DuPont A Market Driven Science Company. John Ranieri Vice President & General Manager DuPont Applied BioSciences

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1 DuPont A Market Driven Science Company John Ranieri Vice President & General Manager DuPont Applied BioSciences Citi 2008 Agriculture Conference ctober 2, 2008

2 2 Regulation G The attached charts include company information that does not conform to generally accepted accounting principles (GAAP). Management believes that an analysis of this data is meaningful to investors because it provides insight with respect to ongoing operating results of the company and allows investors to better evaluate the financial results of the company. These measures should not be viewed as an alternative to GAAP measures of performance. Furthermore, these measures may not be consistent with similar measures provided by other companies. This data should be read in conjunction with previously published company reports on forms 10-K, 10-Q, and 8-K. These reports, along with reconciliations on non-gaap measures to GAAP are available on the Investor Center of Forward Looking Statements During the course of this presentation we may make forward-looking statements or provide forward-looking information. All statements that address expectations or projections about the future are forward-looking statements. Some of these statements include words such as "expects," "anticipates, "plans," "intends," "projects," and "indicates. Although they reflect our current expectations, these statements are not guarantees of future performance, but involve a number of risks, uncertainties, and assumptions. Some of those risk factors include economic conditions, competitive pressures, challenges associated with research and development, market acceptance of new products, and regulatory approval. We urge you to review DuPont's SEC filings, particularly its latest annual report on Form 10-K and quarterly report on Form 10-Q, for a discussion of some of the factors which could cause actual results to differ materially. The Company does not undertake to update any forward-looking statements as a result of future developments or new information.

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4 4 DuPont Applied BioSciences Large addressable markets growing rapidly Markets growing 10% - 15% per year Unique DuPont science Focused to deliver maximum value Large market penetration opportunity Strengthened by key value chain partners

Susterra, Zemea Cerenol Sorona Hytrel RS BioSpecialties BioSurfaces mega 3 BioMedical ActaMax sealants Anti-adhesives Embolics Value in

5 5 DuPont Applied BioSciences Project Pipeline Unique, disruptive science with significant opportunity to capture above average return on investment BioFuels Cellulosic ethanol JV with Danisco Biobutanol JV with BP Market Size BioMaterials Bio-PD Loudon plant start-up Susterra, Zemea Cerenol Sorona Hytrel RS BioSpecialties BioSurfaces mega 3 BioMedical ActaMax sealants Anti-adhesives Embolics Value in Use / Unit Zemea and Susterra are trademarks of DuPont Tate & Lyle Bio Products Company LLC, a joint venture company of DuPont and Tate & Lyle

6 6 Biofuel Imperatives Low Cost Renewable Carbon Upstream High Value Sustainable Fuels Downstream Feedstock Adequate Regional Supply Refinery & Pipeline Compatibility With Existing Infrastructure Retail & Consumer Uncompromised Fuel Performance Current biofuel solutions are inadequate to meet global needs

7 7 Cellulosic Ethanol Value Proposition DuPont technology delivers lower-cost production vs grainbased ethanol using cellulosic non-food feedstocks Increase biofuel output per acre e.g. corn stover, bagasse, wheat straw New feedstocks e.g. fiber sorghum, switchgrass

8 8 Cellulosic Ethanol Substantial market growth and C 2 reduction Estimated Biofuel Volume Potential 20-40% C 2 reduction vs. gas 65-95% C 2 reduction vs. gas Energy crops / new acres Grain / Sugar Feedstocks % Reduction in C 2 equivalents per the International Energy Agency Corn stover / Sugarcane Bagasse Switch Grass / Fiber Sorghum

9 9 Cellulosic Ethanol Technology ptions Biochemical Enzymatic Conversion Microbial Fermentation Cellulosic Feedstocks Thermochemical Ethanol Gasification Reforming Biochemical Conversion using Enzymes is the Leading Technology for Sustainable Biofuels

Corn cob & stover Sugarcane bagasse Wheat straw Rice straw

10 10 Cellulosic Ethanol Commercial Concept Biomass Raw Material Biomass Processing Sugars Fermentation Ethanol Corn cob & stover Sugarcane bagasse Wheat straw Rice straw Energy crops Saccarification C5 C6 Proprietary conversion microbes

11 Land Use Requirements To support different commercial plant capacities (MGPY = Million Gallons Per Year) MGPY Ag Residues 300, , ,000 Dedicated Energy 300, , MGPY Biomass Required Tons/Yr Feedstock Proximity Radius Sq. Miles Acres Dedicated Energy 600, , MGPY Dedicated Energy 1,200, ,000 Dedicated energy = energy crops (i.e., switchgrass)

$12 Plants distributed over half the country Corn fractions from land already used for corn Switchgrass has three times the carbon per acre and is planted on additional acres Feed Acres BGY Potential$

12 Focus on Two Feedstocks in the U.S. 12 Plants distributed over half the country Corn fractions from land already used for corn Switchgrass has three times the carbon per acre and is planted on additional acres Feed Acres BGY Potential stock Cob Stover * Switchgrass * Removal at 50% of stover rate Potential switchgrass acres Current corn acres Source: DDCE, Univ. Tenn., USDA

13 13 DuPont Danisco Cellulosic Ethanol The world s first robust,

Hydrolysis Fermentation to Ethanol 50/50 joint venture between Danisco

investment by both partners over >3 years Feedstock-flexible pilot plant

13 13 13 DuPont Danisco Cellulosic Ethanol The world s first robust, integrated solution for biomass-to-ethanol Pretreatment Enzymatic Hydrolysis Fermentation to Ethanol 50/50 joint venture between Danisco and DuPont Commercialize integrated technology solution $140 million investment by both partners over >3 years Feedstock-flexible pilot plant in 2009 Cobb & switchgrass, Eastern Tennessee Commercial demonstration facility targeted by 2012

