Department of Biological Sciences. Proposed Program Changes. Major in General Biology. Bachelor of Arts. Bachelor of Science

Department of Biological Sciences Proposed Program Changes Major in General Biology Bachelor of Arts Bachelor of Science General Biology Track Cellular/Molecular/Genetics Track Ecology/Evolution/Organismal Track Submitted: 1 September 2004 Effective: Fall 2005

Table of Contents Introduction 1 Current Catalog Copy 3 Details of New Tracks Core Requirements (All Tracks) 5 Bachelor of Arts in Biological Sciences 6 Bachelor of Science in Biological Sciences: General Biology Track 7 Cellular/Molecular/Genetics Track 8 Ecology/Evolution/ Organismal Track 9 New Courses General Listing Catalog Descriptions 11 Syllabi 12 Course Changes General Listing 26 Old and New Catalog Descriptions 27

Introduction The Department of Biological Sciences is proposing to change the format and requirements for the Bachelors Degrees, with a major in General Biology. Currently we offer a Bachelors of Arts in General Biology and a Bachelor of Science in General Biology. The science courses required for these degrees are identical, the differences between the B.A. and the B.Sc. are in non-science courses (philosophy, foreign language, and fine arts) specified to accompany the major for the B.A.. The scope of the Biological Sciences has expanded to such a degree that offering a single program for the major becomes either so extensive it is prohibitive, or, if kept to a manageable size, inadequate. To fit the variety of needs for our students, we are proposing to offer four different tracks in the Major in Biological Sciences. We remain committed to the principle that all students must have a broad basis in the full scope of the biological sciences. Because students goals change, they need to have a foundation from which they can go in any direction and change directions should the need arise. Therefore we are still requiring a basic core of courses to be taken by students in all tracks. Beyond this core, each track emphasizes the courses for its own particular focus. Within each track there is still opportunity for students to follow their individual interests. Because there is a core of courses required of all tracks, students will not need to declare their choice of track until the end of their second year, or will be able to change tracks as their goals change. The current requirement that all students will satisfy the humanities requirement of the General Education Requirements by taking a sequence of two courses in the same foreign language will be continued and will apply to all tracks. Students will be required to earn a grade of C or better in all courses for the major, both Biology Courses and Support Courses. The tracks we are proposing to offer are: 1. Bachelor of Arts in the Biological Sciences. This program will attract students who are integrating biology with other interests, and who are not intending to continue to postgraduate programs. It provides a wide range of biology courses coupled with the basic support courses from related disciplines. a. Total Biology Credit Hours 42-45 b. Total Support Core Credit Hours 25 c. Total Required Credit Hours 67-70 1

2. Bachelor of Science in the Biological Sciences: General Biology Track. This program maintains the breadth of the B.A. program, but significantly increases the requirements for support courses in related disciplines. Students with broad interests in the Biological Sciences or who are undecided about which area the wish to follow will be accommodated in this track. They will have a very firm broad foundation from which they will be able to go in any direction future events may require. Students in this program will be able to combine their biological studies with other interests, and will have the basis for continued study in postgraduate programs. a. Total Biology Credit Hours 39-42 b. Total Support Core Credit Hours 32-36 c. Total Required Credit Hours 71-78 3. Bachelor of Science in the Biological Sciences: Cellular/Molecular/Genetics Track. Students completing this track will be able to go into post graduate programs and employment in the burgeoning area of cell and molecular biology. They will have learned necessary techniques in this very important specialization. a. Total Biology Credit Hours 39-42 b. Total Support Core Credit Hours 38-41 c. Total Required Credit Hours 77-83 4. Bachelor of Science in the Biological Sciences: Ecology/Evolution/Organismal Track. Students whose primary interests are in ecological and organismal area will choose this track. Again, they will have a broad foundation which will prepare them for employment or postgraduate work in a wide array of specialities. a. Total Biology Credit Hours 42-47 b. Total Support Core Credit Hours 32-35 c. Total Required Credit Hours 74-82 Requirements for Academic Minor or Area of Concentration. All these programs necessarily have very high numbers of required credit hours, both in Biology (39-47) and in the support courses in mathematics and other sciences (25-41). Additionally, most of these courses involve laboratories which demand additional time beyond the hours of credit hours. We are therefore asking that students who successfully complete one of these programs be considered to have satisfied the Graduation Requirement of an Academic Minor or Area of Concentration. 2

