Regenerative and Immune Engineering Focus Area Upper-Level Engineering Courses updated October, 2018 For BME Class of 2021 and beyond EN.510.311 Structure of Materials 3 EN.510.312 Thermodynamics/Materials 3 EN.510.313 Mechanical Properties of Materials 3 EN.510.314 Electronic Properties of Materials 3 EN.510.315 Physical Chemistry of Materials II 3 EN.510.316 Biomaterials I 3 EN.510.403 Materials Characterization 3 EN.510.407 Biomaterials II: Host response and biomaterials applications 3 EN.510.415 The Chemistry of Materials Synthesis 3 EN.510.421 Nanoparticles 3 EN.510.422 Micro and Nano Structured Materials & Devices 3 EN.510.426 Biomolecular Materials I - Soluble Proteins and Amphiphiles 3 EN.510.430 Biomaterials Lab 3 EN.510.435 Mechanical Properties of Biomaterials 3 EN.510.442 Nanomaterials Lab 3 EN.510.606 Polymer Chemistry & Biology 3 EN.530.410 Biomechanics of the Cell 3 EN.530.426 Biofluid Mechanics 3 EN.530.436 Bioinspired Science and Technology 3 EN.530.446 Experimental Methods in Biomechanics 3 EN.530.448 Biosolid Mechanics 3 EN.540.301 Kinetic Processes 4 EN.540.303 Transport Phenomena I 3 EN.540.304 Transport Phenomena II 4 EN.540.306 Chemical & Biomolecular Separations 3 EN.540.400 Project in Design: Pharmacokinetics 3 EN.540.402 Metabolic Systems Biotechnology 3 EN.540.403 Colloids and Nanoparticles 3 EN.540.405 The Design of Biomolecular Systems 3 EN.540.414 Computational Protein Structure Prediction and Design 3 EN.540.421 Project in Design: Pharmacodynamics 3 EN.540.422 Introduction to Polymeric Materials 3 EN.540.428 Supramolecular Materials and Nanomedicine 3 EN.540.437 Application of Molecular Evolution to Biotechnology 3 EN.540.440 Micro/Nanotechnology: The Science and Eng. of Small Structures 3 EN.540.465 Engineering Principles of Drug Delivery 3 EN.540.602 Metabolic Systems Biotechnology 3 EN.550.391 Dynamical Systems 4 EN.580.418 Pulmonary Physiology 3
EN.580.430 Systems Pharmacology and Personalized Medicine 3 EN.580.434 Bioelectricity 3 EN.580.435 Applied Bioelectrical Engineering I 1.5 EN.580.436 Applied Bioelectrical Engineering II 1.5 EN.580.441 Cellular Engineering 3 EN.580.442 Tissue Engineering 3 EN.580.444 Biomedical Applications of Glycoengineering 3 EN.580.446 Physical Epigenetics 3 EN.580.448 Biomechanics of the Cell 3 EN.580.451/2 Cell and Tissue Engineering Lab 3 EN.580.456 Introduction to Rehabilitation Engineering 3 EN.580.457 Rehabilitation Engineering Design Laboratory 3 EN.580.492 Build-a-Genome Mentor 4 EN.580.495 Microfabrication Lab 4 EN.580.643 Advanced Orthopaedic Tissue Engineering 3 EN.580.646 Molecular Immunoengineering 3 EN.670.619 Fundamentals of Physics and Chemistry in Nanomaterials 3 Contact the BME Department advising office for course additions. Non Upper-Level Focus Area Courses (maximum of 3 credits from this list may count in focus area) AS.020.303 Genetics 3 AS.020.337 Stem Cells & the Biology of Aging & Disease 2 AS.020.363 Developmental Biology 3 AS.020.373 Developmental Biology Lab 2 EN.580.112 BME Design Group 3 EN.580.211 BME Design Group 3 EN.580.212 BME Design Group 3 EN.580.311 BME Design Group 3 EN.580.312 BME Design Group 3 EN.580.411 BME Design Group 3 EN.580.412 BME Design Group 3 EN.580.413 Design-Team, Team Leader 4 EN.580.414 Design Team/Team Leader 4 EN.580.580 Senior Design Project 3 EN.580.581 Senior Design Project 3 Students may use a maximum of 3 research credits as a non-upper-level engineering course.
