University of Groningen Artificial nerve guides Meek, Marcel Frans IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2000 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Meek, M. F. (2000). Artificial nerve guides: assessment of nerve function Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018
Artificial Nerve Guides assessment of nerve function
Financial support was gratefully received from the following instances or firms: Polyganics B.V. NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek) Stichting Het Remmert Adriaan Laan Fonds AB Medical prs B.V. Stichting Anna Fonds J.E. Jurriaanse Stichting NVPC (Nederlandse Vereniging voor Plastische Chirurgie, handchirurgie, reconstructieve en esthetische chirurgie) Diabureau Pleiter, Janssen-Cilag B.V., BCN (School of Behavioral and Cognitive Neurosciences), NVB (Nederlandse Vereniging voor Biomaterialen), Carl Zeiss B.V., Smith & Nephew B.V., Harlan Nederland B.V., Ortomed B.V. KCI-Medical B.V. Copyright 2000 by M.F. Meek. All Rights Reserved. Artificial Nerve Guides - assessment of nerve function may not be reproduced in whole or in part, by any means, without permission from the author. ISBN: 90-3671303-x Page lay-out: P. van der Sijde, Groningen, The Netherlands Printed by: Ponsen & Looijen B.V., Wageningen, The Netherlands
RIJKSUNIVERSITEIT GRONINGEN Artificial Nerve Guides assessment of nerve function PROEFSCHRIFT ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. D.F.J. Bosscher, in het openbaar te verdedigen op woensdag 13 december 2000 om 14.15 uur door MARCEL FRANS MEEK geboren op 14 juni 1973 te Groningen
Promotores: Prof. dr. P.H. Robinson, FRCS Prof. dr. A.A. Gramsbergen Referenten: Dr. J.M. Schakenraad Dr. W.F.A. den Dunnen
Promotiecommissie: Prof. dr. A. Vermey, FACS Prof. dr. J.L.N. Roodenburg Prof. dr. J.H.A. de Keyser Paranimfen: Drs. R. Wolf Drs. T. Ehling
A man should never be ashamed to own he has been in the wrong, which is but saying, in other words, that he is wiser today than he was yesterday. Alexander Pope (1706)
CONTENT Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Summary Introduction Peripheral nerve regeneration and functional nerve recovery after reconstruction with a thin-walled biodegradable poly(dllactide-ε-caprolactone) nerve guide Cells and Materials 1997;7:53-62 Long-term evaluation of functional nerve recovery after reconstruction with a thin-walled biodegradable poly(dllactide-ε-caprolactone) nerve guide, using walking track analysis and electrostimulation tests Microsurgery 1999;19:247-253 Evaluation of several techniques to modify denatured muscle tissue to obtain a scaffold for peripheral nerve regeneration Biomaterials 1999;20:401-408 Evaluation of functional nerve recovery after reconstruction with a poly(dl-lactide-ε-caprolactone) nerve guide, filled with modified denatured muscle tissue Microsurgery 1996;17:555-561 Electronmicroscopical evaluation of short-term nerve regeneration using a thin-walled biodegradable poly(dl-lactideε-caprolactone) nerve guide filled with modified denatured muscle tissue Biomaterials 2000;accepted for publication in a special issue on Neural Tissue Engineering Functional assessment of sciatic nerve reconstruction: biodegradable poly(dlla-ε-cl) nerve guides versus autologous nerve grafts Microsurgery 1999;19:381-388 Functional nerve recovery after bridging a 15 mm rat sciatic nerve gap with a biodegradable nerve guide Submitted for publication, 2000 Biodegradable poly(dlla-ε-cl) nerve guides versus autologous nerve grafts: EMG and walking patterns Submitted for publication, 2000 Discussion page 9 29 43 57 69 81 95 109 123 135 147 Samenvatting 149 Addenda Dankwoord Curriculum vitae auctoris List of publications 151