For research use only. Not for use in diagnostic procedures. CHEMTREC: (INTERNATIONAL) (NORTH AMERICA)

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1 SAFETY DATA SHEET Issuing date 29-Jun-2007 MSDS PN: REV. D 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Product Code Product Name Trade Name(s) Recommended Use , N Acetic Anhydride ACETIC ACID, ANHYDRIDE; ACETIC OXIDE; ACETYL ANHYDRIDE; ACETYL ETHER; ACETYL OXIDE; ETHANOIC ANHYDRIDE; ACETYL ACETATE; ETHANOIC ACID ANHYDRIDE; PEPTIDE SYNTHESIS REAGENT #4 For research use only. Not for use in diagnostic procedures. Contact Manufacturer APPLIED BIOSYSTEMS 7 KINGSLAND GRANGE, WOOLSTON WARRINGTON, CHESHIRE WA1 4SR Telephone: (UK) Fax: Emergency Telephone Number CHEMTREC: (INTERNATIONAL) (NORTH AMERICA) 2. COMPOSITION/INFORMATION ON INGREDIENTS Haz/Non-haz Chemical Name EINECS-No. CAS-No Weight % Classification R10 Xn;R20/22 C;R34 For the full text of the R phrases mentioned in this Section, see Section HAZARDS IDENTIFICATION The preparation is classified as dangerous in accordance with Directive 1999/45/EC. Classification R10 C;R34 Xn;R20/22 C - Corrosive. Most Important Hazards Flammable. Causes burns. Harmful by inhalation and if swallowed. 4. FIRST AID MEASURES General advice Eye contact Immediate medical attention is required. Show this safety data sheet to the doctor in attendance. Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. Do not rub affected area. Call a physician immediately. Page 1 / 7

2 Skin contact Ingestion Inhalation Notes to physician Protection of first-aiders Wash off immediately with soap and plenty of water removing all contaminated clothes and shoes. Call a physician immediately. Clean mouth with water and afterwards drink plenty of water. Do NOT induce vomiting. Drink plenty of water. Never give anything by mouth to an unconscious person. Call a physician or Poison Control Centre immediately. Move to fresh air. If not breathing, give artificial respiration. Consult a physician. Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated. Do not give chemical antidotes. Asphyxia from glottal edema may occur. Marked decrease in blood pressure may occur with moist rales, frothy sputum, and high pulse pressure. Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation. 5. FIRE-FIGHTING MEASURES Suitable extinguishing media Dry chemical or CO2. Extinguishing media which must not be used for safety reasons Decomposition by contact with water may generate vapours which can be ignited by heat or open flame. Specific hazards Flammable. Produce toxic and/or corrosive substances on contact with water. Special protective equipment for firefighters Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Environmental precautions Personal precautions Methods for cleaning up Methods for Containment Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Do not flush into surface water or sanitary sewer system. Local authorities should be advised if significant spillages cannot be contained. Look out! Corrosive material. Remove all sources of ignition. Ensure adequate ventilation. Use personal protective equipment. Evacuate personnel to safe areas. Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Contain and collect spillage with non-combustible absorbent material, (e.g. sand, earth, diatomaceus earth, vermiculite) and place in container for disposal according to local / national regulations (see Section 13). Other information Refer to protective measures listed in Sections 7 and HANDLING AND STORAGE Handling Storage Ensure adequate ventilation. Wear personal protective equipment. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Avoid contact with skin and eyes. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition. Page 2 / 7

3 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Exposure Limits Chemical Name EU The United Kingdom France Spain Germany VLCT: 5 ppm VLA-ED: 5 ppm VLA VLCT: 20 mg/m 3 ED; 21 mg/m 3 VLA-ED TWA: 0.5 ppm STEL: 10 mg/m³ STEL: 2 ppm TWA: 2.5 mg/m³ MAK: 5 ppm MAK: 21 mg/m 3 Ceiling / Peak: 21 mg/m 3 Ceiling / Peak: 5 ppm TWA: 5 ppm TWA: 21 mg/m 3 Chemical Name Italy Portugal The Netherlands Finland Denmark TWA: 5 ppm STEL: 2.5 mg/m 3 STEL STEL: 21 mg/m 3 Ceiling: 20 mg/m MAC: 2.5 mg/m 3 MAC STEL: 5 ppm Ceiling: 5 ppm Chemical Name Austria Switzerland Poland Norway Ireland Occupational Exposure Controls STEL: 10 ppm STEL; 40 mg/m 3 STEL MAK: 5 ppm MAK; 20 mg/m 3 MAK STEL: 5 ppm STEL (15 min); 20 mg/m 3 STEL (15 min) MAK: 5 ppm MAK; 20 mg/m 3 MAK NDSP: 20 mg/m 3 NDS: 10 mg/m 3 Ceiling: 20 mg/m 3 TWA: 0.1 mg/m 3 TWA: 0.5 ppm STEL: 0.4 mg/m 3 STEL: 2 ppm Engineering measures Personal protective equipment Respiratory protection Eye protection Skin and body protection Hand protection Hygiene measures Environmental exposure controls Showers, eyewash stations, and ventilation systems. In case of insufficient ventilation wear suitable respiratory equipment. Tightly fitting safety goggles. Impervious clothing. Chemical resistant apron. Boots. Impervious butyl rubber gloves. Remove and wash contaminated clothing before re-use. Wash hands before breaks and immediately after handling the product. No information available 9. PHYSICAL AND CHEMICAL PROPERTIES Page 3 / 7

