Patents List. FileRefNo / CSIRRefNo. Title Inventors Countries Filing Date Application No Grant Date Granted No. S.No PT-135

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S.No FileRefNo / CSIRRefNo Patents List Title Inventors Countries Filing Date Application No Grant Date Granted No 1 PT-135 NF-238/97 A Novel Biocatalytic process for the steroeselective synthesis of s-propanolol and their related analogues M Venkateswara Rao 24-Dec-1998 3829/DEL/98 26-Apr-2004 191210 2 PT-165 NF-11/96 An efficient process for the synthesis of 4-aryl amino/alkylamino-4'-dimethyl podophyllo-toxins as potential anticancer agents N L Gayathri 27-Mar-1996 650/DEL/96 3 PT-174 NF-155/96 A Novel biocatalytic process for the regio-selective preparation of 1,2-Azidoalchols and their related analogues Y Damayanthi M Venkateswara Rao 29-Nov-1996 2634/DEL/96 03-Feb-2006 194315 4 PT-184 0307NF1996 Synthesis of Epipodo phyllotoxin analogues with promissing anti-cancer activity N L Gayathri 24-Jun-1997 1712/DEL/97 25-Jan-2002 186131 5 PT-185 NF-331-96 An Improved process for the preparation of amines from azides Y Damayanthi B Lakshmi Narayana B Satyanarayana Reddy 16-Jan-1998 108/DEL/98 11-Oct-2002 187308 6 PT-198 NF-249/97 A New and Improved process for the preparation of 4'- dimethyl epipodo-phyllotoxin key precursor for the anti cancer drugs such as etoposide and temiposide N Venugopal Rao 24-Oct-1997 3605DEL1997 07-Jun-2002 186737 7 PT-253 NF-230/99 A Process for the preparation of 1,8-napthalimide linked pyrrolo02,1-c) (1,4) benxodiazepine-5-one, analogues as potential antitumour antibioties B Satyanarayana Reddy 09-Mar-2000 209/DEL/2000 8 PT-253A NF-411/99 A Process for the preparation of 1,8-napthalimide linked pyrrolo(2,1-c) (1,4) benxodiazepine-5-one, analogues as potential antitumour antibioties B Satyanarayana Reddy 09-Mar-2000 210/DEL/2000 14-Nov-2007 212061 9 PT-263 NF-296/99 An Improved Process for the preparation of 4'-Dimethyl epipodo-phyllotoxin key precursor for the anti cancer drugs such as etoposide and teniposide N Laxman G Ramesh 03-Feb-2000 92/DEL/2000 29-Sep-2005 192492 10 PT-264 NF-329/99 Facile and efficient one-pot process for the preparation of 4 beta-substituted epipodophyllotoxins synthesis of DNA topoisomerase II inhibitors (NPF and w-68) N Laxman G Ramesh 03-Feb-2000 84/DEL/2000 16-Nov-2004 191366 11 PT-291 NF-263/2000 A Process for the preparation of new pyrrolo [2,1-C][1,4] benzodiazepines as potential antitumour agents N C Laxman G Ramesh P Ramulu O Srinivas 30-Jan-2001 116/DEL/2001 28-Feb-2009 230908 12 PT-291A NF-51/2001 A Process for the preparation of new pyrrolo [2,1-C][1,4] benzodiazepines as potential antitumour agents N C Laxman G Ramesh P Ramulu O Srinivas 30-Jan-2001 30-Mar-2001 97/DEL/2001 822782 26-Mar-2002 6362331 13 PT-296 NF-317/2000 A Process for the synthesis of new podophyllotoxin dimers as potential DNA-topoisomerase II inhibitors E Laxman Md Arifudin 29-Mar-2001 381/DEL/2001 14-Oct-2005 192516

