and unattended analysis. Multiflow Breath for analysis of 13 C in whole breath and air. Results are available within 3 minutes (air analysis is an optional kit) MultiFlow Bio for water analysis (H/D and 18 O) via equilibration methods. Sample results are available within 2 minutes. The Multiflow Bio features a short equilibration time as standard and no need to change the needle between flushing and analysis to make this a true high-throughput method for water analysis. Capabilities include water sample sizes down to 200 µl. Comes with a 60 sample heated tray (breath and air analysis as optional on MultiFlow Bio). MultiFlow Geo includes all the features of MultiFlow Breath and Bio together with the ability to investigate 13 C and 18 O in carbonates. MultiFlow Geo also incorporates an automated acid delivery system for unattended reaction with H 3 PO 4. The Multiflow is the inlet of choice for highthroughput analysis of carbonates. (δ 13 C of CO 2 in breath, δ 13 C and δ 18 O of CO 2 in air and δ 13 C of DIC available as optional kits on MultiFlow Geo)

11 TraceGas For environmental science and geosciences applications, TraceGas is the ultimate automated system for on-line pre-concentration and purification of trace gases from air. TraceGas is specifically designed to analyse concentrations at the ppm level for CH 4 and CO 2 and ppb N 2 O. Chemical traps are integrated for removal of H 2 O, CO 2 ( for N 2 0 and CH 4 analysis ) and conversion of CO to CO 2 ( for analysis of CH 4 ). A membrane dryer removes water of combustion and Poraplot Q GC column separates N 2 O and CO 2. Switching between configurations is a simple switch of two three way valves. To enable CH 4 analysis a combustion furnace is used to convert methane to CO 2. As with many of the IsoPrime inlets, TraceGas is available with an autosampler which is particularly well suited to analysing N 2 O samples derived by the denitrification method and CO 2 samples in exetainers.

12 Isoprime Isoprime Limited Isoprime House Earl Road, Cheadle Hulme, Cheadle, SK8 6PT, UK t: +44 (0) f: +44 (0) e: w: isoprime.co.uk