Advanced Biofuels and Bioproducts Process Demonstration Unit. BIO World Congress. July Bioenergy Technologies Office 1

Transcription

1 Advanced Biofuels and Bioproducts Process Demonstration Unit BIO World Congress July 2017 Bioenergy Technologies Office 1

2 Relevant Mission Areas at the Berkeley Lab Biological Systems and Engineering: To lead efforts that combine the power of biology with the tools of engineering to develop sustainable energy solutions and improve human health ABPDU: Partner with researchers from industry, the National Labs, and academia to optimize and scale technologies for bio-based chemicals / materials / fuels commercialization. Bioenergy Technologies Office 2

3 ABPDU enabling biofuel/product commercialization 15,000 square foot Demonstration Lab established by American Recovery and Reinvestment Act funds in 2009 Work closely with DOE EERE s BioEnergy Technologies Office (BETO) A bio-process research incubator / accelerator industry-friendly IP rights, costrecovery project fee structure, experienced team, and Bay Area location Bioenergy Technologies Office 3

4 Bench-scale & process pilot prototyping to enable industry deployment Process demonstration, integration and techno-economic analysis across varied bio-process configurations, feedstocks and products Simple sugars Fermentation Biomass deconstruction / extraction Many feedstocks Many processes Chemical catalysis Advanced recovery and purification Fuels / Chemicals Proteins / Enzymes Polymers Microbial biomass Can focus on individual unit operations or several processes in succession Bioenergy Technologies Office 4

5 Broad product and industry partner base Biofuels & biomass Materials & chemicals Food & health Waste & water Completed projects Ongoing Bioenergy Technologies Office 5

6 Facility at a glance from bench-to-pilot scale Bioenergy Technologies Office 6

7 Multi-disciplinary and cross-trained team Decon & Analytical Ning Sun, PhD Fermentation & Recovery Deepti Tanjore, PhD Process & Facilities Eng. / scrum lead Akash Narani, MS 3 Senior Research Associates 1 post-doc 2 Senior Engineers 1 post-doc 1 Research Associate 1 multipurpose engineer (Eng Div) Agile Project Management employed for day-to-day Ops on the process floor 1 Research Associate 3 RA / Senior RA staff Building owner and EH&S POC Workforce development via internships a key activity - DOE CCI & SULI, UC Berkeley Manufacturing-to-Market Bioenergy Technologies Office 7

8 The why - addressing gaps with our partners Transition from lab- to bench-scale bioreactor process development o o o Cell bank and seed train Media formulation Technology transfer inbound and outbound Analytical method implementation o Sample and data sharing, troubleshooting, method development Pilot-scale biomass handling, fermentation, & downstream processing o o o o Primary recovery and separations (S/L, L/L, S/L/L, volatiles) Purification Chemical finishing and polishing Packaging and stability Definition of target product profile, QA/QC specs, and TEA Bioenergy Technologies Office 8

9 Providing a critical resource with several DOE / EERE / BETO programs and consortia co-optima Feedstock Conversion Interface Consortium BETO Small Business Lab Calls and Industrial Seedlings Bioenergy Technologies Office 9

10 Working with industry partners via other agency programs Bioenergy Technologies Office 10

11 Implementing Lygos cellulosic malonic acid validation Bioenergy Technologies Office 11

12 Translating basic scientific discoveries into more applied and scaled demonstrations Bioenergy Technologies Office 12

13 Enabling advances in scalable protein production at commercially relevant quality with industry partner Bioenergy Technologies Office 13

14 Enabling advances in scalable protein production at commercially relevant quality (cont.) Bioenergy Technologies Office 14

15 Developing prototype commercial-scale bioproduct processes Bioenergy Technologies Office 15

16 Working to make partners scale-up more predictable Biomarker level Reduced culture growth periodically observed during scale-up 2 L bioreactor Flask 2 L 300 L Inter-campaign variability pointed to need for greater process robustness Bioenergy Technologies Office 16

17 Thank you! Bioenergy Technologies Office 17