G B Ramesh Khanna 22-Dec-2000 09/747499 27-Aug-2002 6441198 14 PT-297 NF-318/2000 A One-pot Process for the synthesis of new podophyllotoxin dimers as potential anticancer agents E Laxman P S Murali Mohan Reddy 10-Nov-2000 1006/DEL/2000 29-Sep-2005 192491 16-Feb-2001 167/DEL/2001 20-Jan-2006 192964 15 PT-300 NF-329/2000 A chemoenzymatic process for the selective preparation of both R & S enantiomers of 3-hydroxy-3-phenyl propane nitrile G B Ramesh Khanna M Venkateswara Rao K V Raghavan 19-Sep-2003 25-Jul-2003 31-Jan-2001 2002-558527 0317492.7 /IN01/0008 10-Nov-2004 GB 2387597 22-Jul-2004 2135/DELNP/04 31-Mar-2003 10/381027 08-Aug-2006 7087641 25-Mar-2003 2718512.3 10-Aug-2005 GB 1377588 13-Mar-2003 2003-580341 10-Nov-2005 02718512.3 10-Aug-2005 EP 1377588 16 PT-369 NF-233/2002 New 4 Beta-1"-[2,-(Substituted Benzoyl)Anilino] podophyllotoxin analogues useful as anti cancer agents P S Murali Mohan Reddy Switzerland 28-Mar-2002 04-Feb-2009 10-Nov-2005 /IN02/00091 2009-24314 02718512.3 Spain 10-Nov-2005 02718512.3 10-Nov-2005 02718512.3 10-Nov-2005 02718512.3 Italy 10-Nov-2005 02718512.3 17 PT-370 NF-234/2002 One-Pot Chemoenzymatic process for the preparation of chiral secondary alcohols from carbonyl compounds by in -situ transesterification M S Sandbhor M Venkateswara Rao K Venkata Ramana 28-Mar-2002 399/DEL/02 12-Jan-2009 227502 30-Sep-2004 2980/DELNP/04 05-Mar-2009 231500 31-Mar-2003 10/401754 21-Mar-2006 7015215 18 PT-381 379NF2002 New Pyrrolo[2,1-c][1,4] benzodiazepines useful as antitumour agents P S Murali Mohan Reddy D Rajasekhar Reddy Russia 28-Oct-2005 31-Mar-2003 03816507.2 2005133442 /Ib03/01164 05-Nov-2008 21-Nov-2008 1608663 2338747 Australia 2003215810 18-Jun-2009 2003-215810 Canada 2520897 24-Aug-2010 2520897

60324607.9-08 05-Nov-2008 1608663 03816507.2 05-Nov-2008 1608663 03816507.2 05-Nov-2008 1608663 20-Oct-2004 3250/DELNP/04 02-Jul-2009 235418 31-Mar-2003 10/401782 26-Apr-2005 6884799 03816509.8 28-Jan-2009 1608664 19 PT-387 436NF2002 New Non-Cross-Linking pyrrollo [2,1-c][1,4] Benzodiazepines useful as potential anti cancer agents G Ramesh O Srinivas P Ramulu Australia Canada Russia 31-Oct-2005 2003215821 2520898 2005133443 23-Apr-2009 20-Oct-2009 10-Jan-2008 AU 2003215821 CA 2520898 RU 2314309 03816509.8 28-Jan-2009 1608664 03816509.8 28-Jan-2009 1608664 03816509.8 28-Jan-2009 1608664 27-Mar-2003 497/DEL/03 31-Mar-2009 233618 20-Mar-2003 10/393406 16-May-2006 7045341 16-Dec-2002 /IB02/05508 20 PT-389 450NF2002 A Chemoenzymatic process for the stereoselective preparation of both R and S enantiomenrs of 3-Hydroxyx(2-theienyl) propanenitrile G B Ramesh Khanna R Ramu M Venkateswara Rao 16-Jun-2005 21-Jun-2005 21-Jun-2005 2004-559953 02781684.2 02781684.2 15-Apr-2009 15-Apr-2009 1573018 1573018 21-Jun-2005 02781684.2 15-Apr-2009 1573018 21-Jun-2005 02781684.2 15-Apr-2009 1573018 29-May-2003 747/DEL/03 18-Aug-2010 242189 21 PT-418 NF-152/03 New Pyrimidine linked pyrrolo[2,1-c][1,4] benzodiazepines as potential antitumour agents K Laxma Reddy 25-Mar-2003 31-Mar-2003 10/396103 /IN03/00122 27-Jan-2004 6683073 22 PT-420 150NF2003 Pyrene-Linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids as anti-cancer agents G Ramesh P Ramulu O Srinivas 27-Mar-2003 25-Mar-2003 24-Oct-2005 456/DEL/03 10/396129 03719078.2 16-Mar-2009 05-Oct-2004 02-Jun-2010 232387 6800622 1608650

