SAFETY DATA SHEET 1. Identification Product identifier Other means of identification None. Recommended use Research use only. Recommended restrictions None known. Manufacturer/Importer/Supplier/Distributor information Company Name Synthetic Genomics, Inc. Address 11099 North Torrey Pines Rd. Suite 150 La Jolla, CA 92037 USA Telephone 1-855-474-4362 (North American Toll free number) 1-858-228-4115 (All other locations) Fax 1-858-777-5694 E-mail info@sgidna.com Emergency phone number (858)754-2900 Contact person Customer Service 2. Hazard(s) identification Physical hazards Health hazards OSHA defined hazards Label elements Hazard symbol Signal word Hazard statement Precautionary statement Prevention Response Storage Disposal Hazard(s) not otherwise classified (HNOC) Supplemental information None. None. The mixture does not meet the criteria for classification. Observe good industrial hygiene practices. Wash hands after handling. Store away from incompatible materials. Dispose of waste and residues in accordance with local authority requirements. None known. 3. Composition/information on ingredients Mixtures This product contains live cells. It is a potential biohazard and should be handled according to good lab practices, with proper personal protective equipment, proper engineering controls and within the parameters of the purchaser's safety program. Wild-type Vibrio natriegens is not known to be pathogenic or toxigenic to humans, animals or harmful to the environment. BIOSAFETY LEVEL 1 (BSL-1) CELL CULTURE - Maintain under Biosafety Level 1 handling conditions. The manufacturer lists no ingredients as hazardous according to OSHA 29 CFR 1910.1200. Composition comments 4. First-aid measures Inhalation Frozen culture in growth medium. Move to fresh air. Call a physician if symptoms develop or persist. 936663 Version #: 01 Revision date: - Issue date: 14-February-2017 1 / 6
Skin contact Eye contact Ingestion Most important symptoms/effects, acute and delayed Indication of immediate medical attention and special treatment needed General information 5. Fire-fighting measures Suitable extinguishing media Unsuitable extinguishing media Specific hazards arising from the chemical Special protective equipment and precautions for firefighters Fire fighting equipment/instructions Specific methods General fire hazards 6. Accidental release measures Personal precautions, protective equipment and emergency procedures Methods and materials for containment and cleaning up Environmental precautions 7. Handling and storage Precautions for safe handling Conditions for safe storage, including any incompatibilities Immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if irritation develops and persists. Rinse with water. Get medical attention if irritation develops and persists. Rinse mouth. Do not induce vomiting unless told to do so by a poison control center or doctor. Get medical attention if symptoms occur. Treat symptomatically. Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves. Water fog. Foam. Dry chemical powder. Carbon dioxide (CO2). Do not use water jet as an extinguisher, as this will spread the fire. During fire, gases hazardous to health may be formed. Self-contained breathing apparatus and full protective clothing must be worn in case of fire. Use water spray to cool unopened containers. Move containers from fire area if you can do it without risk. Responders should take into consideration the biohazard risk associated with responding to a fire in the area where the material may be stored or handled. The product is non-combustible. 8. Exposure controls/personal protection Occupational exposure limits Biological limit values Appropriate engineering controls Keep unnecessary personnel away. Contaminated work clothing should not be allowed out of the workplace. For personal protection, see section 8 of the SDS. Gently cover spill with paper towel and apply suitable disinfectants such as chlorine bleach or 70% ethyl or isopropyl alcohol. Allow sufficient contact time before clean-up (30 minutes). Stop the flow of material, if this is without risk. Following product recovery, flush area with water. For waste disposal, see section 13 of the SDS. Avoid discharge into drains, water courses or onto the ground. Wash hands after handling. Observe good industrial hygiene practices. Store in original tightly closed container. Store away from incompatible materials (see Section 10 of the SDS). No exposure limits noted for ingredient(s). No biological exposure limits noted for the ingredient(s). Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level. Individual protection measures, such as personal protective equipment Wear safety glasses with side shields (or goggles). Eye/face protection Skin protection Hand protection Wear appropriate chemical resistant gloves. Other suitable gloves can be recommended by the glove supplier. Skin protection Other Wear suitable protective clothing. Respiratory protection In case of insufficient ventilation, wear suitable respiratory equipment. Thermal hazards Wear appropriate thermal protective clothing, when necessary. 936663 Version #: 01 Revision date: - Issue date: 14-February-2017 2 / 6
General hygiene considerations 9. Physical and chemical properties Appearance Odor Physical state Form Color Odor threshold ph Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Flammability (solid, gas) Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants. Solid. Frozen liquid. Light yellow. Upper/lower flammability or explosive limits Flammability limit - lower (%) Flammability limit - upper (%) Explosive limit - lower (%) Explosive limit - upper (%) Vapor pressure Vapor density Relative density Solubility(ies) Solubility (water) Partition coefficient (n-octanol/water) Auto-ignition temperature Decomposition temperature Viscosity Other information Explosive properties Oxidizing properties 10. Stability and reactivity Reactivity Chemical stability Possibility of hazardous reactions Conditions to avoid Incompatible materials Hazardous decomposition products 11. Toxicological information Not explosive. Not oxidizing. The product is stable and non-reactive under normal conditions of use, storage and transport. Material is stable under normal conditions. No dangerous reaction known under conditions of normal use. Contact with incompatible materials. Strong oxidizing agents. No hazardous decomposition products are known. Information on likely routes of exposure Inhalation No adverse effects due to inhalation are expected. Skin contact Eye contact Prolonged skin contact may cause temporary irritation. 936663 Version #: 01 Revision date: - Issue date: 14-February-2017 3 / 6