Current Catalog Requirements (2004-2005) The degree of Bachelor of Science, Major in biological sciences, is conferred upon students completing: (a) requirements for a major in biological sciences, and (b) other NKU requirements for the degree. The degree of Bachelor of Arts, major in biological sciences, in conferred upon students completing, in additional to requirements for the Bachelor of Science, the following: (a) at least 8 semester hours in a modern foreign language, (b) at least 3 semester hours in philosophy, and ) at least 3 semester hours in fine arts. NOTE: These additional courses may also be used to satisfy, in part, the general education requirements........... BACHELOR S DEGREE PROGRAMS General Biology The general biology program is designed to give students a strong background in biological sciences preparatory to a biologically oriented career or to graduate work. Student interest in botany, aquatic biology, microbiology, medical technology, zoology, or other facets of biology or any combination of these can be met by taking, as electives in the curriculum suggested below, courses in these disciplines; details of such emphases should be worked out in consultation with an adviser. Requirements for a major in general biology are as follows: A. At least 39 semester hours of courses in biological sciences or biochemistry (CHE 482, 482L, 483) (minimum acceptable grade: C), including: 1. BIO 150-150L-150R, 151-151L-151R Introduction to Biology I and II 2. BIO 240 Information Resources in Biological Sciences 3. BIO 352-352L Genetics 4. BIO 340 Principles of Research 5. At least one of the following four courses (the course selected cannot also be used to fulfill an area requirement in A.7 below). a. BIO 360 Biology of the Cell b. BIO 400 Molecular Biology c. BIO 426-426L Mammalian Anatomy and Physiology II d. BIO 446-446L Plant Physiology 6. At least one of the following four courses (the course selected cannot also be used to fulfill an area requirement in A.7 below). a. BIO 300-300L Comparative Vertebrate Anatomy b. BIO 304 General Ecology c. BIO 358 Evolution of Organisms d. BIO 409 Biogeography 3

7. At least one course from two of the following three areas with a minimum of 3 semester hours from each selected area (a course from the remaining area is strongly recommended), a course used to fulfill one area cannot also be used to fulfill another area: a. Animal Biology: BIO 300, 301, 303, 305, 320, 381, 404, 407, 421, 425, 440. b. Plant Biology: BIO 211, 308, 309, 310, 311, 312, 416, 445, 446. c. Field Biology: BIO 129, 131, 306, 309, 312, 330, 404, 407, 416, 421, 422, 460, 465. 8. BIO 491 Comprehensive Examination. B. The following courses in supporting disciplines (minimum acceptable grade: C): 1. CHE 120-120L, 121-121L General Chemistry I and II (8 credit hours) 2. One of the following two options a. Option 1. CHE 310-310L, 311-311L Organic Chemistry I and II0 (8 credit hours) b. Option II. CHE 310-310L Organic Chemistry I. Plus one additional upper-division course of at least 3 semester hours in Chemistry, Geology, or Physics to be selected from the following: CHE 340-340L Analytical Chemistry (5 credit hours) CHE 440 Environmental Chemistry (3 credit hours) GLY 302 Historical Geology with lab (4 credit hours) GLY 315 Structural Geology with lab (4 credit hours) GLY 330 Geomorphology (3 credit hours) GLY 402 Invertebrate Paleontology with lab (4 credit hours) PHY 304 Electronics and Circuit Analysis with lab (4 credit hours) PHY 315 Introduction to Astrophysics (3 credit hours) Option II is not open to students with interests in pre-dentistry, pre-medicine, pre-optometry, preveterinary medicine, pre-pharmacy, or with plans for graduate school in areas such as biochemistry, physiology, microbiology, molecular biology, and others. It requires approval of student s adviser and department chair. Approval must be obtained during the semester that CHE 310 is being taken or before, not during program certification. 3. MAT 120 Calculus I (or MAT 205 Introduction to Statistical Methods (5 [3] credit hours) 4. PHY 211, 213 General Physics with Laboratory I and II or PHY 220, 222 University Physics with Laboratory I and II (10 credit hours). C. General Education Stipulation. Student will satisfy the humanities requirement 5

of the General Education Requirements (see HUMANITIES on pag 27) by taking a sequence of two courses in the same Foreign Language. 6

Core Requirements All Tracks Biology Core: Course Credit Hours BIO 150, 150L Introduction to Biology I, with Lab** 4 BIO 151, 151L Introduction to Biology II, with Lab** 4 BIO 155 Orientation to Biology* 1 BIO 251 Gen/Cell/Molecular Biology I* 3 BIO 252, 252L Gen/Cell/Molecular Biology II* 4 BIO 255 Biological Literature and Research* 3 BIO 304, 304L General Ecology, with Lab** 4 BIO 491 Comprehensive Exam** 0 Total Core Credit Hours 23 Support Core: Course Credit Hours PHY 211 and 213 General Physics I & II, with labs or PHY 220 and 222 University Physics I & II, with labs 10 CHE 120, 120L, 121, and 121L General Chemistry I & II with labs 8 MAT 205 Elementary Statistics 3 Total Support Core Credit Hours 21 General Education Stipulation: Student will satisfy the humanities requirement of the General Education Requirements by taking a sequence of two courses in the same foreign language.. * Indicates a New Course. Course numbers are tentative. ** Indicates a changed course 7