4 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Colourless. Odour strong, Pungent, vinegar-like. Odour Threshold 0.14 ppm Physical state Liquid. ph No information available Flash point 49 C / 120 F Method Closed cup. Autoignition temperature 316 C / 601 F Boiling point/range 140 C / 284 F Melting point/range -73 C / -99 F Flammability Limits in Air Upper 2.7 Lower 10.3 Specific Gravity Molecular Weight Water solubility Reacts with water. Solubility Ether. Alcohol. Acetic acid. Benzene. Ethyl acetate. Evaporation rate 0.46 (BuAc = 1). Vapour pressure C Vapour density 3.52 (air=1) VOC content 100% Viscosity C 10. STABILITY AND REACTIVITY Stability Conditions to avoid Materials to avoid Stable under recommended storage conditions. Keep away from open flames, hot surfaces and sources of ignition. water. Acids. Bases. Amines. Strong oxidizing agents. Hazardous decomposition products Thermal decomposition can lead to release of irritating gases and vapours. 11. TOXICOLOGICAL INFORMATION Acute Toxicity Product Information. Chronic Toxicity Corrosivity Reproductive Toxicity Developmental Toxicity Target Organ Effects This product is corrosive to living tissue. Eyes. Respiratory system. Skin. Page 4 / 7

5 12. ECOLOGICAL INFORMATION Ecotoxicity Ecotoxicity effects. Chemical Name Toxicity to algae Toxicity to fish Microtox Data Daphnia magna (Water flea) EC50 = 55 mg/l 24 h Persistence and degradability Bioaccumulative potential Mobility No product level data available. Chemical Name log Pow DISPOSAL CONSIDERATIONS Waste from residues / unused products Contaminated packaging Dispose of as hazardous waste in compliance with local and national regulations. Do not re-use empty containers. Dispose of in accordance with local regulations. EWC waste disposal No Other information According to the European Waste Catalogue, Waste Codes are not product specific, but application specific. Waste codes should be assigned by the user based on the application for which the product was used. 14. TRANSPORT INFORMATION IMDG/IMO Subsidiary Risk 3 EmS F-E, S-C,,8(3),PG RID ADR Classification Code CF1,8,,RID ADR/RID-Labels Classification Code CF1,8,,ADR Page 5 / 7

6 14. TRANSPORT INFORMATION ADR/RID-Labels ICAO Subsidiary Risk 3,8(3),,PG ICAO/IATA Subsidiary Risk 3 ERG Code 8F,,8(3),PG 15. REGULATORY INFORMATION The preparation is classified as dangerous in accordance with Directive 1999/45/EC. Labelling Contains. EU Labeling EC Label Symbol(s) C - Corrosive. R-phrase(s) R10 - Flammable. R34 - Causes burns. R20/22 - Harmful by inhalation and if swallowed S-phrase(s) S 7 - Keep container tightly closed. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S35 - This material and its container must be disposed of in a safe way. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Take note of Dir 94/33/EC on the protection of young people at work Not to be used by professional users below 18 years of age, see the National Working Environment Authorities Executive Order on young peoples dangerous work. International Inventories Page 6 / 7

7 Chemical Name EINECS ELINCS TSCA DSL NDSL PICCS ENCS China AICS KECL Present X - X X X X KE Text of R phrases mentioned in Section 2 R34 - Causes burns. R10 - Flammable. R20/22 - Harmful by inhalation and if swallowed 16. OTHER INFORMATION Issuing date Revision Date Revision Note 29-Jun Jun-2007 No information available Disclaimer The information provided on this SDS is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text. End of Safety Data Sheet Page 7 / 7