Ingestion Symptoms related to the physical, chemical and toxicological characteristics Information on toxicological effects Acute toxicity Skin corrosion/irritation Serious eye damage/eye irritation Respiratory or skin sensitization Respiratory sensitization Skin sensitization Germ cell mutagenicity Carcinogenicity Expected to be a low ingestion hazard. Not known. Prolonged skin contact may cause temporary irritation. Not a respiratory sensitizer. This product is not expected to cause skin sensitization. No data available to indicate product or any components present at greater than 0.1% are mutagenic or genotoxic. Not classifiable as to carcinogenicity to humans. IARC Monographs. Overall Evaluation of Carcinogenicity NTP Report on Carcinogens OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) Reproductive toxicity Specific target organ toxicity - single exposure Specific target organ toxicity - repeated exposure Aspiration hazard 12. Ecological information Ecotoxicity Persistence and degradability Bioaccumulative potential Mobility in soil Other adverse effects 13. Disposal considerations Disposal instructions Local disposal regulations Hazardous waste code Waste from residues / unused products Contaminated packaging 14. Transport information DOT UN number UN proper shipping name Transport hazard class(es) Class Subsidiary risk This product is not expected to cause reproductive or developmental effects. Not an aspiration hazard. The product is not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment. None known. No data available. No other adverse environmental effects (e.g. ozone depletion, photochemical ozone creation potential, endocrine disruption, global warming potential) are expected from this component. Decontaminate all wastes before disposal (steam sterilization, chemical disinfection, and/or incineration). Collect and reclaim or dispose in sealed containers at licensed waste disposal site. Dispose in accordance with all applicable regulations. The waste code should be assigned in discussion between the user, the producer and the waste disposal company. Dispose of in accordance with local regulations. Empty containers or liners may retain some product residues. This material and its container must be disposed of in a safe manner (see: Disposal instructions). Since emptied containers may retain product residue, follow label warnings even after container is emptied. Empty containers should be taken to an approved waste handling site for recycling or disposal. UN3373 Biological Substance, Category B 6.2-936663 Version #: 01 Revision date: - Issue date: 14-February-2017 4 / 6
Packing group Special precautions for user IATA Read safety instructions, SDS and emergency procedures before handling. UN number UN3373 UN proper shipping name Biological substance, Category B Transport hazard class(es) Class 6.2 Subsidiary risk - Packing group Environmental hazards No. ERG Code 11L Special precautions for user Read safety instructions, SDS and emergency procedures before handling. IMDG UN number UN3373 UN proper shipping name BIOLOGICAL SUBSTANCE, CATEGORY B Transport hazard class(es) Class 6.2 Subsidiary risk - Packing group Environmental hazards Marine pollutant No. EmS F-A, S-T Special precautions for user Read safety instructions, SDS and emergency procedures before handling. Transport in bulk according to Not applicable. Annex II of MARPOL 73/78 and the IBC Code 15. Regulatory information US federal regulations This product is not known to be a "Hazardous Chemical" as defined by the OSHA Hazard Communication Standard, 29 CFR 1910.1200. TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D) OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) CERCLA Hazardous Substance List (40 CFR 302.4) Superfund Amendments and Reauthorization Act of 1986 (SARA) Hazard categories Immediate Hazard - No Delayed Hazard - No Fire Hazard - No Pressure Hazard - No Reactivity Hazard - No SARA 302 Extremely hazardous substance SARA 311/312 Hazardous chemical SARA 313 (TRI reporting) Other federal regulations No Clean Air Act (CAA) Section 112 Hazardous Air Pollutants (HAPs) List Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130) Safe Drinking Water Act (SDWA) US state regulations California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): This material is not known to contain any chemicals currently listed as carcinogens or reproductive toxins. 936663 Version #: 01 Revision date: - Issue date: 14-February-2017 5 / 6
US. Massachusetts RTK - Substance List US. New Jersey Worker and Community Right-to-Know Act US. Pennsylvania Worker and Community Right-to-Know Law US. Rhode Island RTK International Inventories Country(s) or region Inventory name On inventory (yes/no)* United States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory No *A "Yes" indicates this product complies with the inventory requirements administered by the governing country(s). A "No" indicates that one or more components of the product are not listed or exempt from listing on the inventory administered by the governing country(s). 16. Other information, including date of preparation or last revision Issue date Revision date Version # 01 Disclaimer 14-February-2017 - Synthetic Genomics, Inc. cannot anticipate all conditions under which this information and its product, or the products of other manufacturers in combination with its product, may be used. It is the user s responsibility to ensure safe conditions for handling, storage and disposal of the product, and to assume liability for loss, injury, damage or expense due to improper use. The information in the sheet was written based on the best knowledge and experience currently available. 936663 Version #: 01 Revision date: - Issue date: 14-February-2017 6 / 6