Detailed Information of APIs And Intermediates for Cephalosporin and Cardiovascular Drugs

Transcription

1 B&H BIOTECHOLOGY CO., LTD. 必致生物科技有限公司 Detailed Information of APIs And Intermediates for Cephalosporin and Cardiovascular Drugs 1 5-Ethylthio-1H-Tetrazole CAS O.: Appearance: White crystals Assay: 98% Moisture: 0.5% Melting Point: Use: Medicine, pesticide intermediates and for the synthesis of DA and RA active agent of the protective gene activity. customized product 2 5-Benzylthio-1H-Tetrazole CAS O.: Appearance: White granulated crystals Assay: 98.5% Moisture: 0.1% Melting Point: Use: Cephalosporin drugs for the synthesis of RA synthesis is as 2-O-TBDMS activator. customized product 3 1-methyl-5-mercapto-1H-tetrazole (MMTZ) By name: 1-mathyl-1H-tetrazloe-5-thiol; 1-methyl-5-mercapto-1,2,3,4-tetrazlole

2 structure Formula: intermediate for making cefoperazone, cefeminox, cefmenoxime, Cefpiramide, 7-MAC etc. CAS: Assay: 99% Water: 0.3% Melting point: 124~136 Package: 25kg fiber drum 4 Sodium Azide By name: DDH Molecular: a 3 CAS O.: Usage: Intermediate of TAA and some other pharmaceuticals Assay: 99%; 99.5% Free alkali : 0.2% LOD: 0.2% Package: 25kg fiber drum or on demand 5 Intermediate of Cefuroxime acid (DCC) Packing: 25kg/drum Packing Spec: 35x44cm Gross Weight:28kg 6 1,1,3,3-Tetramethylguanidine (TMG) Packing:25kg/drum Packing Spec. :56.7cm 90cm 7 5-mercapto-1,2,3,4-tetrazole methyl sulfonic acid disodium salt (SMT-DS) By name: SMT-DS

3 a side chain if cefonicid CAS O.: H-tetrazol-5-ethyl formate (ETC) BEST SELLER By name: ETC O C 2 H 5 O C H CAS O.: Usage: Intermediate of Pranlukast Package: 25kgs fiber drum(35cm 44cm) Manufacture capacity: 5MT/mon. Build-to-Order Quality specification: SPECIFICATIOS White crystal Assay 98% Purity 99% Loss on drying 1.0% 1.0% Melting point 88.0~93.0 Individual impurity 0.5% 9 7-MAC a parent nucleus for cefeminox, cefmetazole, cefoperazone, cefotetan

4 10 Cefepime CAS O.: (2-Dimethylaminoethyl)-5-Mercapto-1,2,3,4-Tetrazole (DMMT) BEST SELLER By name: DMMT CH 3 CH 2 CH 2 CH3 SH CAS O.: Package: 25kgs fiber drum(35cm 44cm) Manufacture capacity: 2MT/mon. Build-to-Order Usage: Intermediate of Cefotiam Quality capacity: SPECIFICATIOS Off white crystalline powder Assay 99% 0.50% 12 2-(2-Formylaminothiazol-4-yl) acetic acid (F-ATAA) BEST SELLER CAS O.: Assay : 98% Water: 0.5% Packaging: 40kgs fiber drum Usage: intermediates for Cefotiam

5 13 2-(2-Aminothiazol-4-yl) acetic acid, hydrochloride (ATAA.HCL) BEST SELLER By name: ATAA.HCl CH 2 COOH H 2 S HCl CAS O.: Usage: Intermediate of Cefotiam Package: 25kgs fiber drum(35cm 44cm) Manufacture capacity: 8MT/mon. Build-to-Order Quality specification: SPECIFICATIOS Off white crystalline powder Assay 98% 0.50% 14 Ethyl 2-(2-aminothiazol-4-yl) acetate (EATA) CAS O.: Assay : 98% Moisture: 0.5% Packaging: 25kgs fiber drum Usage: intermediates for Cefotiam 15 2-(2-Aminothiazol-4-yl) acetic acid (ATAA) By name: ATAA CH 2 COOH H 2 S CAS O.: Usage: Intermediate of Cefotiam

