The following information is designed to help you determine which implant program(s) work best for your feedyard:

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Implant Strategies for Finishing Cattle using Revalor (trenbolone acetate and estradiol), Finaplix (trenbolone) and/or Ralgro (zeranol) Revalor, Ralgro and Finaplix IMPLANT STRATEGIES FOR STEERS AND HEIFERS The following information is designed to help you determine which implant program(s) work best for your feedyard: Part 1: Steer Implant Strategies Part 2: Steer Implant / Re-implant Strategies Part 3: Heifer Implant / Re-implant Strategies Part 4: Implant Strategies Summary Part 5: Implant Strategy Selection Criteria For more information, be sure to discuss with your consulting nutritionist, consulting veterinarian and/or your Merck Animal Health representative. Part 1: Steer Implant Strategies 130-220 Days on Feed I. THE MOST CONSISTENT ALL-AROUND IMPLANT PROGRAM Revalor -XS (trenbolone acetate and estradiol) is the most consistent all-around implant on the market today. Its timed release of active ingredients from the coated pellets on approximately day 70 gives you the absolute best in terms of consistent carcass growth and quality, with exceptional feedyard growth performance. It is absolutely the most consistent, reliable and value-based implant on the market today. Single-implant Steers to 130 Days on Feed Less than 130 days REVALOR-S Single-implant Steers 130-220 Days on Feed 130-220 days REVALOR-XS Wade Nichols, Ph.D., John Hutcheson, Ph.D., Marshall Streeter, Ph.D., Mark Corrigan, Ph.D., Brandon Nuttelman, Ph.D.

Implant Strategies for Finishing Cattle Payout Data: Payout characteristics versus non-implanted steers with a single Revalor-S implant. Serum Concentration, pg/ml 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 0 Revalor-S Payout Single Revalor-S Implant 0 50 100 150 200 250 300 Days After Implantation Period Gain Data Average Daily Gain (ADG) period response versus non-implanted steers with a single Revalor-S implant. Period Daily Gain Response 0-35 days +28% 35-70 days +23% 70-105 days +17% 105-135 days +10% Rains, J.R., R.L. Preston, Revalor-S Tech Bulletin 10

Payout Data: Payout characteristics comparing non-implanted steers with a single Revalor-S or Revalor-S initial with a re-implant on day 70. Serum Concentration, pg/ml 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 0 Re-implant with Revalor-S Payout Re-implant with Revalor-S on Day 70 Single Revalor-S Implant 0 50 100 150 200 250 300 Days After Implantation Period Gain Response Average Daily Gain (ADG) period response versus non-implanted steers with a single Revalor-S or Revalor-S initial with a re-implant on day 70. Period Daily Gain Response 0-35 days +28% 35-70 days +23% 70-105 days +30% 105-135 days +32% Rains, J.R., R.L. Preston, Revalor-S Tech Bulletin 10

Implant Strategies for Finishing Cattle Payout Data: Theoretical payout characteristics of non-implanted steers compared with a single Revalor-S or Revalor-XS. Serum Concentration, pg/ml 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 0 Revalor-XS Payout Revalor-XS Single Revalor-S Implant 0 50 100 150 200 250 300 Days After Implantation Period Data Average Daily Gain (ADG) period response versus non-implanted steers compared with Revalor-XS. Period Daily Gain Response 0-35 days +28% 35-75 days +18% 75-140 days +30% 140-177 days +27% 2009 Feedyard Study Data on File

Part 2: Steer Implant / Re-implant Strategies I. ALL-AROUND RE-IMPLANT PROGRAM Excellent performance in terms of ADG and feed efficiency (F:G). Minimal to no quality grade reduction as long as cattle are finished to their physiological/biological end-points. Single-implant Steers to 130 Days on Feed Less than 130 days REVALOR-S Single Implant Steers 130-220 Days on Feed 130-220 days REVALOR-XS Re-implant Steers 130-220 Days on Feed 50-120 days Re-implant 80-100 days REVALOR-IS REVALOR-S Single Re-implant Steers 220-340 Days on Feed 90-120 days Re-implant 130-220 days REVALOR-IS REVALOR-XS

Implant Strategies for Finishing Cattle II. SPECIAL-PERFORMANCE-BASED RE-IMPLANT PROGRAM Superior performance in terms of ADG and F:G is the main goal. Heavier weights will need to be achieved to minimize grade reduction. Single-implant Steers to 130 Days on Feed Less than 130 days REVALOR-200 Re-implant Steers 130-220 Days on Feed, Performance-Based 50-120 days Re-implant 80-100 days REVALOR-IS REVALOR-200 Re-implant Steers 220-340 Days on Feed 140-220 days Re-implant 80-120 days REVALOR-XS REVALOR-200

