Trends in Technology and Applications Dr. Manfred Kircher Chairman CLIB 2021 January 13th, 2010 ECD Workshop on the utlook on Industrial Biotechnology Vienna
State of the Art Emerging Trends Priorities Coordinating the Development Supporting Measures by Governments and Industry
Biotechnology is Key in Biobased Production 2 mio t/a BioRenewable Feedstocks are Exploited by the Chemical Industry 85% Bio-based Chemical Sales Based on Biotechnology Fossil il 80% Coal 8% Natural Gas 2% BioRenewable Feedstocks 10% ils & Fats Starch 15 % Products from Chemical Processes 10 % BioCatalytic Microbes & Enzymes ther Cellulose Saccharose 75 % Products from Biotech-Processes 0 5 10 15 20 25 bio $ Germany 2008; Source: VCI 30 bio $; USA (2007) USITC publication 4020: Industrial Biotechnology: Development and adoption by the US Chemicals and Biofuel industries July 2007
Biotechnology is Established in the Chemical Industry..but still a Niche Polymers Pharmaceuticals Fine & Special Chemistry Petrochemicals and Derivates Detergents & Bodycare 94% ChemoProducts 6% BioProducts Anorg. Basic Chemistry 0 5 10 15 20 25 30 35 40 45 50 Annual Sales of the German Chemical Industry ( bio; 2007) Blue: Biotechnological products established Source: VCI 2009
Available only by Biotechnology: L-Lysin for Feed, Food & Pharma Midwest Lysine LLC, Blair Neb.USA
Biotechnology is More Competitive: Emmolients (Cosmetic Esters) Conventional Enzymatic raw mat. raw mat. volatile comp. reaction catalyst reaction aqueous waste desodor. steam catalyst recycled bleaching bleach aqueous waste solid waste drying filtration temperature > 180 C 140 C 100 C 60 C 20 C packing packing
Most established Processes are pure BioCatalysis BioCatalysis BioRenewable Feedstock Product
Current Industrial Biotechnology is Based on Pathways given by Nature Amino acids rganic acids Fuels & Solvents
Strengths & Weaknesses Biotechnological Products are established in higher value business segments Feedstock BioCatalysis Products insufficient feedstock flexibility theoretical productivity & yield not fully exploited insufficient genetic stability enzymatic catalysis limited to hydrolases product removal & purification costly limited to biological products limited to natural pathways
State of the Art Emerging Trends Priorities Coordinating the Development Supporting Measures by Governments and Industry
Biorenewable Feedstocks Compete with Petrochemical Carbon Sources rganic Chemicals Pharmaceuticals Fine & Specialty Chemistry succinic acid NH 2 2,5-furandicarboxylic acid 3-hydroxypropionic acid Detergent & Hygiene Chemicals Polymers NH 2 Corn aspartic acid CH 2 glucaric acid CH 3 glutamic acid Petrochemicals & Derivatives itaconic acid glycerol levulinic acid sorbitol 3- hydroxybutyrolactone xylitol Agrochemicals Fig. 2 DE TP12 Platform Chemicals from Carbohydrates [8]
The Chemical Industry gets ready for launching the KBBE Press Release Company Carbon Source BioProduct Product Launch 03/2009 Braskem BRA Sugar Ethanol 200 kt Ethylene HDPE 2010 12/2008 Perstorp SWE Starch/Sugar 3-Hydroxypropionic acid (meth)acrylic acid/ 1,3-PD 2012 09/2008 Genomatica USA Sucrose 1,4-butanediol Platform chemical 2010 09/2008 Genencor/Goodyear USA Corn cobs Switchgras Isoprene Rubber 2013 12/2007 Solvay Indba BRA Sugar Ethenol 60 kt Ethylene PVC 2010 07/2007 Dow/Crystalsev BRA Sugar Ethanol 350 kt Ethylene HDPE 2011
BioCatalysis Enters Production of Polymers Polymers Pharmaceuticals 94% ChemoProducts Fine & Special Chemistry Detergents & Bodycare Petrochemicals and Derivates 6% BioProducts Anorg. Basic Chemistry 0 5 10 15 20 25 30 35 40 45 50 Annual Sales of the German Chemical Industry ( bio; 2007) Blue: Biotechnological products established Blue checkered: Early biotechnological products on the market Source: VCI 2009
