RegenACR. autologous cellular regeneration. RegenACR A-PRP treatment. collagen fibers. 1,2 texture and elasticity. 3 volume & strength.

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RegenACR autologous cellular regeneration RegenACR A-PRP treatment collagen fibers. 1,2 texture and elasticity. 3 volume & strength. 4,5

WHAT IS A-PRP Autologous Platelet Rich Plasma Plasma contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes and proteins. Among the plasma proteins, there are the essential molecules for the coagulation process and generation of the fibrin polymer that will serve as a scaffold for cell migration, differentiation and proliferation. Platelets the essential growth factors FGF, PDGF, TGF-ß, EGF, VEGF, IGF which are involved in stem cell migration, differentiation and proliferation, and stimulation of cells such as fibroblasts and endothelial cells, to induce new extracellular matrix deposition and neo-vascularisation. MECHANISM OF ACTION 1. Formation of tridimensional fibrin network. 2. Release of chemo-attractants by leukocytes and platelets present in the network. 4. Stem cell proliferation. 5. Stem cell differentiation into different cell types needed for tissue restoration. 3. Migration of macrophages and stem cells. ILLUSTRATION OF A-PRP BENEFITS IN THE HEALING CASCADE Normal Healing Haemostasis Inflammation Regeneration Remodeling TIME Acceleration of healing with A-PRP

RegenACR Kit RegenACR Kit cell separator gel facilitates the easy, rapid and consistent preparation, from a small volume of blood, of A-PRP with optimal platelet concentration and viability. RegenACR is available in the form of procedure Kit comprising all the necessary components for A-PRP preparation and application. CLOSED SYSTEM RegenACR Kit A-PRP does not present safety concerns and preparation with RegenACR Kit is carried out in a closed system in a single step thereby guaranteeing sterility. *BCT stands for Blood Cell Therapy; Vol. = 8ml. Platelet concentration White blood cell concentration RegenACR Kit provides A-PRP with an optimal cellular profile & optimal platelet viability. PLT 10 3 /mm 3 WBC 10 3 /mm 3 Red Blood Cell concentration White blood cell repartition RBC 10 6 /mm 3 WBC 10 3 /mm 3

COLLAGEN FIBERS RegenACR A-PRP treatment results in an increased number of collagen fibers. 1 Before treatment - Masson s Trichrome After 1 treatment - 8 weeks (D56) resulting in accelerated healing post laser and chemical peels. It also improves the elasticity, tone and SKIN TEXTURE & ELASTICITY CHEEK BEFORE CHEEK AFTER 3 TREATMENTS Dermascope RegenACR A-PRP treatment texture and elasticity. 3 DECOLLETE BEFORE DECOLLETE AFTER 3 TREATMENTS REFERENCES ). Case study, 2008. 4- Betsi E-E, Esnault G, Kalbermatten D, Tremp M, Emmenegger V. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg

HAIRLOSS 3 sessions of RegenACR A-PRP in 3 months time increases hair density, and reduces hair loss to normal levels. 4,5 WRINKLES & DARK CIRCLES RegenACR PLUS completes the RegenACR Kits line for the preparation of Autologous Platelet Rich Plasma (A-PRP) in Aesthetics, offering the exclusive PLUS technology for small to medium treated areas. 3,4 BEFORE AFTER 3 TREATMENTS BEFORE AFTER The combination of Autologous Platelet Rich (A-PRP) and its natural activator, the Autologous Thrombin Serum (ATS) induces the formation of a biological glue and a three dimensional matrix, 100 % autologous. factors delivery.

RegenACR autologous cellular regeneration ORDERING INFORMATION Preparation of Autologous Platelet Rich Plasma (A-PRP) & other plasma-derived products R-ACR C1/B R-ACR C2/B RegenACR Classic 1 Collection holder and 1 Transfer device 1 Regen BCT* tube 1 x 2 ml ampoule of 10% calcium gluconate 1 Luer-Lok TM syringe 3 ml 1 transfer needle 2 x 30 G needles for injection 2 x 4 mm, 27 G needle for mesotherapy RegenACR Extra 1 Collection holder and 1 Transfer device 2 Regen BCT* tubes 1 x 2 ml ampoule of 10% calcium gluconate 2 Luer-Lok TM syringes, 1 ml (1) and 5 ml (10) 1 transfer needle 3 x 30 G needles for injection 1 x 4 mm, 27 G needle for mesotherapy 1 x 80 mm transfer cannula 1 Compressed paper mask R-ACR C1/BA R-ACR C/BA RegenACR Plus ONE 1 Collection holder 1 Regen BCT* tube 1 Transfer device 2 x 1 ml Luer-Lok TM syringe 1 x 80 mm transfer cannula 4 x 30 G needles for injection 1 RegenATS** tube RegenACR Plus 1 Collection holder 2 Regen BCT* tubes 1 RegenATS** tube 1 Transfer device 1 x 1 ml Luer-Lok TM syringe 1 x 80 mm transfer cannula 3 x 30 G needles for injection 1 x 4 mm, 27 G needle for mesotherapy 1 transfer needle 2 x 5 ml Luer-Lok TM syringes Regen BCT TUBE PRP VOL PER TUBE 4 to 5 ml RED BLOOD CELL DEPLETION > 99.7% PLATELET RECOVERY > 80 % PLATELET CONCENTRATION FACTOR (NATIVE) 1.6 X *BCT stands for Blood Cell Therapy; Vol. = 8ml. REGEN LAB SA En Budron B2 CH - 1052 Le Mont-Sur-Lausanne (CH) Tel. +41(0)21 864 01.11 Fax. +41(0)21 864 01.10 www.regenlab.com BCTACR-MD -V150806