Bachelor of Arts Requirements Biology Core: Course Credit Hours BIO 150, 150L Introduction to Biology I, with Lab** 4 BIO 151, 151L Introduction to Biology II, with Lab** 4 BIO 155 Orientation to Biology* 1 BIO 251 Gen/Cell/Molecular Biology I* 3 BIO 252, 252L Gen/Cell/Molecular Biology II* 4 BIO 255 Biological Literature and Research* 3 BIO 304, 304L General Ecology, with Lab** 4 BIO 491 Comprehensive Exam** 0 Additional Biology Courses BIO 358 Evolution of Organisms 3 One course from Cellular/Molecular.Genetics Group*** 3-4 One course from Ecology/Evolution/Organismal Group*** 3-4 One course from Field Biology Group*** 3-4 BIO 410 Conservation Biology 3 Biology Elective 4 Total Biology Credit Hours 42-45 Support Core: Course Credit Hours PHY 211 and 213 General Physics I & II, with labs or PHY 220 and 222 University Physics I & II, with labs 10 CHE 120, 120L, 121, and 121L General Chemistry I & II with labs 8 MAT 205 Elementary Statistics 3 Additional Support Course CHE 310 and 310L Organic Chemistry I, with Lab 4 Total Support Course Credit Hours 25 Total Required Credit Hours: 67-70 General Education Stipulation: Student will satisfy the humanities requirement of the General Education Requirements by taking a sequence of two courses in the same foreign language. 8

* Indicates a New Course. Course numbers are tentative. ** Indicates a changed course. *** Lists will be maintained by the Department of Biological Sciences and will be available from the Department Office. Although a course may be included in more than one list, no single course may be used to satisfy more than one group requirement. 9

Bachelor of Science, General Biology Track, Requirements Biology Core: Course Credit Hours BIO 150, 150L Introduction to Biology I, with Lab** 4 BIO 151, 151L Introduction to Biology II, with Lab** 4 BIO 155 Orientation to Biology* 1 BIO 251 Gen/Cell/Molecular Biology I* 3 BIO 252, 252L Gen/Cell/Molecular Biology II* 4 BIO 255 Biological Literature and Research* 3 BIO 304, 304L General Ecology, with Lab** 4 BIO 491 Comprehensive Exam** 0 Additional Biology Courses BIO 358 Evolution of Organisms 3 One course from Cellular/Molecular.Genetics Group*** 3-4 One course from Ecology/Evolution/Organismal Group*** 3-4 One course from Field Biology Group*** 3-4 Biology Elective 4 Total Biology Credit Hours 39-42 Support Core: Course Credit Hours PHY 211 and 213 General Physics I & II, with labs or PHY 220 and 222 University Physics I & II, with labs 10 CHE 120, 120L, 121, and 121L General Chemistry I & II with labs 8 MAT 205 Elementary Statistics 3 Additional Support Courses CHE 310, 310L, 311, and 311L Organic Chemistry I & II, with Labs 8 (With written permission of the Department Chair prior to taking CHE 310, other advanced CHE, GLY, or PHY courses with lab may be substituted for CHE 311.)*** MAT 112 Applied Calculus or MAT 120 Calculus I 3-6 Total Support Course Credit Hours 32-36 Total Required Credit Hours: 71-78 General Education Stipulation: Student will satisfy the humanities requirement of the General Education Requirements by taking a sequence of two courses in the same foreign language. 10

Bachelor of Science, Cellular/Molecular/Genetics Track, Requirements Biology Core: Course Credit Hours BIO 150, 150L Introduction to Biology I, with Lab** 4 BIO 151, 151L Introduction to Biology II, with Lab** 4 BIO 155 Orientation to Biology* 1 BIO 251 Gen/Cell/Molecular Biology I* 3 BIO 252, 252L Gen/Cell/Molecular Biology II* 4 BIO 255 Biological Literature and Research* 3 BIO 304, 304L General Ecology, with Lab** 4 BIO 491 Comprehensive Exam** 0 Additional Biology Courses BIO 302 General Microbiology 4 BIO 400 Advanced Molecular Biology/Genetics** or BIO 360 Advanced Cell Biology** 3-4 Two courses from Cellular/Molecular/Genetics Group*** 6-8 BIO 241 Biometry** 3 Total Biology Credit Hours 39-42 Support Core: Course Credit Hours PHY 211 and 213 General Physics I & II, with labs or PHY 220 and 222 University Physics I & II, with labs 10 CHE 120, 120L, 121, and 121L General Chemistry I & II with labs 8 MAT 205 Elementary Statistics 3 Additional Support Courses CHE 310, 310L, 311, and 311L Organic Chemistry I & II, with Labs 8 CHE (BIO) 482 and 483 Biochemistry I & II 6 MAT 112 Applied Calculus or MAT 120 Calculus I 3-6 Total Support Course Credit Hours 38-41 Total Required Credit Hours: 77-83 General Education Stipulation: Student will satisfy the humanities requirement of the General Education Requirements by taking a sequence of two courses in the same foreign language. 12

