Material Safety Data Sheet Revision Date 26-Mar-2012

Transcription

1 Creation Date 16-v-2010 Material Safety Data Sheet 1. PRODUCT AND COMPANY IDENTIFICATION Revision Number 1 Product Name Cat. Tris EDTA ph 7.4 (TE) BP2476-1; BP ; BP Synonyms Recommended Use Company Fisher Scientific One Reagent Lane Fair Lawn, NJ Tel: (201) Tromethane; Tromethamine; Tris buffer; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; TRIS Laboratory chemicals Emergency Telephone Number CHEMTREC, Inside the USA: CHEMTREC, Outside the USA: HAZARDS IDENTIFICATION CAUTION! Emergency Overview May cause eye, skin, and respiratory tract irritation. May be harmful by inhalation, in contact with skin and if swallowed. Appearance Colorless Physical State Liquid odor odorless Target Organs ne known. Potential Health Effects Acute Effects Principle Routes of Exposure Eyes Skin Inhalation Ingestion Chronic Effects May cause irritation. May cause irritation. May be harmful in contact with skin. Irritating to respiratory system. May be harmful if inhaled. Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhea. May be harmful if swallowed. ne known See Section 11 for additional Toxicological information. Aggravated Medical Conditions Page 1 / 8

2 3. COMPOSITION/INFORMATION ON INGREDIENTS Haz/n-haz Component CAS- Weight % Water Tris (hydroxymethyl) aminomethane <2 Hydrochloric acid <1 Ethylenediamine tetraacetic acid (EDTA) <1 4. FIRST AID MEASURES Eye Contact Skin Contact Inhalation Ingestion tes to Physician Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention. Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Obtain medical attention. Remove from exposure, lie down. Move to fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Obtain medical attention. Do not induce vomiting. Clean mouth with water. Get medical attention. Treat symptomatically. 5. FIRE-FIGHTING MEASURES Flash Point Method Autoignition Temperature Explosion Limits Upper Lower Suitable Extinguishing Media Unsuitable Extinguishing Media Hazardous Combustion Products Sensitivity to mechanical impact Sensitivity to static discharge data available data available Water spray. Carbon dioxide (CO2). Dry chemical. chemical foam. Specific Hazards Arising from the Chemical Keep product and empty container away from heat and sources of ignition Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. NFPA Health 1 Flammability 0 Instability 0 Physical hazards N/A Page 2 / 8

3 6. ACCIDENTAL RELEASE MEASURES Personal Precautions Environmental Precautions Methods for Containment and Clean Up Ensure adequate ventilation Should not be released into the environment Sweep up or vacuum up spillage and collect in suitable container for disposal. 7. HANDLING AND STORAGE Handling Storage Avoid contact with skin and eyes. Do not breathe dust. Do not breathe vapors or spray mist. Keep in a dry, cool and well-ventilated place. Keep container tightly closed. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Engineering Measures Exposure Guidelines Ensure adequate ventilation, especially in confined areas. This product does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Component ACGIH TLV OSHA PEL NIOSH IDLH Hydrochloric acid Ceiling: 2 ppm Ceiling: 5 ppm Ceiling: 7 mg/m 3 (Vacated) Ceiling: 5 ppm (Vacated) Ceiling: 7 mg/m 3 IDLH: 50 ppm Ceiling: 5 ppm Ceiling: 7 mg/m 3 Component Quebec Mexico OEL (TWA) Ontario TWAEV Hydrochloric acid Ceiling: 5 ppm Peak: 5 ppm CEV: 2 ppm Ceiling: 7.5 mg/m 3 Peak: 7 mg/m 3 NIOSH IDLH: Immediately Dangerous to Life or Health Personal Protective Equipment Eye/face Protection Skin and body protection Respiratory Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR or European Standard EN166 Wear appropriate protective gloves and clothing to prevent skin exposure. Follow the OSHA respirator regulations found in 29 CFR or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. 9. PHYSICAL AND CHEMICAL PROPERTIES Physical State Liquid Appearance Colorless odor odorless Odor Threshold ph Vapor Pressure Vapor Density Viscosity Boiling Point/Range Page 3 / 8