Canada 2520901 08-Sep-2009 CA 2520901 31-Mar-2003 /IN03/00102 24-Oct-2005 03719078.2 02-Jun-2010 1608650 24-Oct-2005 03719078.2 02-Jun-2010 1608650 24-Oct-2005 03719078.2 02-Jun-2010 1608650 28-Mar-2005 01267DELNP2005 23 PT-427 NF-333/03 C8-Linked pyrrolo[2,1-c][1,4] Benzodiazepine- Acridone/Acridine Hybrids as anti -tumour agents O Srinivas P Ramulu G Ramesh P Praveen Kumar 30-Mar-2007 25-Jul-2006 29-Jun-2006 31-Dec-2003 10/812841 0614754.0 2005-512763 /IN03/00464 06-Jun-2006 11-Jun-2008 08-Apr-2011 7056913 GB 2424884 4718328 28-Mar-2005 01270DELNP2005 31-Dec-2003 10/812840 13-Mar-2007 7189710 24 PT-431 NF-435/03 Novel C2-fluoropyrrolo[2,1-c][1,4] benzo diazepine dimers useful as anticancer agents P S Murali Mohan Reddy D Rajasekhar Reddy 31-Dec-2003 25-Jul-2006 /IN03/00448 0614749 09-Jul-2008 GB 2425309 29-Jun-2006 2005-512747 30-Sep-2011 4833663 12-Aug-2005 3821/DELNP/05 30-Mar-2004 10/812842 04-Oct-2005 6951853 25 PT-432 NF-437/03 Subsituted benzimidazoles linked to pyrrolo [2,1-C][1,4] benzodiazepines as anticancer agents P Ramulu O Srinivas 31-Dec-2003 25-Jul-2006 /IN03/00462 0614750.8 22-Oct-2008 GB 2424883 29-Jun-2006 2005-512761 28-May-2010 4520411 30-Jul-2004 1423DEL2004 22-Feb-2013 255437 30-Jul-2004 11/024240 06-Feb-2007 7173026 26 PT-456 NF-245/04 New Pyrrolo[2,1-C][1,4] benzodiazepine -anthraquinone conjugates useful as antitumour agents R Ramu G B Ramesh Khanna 30-Jul-2004 25-May-2007 /IN04/00212 0710111.6 26-Jun-2007 2007-547794 27 PT-457 New Pyrrlo[2,1-C][1,4] benzodiazepine-nepthalimide conjugates linked through piperazine moiety useful as R Ramu 30-Jun-2004 1218/DEL/04 19-Nov-2013 257917

NF-269/04 potential antitumour agents G B Ramesh Khanna 30-Jun-2004 10/881729 27-Dec-2005 6979684 30-Jun-2004 /IN04/00191 29-Sep-2006 04745134.9 03-Aug-2011 1761537 18-Oct-2006 2007-509062 03-Dec-2010 4638485 29-Sep-2006 04745134.9 03-Aug-2011 03-Aug-2011 29-Sep-2006 04745134.9 03-Aug-2011 03-Aug-2011 29-Sep-2006 04745134.9 03-Aug-2011 03-Aug-2011 13-Apr-2005 963/DEL/05 15-Oct-2007 11/911643 19-Oct-2010 7816119 28 PT-458 NF-322/04 A Chemoenzymatic process for the stereoselective preparation of (R)-gama-amino-beta-hydroxybutyric acid [(R)-GABOB] and (R) carnitine G B Ramesh Khanna T Krishnaji R Ramu 29-Nov-2005 29-Nov-2005 29-Nov-2005 /IN05/00387 05824669.5 05824669.5 06-Jan-2010 06-Jan-2010 1869199 1869199 29-Nov-2005 05824669.5 06-Jan-2010 1869199 29-Nov-2005 05824669.5 06-Jan-2010 1869199 30-Mar-2005 802/DEL/2005 27-Jun-2011 248183 23-Dec-2004 11/022275 20-May-2008 7374926 02-Dec-2005 /IN05/00398 29 PT-471 NF-469/04 An Enantioconvergent chemoenzymatic synthesis of (R)- gamma-amino-beta-hydroxybutyric acid((r)-gabob) G B Ramesh Khanna T Krishnaji R Ramu Switzerland 11-Oct-2006 16-Oct-2007 16-Oct-2007 2007507932 05824261.1 05824261.1 14-May-2010 29-Apr-2009 29-Apr-2009 4510879 EP 1833977 1833977 16-Oct-2007 05824261.1 29-Apr-2009 1833977 16-Oct-2007 05824261.1 29-Apr-2009 1833977 16-Oct-2007 05824261.1 29-Apr-2009 1833977 26-Dec-2005 3487/DEL/05 30-Dec-2005 /IN05/000459 WO/2007/00459 30 PT-481 NF-205/05 Process for production of Brassylic acid from tridecane microbial oxidation G Sheelu N W Fadnavis Canada China 12-Jun-2008 26-Jun-2008 2633020 200580052425.6 23-Nov-2011 ZL200580052425.6 30-Dec-2005 2008-548080 25-May-2012 5001953

