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www.biospektrum.de 2011 Media Information in Kooperation mit

MEDIA INFORMATION 2011 INSERTION SCHEDULE Issue Publication Deadline Specials Market Surveys/Topics Conferences/Events date incl. list of producers 1 11.02.2011 14.01.2011 Next Generation Market Survey: Pipettes Pittcon, Atlanta, USA: Sequencing DNA-Analysis 13.03. 18.03.2011 Immunodiagnostics, Cell Cycle, GfH Congress, Regensburg: Ecological Microbiology, 16. 18.03.2011 Pharmacology, Neurogenetics, 50. Annual Meeting & ToxExpo, Bio-Computing Washington, D.C. USA: Biotechnology 06. 10.03.2011 VAAM- 08.03.2011 08.02.2011 New Imaging, Cell Biology, VAAM Congress, Karlsruhe: Congress Environmental Microbiology, 03. 06.04.2011 Issue (see separate Rate Card) Food Microbiology, White Biotechnology 2 22.03.2011 22.02.2011 Forensics Flow Cytometry GfE-Meeting, Dresden: Pharmaceutical Chemistry, 23. 26.03.2011 Medical Pharmacology, DGPT Congress, Frankfurt: Chip-Technology, Molecular 30.03. 01.04.2011 Processtechnique DGZ Congress, Bonn: Biotechnology 30.03. 02.04.2011 VAAM Congress, Karlsruhe: 03. 06.04.2011 62. Mosbacher Kolloquium, Mosbach: 07. 09.04.2011 3 03.05.2011 31.03.2011 PCR Market Survey: Microscopes Laboratory Medicine/ Diagnostics Evolutionary Research, Protein Biochemistry, Bacteria Genetics, Biotechnology

MEDIA INFORMATION 2011 INSERTION SCHEDULE Issue Publication Deadline Specials Market Surveys/Topics Conferences/Events date incl. list of producers 4 21.06.2011 20.05.2011 Cell Biology Genomics 36. FEBS Congress, Turin, Pharmacology, Clinical Protein Italien: 25.06. 30.06.2011 Biochemistry, Experimental 4. FEMS Congress, Genf, Toxicology, Human Genetics, Schweiz: 26. 30.06.2011 RNA-Diagnostics BIO 2011, Washington, D.C., Biotechnology USA: 27.06. 30.06.2011 5 01.09.2011 04.08.2011 Gene Targeting: Proteomics/ GfG Congress, Würzburg BIOTECHNICA Knock-out/ Mass Spectrometry 14. 16.09.2011 Preview Knock-in Immunology, Microbiology, MipTec, Basel, Schweiz: Epigenetics, Bioanalytics, 20. 22.09.2011 Virology, Gene Expression GBM Congress, Frankfurt: Biotechnology 25. 28.09.2011 DECHEMA Congress, Berlin: 25. 29.09.2011 6 04.10.2011 08.09.2011 Laboratory Molecular Cell Biology Biotechnica, Hannover: BIOTECHNICA Automation/ Cellular Metabolic, Biocatalysis, 11. 13.10.2011 Issue Lab-on-a-Chip Immunobiology, Systems Biology, SIM-Microscopy Biotechnology 7 17.11.2011 20.10.2011 Proteom PCR Medica, Düsseldorf: Analysis Protein-Splicing, Genetic Tools, 16. 19.11.2011 Biochemistry, Enzymes, Cell Biology, Pharmacology Biotechnology

MEDIA INFORMATION 2011 RATE CARD #17 Valid from October 1 st 2010 1 Back Format 210 mm wide x 297 mm high, DIN A4 2 Type area 180 mm x 260 mm Number of columns: 3 columns à 58 mm or 4 columns à 42.5 mm 3 Print process, binding, mechanical data Offset printing. Our printing office produces with Ctp (Computer to Plate). We therefore prefer digital data files. For delivery of data please see page 8 Media Information. 4 Dates Publishing 7 issues/year Publishing dates and deadlines: please see insertion schedule 5 Advertisement Department Telephone: +49 (6201) 2 90 92-0 Fax: +49 (6201) 2 90 92-20 email: info@top-ad-online.de homepage: www.top-ad-online.de 10 Surcharge for Special Formats For Bleed Formats (no discount) 1 220. Sizes (width x height) for bleeds ads (including 3 mm bleed): 1/1 page 216 x 303 mm 1/2 page horizontal 216 x 151.5 mm 1/2 page vertical 105 x 303 mm 1/3 page b/w vertical 75 x 303 mm 1/3 page b/w horizontal 216 x 102 mm 11 Rates for Recruitment, Cobgress and Casual Ads Vacancies per mm (per column 45 mm) 1 3. Positions wanted per mm (per column 45 mm) 1 1.50 Code fee 1 7. Special Sizes and rates (width x height in mm): 1/1 page b/w vertical 180 x 260 1 2,500. 1/2 page b/w vertical 90 x 260 or 1 1,250. 1/2 page b/w horizontal 180 x 130 1/4 page b/w vertical 90 x 130 1 625. The following special rates apply for individual members of the scientific societies GBM, GfG, GfE and VAAM: Vacancies 1 55. 6 Terms of Payment 2% discount on payment within 10 days net within 30 days of invoice USt.Ident.-No. 27278 00526

