Spotfire DecisionSite Overview Dylan Cotter Application Specialist, Business Development dylan.cotter@spotfire.com
Spotfire Overview Leader in Guided Analytic Applications and Services 700+ Global 2000 Customers; 25,000+ users 160+ World Wide Employees- Sales and Support Headquartered in Somerville, MA and Göteborg, Sweden Dominant in life science All major Pharmas + 250 Biotechs Discovery: Proteomics, Genomics, HTS, Lead Optimization, ADME/Tox Development: Clinicals, Pilot, Manufacturing, Supplychain, Sales/Marketing
Product Overview Access to any data One-click data retrieval to ad-hoc querying Integrated Multiple sources Unified data view Continuous data exploration and analysis Linked Visualization Dynamic filtering One-click analytic formulae and computations Drill down to details
DecisionSite Posters Enable teams to collaborate around data driven decisions Across geographies, Across time zones Across boundaries Across disciplines Extends the value of Guided Analytics across the enterprise to facilitate better, faster team decision-making Manages decisions as company assets creating Decision I.P. Interactively filters data via range sliders, check boxes, or radio buttons with dynamic detail drill down
DecisionSite Benefits Unifies information from multiple sources into a single analytic interface Provides access to specific analytical tools to understand and interpret scientific data Environment appropriate for specialists and end users Fast learning curve Powerful analytics capabilities Environment configurable for integration with existing core infrastructure Captures critical analysis and decision IP
DecisionSite Architecture DecisionSite Browser Information links DecisionSite Server Information Interaction Services Oracle Model Store Join Engine Datamart Oracle JDBC DB
Oracle Features Used Today Spotfire DecisionSite Server supports Oracle Enterprise/Standard Databases: -Oracle9i Release 2 (9.2.0.x) -Oracle9i Release 1 (9.0.1) -Oracle8i Releases 8.1.7 and 8.1.6. DecisionSite s Information Interaction Services uses Oracle as as federated database access Query and Join Engine for multiple and disparate database access Storage of the Meta Layer of Disparate data sources as an Information model that is a business representation of data sources
Oracle Features Used Use of Oracle SQL functions for data manipulations Oracle Chemistry cartridges in combination with partner companies provide: Chemical Storage technologies Chemical content repositories Integration capabilities Screening data repositories
New in the DecisionSite 8.0 Release Support for Oracle 10g Enhanced Information Link APIs for Oracle name resolver service provides row level security to data retrieved for analysis
1. High-Throughput Screening Spotfire configuration High Throughput Screening Shared users Biologists in primary & secondary screening Solution Business Impact Automated workflow/processing of high throughput screening data Multiple views and slices of the processed data revealing inconsistencies Best practices for analyzing HTS data are institutionalized Better quality/confidence leads delivered to secondary screening and medicinal chemistry
2. Lead Identification Spotfire configuration Chemogenomic analytics Shared users Toxicologists, pharmacologists, chemists Solution Business impact Identify compounds with similar gene expression signatures ( fingerprints ) Incorporate chemical structure, clinical chemistry and histopathology data into the analysis to better define relationships between compounds Use compound relationships to anticipate toxic behavior in unknown compounds
3. Compound Profiling Spotfire configuration Lead Discovery Shared users Medicinal Chemists Business impact Compounds profiled across departmental and domain borders Chemists get insight into biology, biologists insight into chemistry Best practices for compound selection can be institutionalized Better quality leads delivered to ADME/Tox / pre-clinical areas
4. Functional Genomics Spotfire configuration microarray data analysis Shared users Biologists in target discovery Business impact Identify data sources Select methods of data transformation Incorporate appropriate tools analysis to test hypothesis Add known information to extend the analysis Identify subsets of genes for further study Decision process involves identifying subsets of genes for further study, accept or reject hypothesis and share conclusions
5. Clinical Trials Phase I, II, III Spotfire configuration Adverse Event Analysis Shared users Clinical trial/data managers, statisticians, and medical monitors Business impact Identify types/frequency of adverse events Outliers indicating errors in data recording Explore frequency/severity of adverse events, demographic influences, statistically significant dependencies between event type and dosage Issues in clinical trials can be detected earlier
6. Pharmaceutical Sales & Marketing Spotfire configuration Pharmaceutical Sales & Marketing Shared users Business analysts, brand/product managers, sales/marketing managers Business impact Leverage very expensive IMS into analytic environment Drive informed sales force deployment decisions Integrate IMS / prescription data, patient demographics, physician data, and GIS data Market and sell in area where effect is optimal
Analytic Applications Support Many Needs xtend the Analysis: Validate microarray results with rtpcr Compare gene expression with protein expression Chemogenomics: integrate chemistry support Toxicogenomics: integrate Toxicology data Protein expression Compare microarray and rtpcr data Chemogenomics Toxicogenomics
Summary Powerful data access access to many data sources State of the art visualizations multiple, linked, dynamic plots Easy to use intuitive UI, Guides Extend analysis methods deploy new algorithms or tools Develop new Analytic Applications support future analysis processes Share decisions dynamic, interactive reports
Contact Information Thank you for your attention! www.spotfire.com /freedom to wonder_power to decide dylan.cotter@spotfire.com