30-Dec-2005 12/096091 26-Feb-2013 8383373 10-Nov-2005 3013/DEL/05 21-Sep-2012 254119 03-Mar-2006 11/367223 25-Dec-2007 7312210 31 PT-483 NF-334/05 Coumarin linked pyrrolo[2,1-c]1[1,4] benzodiazepine hybrids as potential anticancer agents A Hari Babu A Venkata Ramana E Vijaya Bharathi 27-Dec-2005 23-Apr-2008 08-May-2008 /IN05/00442 0807429.6 112005003752.5 27-May-2009 GB 2446080 12-May-2008 2008-539617 07-Dec-2012 5149193 13-Feb-2006 383/DEL/06 09-Oct-2012 254250 12-Feb-2007 11/705660 16-Dec-2008 7465724 32 PT-484 NF-361/05 New Bis-pyrrolo[2,1-c][1,4] benzodiazepine anthraquinone conjugates useful as potential antitumour agents R Ramu G B Ramesh Khanna 12-Feb-2007 06-Sep-2008 07-Jul-2008 /IB07/00320 112007000079.1 2008-553851 12-Feb-2007 0807702.6 22-Dec-2010 2453402 08-Mar-2006 669/DEL/06 26-Feb-2007 /IB07/00448 07-Mar-2007 11/715592 13-Jan-2009 7476664 33 PT-487 0039NF2006 C2-Difluoro pyrrolo[2,1-c][1,4] benzodiazepine dimers D Rajasekhar Reddy Rajender Canada 10-Sep-2008 26-Feb-2007 26-Feb-2007 2645350 07705647.1 07705647.1 22-Dec-2010 22-Dec-2010 2001894 2001894 26-Feb-2007 07705647.1 22-Dec-2010 2001894 26-Feb-2007 07705647.1 22-Dec-2010 2001894 08-Aug-2006 1882/DEL/06 24-Aug-2012 253782 34 PT-496 NF-141/06 Quinazolinone linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents A V Ramana A Hari Babu 10-Aug-2007 14-Aug-2007 10-Mar-2009 /IN07/00337 11/893380 0904091.6 27-Oct-2009 26-Oct-2011 7608615 GB2454629 35 PT-497 NF-143/06 Synthesis and biological evaluation of benzophenone linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anti cancer agents B Rajendra Prasad 08-Aug-2006 13-Aug-2007 1823/DEL/06 11/893101 05-May-2009 7528128

10-Aug-2007 /IN07/00336 Canada 13-Feb-2009 2660799 19-Mar-2013 2660799 06-Mar-2009 07805640.5 06-Mar-2009 07805640.5 06-Mar-2009 07805640.5 06-Mar-2009 07805640.5 03-May-2007 953/DEL/07 30-Apr-2008 12/112637 16-Jun-2011 7960418 36 PT-498 149NF2006 New - 4 beta-[4"-(1"-3"-subsituted benzothiazole-2"-yl) anilino podophyllotoxin analogues as antitumour agents B Ashwini Kumar 23-Apr-2008 02-Nov-2009 /IN08/00256 2010-505015 06-Sep-2013 5355550 23-Apr-2008 0919517.3 16-Nov-2011 GB 2461667 19-Mar-2007 594/DEL/07 13-Mar-2008 /IN08/00143 WO/2008/114275 05-Jan-2009 12/307570 13-Nov-2012 8309726 37 PT-505 NF-227/06 Synthesis and biological evaluation of anthranilic acid hybrids as potential anti cancer agents B Rajendra Prasad 27-Jan-2009 13-Mar-2008 13-Mar-2008 2009-554128 08720162.0 08720162.0 07-Jun-2013 19-Jan-2011 19-Jan-2011 5284291 2150527 2150527 13-Mar-2008 08720162.0 19-Jan-2011 2150527 13-Mar-2008 08720162.0 19-Jan-2011 2150527 30-Mar-2007 698/DEL/07 26-Mar-2008 /IN08/00192 WO/2008/120235 28-Sep-2009 2010-500443 02-May-2013 5260627 38 PT-506 228NF2006 Synthesis and biological evaluation of benzophenone hybrids as potential anticancer agents B Rajendra Prasad 30-Sep-2009 15-Oct-2009 12/594102 08738388.1 12-Mar-2013 16-Oct-2013 8394954 2142506 Canada 29-Sep-2009 2682384 15-Oct-2009 08738388.1 16-Oct-2013 2142506 15-Oct-2009 08738388.1 16-Oct-2013 2142506

