State of the Art of Health Research & Innovation in the EU-28 countries and regions: preliminary results

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State of the Art of Health Research & Innovation in the EU-28 countries and regions: preliminary results Claudio Cozza DEAMS - University of Trieste, Italy WP1 Team: University of Trieste: Claudio Cozza (leader); Monica Plechero; Lovro Ziberna

Outline Introduction: variables and data sources Analysis of the national and regional disparities in terms of Health research and innovation Detection of common patterns and analysis of key variables on Health R&I within the less performing EU regions Analysis of the participation of European regions in Health areas of FP7 program

Category of Indicator Indicator All fields / Health Country / regional level Data sources R&I investment R&D expenditures R&D personnel Human Resources S&T R&I education and infrastructures New products and processes PhD graduates Life Sciences infrastructures ALL / ALL ALL / ALL / / COUNTRY / COUNTRY COUNTRY COUNTRY EUROSTAT, WHO, EFPIA, R&D Scoreboard EUROSTAT Ongoing clinical trials COUNTRY WHO EUROPEAN COMMISSION Knowledge creation Peer-reviewed publications Top publications Patent applications EUROPEAN COMMISSION Knowledge transfer Intra-country and international copublications Co-patenting EUROPEAN COMMISSION Project success Participation in FP7 EUROPEAN COMMISSION

Category of Indicator Knowledge creation R&I investment R&D expenditures R&D personnel Human Resources S&T R&I education and infrastructures New products and processes Knowledge transfer Knowledge creation Knowledge transfer PhD graduates Life Sciences infrastructures Indicator All fields / Health Peer-reviewed publications Top publications Patent applications ALL / ALL ALL / ALL / Country / regional level / COUNTRY / COUNTRY COUNTRY COUNTRY Data sources EUROSTAT, WHO, EFPIA, R&D Scoreboard EUROSTAT Ongoing clinical trials COUNTRY WHO Intra-country and international co-publications Peer-reviewed publications Top publications Patent applications Co-patenting Intra-country and international copublications Co-patenting EUROPEAN COMMISSION EUROPEAN COMMISSION EUROPEAN COMMISSION Project success Participation in FP7 Project success Participation in FP7 EUROPEAN COMMISSION

Analysis of the national and regional disparities in terms of Health research and innovation

4500 Health publications fractional count ( years 2008-2012, by population) 4000 3500 3000 2500 2000 1500 1000 500 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

100 Total Health EPO patent applications 2008-2010 by country of inventor (by population) 90 80 70 60 50 40 30 20 10 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

400 Total Health EPO patent applications 2008-2010 by country of applicant (by population) 350 300 250 200 150 100 50 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

18 Average Percentage of Top-10% Health Most Highly Cited Publications (fractional count, 2008-2009) 16 14 12 10 8 6 4 2 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

18 Top 10% publications in Health and in all fields of science 16 14 12 10 PT LU 8 EE 6 4 2 0 0 2 4 6 8 10 12 14 16 18

Total Health publications fractional count 2008-2012 (by population): EU regions

Total Health EPO patent applications 2008-2010 by region of inventor (by population)

COUNTRY (W=Widening) Bulgaria (W) Czech Republic (W) Hungary (W) Poland (W) Romania (W) Slovakia (W) PUBLICATIONS Regions in the last quartile % on total country regions Severen tsentralen; Yugoiztochen; Severozapaden;Yuzhen tsentralen;severoiztochen 83% Severozápad;Strední Cechy; Moravskoslezsko 38% Észak-Magyarország; Közép- Dunántúl; Nyugat-Dunántúl 43% Lubuskie; Opolskie; Podkarpackie; Swietokrzyskie; Warminsko- Mazurskie 31% Sud Muntenia; Sud-Est; Centru; Sud-Vest Oltenia; Nord-Est; Vest; Nord-Vest 88% Západné Slovensko; Stredné Slovensko 50% Slovenia (W) Vzhodna Slovenija 50% PATENTS Regions in the last quartile % on total country regions Severozapaden;Severen tsentralen;severoiztochen; Yugoiztochen;Yuzhen tsentralen; Yugozapaden; 100% Severozápad; Jihozápad; Moravskoslezsko; Jihovýchod; 50% Észak-Magyarország; Közép- Dunántúl; Dél-Dunántúl 43% Warminsko-Mazurskie; Opolskie; Podlaskie; Podkarpackie; Swietokrzyskie; Zachodniopomorskie; Kujawsko- Pomorskie; Slaskie; Lubelskie; Lódzkie; Pomorskie; Lubuskie; Wielkopolskie; Dolnoslaskie 88% Nord-Vest; Centru; Sud-Est; Sud Muntenia; Sud-Vest Oltenia; Vest; Nord-Est; Bucuresti Ilfov; 100% Východné Slovensko; Stredné Slovensko; Západné Slovensko 75%