14 14 Cellulosic Ethanol Process Performance Integration of key process elements Integrated process established Scale-up work in progress Cell software >80% complete % of Cost Goal Cell software optimization Process optimization Commercial Goal: < grain-based EtH total cost Time (yr) 7 8

15 15 15 DuPont Danisco Cellulosic Ethanol Two leaders unite to deliver cellulosic ethanol economically Refiners cost per gallon Fixed cost incl deprec. ther Input costs * Net feedstock cost Cellulose from Cob ($50/ton) Corn Grain Ethanol ($5/bu) Regular Gasoline ($80/bbl) Regular Gasoline ($120/bbl) * Enzymes, chemicals, utilities, other Target Source: DuPont Danisco estimates, on a volume basis. For illustration purposes only. Grain Ethanol indexed to 100

16 16 Cellulosic ethanol market opportunity: $75-140B * Creating the Standard Investment Capabilities DuPont Danisco Cellulosic Ethanol LLC R&D Intellectual Property Equity wner Technology

16 16 16 Cellulosic ethanol market opportunity: $75-140B * Creating the Standard Investment Capabilities DuPont Danisco Cellulosic Ethanol LLC R&D Intellectual Property Equity wner Technology Provider perations Management Business Model Anticipates Multiple Value Capture Mechanisms * 2020 market opportunity for cellulosic ethanol, based on a McKinsey study and DuPont Danisco estimates

17 17 Cellulosic Ethanol Pilot Plant 250,000 gallons/yr Dec start-up 250,000 gallons/yr Dec start-up

18 18 Cellulosic Ethanol Financial pportunity $ Billion Pilot / Demo Plants perational Cellulosic Revenue pportunity* Commercial Plant Construction % CAGR Key Success Factors Biocatalyst development Pretreatment efficiency Applicable to multiple feedstocks Financial Expectations Capture significant portion of value through licensing PTI margin on equity interest sales > corporate average * Cellulosic revenue refers to the potential revenue in which DuPont would have either a royalty interest on sales or equity interest in sales from production facilities.

19 19 Biobutanol Value Proposition Biobutanol delivers significantly improved logistics & fuel performance across the value chain Lower distribution costs Higher blending value Higher energy density (26%) Higher blend ratios with existing engine designs

20 20 Biobutanol Commercial Concept Ag Inputs Feedstock Processing Sugars Fermentation Biobutanol Plant Feedstocks Performance Fuels

21 21 Butanol Economic Value Miles per gal. Refinery efficiencies Distribution flexibility Price * Ethanol CM Volume Basis Biobutanol * Normalized ethanol price / Graph illustrates sources of value / Not to scale

22 22 Production of high octane isomers First to demonstrate via synthetic pathways Iso-BuH H 2 C 2 H H H H H 2e -,2H + Patents Filed in ctober 2005 isobutyraldehyde 2e -,2H + H H H 2 C 2 H pyruvate acetolactate H α-keto isovalerate H isobutanol 2,3 dih-3-methyl butyrate 2-BuH Patents Filed in May e -, 2 H + H H2 2e -,2H + H 2 H C 2 H H C 2 (R) H (S) (R) H pyruvate acetolactate acetoin 2,3 butanediol MEK 2-butanol

(proposed) 100MM GPY EtH Plant (proposed) Accelerate availability of

23 23 Biobutanol Demonstration Plant Biobutanol demonstration plant sited on existing BP site at Kingston upon Hull in UK Biobutanol Demo Plant (proposed) 100MM GPY EtH Plant (proposed) Accelerate availability of commercial technology for scaleup to MM GPY Same site as 100 MM GPY ethanol plant

24 24 DuPont Biobutanol Process Performance Metrics & Goals % of Cost Goal Proof of Concept Foundation IP established Synthetic pathways optimized Host microorganisms selected Demonstration plant designed Demonstration plant operation Production strain optimization Process optimization Commercial Goal 2007 superior to ABE process 2010 economics equivalent to ethanol Patents ver 60 patent applications Biology Fermentation process Chemical conversion End use applications Time (yr)

25 25 Early Biobutanol Production Sugar Juice Sugar Cane Bagasse Grain Dry Dry Grind Grind Sucrose Sugar Wet Mill C6 Fermentation Steam Electricity Glucose Butanol Vinasse C6 Fermentation DDGS Butanol

26 26 Migration to Cellulosic Butanol Crop Residues Energy Crops Milling Coproducts Pretreatment Saccharification Glucose/Xylose C6/C5 Fermentation Separation Ethanol Butanol Lignin Steam Electricity

27 27 Biobutanol Financial pportunity Biobutanol Revenue pportunity* $ B % CAGR Pilot / Demo Plants perational Commercial Plant Construction Key Success Factors Biocatalyst development Conversion feasibility Preferred EU biofuel Financial Expectations Blend of equity investments and licensing Capture significant portion of value PTI margin on equity interest sales > corporate average * Biobutanol revenue refers to the potential revenue in which DuPont would have either a royalty interest on sales or equity interest in sales from production facilities.

28 28 DuPont Innovations that Transform the Market Low Cost Renewable Carbon Upstream High Value Sustainable Fuels Downstream Feedstock Adequate Regional Supply Refinery & Pipeline Compatibility With Existing Infrastructure Retail & Consumer Uncompromised Fuel Performance Cellulosic Ethanol Biobutanol

DuPont Applied Biosciences: Initiatives on next generation biofuels

DuPont Applied Biosciences: Initiatives on next generation biofuels Dr. Wilson Andalécio Araujo Biofuels Technology Manager LA DuPont Applied BioSciences Biofuels State of São Paulo Research Foundation