28 March Product Innovation. Jonathan Howard-Brand Supply Specialist, Innovation Unit. UNICEF/UNI197921/Schermbrucker
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2 28 March 2017 Product Innovation Jonathan Howard-Brand Supply Specialist, Innovation Unit UNICEF/UNI197921/Schermbrucker
3 UNICEF Supply Division: Product Innovation Need Development Scale
4 Need: in depth analysis of full context Purpose is to communicate requirements for products which are currently not available Less prescriptive than an RFP to allow for creativity and innovation flexibility. Not final procurement specifications Useful tool to gain understanding of UNICEF and partners product needs and to gain internal buy-in for driving R&D In 2016, 7 Target Product Profiles were published Available online here: 4 UNICEF Product Innovation UNICEF for every child UNICEF Product Innovation UNICEF for every child
5 Development: working non-exclusively with developers Industry : Dialogue with UNICEF on maturity of technology Ensure clinical and regulatory approvals UNICEF Clarity on needs (e.g amendments to a TPP or industry consultations) Field trials in UNICEF context to prove value and inform scale Convene regulatory partners/advisory committees for feedback
6 Scale: incentivizing through volume guarantees and trials UNICEF has a number of ways to incentivise ( pull ) developers to invest in R&D, regulatory and related to the product. Concretely, UNICEF can do one of the following ranging from less to more committing: Indicate willingness to procure products meeting the TPP Commit to carrying out field trials of selected products meeting the TPP selected through competitive bidding Commit to working with key actors and national agencies (governments and implementing partners) to drive interest in uptake of products meeting the TPP Legally commit (through an Advanced Purchase Commitment or an Advanced Market Commitment) to procure a given amount of products
7 Convergence of Product Innovation and Influencing Markets How we increase perceived value: * Market pull Tipping Point Sustainable Market Field Trials (FT) Programmatic and technical guidance Engagements with partners, such as WHO Advocacy to end-users and implementing partners How we reduce cost Foster competition Drive voloume Strategic/transparent procurement *Supply Financing Mechanism
8 Our Value Add Supply Division Define & Communicate Field Needs Enable Product Development Field Trial/Pilot Implementation & Scale Field Communicate bottlenecks Highlight Demand Implementation/scale Developers/ Suppliers Product Development Quality Assurance Clinical Validation Production
9 Challenges Need Development Scale Working through the tradeoffs to create a TPP that matches the field needs. Designing a PULL that ensure the right R&D gets pulled. Ensuring impact actually happens.
10 Stage-Gate Process UNICEF Product Innovation UNICEF for every child
11 Product Innovation Example 11 Title of Presentation UNICEF for every child
12 Zika Virus (ZIKV) Diagnostic Key Activities: Creation of TPPs to communicate the desired performance of products. First time WHO, PAHO and UNICEF launched joint TPPs. Zika Partner- Industry Consultation at SD with over 50 people subject experts to share UNICEF s Zika response strategy, exchange knowledge in an open and transparent forum, and communicate the need to accelerate product development through increased awareness of stakeholders challenges and needs. Initial forecast developed based on WHO classification of ZIKV transmission, environmental suitability for vector-borne transmission, potential target cohorts and various uptake scenarios. Coordination with USAID engaged in pull-mechanism, i.e. funding R&D to reduce time-to-market for POC diagnostics What s Next: Continuous monitoring of the R&D landscape and consultations with industry. Additionally, bilateral consultations with key pipeline manufacturers. Tendering With Zika and market uncertainties, ensuring we share risk with industry and make a balance to create a tipping point that makes a push-pull incentive that creates the right products and a healthy market.
13 Looking Ahead: Equipment for Injection Safety 13 Title of Presentation UNICEF for every child
14 AD 1999 SB Joint UNICEF, WHO, UNFPA Policy Issued Auto-Disable (AD) as a step-stage technology (added attribute to already established technology) AD Safe Injection Device Development start 2005 UNICEF Expressed preference for early activation of the disabling mechanism (to reduce risk of reuse) leading to redefining technology and improve product design 2009 Adequate Supply Available with preferred AD mechanism for full award - with multiple suppliers RUP 2008 Introducing the RUP & RUP/SIP feature for reconstitution of freeze dried vaccines start RUP/SIP 2015 Introducing the RUP & RUP/SIP in therapeutic injections- participation in WHO expert group for new guideline recommendation RUP/SIP RUP Needle-free devices
15 What we want: Innovation
16 What we are going to do? our next steps 1. RFI / market analysis what are you doing? 2. If market does not meet UNICEF s needs a. Development of TPP(s) b. Industry Consultation (face-to-face/ online) c. Online transparency 3. If/when market meets UNICEF s needs a. Field Trials (if needed) b. Share results and recommendations 4. Subject to FT results two routes: a. Positive results: i. Procurement b. Negative results: i. Work with industry on improvements
17 In the end, it s all about getting to Scale UNICEF/NYHQ /DORMINO
18 Get in touch
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