Cell and Tissue Engineering (CTE) is an interdisciplinary field that covers research areas ranging from materials science, stem cell engineering to regenerative tissue engineering and immunology. There are several subjects that all CTE students should master, which can be accomplished by taking courses that include Biomaterials I and II and both the Cell Engineering and Tissue Engineering courses. When selecting your CTE courses beyond these platform classes, the following specialization areas may provide guidance. While designed only to serve as a guide, the areas of specialization represent important subfields within CTE where cutting edge research that promises to transform the practice of medicine and patient care over the next generation are now taking place. BIOMATERIALS AREA SPECIALIZATION. This area of specialization is for students who desire a strong foundation in designing, synthesizing, processing, and characterizing biomaterials; in addition to creating these materials students will gain an understanding they interact with living cells and tissues in biological systems. Students can select a set of upper level electives from the following list that covers a variety of topics ranging from biomaterials synthesis and characterization, to biocompatibility of materials, and to various applications of biomaterials. ULE Focus Area Courses: 510.430 Biomaterials Lab (3) 510.311 Structure of Materials (3) 510.313 Mechanical Properties of Materials (3) 510.314 Electronic Properties of Materials (3) 510.403 Materials Characterization (3) 510.415 The Chemistry of Materials Synthesis (3) 510.426 Biomolecular Materials (3) 510.606 Polymer Chemistry and Biology (3) 510.617 Advanced Topics in Biomaterials (3) 540.403 Colloids and Nanoparticles (3) 580.495 Microfabrication Laboratory (4) 670.619 Fundamentals of Physics and Chemistry in Nanomaterials (3) BIOMECHANICS AREA SPECIALIZATION. This area incorporates traditional engineering approaches into understanding tissue structure and function. Students who plan to build a strong foundation on cell and tissue biomechanics and mechanobiology may select from these upper electives. These courses cover topics that range from the mechanical characterization of cells and tissues, cellular responses to mechanical cues, the general properties of materials, and orthopaedic biomechanics. This area complements the Biomaterials specialty.
Biomechanical Specialty Courses: 510.313 Mechanical Properties of Materials (3) 510.403 Materials Characterization (3) 530.410 Biomechanics: Cells and Organisms (3) 530.445 Introductory Biomechanics (3) 530.446 Experimental Methods in Biomechanics (3) 530.448 Biosolid Mechanics (3) 530.495 Microfabrication Laboratory (4) 580.451/2 Cellular and Tissue Engineering Laboratory (2) 580.448 Biomechanics of Cells and Organisms (3) 580.643 Advanced Orthopaedic Tissue Engineering (3) CELL ENGINEERING AREA SPECIALIZATION. This area of specialization is for students who wish to incorporate a strong foundation of cell level and smaller scale (e.g., biochemical and molecular) knowledge into the systems and organism-level knowledge gained from other parts of the BME undergraduate curriculum. To pursue this option, students can select electives that primarily focus on the biochemistry of molecules found within a cell or molecular scale phenomenon (e.g., kinetic processes or transport phenomenon courses). Another cell-based option is to focus on stem cells and complementary coursework (e.g., developmental biology). Cell Engineering Specialty Courses: 530.410 Biomechanics: Cells and Organisms (3) 540.301 Kinetic Processes (4) 540.303 Transport Phenomena I (3) 540.304 Transport Phenomena II (4) 540.402 Metabolic Systems Biotechnology (3) 540.426 Biomacromolecules at the Nanoscale (3) 540.460 Computational and Experimental Design of Biomolecules (3) 550.391 Dynamical Systems (4) 580.420 Build-A-Genome (4) 580.444 Biomedical Engineering Applications of Glycoengineering (3) 580.446 Physical Epigentics 580.448 Biomechanics of Cells and Organisms (3) 580.451/2 Cellular and Tissue Engineering Laboratory (3) 580.492 Build-A-Genome Mentor (4)