Biotechnology and Chemistry Complement one another BioCatalysis BioRenewable Feedstock Intermediate BioProduct Chemistry Product
Technology Push by Synthetic Biology H H H H H Escherichia coli 1,3 PD ~ P Klebsiella pneumoniae Saccharomyces cerevisiae
Today Biotechnology is based on Agricultural Carbon Sources fractionation + aerob 30% 70% of Biomass Carbon
BioEnergy Markets will be Dominant 50 40 Bioethanol Production [mio m³] 30 20 BRA 10 USA 0 EU 2004 2005 2006 2007 2008 Germany: Bioethanol Consumption 2008-2009 +61% Bioethanol-Plant Pischelsdorf
Lignocellulose is not yet Competitive fractionation + aerob 30% 70% of Biomass Carbon fractionation + + aerob 20% 80% of Biomass Carbon
Syngas Fermentation may Provide C 4 -Platform Chemicals ur collection of various acetogens from a variety of diverse ecological niches is a great pool of genes essential for engineering of microbial catalysts fermenting syngas to linear (4-5 carbons and up) or cyclic carbon backbone Syngas Biofuels Energy, Inc. Houston 25.8.2009
Gasification 99 % Carbon Yield fractionation + aerob Total Carbon Share 20-30% Total Carbon Share 70-80% fractionation + + aerob Total Carbon Yield >99%% gasification C 2 C H 2 anaerob
ptions & Challenges Biotechnological Products enter high volume & bulk business segments Feedstock BioCatalysis Products economics of lignocellulosic carbon sources transformation of syngas availability of chassis cells standardization of metabolic modules high-through-put (HTP) bioproducts cell engineering and screening precursors for continuous processes chemical in situ product recovery (ISPR) production integration of bio- and chemical processes anaerobic processes and reactors
State of the Art Emerging Trends Priorities Coordinating the Development Supporting Measures by Governments and Industry
Priorities Biological Catalyst synthetic biology whole cell and enzymatic catalysis Process continuos processes anaerobic processes in-situ product recovery (ISPR) bio-/chemo process-integration process flexibility in biorefineries Product Evaluation standardized life cycle analysis (LCA)
State of the Art Emerging Trends Priorities Coordinating the Development Supporting Measures by Governments and Industry
Industrial Biotechnology: Cooperation all over the Value-Chain Consumer Value Agro-Industry Seed Feedstock-Supplier Plant biomass Sugar cane Soy Corn Wood Syngas Fatty C5 Sugars acids C6 Sugars Lignin Lignocellulose Chemical Industry Succinic acid Amino Acid Microbial intermediates Butanol Ethanol Butadiene Acetaldehyde Acrolein Adhesive Peptides Polylamides Enantiomerically pure drug Adhesives Diaper Super Yoghurt absorber Polyurethane Cosmetic Food Additives Acrylic Acid Consumer Industries Plastics Chemical products Pyridines Energy Value Chain Bottle
Members of CLIB 2021 Include all Stakeholders Industry 8 Lawyer; 1 Data&Studies; 1 Consulting; 1 Patents; 2 Equipment; 4 Infrastructure 10 SME 34 BioProcess; 14 Investors 5 Academia 13 BioProducts; 11 Hachured segments: international members
State of the Art Emerging Trends Priorities Coordinating the Development Supporting Measures by Governments and Industry
Supporting Measures Financing setting off R&D expenses public promotion of demo-plants Cooperation promote partnering in clusters promote R&D partnering in prioritized fields both by governments and industry Training promote international exchange of graduates in academia and industry
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