Bachelor of Science, Ecology/Evolution/Organismal Track, Requirements Biology Core: Course Credit Hours BIO 150, 150L Introduction to Biology I, with Lab** 4 BIO 151, 151L Introduction to Biology II, with Lab** 4 BIO 155 Orientation to Biology* 1 BIO 251 Gen/Cell/Molecular Biology I* 3 BIO 252, 252L Gen/Cell/Molecular Biology II* 4 BIO 255 Biological Literature and Research* 3 BIO 304, 304L General Ecology, with Lab** 4 BIO 491 Comprehensive Exam** 0 Additional Biology Courses BIO 358 Evolution of Organisms 3 Ecology Elective*** 4 Two courses from Organismal Group*** 6-10 One course from Field Group*** 3-4 BIO 241 Biometry** 3 Total Biology Credit Hours 42-47 Support Core: Course Credit Hours PHY 211 and 213 General Physics I & II, with labs or PHY 220 and 222 University Physics I & II, with labs 10 CHE 120, 120L, 121, and 121L General Chemistry I & II, with labs 8 MAT 205 Elementary Statistics 3 Additional Support Courses CHE 310, 310L, 311, and 311L Organic Chemistry I & II, with Labs 8 (With written permission of the Department Chair prior to taking CHE 310, other advanced CHE, GLY, or PHY courses with lab may be substituted for CHE 311.)*** MAT 112 Applied Calculus or MAT 120 Calculus I 3-6 Total Support Course Credit Hours 32-35 Total Required Credit Hours: 74-82 General Education Stipulation: Student will satisfy the humanities requirement of the General Education Requirements by taking a sequence of two courses in the same foreign language. 14

New Courses (Appendix H) 16

New Courses BIO 155 BIO 251 BIO 252 BIO 252L BIO 255 Orientation to Biology (1,0,1) [possibly (2,0,1)???] Biology issues and applications, methodology, career opportunities, and postgraduate options. Classroom discussions, faculty panels, and written essays. PREREQ or COREQ: BIO 151. Genetics, Molecular and Cell Biology I (3,0,3) Essential concepts in genetics, molecular and cell biology: macromolecules, DNA and chromosomes, DNA replication, recombination and repair, mitosis and meiosis, Mendelian genetics, gene expression, structure and function of cellular organelles. Fall. PREREQ: BIO 150-151 and CHE 120-121. Genetics, Molecular and Cell Biology II (3,0,4) Applications of knowledge gained in Bio 2x1. Human gene therapy, genetically modified crops, the biology and genetics of cystic fibrosis, molecular phylogenetics, bioremediation, fermentation processes, conservation genetics, and cancer. Spring. PREREQ: BIO 251. COREQ: BIO 252L. Genetics, Molecular and Cell Biology Lab (0,3,0) Laboratory to accompany BIO 22. Hands-on experience with basic genetics, molecular, and cell biology techniques. Spring. COREQ: BIO 2x2. Biological Literature and Research (3,0,3) Information retrieval and presentation, introduction to biological literature. Scientific methodology including research problem selection, experimental design, literature survey, and proposal development. A course for the sophomore year. PREREQ: BIO 150-151. 17

Syllabus, BIO 155 Orientation to Biology This course will serve to provide discussions and introductions to biology in a much broader sense then a strict introductory course can provide. They will also introduce students to the Department of Biological Sciences -- its faculty, procedures, and programs. It will cover biology applications, methodology, study skills, career opportunities, and postgraduate options. Among the class topics will be: 1. Introduction to the departmental programs and courses. 2. Guest panels of faculty of the Department of Biological Sciences and, when possible, seminars by visiting biologists. Each faculty panel may discuss their particular interests and research programs, and/or career opportunities in their particular branches of biology. 3. Discussions of the applications of various biological topics in a broader social sense. e.g. human ecology, historical applications, medical ethics, etc.. 4. Discussions of career planning in the biological sciences. This will include the various postgraduate opportunities for biologists (professional schools and graduate schools), their nature, prerequisites, and application procedures. When possible, this may involve guest presentations. 18

Determination of the Orientation Grade Students will be evaluated on the basis of attendance and on written reviews and responses to assigned readings and current news events. Attendance: (50% of grade) There are 14 sessions of the class, not including the first introductory session. Percentage points will be earned as follows: Number of sessions Attended Points Earned 13-14 50 12 46 11 42 10 38 9 34 <9 00 If you miss a session, you may not make it up by attending a different section. You will have the opportunity to make up one absence by attending a departmental seminar (approved in advance by your instructor) and writing a one-page response to the seminar. This written response must be handed in at the regular meeting of your recitation section during the week immediately following the seminar you attend. Written assignments: (50% of grade) You will be given 5 writing assignments and a book report. Each writing assignment will be worth up to eight percentage points for a total of 40 possible points. >>----> Each assignment must be one page, typewritten, double-spaced, and must be handed in during the period for which it is assigned. Late work will not be accepted. work not in the proper format will not be accepted. The book report (10% of grade) will be due on the last class meeting of the semester. It must follow the format described in the preceding paragraph, except that it should be two to four pages, and will cover >100 pages of any book listed on the hand-out. If you find a book not listed on the handout which you think might be appropriate, ask your instructor for permission to use it for your report. Your instructor may also suggest additional books not on the list. Plagiarism, copying from the book or loosely rewriting any portion of the book, without acknowledgment of the source, will result in an automatic F for the Recitation Course. 19