7 Advertising Formats and Rates in 5 Format Width x Height in mm 1/1 page 180 x 260 1 4,360. Junior page 135 x 190 1 2,380. 1/2 page 90 x 260 or 1 2,290. 180 x 130 1/3 page 60 x 260 or 1 1,680. 180 x 85 1/4 page 90 x 130 or 1 1,250. 180 x 65 or 45 x 260 1/6 60 x 130 or 1 870. 180 x 40 1/8 90 x 65 or 1 650. 180 x 32.5 Millimeter price 1 column (58 mm) 1 5.20 8 Special Placement 2 nd and 4 th Coverpage 1 4,520. Banderole 1 6,200. plus technical costs (no discount) 1 1,900. 9 Colour Surcharge (no discount) Charge per colour (Euro Scale) 1 390. Charge per 4-colour advertisement 1 1,100. Special colour 1 700. (a special colour that can be printed from a 4-colour print, will be charged according to the Euro Scale of 1 390. ) 12 Discounts Within 12 months on the b/w rates: Series Discount: Quantity Discounts: Upwards from 3 insertions = 5% upwards from 2 pages = 5% Upwards from 6 insertions = 10% upwards from 4 pages = 10% Upwards from 9 insertions = 15% upwards from 6 pages = 15% Upwards from 12 insertions = 20% upwards from 8 pages = 20% 13 Bound Inserts 2-page (DIN A4), 216 x 303 mm 1 4,190. 4-page (2 x DIN A4), 432 x 303 mm 1 5,500. Inserts should be delivered untrimmed. 14 Loose Inserts up to 25 g (incl. costs for postage) 1 4,680. (incl. postage) up to 50 g (incl. costs for postage) 1 5,380. (incl. postage) Sending a sample is required before order acceptance. 15 Postal Adress for Bound and Loose Inserts Stürtz GmbH, Lager, z. Hd. Frau Morgenstern Alfred-Nobel-Strasse 33, Einfahrt 1 D-97080 Würzburg Delivery times Mon. Fri. 6:30 19:30, delivery 10 days before publication date at the latest. Way-bill remark: BIOspektrum, Heft Nr.

MEDIA INFORMATION 2011 RATE CARD BIOspektrum Conference Issue: VAAM annual meeting, April 3 rd 6 th, Karlsruhe Advertising Formats and Rates in 5 Format Width x Height in mm Basic Rate b/w 1/1 page 180 x 260 1 1,100. 1/2 page 90 x 260 or 1 590. 180 x 130 1/3 page 60 x 260 or 1 410. 180 x 85 1/4 page 90 x 130 or 1 320. 180 x 65 Special Placement 2 nd and 4 th Coverpage, 1 st right page 1 1,300. Colour Surcharge (no discount) Surcharge per colour Euro Scale 1 300. Special Colour 1 460. Surcharge for 4-colour ad 1 600. Loose inserts up to 25 g (incl. postage) 1 1,400. Sending a sample is required before order acceptance. Print-run 4,200 copies to: 3,200 members of the association for General and Applied Microbiology (VAAM) and will receive a copy. In addition, the issue will be handed out to interested visitors at the meeting. MEDIA INFORMATION 2011 BIOspektrum ONLINE Advertising Rates #5 valid from October 1 st 2010 1 Headbanner Field Placement/Format Length Monthly of Time Rate Homepage left or right, monthly 1 740. 250 x 75 pixel other pages left or right, monthly 1 480. 250 x 75 pixel 4 Recruitment ads text ads ads with frame and logo (PDF-file: max. 60 kb) 5 Deadlines and file delivery (button, banner) gratis 1 150. /monthly All Banners and Buttons can only be charged monthly. Advertisement-data is required one week before the publishing date. Please send the data to info@top-ad-online.de.