Part 3: Heifer Implant/Re-implant Strategies I. ALL-AROUND RE-IMPLANT PROGRAM Excellent performance in terms of ADG and feed efficiency (F:G). Minimal to no quality grade reduction as long as cattle are finished to their physiological/biological end-points. Single-implant Heifers to 130 Days on Feed Less than 130 days REVALOR-H Re-implant Heifers 130-220 Days on Feed 50-120 days Re-implant 80-100 days REVALOR-IH REVALOR-H or FINAPLIX-H (trenbolone acetate) * Re-implant Heifers 220-340 Days on Feed 60-100 days 80-120 days 80-120 days Re-implant Re-implant RALGRO REVALOR-IH REVALOR-H or FINAPLIX-H * * Finaplix-H can be used when the terminal implant period is 100 days. II. SPECIAL-PERFORMANCE-BASED RE-IMPLANT PROGRAM Superior performance in terms of ADG and F:G is the main goal. Heavier weights will need to be achieved to minimize grade reduction. Single-implant Heifers to 130 Days on Feed Less than 130 days REVALOR-200

Implant Strategies for Finishing Cattle Re-implant Heifers 130-220 Days on Feed 50-120 days Re-implant 80-100 days REVALOR-IH REVALOR-200 Re-implant Heifers 220-340 Days on Feed 50-90 days 80-120 days 90-130 days Re-implant Re-implant REVALOR-IH REVALOR-H REVALOR-200 Part 4: Implant Strategies Summary Recommended Days on Implant for Steers and Heifers Implant Minimum Ideal Range Maximum Revalor-XS 130 130-210 220 Revalor-S 70 80-120 130 Revalor-IS 50 70-90 120 Revalor-H 70 80-120 130 Revalor-IH 50 70-90 120 Revalor-200 70 80-120 140 Finaplix-H 50 60-90 100 Ralgro 30 60-90 100 EXAMPLE: Steer Single Implant Strategies Days on feed Initial Re-implant Day Terminal 130 or less Revalor-S None None 131-170 Revalor-XS None None 171-180 Revalor-XS None None 181-190 Revalor-XS None None 191-210 Revalor-XS None None 211-220 Revalor-XS None None

EXAMPLE: Steer All-around Re-implanting Strategies Steers Re-implant Strategies Days on feed Initial Re-implant Day Terminal 130 or less Revalor-S N/A N/A 131-150 Revalor-IS Day 50 Revalor-S 151-170 Revalor-IS Day 70 Revalor-S 171-190 Revalor-IS Day 90 Revalor-S 191-200 Revalor-IS Day 100 Revalor-S 201-220 Revalor-IS Day 120 Revalor-S Days on feed Initial Re-implant Day Terminal Intermediate 221-240 Revalor-IS Day 90 Revalor-XS 241-260 Revalor-IS Day 110 Revalor-XS 261-340 Revalor-IS Day 120 Revalor-XS EXAMPLE: Heifer Performance-Based Re-Implant Strategies Days on feed Initial Re-implant Day Terminal * 130 or less Revalor-200 N/A N/A 131-140 Revalor-IH Day 50 Revalor-200 141-150 Revalor-IH Day 60 Revalor-200 151-160 Revalor-IH Day 70 Revalor-200 161-170 Revalor-IH Day 70 Revalor-200 171-180 Revalor-IH Day 80 Revalor-200 181-190 Revalor-IH Day 90 Revalor-200 191-210 Revalor-IH Day 100 Revalor-200 211-220 Revalor-IH Day 120 Revalor-200 Days on feed Initial Re-implant Day Intermediate Re-implant Day Terminal * 221-240 Revalor-IH Day 50 Revalor-H Day 130 Revalor-200 241-280 Revalor-IH Day 70 Revalor-H Day 170 Revalor-200 281-340 Revalor-IH Day 90 Revalor-H Day 210 Revalor-200 * Finaplix-H can be used when the terminal implant period is 100 days.