Tentative Orientation Schedule Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Introduction Discussion: Biological and Scientific Literature Ecology Faculty Panel: Boyce, Evans Evolution Faculty Panel: Hastings, Lye, Barton Discussion: Environmental Applications Systematics Faculty Panel: Whitson, Dahlem, Discussion: Student Campus Opportunities and Involvement Aquatic Biology Faculty Panel: Acosta, Kannan Discussion: Scheduling and Careers Vertebrate Zoology Faculty Panel: Durtsche, Rambo, Sproat Discussion: Animal Care and Use in Education and Research Physiology Faculty Panel: Giesmann, Martines, Pearce Cell Biology Faculty Panel: Minor, Schultheis Biology Education Panel: Sproat, Warner Wrap-up 20

Syllabus: BIO 251 Genetics, Molecular and Cell Biology I Objective: Recent advances in genetics, molecular and cell biology have had a profound impact on all disciplines of biology from plant systematics to physiology. A thorough understanding of the concepts and experimental approaches used in these fields is necessary for positions in graduate school, industry, professional school, and teaching. Instructors: The course will be team-taught.: Dr. Debra Pearce SC 248 ext. 5362 pearce@nku.edu Dr. Patrick Schultheis SC 345 ext. 5933 schultheisp@nku.edu Dr. Nicole Minor SC 3352 ext. 6914 minorn@exchange.nku.edu Required Texts: Essential Cell Biology. Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, and Walter. Garland Science, 2004. ISBN 0-8153-3480-X Course Description: BIO 251 Genetics, Molecular and Cell Biology I (3,0,3) Introduction to the essential concepts in genetics, molecular and cell biology: macromolecules, DNA and chromosomes, DNA replication, recombination and repair, mitosis and meiosis, Mendelian genetics, gene expression, structure and function of cellular organelles. Fall. PREREQ: BIO 150-151 and CHE 120-121. 21

Tentative Syllabus: Week Topic 1 macromolecules: a review nucleic acid and chromosome structure (genes are made of DNA) 2 DNA replication, recombination and repair 3 mitosis and meiosis 4 Mendelian Genetics 5 basic genetics problems with probability 6 beyond Mendel 7 the flow of genetic information: from DNA to protein (transcription and translation) 8 the molecular structure of genes 9 regulation of gene expression in prokaryotes 10 regulation of gene expression in eukaryotes 11 membrane structure and function 12 the cytosol 13 mitochondria 14 chloroplasts 15 the nucleus endoplasmic reticulum 16: the Golgi apparatus lysosomes Note: coverage of cellular organelles will include the essential cellular processes that occur within them. For example, the TCA cycle and photosynthesis will be covered in weeks 13 and 14, respectively. Course Evaluation: The course grade will be based on the average of four lecture exams, each worth 100 points. The final exam (4 th exam) is comprehensive. 90-100% A 80-89% B 70-79% C 60-69% D < 60% F Student Honor Code: The work you will do in this course is subject to the Student Honor Code. The Honor Code is a commitment to the highest degree of ethical integrity in academic conduct, a commitment that, individually and collectively, the students of 22

Northern Kentucky University will not lie, cheat, or plagiarize to gain an academic advantage over fellow students or avoid academic requirements. 23

Syllabus: BIO 251 Genetics, Molecular and Cell Biology II Objective: Recent advances in genetics, molecular and cell biology have had a profound impact on all disciplines of biology from plant systematics to physiology. A thorough understanding of the concepts and experimental approaches used in these fields is necessary for positions in graduate school, industry, professional school, and teaching. Instructors: The course will be team-taught.: Dr. Debra Pearce SC 248 ext. 5362 pearce@nku.edu Dr. Patrick Schultheis SC 345 ext. 5933 schultheisp@nku.edu Dr. Nicole Minor SC 3352 ext. 6914 minorn@exchange.nku.edu Required Texts: Essential Cell Biology. Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, and Walter. Garland Science, 2004. ISBN 0-8153-3480-X Catalog Description: BIO 252 Genetics, Molecular and Cell Biology II (3,0,4) Practical and real-world applications of knowledge gained in Bio 2x1. Topics covered include human gene therapy, genetically modified crops, the biology and genetics of cystic fibrosis, molecular phylogenetics, bioremediation, fermentation processes, conservation genetics, and cancer among others. Spring. PREREQ: BIO 251. COREQ: BIO 252L. Tentative Lecture Syllabus: Week Topic 1-2 Genetically modified crops 3 Biology and genetics of cystic fibrosis 4 Human gene therapy 5 The evolution of genes/genomes 6 Molecular Phylogenetics 24