2 Button Field Placement/Format Length Monthly of Time Rate Homepage 200 x 75 pixel monthly 1 740. (max. 3) other page 200 x 75 pixel monthly 1 480. 3 Discounts From annual turnover 1 2,000. : 5 % From annual turnover 1 5,000. : 10 % From annual turnover 1 10,000. : 15 % From annual turnover 1 15,000. : 20 % 6 Document format jpg-data, gif-data max. data-size: 60 KB Banner: 250 x 75 Button: 200 x 75 7 document-data for recruitment text-ads Please send a free text-ad or a cost-efficient ad in PDF-format to biospektrum@springer.com. If you would like to place an ad in PDF-format, please contact top-ad Bernd Beutel. www.biospektrum.de: A lively online portal www.biospektrum.de Our website BIOspektrum-online is freely accessible for the most part due to networking and usability for scientific newcomers. All scientific articles are for society members with a personal access free available on publication date. For all others, free download is possible after a 6 month cooling period. BIOspektrum-online provides space for banner advertisement, weekly updated news, product descriptions (our service for companies), and many services for scientists: a broad calendar with a preview until 2013/14, job offers, a complete BIOspektrum archive (1999 today) incl. full text search over all published articles and clearly all information about the journal and the subscription. From 2010, all articles of BIOspektrum will be available online on the database SpringerLink and will be published on online first before printing.

MEDIA INFORMATION 2011 EDITORIAL/PUBLISHER 1 Short Characterization BIOspektrum 2010/2011 higher, faster, further BIOspektrum is the leading journal of the publisher Spektrum Akademischer Verlag, which is a part of Springer Verlag Heidelberg since October 2009. Since foundation in 1995, BIOspektrum expanded increasingly. This positive development was even enhanced by its relaunch in 2006. The magazine BIOspektrum reflects an intensive exchange of the active scientific disciplines as a collective publication of the leading professional societies in molecular biological research (GBM, VAAM, GfG, GfE and DGPT) and of the partner organizations in the field of biotechnology (VBU & DECHEMA) as well as of the umbrella organization VBIO. Due to this fruitful partnership BIOspektrum shows a high reader acceptance and recognition of the journal. Right from the start and increasing, the authors are outstanding scientists. Positive trends of BIOspektrum: Increasing readers In 2009, we obtained a new group of readers: the German biotechnologists. Since the beginning of 2009, BIOspektrum gained thereby 1.800 new readers and is now partner of the German biotechnological organizations DECHEMA and VBU. New contents We have launched a new category: the section Biotechnology. Since our co-operation with the German biotechnologists you will find 8 pages of background information and comments out of the branch. New editorial department biotechnology With our biotechnology crew, we received all requirements for a competent and professional presentation of our new subject area. Thus BIOspektrum opens its horizons for potential new alliances. New paths of publication With the database SpringerLink and online first, beside our website www.biospektrum.de, we gained new online publication paths which underline the status of BIOspektrum as a highly scientific journal. For our authors, online publication provides a higher accessibility, presence of their papers and feedback to their work. Honored twice with the prize Business medium of the year And the winner is.biospektrum! FACHMEDIUM DES JAHRES 2009 0 Kategorie: Wissenschaft BIOspektrum has already been twice awarded for being one of the best German business publications in the category Science with a silver medal in 2007 and a gold medal in 2009. Since 2005, the German Business Media decorates the best German business media. The aim of the prize is to direct the intention of the branch to excellent information tools for professional stakeholders. Extract from the statement of the jury: BIOspektrum combines contents and aesthetics. It is clearly structured and arouses the reader s curiosity. Every section contains detailed scientific articles with excellent illustrations, shorter essays and news. The attractive layout and the typography are exemplary. This is science wrote by scientist for scientists, their institutions and companies, here scrolling is fun, even for non-scientists.

2 Membership 3 Organ GBM German Society for Biochemistry and Molecular Biology, Frankfurt a. M. VAAM Association for General and Applied Microbiology, Lieskau GfG German Genetics Society, Konstanz GfE German Society of Developmental Biology, Ulm DGPT German Society for experimental and clinical Pharmacology and Toxicology, Mainz 4 Partners VBU Association of German Biotechnology Companies DECHEMA Society for Chemical Engineering and Biotechnology, Frankfurt a. M. VBIO Association for Biology, Biological Sciences & Biomedicine in Germany 5 Published by Springer-Verlag GmbH 6 Editorial BIOspektrum Springer Verlag GmbH/Spektrum Akademischer Verlag Tiergartenstraße 17 D-69121 Heidelberg Telephone: +49 (6221) 4878043 Fax: +49 (6221) 48768043 email: biospektrum@springer.com www.biospektrum.de 7 Advertising top-ad Bernd Beutel Hammelbächer Straße 30, D-69469 Weinheim Telephone: +49 (6201) 290 92-0 Fax: +49 (6201) 290 92-20 email: info@top-ad-online.de www.top-ad-online.de 8 Volume Volume 17 (2011), publishing 7 issues 9 Publisher Springer-Verlag GmbH Tiergartenstraße 17, D-69121 Heidelberg 10 Telephone +49 (6221) 4870 11 Internet www.biospektrum.de 12 Dates and Topics see insertion schedule 13 Subscription Price Private suscribers 1 59. Company/library 1 137.50 Students 1 25. Single Issue 1 22. All prices include 7% value-added tax, prices do not include postage: inside Germany 1 20., all other countries 1 23. p.a.