15-Oct-2009 08738388.1 16-Oct-2013 2142506 14-Feb-2007 277/DEL/07 39 PT-509 NF-303/06 Novel Benzothiazole and benzoxazole linked pyrrolo [2,1- c][1,4] benzodiazepine hybrids as potential antitumour agents and process for the K Srinivasa Reddy M Naseer Ahmed Khan Rajesh V C R N C Shetti 31-Dec-2007 12-Aug-2009 04-Sep-2009 /IN07/00619 12/526914 0915454.3 22-Nov-2011 14-Sep-2011 8063204 GB2459808 01-Aug-2007 1626/DEL/07 16-Jan-2008 12/015023 13-Jul-2010 7754694 26-Oct-2007 /IN07/00510 40 PT-510 0023NF2007 Pyrrolo [2,1-C][1,4] Benzodiazepine glycoside prodrugs with potential for selective cancer therapy J Venkatesh 01-Feb-2010 25-Feb-2010 2010-618816 07827604.5 08-Nov-2013 01-Feb-2012 5404624 2188297 25-Feb-2010 07827604.5 01-Feb-2012 2188297 25-Feb-2010 07827604.5 01-Feb-2012 2188297 05-Mar-2008 517/DEL/08 03-Mar-2009 /IN2009/000141 WO/2009/110000 41 PT-518 NF-172/07 Novel Napthalimide-benzimidazole hybrids as potential anticancer agents and process for the P Praveen Kumar 31-Jul-2009 03-Sep-2010 12/920911 16-Oct-2012 8288387 10-Sep-2010 1015043.1 22-Feb-2012 GB2469980 05-Mar-2008 518/DEL/08 /IN08/000712 WO/2009/109986 02-Sep-2010 12/920654 10-Apr-2012 8153627 42 PT-520 0014NF2008 Quinazoline linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the B Rajendra Prasad 03-Sep-2010 2010-549255 08873110.4 08873110.4 24-Jul-2013 24-Jul-2013 2265613 2265613 08873110.4 24-Jul-2013 2265613 08873110.4 24-Jul-2013 2265613 43 PT-521 0012NF2008 Benzophenone-piperazine linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the preparation there of B Rajendra Prasad 26-Mar-2008 787/DEL/08 /IN08/000714

09-Sep-2010 8873530.3 24-Sep-2010 05-Mar-2008 537/DEL/08 /IN08/000721 44 PT-522 0013NF2008 Chalcone linked pyrrolo[2,1-c][1,4] benzodiazepine hybrids as potential anticancer agents and process for the B Rajendra Prasad 01-Oct-2010 03-Sep-2010 01-Oct-2010 08873071.8 12/921016 08873071.8 11-Jun-2013 8461150 01-Oct-2010 08873071.8 11-Mar-2008 603/DEL/08 /IN08/000718 WO/2009/113085 45 PT-526 0027NF2008 Novel benzimidazole linked pyrrolo [2,1-C][1,4] benzodiazepine hybrids as potential anticancer agents and process for the P Praveen Kumar B N Seshadri K Sreekanth 09-Sep-2010 09-Sep-2010 09-Sep-2010 8873307.6 12/921594 8873307.6 09-Sep-2010 8873307.6 09-Sep-2010 8873307.6 11-Mar-2008 602/DEL/08 12-Mar-2009 /IN2009/000168 WO/2009/113109 46 PT-527 0026NF2008 Novel phenanthrylphenol linked pyrrole [2,1-C][1,4] benzodiazepine hybrids as potential antitumour agents and process for the preparation there of K Sreekanth P Praveen Kumar G Balakishan 10-Sep-2010 11-Oct-2010 11-Oct-2010 12/922123 09719087 09719087 10-Jul-2012 05-Oct-2011 05-Oct-2011 8217167 2294070 2294070 11-Oct-2010 09719087 05-Oct-2011 2294070 11-Oct-2010 09719087 05-Oct-2011 2294070 11-Mar-2008 608/DEL/08 47 PT-528 0038NF2008 C2-Fluoro subsituted piperazine linked pyrrolo [2,1- C][1,4] benzodiazepine dimers and a process for the Rajender M Kashi Reddy G Balakishan 10-Sep-2010 /IN08/000715 12/921841 08873240.9 26-Feb-2013 05-Dec-2012 WO/2009/113084 8383618 2271647 08873240.9 05-Dec-2012 2271647

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