7-8 Molecular Epidemiology of Emerging Infectious Diseases (SARS, HIV) 9 Loss of genetic variation in natural populations and extinction risks 10 Genetic engineering (production of humulin and taxol) 11 Fermentation processes 12 Gene knockouts: a tool for assessing gene function 13 Signal transduction: an introduction 14 Cell-Cycle Control and Cell Death 15-16 Cancer (colorectal and breast) Course Evaluation: A single grade will be earned for BIO 252 and BIO 252L and will be calculated as follows: Four lecture exams, each worth 100 points. The final exam (4 th exam) is comprehensive. Two laboratory exams, each worth 100 pts. Homework/quizzes, attendance, and lab participation will be worth an additional 100 pts. The percentage earned out of 700 total points will be used to calculate the overall course grade. 90-100% A 80-89% B 70-79% C 60-69% D < 60% F Student Honor Code: The work you will do in this course is subject to the Student Honor Code. The Honor Code is a commitment to the highest degree of ethical integrity in academic conduct, a commitment that, individually and collectively, the students of Northern Kentucky University will not lie, cheat, or plagiarize to gain an academic advantage over fellow students or avoid academic requirements. 25

Syllabus: BIO 252 Genetics, Molecular and Cell Biology II Laboratory Objective: Recent advances in genetics, molecular and cell biology have had a profound impact on all disciplines of biology from plant systematics to physiology. A thorough understanding of the concepts and experimental approaches used in these fields is necessary for positions in graduate school, industry, professional school, and teaching. Instructors: The course will be team-taught.: Dr. Debra Pearce SC 248 ext. 5362 pearce@nku.edu Dr. Patrick Schultheis SC 345 ext. 5933 schultheisp@nku.edu Dr. Nicole Minor SC 3352 ext. 6914 minorn@exchange.nku.edu Required Texts: Essential Cell Biology. Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, and Walter. Garland Science, 2004. ISBN 0-8153-3480-X Catalog Description: BIO 252L Genetics, Molecular and Cell Biology II Lab (0,3,0) Laboratory to accompany BIO 252. Exercises are designed to provide students with hands-on experience with basic genetics, molecular, and cell biology techniques. Spring. COREQ: BIO 252. Lab Syllabus: Week Topic 1 Isolation of polytene chromosomes from Drosophila salivary glands 2 Micropipetting/Bacterial Culture Techniques 3 DNA Restriction and Electrophoresis 4-5 Effects of DNA Methylation on Restriction 5 Transformation of E. coli with Plasmid DNA 6-7 Purification and Identification of Plasmid DNA 8-10 Recombination of Antibiotic Resistance Genes 26

11-12 pbr322 Restriction Mapping 12-13 Introduction to PCR 14-15 DNA fingerprinting: PCR detection of Alu insertion polymorphisms 16 Chromatography of chloroplast pigments 27

Course Evaluation: A single grade will be earned for BIO 2x2 and BIO 2x2L and will be calculated as follows: Four lecture exams, each worth 100 points. The final exam (4 th exam) is comprehensive. Two laboratory exams, each worth 100 pts. Homework/quizzes, attendance, and lab participation will be worth an additional 100 pts. The percentage earned out of 700 total points will be used to calculate the overall course grade. 90-100% A 80-89% B 70-79% C 60-69% D < 60% F Student Honor Code: The work you will do in this course is subject to the Student Honor Code. The Honor Code is a commitment to the highest degree of ethical integrity in academic conduct, a commitment that, individually and collectively, the students of Northern Kentucky University will not lie, cheat, or plagiarize to gain an academic advantage over fellow students or avoid academic requirements. 28

Syllabus BIO 255 Biological Literature and Research BIO 255 is designed as an introduction to the steps involved in biological research and production of papers and presentations. The course includes choosing a project, learning how to do a thorough literature search, the steps involved in designing and producing a good experiment, paper and presentation, and the ethics of scientific research. We will also discuss the practicalities of designing a budget, resume writing, web design, and letters of application. BIO 255 is a required course for sophomore biology majors because the Department of Biological Sciences believes that all of our students and graduates need to have a working understanding of these skills. The course will be team-taught. You will do some projects on your own, some in groups and some with a single partner. Cooperation and responsible interaction will be very important. The class will be involved in evaluation of oral presentations. Attendance is therefore very important and will make up one component of your grade. You will lose points for each class that you miss. All assignments must be turned in on their due date. You will lose 10% of an assignment s value for each late day. This rule will be waived only in case of a verified, documented emergency. Assignments must be typed, unless otherwise indicated. Proofread! We will meet in Steely Library for some classes, so always consult your schedule before class. The textbook for the course is: McMillan VE. 2001. Writing papers in the biological sciences. 3 rd ed. Boston:Bedford Books. 207 p. The last date for withdrawal from a course with a W is ----. Withdrawal after that date requires a passing grade and verifiable evidence of a serious emergency necessitating withdrawal. The NKU Honor Code applies to this course: The work you will do in this course is subject to the Student Honor Code. The Honor Code is a commitment to the highest degree of ethical integrity in academic conduct, a commitment that, individually and collectively, the students of Northern Kentucky University will not lie, cheat, or plagiarize to gain an academic advantage over fellow students or to avoid academic requirements. See; http://www.nku.edu/deanstudents/honorcode.htm This statement is highly relevant to BIO 295. If we find evidence of such activities, you will receive a 0 (zero) for the assignment and if another such incident occurs, you will fail the course. We cannot e-mail grades or give them out over the phone. Your final grade will be posted on Norse Express. Come talk to us if you have difficulties. If you have a special learning need, please tell us early. Remember that pagers and phones must be turned off during class. 29