Implant Strategies for Finishing Cattle Part 5: Implant Strategy Selection Criteria All the above implant strategies give you some leeway in marketing cattle. As an example: For those who do not want to re-implant their steers, Revalor-XS provides the greatest marketing flexibility and for those wanting to re-implant a terminal, Revalor-S is mostly utilized 100 days from harvest. This gives you the ability to market cattle earlier than expected and longer than expected, i.e. 170-day cattle can be marketed at 150 or 200 days. There are some trade-offs that we need to be aware of. For example, 150-day cattle will have better ADG and F:G simply because we are selling them somewhat green, the 200-day cattle will have more marbling, maybe higher dressing percentage, more weight, and less ADG and F:G simply because we are selling them over-finished. During times of low ration costs and fair live cattle prices, we can keep cattle on feed longer and cost of gain rarely exceeds breakeven. We can be performance-based in our feeding and cattle management as well as our implant programs. Conversely, when ration costs become expensive and live cattle prices are low, we will adjust the implant strategies to finish cattle at lighter weights and less time on feed (figure 1). The spread between choice and select carcasses becomes of interest when the difference in dollars/cwt is substantial. It should also be considered when selling on a grid that pays a premium for marbling. However, finishing cattle to the correct weight will usually negate any marbling differences. As an example, figure 1 depicts low feed-low spread, which would indicate that we would want to feed for average grading and maximum weight. We can use performance-based implant strategy in this economic example. Feeding heavier weights takes advantage of the low feed costs and the heavier weights will help negate any negative marbling effects. Do not just look at days on feed to determine when cattle are ready for harvest. Let the cattle tell you when they are finished. Look at the cattle s body composition and feed records, since not all 700-weight animals are the same. Adjust days on feed based on animal type, body conformation, and body composition. In addition, analyze carcass data to see if the cattle are achieving the correct end-points of production. If the closeouts have virtually all yield grade (YG) 1s and 2s with very little YG 3s and no 4s, then in general, the cattle are too light or green to achieve their genetic potential to marble. The cattle need a percentage of YG 3s to allow them to achieve their genetic potential to marble (on the average), as well as reach a final end weight that allows the cattle to work both from a carcass perspective and a live perspective. Figure 2 illustrates, as an example, cattle implanted differently and the final end weights needed to achieve an empty body fat (EBF) percentage of 28.6% (Guiroy, et al. 2002, Journal of Animal Science 80:1791-1800). Research has indicated that an EBF of 28.6% is required for cattle to reach low choice marbling. Implanting changes the growth curve upward to a higher level. In other words, when we implant cattle that are a frame score 5, we now change their growth to mimic a frame score 6-7 (figure 3). These cattle will now need to be heavier to reach their genetic physiological/biological maturity. Figure 4 depicts the amount of EBF needed for cattle to grade standard, select, low-choice or mid-choice. On average, if we sell cattle that have less than 28% EBF, they will not exhibit enough finish to reach a USDA quality grade of low-choice. The majority of cattle need to have 28.5-29.5% EBF in order to grade to their genetic potential. Therefore, all these factors need to be taken into consideration when choosing an effective implant strategy, i.e. feed costs, animal costs, quality grade, genetics, economic advantages of weight (live & carcass), production goals and carcass goals. There are trade-offs to all the above. Implants can help you achieve your goals and benefit you economically in all circumstances.

Figure 1: A grid utilizing feed costs and choice/select spread for implant decisions. Cattle Selection High Feed - High Spread High Feed - Low Spread Low Feed - High Spread Low Feed - Low Spread Maximum Grading - Maximum weight - Implant cattle type depend Average Grading - Maximum weight - Maximum implant Average Grading - Maximum YG - Maximum weight - Maximum implant Buy for Growth - Maximum performance - Maximum implant Adapted from schematic developed by M. Hubbert, Ganado Research, Arroyo Seco, NM Feed = Feed costs either high or low Spread = Dollars/cwt difference between choice and select carcasses Figure 2: Growth curve graph depicting finished weights of cattle that are implanted differently. 40 Implants Change the Growth Curve 35 Empty Body Fat, % 30 25 20 15 10 5 No Implant* 1 Implant 28.6% EBF Low Choice 2 Implants or Revalor-XS** 0 800 1100 1165 1230 1265 Finish Weight (lb) * Based on Guiroy, et al. 2002, Journal of Animal Science 80:1791-1800 ** Based on Revalor-XS Serial Study

Implant Strategies for Finishing Cattle Figure 3: This table illustrates the finishing weight by frame score relationship for an animal to reach 28% empty body fat. Weight (lb) at 28% fat Frame size 1 2 3 4 5 6 7 8 9 Steer 882 954 1029 1102 1175 1250 1322 1395 1470 Heifer 705 763 824 882 939 1001 1058 1115 1177 Figure 4. Graph depicting amount of EBF needed to reach a particluar USDA quality grade (Guiroy et al. 2001, Journal of Animal Science 79: 1983-1995). 34 32 Relationship of empty body fat to Quality Grade (total of 1,355 animals) Empty Body Fat, % 30 28 26 24 Select, 26.2% EBF Mid Choice, 29.9% EBF Low Choice, 28.6% EBF 22 20 Standard, 21.1% EBF 3 3.5 4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9 9.5 10 Quality Grade A withdrawal period has not been established for Ralgro, Revalor and Finaplix in pre-ruminating calves. Do not use in calves to be processed for veal. For complete information, refer to product label. Wade Nichols, Ph.D., John Hutcheson, Ph.D., Marshall Streeter, Ph.D., Mark Corrigan, Ph.D., Brandon Nuttelman, Ph.D. merck-animal-health-usa.com 800-521-5767 Copyright 2015 Intervet Inc., doing business as Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. 6/15 BV-53092-Finishing