Other Specialty Area Courses (non-ule) : 020.336 Stem Cell Biology in Development & Disease (3) 020.363 Developmental Biology (3) 020.373 Developmental Biology Laboratory (2) 250.326 Biological Macromolecules: Structure and Function (3) 250.391 Proteins and Nucleic Acids (3) TISSUE ENGINEERING AREA SPECIALIZATION. This specialty area is closely related to cell engineering --- e.g., stem cells are germaine to both areas --- but has more of a focus on larger systems such as building tissues, immunoengineering, and regenerative medicine. Students can select from a number of courses related to stem cells, cell and tissue organization, metabolic systems, and cell biology in addition to the platform courses suggested for all focus area students. Tissue Engineering Specialty Courses: 540.402 Metabolic Systems Biotechnology (3) 540.459 Bioengineering in Regenerative Medicine (3) 580.451/2 Cellular and Tissue Engineering Laboratory (3) 580.xxx Advanced Topics in Regenerative Medicine Other Specialty Area Courses (non-ule): 020.336 Stem Cell Biology in Development & Disease (3) 020.363 Developmental Biology (3) 020.373 Developmental Biology Laboratory (2) NANOBIOTECHNOLOGY AREA SPECIALIZATION. This area of specialization is for students who are interested in complementing the fundamental scientific knowledge obtained in the standard BME undergraduate curriculum with a focus on the technological aspects of cell and tissue engineering, with particular emphasis on the nanoscale. Students can select from a variety of upper level courses that cover the design, fabrication, and characterization of particles, surfaces, devices, and delivery systems and how they interact with biological systems. Topics include designing nanomaterials (including those used as growth substrates or those intended as drug delivery vehicles) to interact with cells, using cells for regenerative medicine applications, and manipulating various sub-cellular components and classes of biomacromolecules.
Nanobiotechnology Specialty Area Courses: 510.415 The Chemistry of Materials Synthesis (3) 510.430 Biomaterials Lab (3) 540.306 Chemical and Biological Separations (3) 540.402 Metabolic Systems Biotechnology (3) 540.403 Colloids and Nanoparticles (3) 540.440 Micro/Nanotechnology (3) 540.459 Bioengineering in Regenerative Medicine (3) 540.460 Computational and Experimental Design of Biomolecules (3) 580.420 Build-A-Genome (4) 580.451/2 Cellular and Tissue Engineering Laboratory (3) 580.492 Build-A-Genome Mentor (4) 580.495 Microfabrication Laboratory (4) 670.619 Fundamentals of Physics and Chemistry in Nanomaterials (3) Other Specialty Area Courses (non-ule): 020.336 Stem Cell Biology in Development & Disease (3) COMBINED UNDERGRADUATE-MSE PROGRAM. BME undergraduates who are interested in Department s Master of Science in Engineering (MSE) program have the opportunity to double count up to 6 credits of graduate level classwork, which generally means that the courses are designated with a 600 (and sometime 700 or 800) level number. In some cases this requirement can be met by taking the graduate level course Cellular Engineering (i.e., 580.641 instead of 580.441), Tissue Engineering (i.e., 580.642 instead of 580.442), or Biomedical Applications of Glycoengineering (i.e., 580.644 instead of 580.444). In other cases, undergraduate students may be provide permission (upon approval of the course instructor) to take graduate level courses, such as Advanced Orthopaedic Tissue Engineering (580.643), Molecular Immunoengineering (580.646), or other 600- or higher level courses listed above.