BIO 295 Syllabus Biological Literature and Research Tentative Schedule Week 1 Introduction; General Library Resources; The Scientific Process Week 2 Choosing a Topic (2 days); Good Searching Techniques (Boolean searching, etc.) Week 3 Good Searching Techniques, con t; Proposal Format (2 days); Week 4 Choosing a Topic; Experimental Design (Materials and Methods) Week 5 Results and Data Analysis; BIOSIS and MEDLINE Week 6 JSTOR, etc; Using the Web; PowerPoint Week 7 PowerPoint; Plagiarism; Reading Scientific Articles (2 days) Week 8 How to Evaluate Primary Research Articles; Scientific Ethics; Peer Review Week 9 Publishing; How to Write Abstracts Week 10 First Draft Reviews (2 days); Summary/Discussions Week 11 How to Cite Articles/References Cited Pages; Keeping a Lab Notebook Week 12 The Time- line; the Budget; Resumes and Letters of Application Week 13 Web Page Construction (2 days); Oral Presentations Week 14 Oral Presentations Week 15 Oral Presentations; Evaluation 31

Grade Determination Assignment Value # 1 Choosing a Topic 50 pts # 2 Search Strategies 50 pts # 3 First Proposal 50 pts # 4 Experimental Design 40 pts # 5 BIOSIS and MEDLINE 30 pts # 6 Using the Web 30 pts # 7 PowerPoint 50 pts # 8a First Abstract 45 pts # 8b First Evaluation 45 pts # 9 Writing Citations 25 pts # 10 Budget Proposal 30 pts # 11 Resume 25 pts # 12 Oral Presentation 70 pts # 13 Critique of Presentation 25 pts # 14 Second Abstract 40 pts # 15 Attendance 45 pts Total Points Possible 650 pts. Letter grade determination: A 585-650 B 520-584 C 455-519 D 390-454 F 389 32

Changes Course (Appendices K and M) 33

Course Changes 34

Course Changes Course Number Current Title Proposed Changes BIO 150 Introduction to Biology I, with lab BIO 150L Introduction to Biology I: Laboratory BIO 151 BIO 151L BIO 150R BIO 151R Introduction to Biology II, with lab Introduction to Biology II: Laboratory Introduction to Biology I Recitation Introduction to Biology II Recitation Del.: COREQ: BIO 150R Change hours to 4 Del.: COREQ: BIO 150R Del.: COREQ: BIO 151R Change hours to 4 Del.: COREQ: BIO 151R Delete Delete BIO 152 Biology Orientation I Delete BIO 153 Biology Orientation II Delete BIO 240 Information Resources in Biological Sciences Delete BIO 241 Biometry Del.: PREREQ of MAT 114 BIO 304 General Ecology Hours to (3,0,4) Add COREQ: 304L BIO 306 General Ecology Lab Number to BIO 304L Hours to (0,2,1) BIO 491 Comprehensive Examination Hours to (1,0,0) BIO 360 Biology of the Cell Title to Advanced Cell Biology BIO 400 Molecular Biology Title to Advanced Molecular Biology/Genetics PREREQ: BIO 251-252... BIO 400L Molecular Biology: Laboratory Title to Advanced Molecular Biology: Laboratory 35

Catalog Description Changes 1. BIO 150 a. Current Description: BIO 150 Introduction to Biology I (3,0,5) Interrelationships between organisms and their environment: evolution, systematics, and diversity; cellular reproduction and Mendelian genetics. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. Fall, spring. PREREQ: A minimum ACT score of 18 in each division (or SAT equivalent), or completion of all pre-college curriculum courses, or consent of instructor. COREQ: BIO 150L and BIO 150R. PREREQ or COREQ: CHE 120. b. Proposed Description: BIO 150 Introduction to Biology I (3,0,4) Interrelationships between organisms and their environment: evolution, systematics, and diversity; cellular reproduction and Mendelian genetics. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. Fall, spring. PREREQ: A minimum ACT score of 18 in each division (or SAT equivalent), or completion of all pre-college curriculum courses, or consent of instructor. COREQ: BIO 150L. PREREQ or COREQ: CHE 120. 2. BIO 150L a. Current Description: BIO 150L Introduction to Biology I: Laboratory (0,3,0) Laboratory to accompany BIO 150. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. COREQ: BIO 150 and BIO 150R. b. Proposed Description: BIO 150L Introduction to Biology I: Laboratory (0,3,0) Laboratory to accompany BIO 150. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. COREQ: BIO 150. 3. BIO 150R Delete. 4. BIO 151 a. Current Description: BIO 151 Introduction to Biology II (3,0,5) Gene regulation; nutrient procurement; fluid transport; cell structure and function; photosynthesis and respiration. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. Spring, summer. PREREQ: BIO 150; COREQ: BIO 151L and 151R. b. Proposed Description: BIO 151 Introduction to Biology II (3,0,4) Gene 37

regulation; nutrient procurement; fluid transport; cell structure and function; photosynthesis and respiration. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. Spring, summer. PREREQ: BIO 150; COREQ: BIO 151L. 38

