Application as liquid carrier

Transcription

1 Application as liquid carrier Calcium Silicate FLORITE 1 Features High liquid absorbency and great compressibility derived from specific pore structure Stable liquid uniformity in powder with simple method Tableting without liquid leaking within suitable absorbing ratio Table1 Physical Characteristics Physical Characteristics FLORITE R FLORITE PS-10 Bulk density Loose (g/cc) Bulk density Tapped (g/ cc ) Particle size (μm) Oil absorption(cc/g) Repose Angle (deg.) Primary Particle Pore Particle-aggregated Space -R -PS-10 Fig.1 Pore volume of FLORITE series 1

2 Fig.2 FLORITE R Fig.3 FLORITE PS-10 2 Powderization of liquid material by FLORITE 2.1 Advantage of powderized liquid material Available new dosage form beyond a limit of liquid characteristics Improve ivity from powderized material with better handling ability Table2 Example of functional liquid material liquid integrant Characteristics Effect Omega-3 (EPA/DHA) Vitamin E Lutein Astaxanthin Oily material Unstable in oxygen Oily material Unstable in ultraviolet lipid soluble material Unstable in light lipid soluble material Unstable in light Decreasing neutral fat in the blood Keeping skin health Improvement of blood flow Antioxidant effect Precaution of maculopathy or cataract Antioxidant effect 2.2 Manufacturing method Skip some processes such as emulsification in powderization Good uniformity of liquid material within powder, by simple mixing machine 2

3 2.3 Example of Powderization: fish oil (EPA/DHA) Although fish oil (EPA/DHA) is well known as good material for health, it is very unstable and easy to oxidize in air. Therefore it is limited in dosage form. We focused on fish oil as powderization model with FLOIRTE. Fish oil is loaded into primary particle pore and particle aggregated space of FLORITE to same amount. Loading capacity is related with pore volume and shape. Primary particle pore of PS-10 was occupied by fish oil when loading ratio was 1 : 2. It can make tableting without leaking when primary particle pore volume remain after loading. Table3 Pore volume after loaded fish oil R PS-10 Loading ratio (pow : fish oil ) particle particle primary particle primary particle aggregated aggregated pore(cc/g) pore(cc/g) space(cc/g) space(cc/g) 1: : : Fig.4 Remaing pore volume ratio of FLORITE R after loading of fish oil 3 Fig.5 Remaing pore volume ratio of FLORITE PS-10 after loading of fish oil

4 2.4 Physical property of powder after loading liquid-fish oil (EPA/DHA)- FLORITE R and PS-10 can keep whiteness after loading fish oil. Table4 Whiteness of powder after loading fish oil FLORITE R FLORITE PS-10 Competitive A Competitive B Competitive C Appearance Color difference (Whiteness) Loading ratio powder : fish oil = 1 : Stability of powder after loading liquid fish oil (EPA/DHA) Comparison with fish oil as liquid Fish oil in powder is more oxidized by air than fish oil at initial point because the surface area of fish oil powder is increased compared with fish oil. After 4weeks, fish oil is oxidized rapidly without 4 keeping. However, fish oil powder is stable. Fish oil powder sample Loading ratio: PS-10 : fish oil =1 : 1 POV : peroxide value Storage form Fish oil powder: poly-aluminum bag Fish oil :glass bottle Fig.6 POV value of fish oil and fish oil powder 4

5 2.5.2 Prevention of oxidation by deoxidizer Deoxidizer, it absorbs oxygen in bag, can inhibit to oxidation on fish oil powder in any temperature. Fish oil powder sample Loading ratio: PS-10 : fish oil =1 : 1 Storage form Fish oil powder: poly-aluminum bag Fig.7 Reducing effect of POV by deoxidizer 5

6 2.6 Compressibility fish oil (EPA/DHA)- Get the tablet without any tableting troubles. The tablet hardness increases in proportion as tableting force. It is recommended to add binding agent, ex. MCC, in the formulation. Lodging ratio; pow : fish oil = 1 : 1 Loading ratio; pow : fish oil = 1 : 2 -FLORITE R competitive A competitive B competitive C Formulation fish oil powder+dilactose 97% disintegrating agent2% lubricants agent1% Tableting condition rotary tableting machine diameter 10 mm φ Fig.8 Tablet hardness 6

7 2.7 Conclusion fish oil (EPA/DHA) Productivity Carrying Capacity 10 5 Compressibility FLORITE R FLORITE PS-10 Other commercial 0 Handling Whiteness after loading 3 Application 3.1 Fish Oil Powder Field Pharmaceutical Food Healthcare Example EPA/DHA drug Adding to food, seasoning agent EPA/DHA supplement in solid dosage form 3.2 Other Liquid loading Powder Field Pharmaceutical Food Healthcare Example Solid dispersion for poorly soluble substances Flavor powder Supplement in solid dosage form 7