4 Melting Point/Range Decomposition temperature Flash Point Evaporation Rate Specific Gravity Solubility log Pow 9. PHYSICAL AND CHEMICAL PROPERTIES data available 10. STABILITY AND REACTIVITY Stability Conditions to Avoid Incompatible Materials Hazardous Decomposition Products Hazardous Polymerization Hazardous Reactions. Stable under normal conditions. Incompatible products. Bases, Strong acids Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2) Hazardous polymerization does not occur. ne under normal processing. 11. TOXICOLOGICAL INFORMATION Acute Toxicity Product Information acute toxicity information is available for this product Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Tris (hydroxymethyl) aminomethane 5900 mg/kg ( Rat ) t listed t listed Hydrochloric acid 700 mg/kg ( Rat ) 5010 mg/kg ( Rabbit ) 3124 ppm ( Rat ) 1 h Ethylenediamine tetraacetic acid (EDTA) 1700 mg/kg ( Rat ) >2000 mg/kg ( Rat ) t listed t listed Irritation Toxicologically Synergistic Products May cause eye, skin, and respiratory tract irritation Chronic Toxicity Carcinogenicity There are no known carcinogenic chemicals in this product Component ACGIH IARC NTP OSHA Mexico Hydrochloric acid t listed group 3 t listed t listed t listed Page 4 / 8

5 Sensitization Mutagenic Effects Reproductive Effects Developmental Effects Teratogenicity Other Adverse Effects Endocrine Disruptor Information The toxicological properties have not been fully investigated.. See actual entry in RTECS for complete information. information available 12. ECOLOGICAL INFORMATION Ecotoxicity Do not empty into drains Component Freshwater Algae Freshwater Fish Microtox Water Flea Hydrochloric acid t listed 282 mg/l LC50 96 h t listed t listed Ethylenediamine tetraacetic acid (EDTA) 1.01 mg/l EC50 = 72 h mg/l LC50 96 h mg/l LC50 96 h t listed 113 mg/l EC50 = 48 h Persistence and Degradability Bioaccumulation/ Accumulation t readily biodegradable. information available Mobility. 13. DISPOSAL CONSIDERATIONS Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification 14. TRANSPORT INFORMATION DOT t regulated TDG t regulated IATA t regulated IMDG/IMO t regulated Page 5 / 8

6 15. REGULATORY INFORMATION International Inventories Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS CHINA KECL Water X X X - X X X 2 Tris (hydroxymethyl) X X X X X X X aminomethane 4 Hydrochloric acid T X X X X X X 7 Ethylenediamine tetraacetic acid (EDTA) X X X X X X X Legend: X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule. U.S. Federal Regulations TSCA 12(b) t applicable SARA 313 t applicable Component CAS- Weight % SARA Threshold Values % Hydrochloric acid <1 1.0 SARA 311/312 Hazardous Categorization Acute Health Hazard Chronic Health Hazard Fire Hazard Sudden Release of Pressure Hazard Reactive Hazard Clean Water Act t applicable Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants Substances Quantities Hydrochloric acid X 5000 lb - - Ethylenediamine tetraacetic acid (EDTA) X 5000 lb - - Page 6 / 8

7 Clean Air Act t applicable Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors Hydrochloric acid X - OSHA t applicable Component Specifically Regulated Chemicals Highly Hazardous Chemicals Hydrochloric acid - TQ: 5000 lb CERCLA t Applicable Component Hazardous Substances RQs CERCLA EHS RQs Hydrochloric acid 5000 lb 5000 lb Ethylenediamine tetraacetic acid (EDTA) 5000 lb - California Proposition 65 This product does not contain any Proposition 65 chemicals. State Right-to-Know t applicable Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island Hydrochloric acid X X X X X Ethylenediamine tetraacetic acid (EDTA) X X X - - U.S. Department of Transportation Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N U.S. Department of Homeland Security This product does not contain any DHS chemicals. Component Hydrochloric acid DHS Chemical Facility Anti-Terrorism Standard 0 lb STQ (anhydrous); lb STQ (37% concentration or greater) Other International Regulations Mexico - Grade information available Canada This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. WHMIS Hazard Class n-controlled Page 7 / 8

8 16. OTHER INFORMATION Prepared By Creation Date Print Date Regulatory Affairs Thermo Fisher Scientific 16-v Mar-2012 Revision Summary (M)SDS sections updated 3 9 Disclaimer The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text. End of MSDS Page 8 / 8