5. BIO 151L a. Current Description: BIO 151L Introduction to Biology II: Laboratory (0,3,0) Laboratory to accompany BIO 151. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. COREQ: BIO 151 and BIO 151R. b. Proposed Description: BIO 151L Introduction to Biology I: Laboratory (0,3,0) Laboratory to accompany BIO 150. A general education course (natural sciences) but suggested only for students majoring or minoring in biological sciences. COREQ: BIO 151. 6. BIO 151R Delete. 7. BIO 152 Delete. 8. BIO 153 Delete. 9. BIO 240 Delete. 10. BIO 241 a. Current Description: BIO 241 Biometry (3,0,3) Statistical techniques for biological sciences. Fundamental experimental design, exploratory data analysis, parametric and non-parametric tests, and selected multivariate procedures as applied to biological data. Use of statistical software. PREREQ: BIO 151-151L and MAT 114 or 205. b. Proposed Description: BIO 241 Biometry (3,0,3) Statistical techniques for biological sciences. Fundamental experimental design, exploratory data analysis, parametric and non-parametric tests, and selected multivariate procedures as applied to biological data. Use of statistical software. PREREQ: BIO 151 and MAT 205. 11. BIO 304 a. Current Description: BIO 304 General Ecology (3,0,3) Interrelationships between organisms and their environment. Fall. PREREQ: BIO 150-151. b. Proposed Description: BIO 304 General Ecology (3,0,4) Interrelationships between organisms and their environment. Fall. PREREQ: BIO 150-151. COREQ: BIO 304L. 12. BIO 306 39

a. Current Description: BIO 306 Ecology Laboratory (0,4,2) Sampling techniques, experimental design, and data analyses in ecological research. Field trips. Fall. COREQ or PREREQ: BIO 304. b. Proposed Description: BIO 304L Ecology Laboratory (0,3,1) Sampling techniques, experimental design, and data analyses in ecological research. Field trips. Fall. COREQ or PREREQ: BIO 304. 40

13. BIO 360 a. Current Description: BIO 360 Biology of the Cell (3,0,3) Structure and function of cellular organelles; role of energy, membranes, nucleic acids, and proteins in cellular regulation; nature of nerve impulse. Spring. PREREQ: BIO 150-151 and one year of college chemistry (with laboratory). b. Proposed Description: BIO 360 Advanced Cell Biology (3,0,3) Structure and function of cellular organelles; role of energy, membranes, nucleic acids, and proteins in cellular regulation; nature of nerve impulse. Spring. PREREQ: BIO 150-151 and one year of college chemistry (with laboratory). 14. BIO 400 a. Current Description: Molecular Biology (2,0,4) Introduction to principles of modern molecular biology; DNA and RNA structure and synthesis; protein synthesis; gene structure, expression and regulation; recombinant DNA techniques; plant and animal models; transgenics; contemporary bioethics issues. Spring. PREREQ: BIO 302, CHE 310-311, and consent of instructor; BIO 482 or CHE 482 recommended. COREQ: BIO 400L. b. Proposed Description: Advanced Molecular Biology (2,0,4) Introduction to principles of modern molecular biology; DNA and RNA structure and synthesis; protein synthesis; gene structure, expression and regulation; recombinant DNA techniques; plant and animal models; transgenics; contemporary bioethics issues. Spring. PREREQ: BIO 251-252,CHE 310-311, or consent of instructor; BIO 482 or CHE 482 recommended. COREQ: BIO 400L. 15. BIO 400L a. Current Description: BIO 400L Molecular Biology: Laboratory (0,4,0) Laboratory to accompany BIO 400. DNA and RNA purification; DNA cloning and restriction enzyme analysis; plasmid vector screening and purification; Southern blotting; hybridization; Polymerase Chain Reaction (PCR); bacterial cell transformation; fusion proteins. COREQ: BIO 400. b. Proposed Description. BIO 400L Advanced Molecular Biology: Laboratory (0,4,0) Laboratory to accompany BIO 400. DNA and RNA purification; DNA cloning and restriction enzyme analysis; plasmid vector screening and purification; Southern blotting; hybridization; Polymerase Chain Reaction (PCR); bacterial cell transformation; fusion proteins. COREQ: BIO 400. 41

16. BIO 491 a. Current Description: BIO 491 Comprehensive Examination (0,0,1) Examination covering entire area of biological sciences. A pass/fail course. PREREQ: 20 hours upper-division courses in Biological Sciences. Fall and Spring. b..proposed Description: BIO 491 Comprehensive Examination (1,0,0) Examination covering entire area of biological sciences. A pass/fail course. PREREQ: 20 hours upper-division courses in Biological Sciences. Fall and Spring. 43