6 Package: 25kgs fiber drum(35cm 44cm) Manufacture capacity: 5MT/mon. Build-to-Order Quality specification: SPECIFICATIOS Off white crystalline powder Assay 98% 0.50% 16 Cefuroxime Acid CAS O: Assay: 99% Water: 1.0% Optical rotation: +63 ~+67 Packaging: 25kgs fiber drum Usage: Intermediate for cefuroxime Acid 17 2-(2-Aminothiazole-4-yl)-2-[2-(tertbutoxycarbonyl)isopropoxyimino]acetic acid (AT-TBA) By name:at-tba CAS O.: Purity: 98% Water: 0.5% Melting point: 170 Package:20kgs fiber drum Usage: intermediate for BPTA 18 Ethyl ( Z )-2-(2-aminothiazol-4-yl)-2- hydroxyiminoacetate (EHATA) By name: EHATA

7 CAS O.: Assay: 99% Water: 0.5% Packaging: 25kgs fiber drum Usage: intermediate for Ceftazidime, cefdinir 19 S-2-benzothiazolyl-(2)-2-(1-terbatoxycanbonyl-1-methylethoxyimino)-4-thiazole acetate (TAEM) By name: TAEM CAS O.: Purity: 98% Water: 0.3% Packaging: 20kgs fiber drum Usage: intermediate for Ceftazidime 20 1H-Tetrazolyl-1-Acetic Acid (TAA) BEST SELLER By name: TAA CH 2 COOH Quality specification: CAS O.: Package:25kgs fiber drum (35cm 44cm) Manufacture capacity: 20MT/mon. Usage: intermediate for Cefazolin

8 SPECIFICATIOS Off white crystalline powder Purity 99% Melting point 128.0~ % Heavy metal 10ppm Iron 10ppm Absorbance Clarity Bright and clear 21 ( Z )-2-Methoxyimino-2-(furyl-2-yl)acetic acid, ammonium salt (SMIA) By ame: SMIA CAS O.: Assay : 99% Moisture : 0.5% Packaging: 25kgs fiber drum Usage: intermediate for Cefuroxime 22 Methoxyamine Hydrochloride (OMHA) By ame: O-Methylhydroxyamine Hydrochloride CAS O.: Structure: CH 3 O-H. 2 HCL Assay: 99% Moisture: 0.5% Melting Point: 148~152 Packaging: 25kgs fiber drum Usage: intermediate for Cefuroxime and bactericide 23 Product name: 3- OH BEST SELLER Chemical name: 7-Phenyl acetylamino-3-hydroxy-3-cephemcyclo-4-carboxylic acid diphenyl methyl ester

9 Formula: C 28 H 24 2 O 5 S O CH 2 C H O S COOCH OH CAS O.: Package: 25kgs fiber drum(35cm 44cm) Usage: Intermediate of several 3 rd generation cephalosporins, such as Ceftizoxime, Ceftibuten and Cefroxadine Manufacture capacity: 8 MT/mon. Quality specification: Identification Assay(HPLC) SPECIFICATIOS White or Off-white crystalline powder IR MR 99.0% 1.0% 24 Product name: 7-ACA BEST SELLER Chemical name: 7-Amino-3-nor-3-cephem-4-carboxylic acid; Formula: C 7 H 8 2 O 3 S H 2 S O O OH CAS O.: Package: 25kgs fiber drum(35cm 44cm) Manufacture capacity: 1 MT/mon Usage: Parent nucleus of several 3 rd generation cephalosporins, such as Ceftizoxime, Ceftibuten

10 Quality specification: Identification Assay(HPLC) Transmittance SPECIFICATIOS White or Off-white crystalline powder IR MR 98.0% 1.0% 90.0% Contact: General Manager Melanie Zhou Tel: , Fax: , Address: Room 602, Unit A, Hong Pu Jie Zuo, o 186, Middle JiangDong Road, anjing City, Jiangsu Province, PRC B&H Biotechnology Co. Ltd. Unit , 34th Floor,AIA Tower,183 Electric Road,orth Point, Hongkong. Company registr o: Tel: Fax: China office: Tel: Fax: melanie@bhbiotech.com melaniezxn@live.cn