The importance of healthcare within a an all cargo carrier S. Evangelakakis Global Product Manager Healthcare and Perishables.

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1 The importance of healthcare within a an all cargo carrier S. Evangelakakis Global Product Manager Healthcare and Perishables Victor Laszlo 1

2 Agenda 1. Who is Cargolux 2. Challenges 3. Lessons learned an all cargo airline 4. Why we went for GDP 2

3 Cargolux Founded in March 1970: over 45 years of experience in all-cargo services Operating a modern and energy-efficient fleet of 26 aircraft (Boeing 747F) 1,817 employees worldwide 1335 employees in Luxembourg Dual Hub Strategy with Zhengzhou Airport initiated in 2014 Europe s #1 all cargo carrier, # 6 worldwide 3

4 Our network Global presence Cargolux Destinations Map 4

5 What these commodities have in common? 5

6 Maintaining the temperature possible if we can do perishable we can do pharma 6

7 Implementation of CV PHARMA Product GDP Certification since January 2014 Healthcare Center Luxembourg Hub GDP-certified trucking partners NOTOC (Notification to Captain) Aircraft thermal mapping Fleet-wide temperature recording Use of thermal covers, active and passive cool containers Dedicated subject-matter experts for day-to-day follow-up CV Pharma product 7

8 Did below drive GDP and new EU directive certification? Curtesy of Exelsius 8

9 Seamless info exchange KPI Dashboard Escalation paths PEOPLES BUSINESS 0 Manufacturing Plant eeend TO END SUPPLY CHAIN and maintainaing Temperature range 1 Transport packaging Loading 2 3 EXPORT IMPORT Contract Manufacturing Packaging contractor API Manufactures 9 8 Destination Handling Company Manufacturing plant 7 Order pick&pack Flight time 6 To warehouse or plant Transit Final delivery 5 12 Origin 3 PL Distributor Wholesaler Phamarcist 4 Coolchain must be maintained all time Doctor Hospital 9

10 Or this? Cause we did not have a standard 10

11 Environmental Control System aircraft 3 Air-conditioning packs provide conditioned air Airflow is not only used for temperature control, but also for pressurization Engine bleed air (with a high pressure) must be used Problem: Bleed air temperature: 180ºC >>4-29ºC Air-conditioning Packs required to cool down bleed air Lesson: the aircraft airflow performs good Source: company material

12 During flight the a/c performed much better then our findings 30 C ATD LUX: 1048z ATA IND: 1938z 25 C Temperature settings and pallet distribution: AFT MD: 15 C PMC43015R7/PMC98313R7/PYB14246R7 Temperature 20 C 15 C AFT LD: 5 C PMC49187R7*/PMC33209R7/PMC34185R7/ AFT LD AFT MD 10 C 8 C 5 C 2 C 0 C 4/08/ :00 4/08/ :00 4/08/ :00 Time (GMT) 4/08/ :00 4/08/ :00 4/08/ :00 12

13 Implementation of CV PHARMA Product Aircraft 4 independently controllable compartments Pilot-reporting in case of deviations Retrofitted data loggers on -400F/ERF part-fleet Automatic downloads for - 8F, scheduled manual downloads for -400F/ERF NOTOC to advise crew of different commodities and required temperature 13

14 818m2 / 350 skids (euro pallets) Implementation of CV PHARMA Product Healthcare Center Luxembourg Hub (2-8 C)

15 1600m2 / 1270 skids (euro pallets) Implementation of CV PHARMA Product Healthcare Center Luxembourg Hub (15-25 C)

16 Pax operation vs. Cargo operation 3/31/

17 On the ground ( Tarmac ) Cool Cell Gate Exit to the tarmac Refrigerated Stacker-System with 40 Cool Cell (0 C to +27 C) Ready to board the aircraft less then 60 minutes of departure No storage on the tarmac 17

18 Cargo carriers simply parked In close proximity of warehouse Short transfer times to/on ramp LUX Same set up would be in Rio 18

19 We were ready for a certification 19

20 Implementation of CV PHARMA Product GDP- certified trucking partners

21 GDP accreditation within CV network BOM and MAA recently added Cargolux Destinations Map 21

22 CV PHARMA Product COL 2-8 C CRT C ERT 2-25 C FRO Transporting pharmaceutical products destined for patients worldwide represents an important responsibility. Drawing on the indepth knowledge of our cool chain experts and on our GDP-certified fleet and hub, we ensure the safe and expedient movement of your high-value temperature sensitive shipments worldwide.

23 Possible schedule challenges, Cargolux has the highest daily utilization in the world close to 16hrs Commercial decisions to reroute aircraft ( LUX-TPE-HKG iso of LUX-HKG-TPE AOG aircraft on Ground due to technical ( anywhere in the world Part-charter on the route LUX-TPE-HKG adding AUH ( LUX-AUH-TPE-HKG ) Aircraft delay ( maintenance air traffic control crew duty ) Weather conditions and aircraft must be divirted to alternate airport

24 Growing Cargolux Healtcare portofolio BERNA BIOTECH KOREA CORP 24

25 Presenting Cargolux Product Overview

26 We have it all? 26

27 Thank you for your attention 27