14 Analysis of Volume 2009 = 7 issues Size: DIN A4 Complete Edition: 824 pages Editorial: 689 pages = 83.6% Advertising: 135 pages = 16.4% including recruitment and casual ads: 7 pages = 5.8% including publisher ads: 14 pages = 10.9% including bound inserts: 6 pages = 5.8% Loose inserts: 7 items BIOspektrum is a reader focussed journal, therefore the editorial part of 82,9% is very high. The ads will be placed alone or next to editorial pages. 15 Analysis of Editorial Content 2009 = 7 issues Category: Cover pages/list of contents/editorial 28 pages = 4.1 % News 42 pages = 6.1 % Science 193 pages = 28.0 % Methods and applications 208 pages = 30.1 % Biotechnology 82 pages = 11.9 % Society news 56 pages = 8.1 % Career Opportunities 80 pages = 11.7 % GUIDELINES FOR DELIVERY OF THE ADVERTISEMENT DATA Print Documents for BIOspektrum Please send us your print documents according to the closing dates. top-ad Bernd Beutel, Hammelbächer Strasse 30, D-69469 Weinheim CD-Rom: with pre-press proof to top-ad PDF: to info@top-ad-online.de Delivery tips for DTP-data: System: Apple Macintosh Programme: QuarkXPress 6/7; InDesign CS4; Freehand 10/MX; Illustrator CS4; Photoshop CS4 Document format Always attach your document in its final size 1:1. Develop your document in single pages so that the document format is the net sheet size, and the trimmed page size results in 3 mm over the page edge. Picture Data Colour pictures are CMYK-separated (not RGB, not unsubscripted) Picture resolution: at least 300 dpi Font: Please use exclusively PostScript fonts. With EPS data text + illustrations (CMYK) embed or deliver separatelywith PDF-data With PDF- data Prepare the PDF in Composite-Mode (colour aspect). Center the pages on the paper format. To develop your PDF data, use the Acrobat Distiller. Please ask for our Distiller-settings. With open data text + illustrations (CMYK) always deliver together

MEDIA INFORMATION 2010 PRINT-RUN/DISTRIBUTION 1 Print-run inspection 2 Print-run analysis Copies per issue: Period 2 nd quarter of 2010 Print-run: 15,042 Distribution of printing 14,969 Paid circulation 12,432 Subscription copies 12,425 (from that) Membership copies 12,220 Other sales 7 Gratis copies 2,537 Surplus archive receipt 73 BIOspektrum has the highest number of paid subscription copies in all life science journals in Germany, Switzeland and Austria. BIOspektrum is IVW inspected a seal-of-approval from the print inspectors. 3 Geographical Distribution 2010 Federal Republic of Germany 91.2 % 13,660 Other countries 8.8 % 1,309 Actual Distribution of printing 14,969 The core readers of BIOspektrum are in Germany. The foreign readers of 1.309 copies are predominately Swiss and Austrian. 4 Branches/Branches of Trade Pharmaceutical Industries 32.5 % 4,865 Biotech/Life Science Industries 12.1 % 1,826 Nutrition and food Industries 3.2 % 464 Research laboratories/institutes, Universities and Large research facilities 44.8 % 6,721 Clinics 6.7 % 973 Other 0.8 % 120 Actual distribution of printing 100 % 14,969 The typical core readers of BIOspektrum are scientists, among them approx. 50 % from the industries and approx. 50 % from universities and large research facilities.

MEDIA INFORMATION 2011 THE TEAMS Your BIOspektrum team for the editorial content: BIOspektrum Springer-Verlag GmbH/ Spektrum Akademischer Verlag Tiergartenstraße 17 D-69121 Heidelberg Telefon: (0 62 21) 4878043 Fax: (0 62 21) 48768043 biospektrum@springer.com v. li. n. re.: Dr. Christine Schreiber Dr. Brigitte Trageser Dr. Claudia Ludy (extern) Your top-ad team for the Advertisements: top-ad Bernd Beutel Hammelbächer Straße 30 D-69469 Weinheim Telefon: (0 62 01) 290 92-0 Telefax: (0 62 01) 290 92-20 info@top-ad-online.de www.top-ad-online.de Susanne Beutel Bernd Beutel