COUNTRY Austria Belgium PUBLICATIONS Regions in the last quartile % on total country regions Burgenland (A); Niederösterreich; Kärnten; Vorarlberg 44% Prov. Luxembourg (B); Prov. West- Vlaanderen; Prov. Hainaut; Prov. Limburg (B) 36% Finland Åland 20% France Corse 5% Germany Lüneburg; Chemnitz; Niederbayern; Koblenz; Schwaben: Weser-Ems; Kassel; Trier 21% Greece Dytiki Makedonia; Peloponnisos; Sterea Ellada; Voreio Aigaio; Ionia Nisia; Notio Aigaio 46% PATENTS Regions in the last quartile Prov. Luxembourg (B) % on total country regions 9% Dytiki Makedonia; Ipeiros; Ionia Nisia; Sterea Ellada; Voreio Aigaio; Notio Aigaio; Kentriki Makedonia; Thessalia; Peloponnisos; Anatoliki Makedonia, hraki;kriti 85% Italy Basilicata; Valle d'aosta/vallée d'aoste 10% Calabria; Molise; Basilicata 14% Zeeland; Drenthe; Friesland (NL); Friesland (NL) Netherlands Flevoland 33% 8% Portugal Alentejo; Algarve 40% Alentejo; Centro (P); Algarve 60% Spain Cantabria; La Rioja; Extremadura; Castilla y León; Principado de Asturias 31% Sweden Norra Mellansverige 13% United Kingdom Cumbria; Herefordshire, Worcestershire and Warwickshire; Highlands and Islands; Lincolnshire; Cornwall and Isles of Scilly 14% Lincolnshire; Lancashire 5%

Analysis of the national and regional disparities in terms of Health research and innovation

Intra-country Health Co-patenting (by population) 70 Health co-patenting and co-publications with partners in the same country 60 50 40 SI 30 20 10 0 0 500 1000 1500 2000 2500 3000 Intra-country Health Co-publications (by population)

160 Total Health intra-domestic co-patents 2008-2010, by region of inventor (Min-Max) 140 120 100 80 60 40 20 0

Detection of common patterns and analysis of key variables on Health R&I within the less performing EU regions

Limited availability of possible explanatory variables, both on Health and for EU regions Category of Indicator Indicator All fields / Health Country / regional level Data sources R&I investment R&D expenditures R&D personnel Human Resources S&T ALL / ALL ALL / / COUNTRY / COUNTRY EUROSTAT, WHO, EFPIA R&I education and infrastructures PhD graduates Life Sciences infrastructures ALL / COUNTRY COUNTRY EUROSTAT EUROPEAN COMMISSION New products and processes Ongoing clinical trials COUNTRY WHO

Health GERD by population 400 Total Health R&D expenditure and Health publications (years 2008-2012) 350 300 250 y = 0,080x - 68,44 R² = 0,695 200 150 SI 100 50 0 CZ HR y = 0,041x - 4,398 R² = 0,469 0 500 1000 1500 2000 2500 3000 3500 4000 4500 Health publications fractional count by population

Health GOVERD+HERD by population 160 Public and University Health R&D expenditure and Health publications (years 2008-2012) 140 120 100 80 60 40 20 0 0 500 1000 1500 2000 2500 3000 3500 4000 4500 Health publications fractional count by population

Health GERD by population 400 Total Health R&D expenditure and Health patents 350 300 250 200 y = 3,252x + 15,24 R² = 0,884 150 100 50 0 0 10 20 30 40 50 60 70 80 90 100 Health patent applications by country of inventor, by population

Regional correlations confirm the same although weaker figure Intra-country regional differences might reduce the overall effect

Analysis of the participation of European regions in Health areas of FP7 program

70 FP7 Health project participants by population Academia Research Organisations Business Other 60 50 40 30 20 10 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

40000000 FP7 Health: EC Contribution (in euros), by population 35000000 30000000 25000000 20000000 15000000 10000000 5000000 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

10000000 FP7 Health: ERC contribution (in euros), by population 9000000 8000000 7000000 6000000 5000000 4000000 3000000 2000000 1000000 0 BG HR CY CZ EE HU LV LT LU MT PL PT RO SK SI AT BE DK FI FR DE EL IE IT NL ES SE UK

FP7 Health project participants by population 70 FP7 Health participation and Health publications 60 50 LU BE EE 40 30 20 10 0 0 500 1000 1500 2000 2500 3000 3500 4000 4500 Health publications (fractional count) by population

FP7 Health project participants by population: regional distribution

200 FP7 Health projects participation, per million population: regional dispersion 180 160 140 120 100 80 60 40 20 0

(1) Top 10% most cited publications (2000-2007) Composite indicators for Research Excellence EC composite indicator research excellence 2010 (2) Top Universities & PROs per GERD (2003-2007, 2004-2008) (3) PCT Patents per population (2000-2008) (4) ERC Grants per public R&D (2007-2011) REG-RI composite indicator research excellence (1) Health Top 10% most cited Publications (2008-2009) (2) Health TOP universities and PROs (2007-2012) (3) PCT patents per population (2008-2010) (4) ERC Grants per public R&D (GERD+HERD) (updated years) Same methodology for both indicators: Normalization with the min-max method into a scale from 10 to 100 Aggregation of the four variables using the geometric average The variable related to ERC has been transformed using the natural logarithm

EC Composite Indicator

RegHealth-RI Composite Indicator