SORRENTO THERAPEUTICS, INC. (Exact name of registrant as specified in its charter)

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2015 SORRENTO THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-36150 33-0344842 (State or other jurisdiction of incorporation or organization) (Commission File Number) 9380 Judicial Drive San Diego, CA 92121 (Address of principal executive offices) Registrant s telephone number, including area code: (858) 210-3700 (Former name or former address, if changed since last report) IRS Employer Identification No.) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 1.01 Entry into a Material Definitive Agreement. On August 7, 2015, Sorrento Therapeutics, Inc. (the Company ) and TNK Therapeutics, Inc. ( TNK ), a wholly-owned subsidiary of the Company, entered into a Membership Interest Purchase Agreement (the Membership Interest Purchase Agreement ) with CARgenix Holdings LLC ( CARgenix ) and the members of CARgenix (the Members ) pursuant to which the Members sold all of their membership interests in CARgenix to TNK for: (1) a cash payment of $100, and (2) such number of shares of Class A common stock of TNK equal to $6,000,000 worth of TNK Class A common stock, subject to adjustment in certain circumstances, to be issued to the Members upon a financing for capital-raising resulting in gross proceeds (individually or in the aggregate) to TNK of at least $50,000,000 (a Qualified Financing ). In the event a Qualified Financing does not occur by March 15, 2016 or TNK does not complete an initial public offering of shares of its capital stock by March 31, 2016, the Members shall receive an aggregate of 309,917 shares of common stock of the Company, subject to adjustment in certain circumstances. The Membership Interest Purchase Agreement further provides that 20% of the shares of TNK or the Company, as applicable, issuable to the Members shall be held in escrow to secure certain post-closing adjustment and indemnification rights of TNK for a period of 12 months following the closing of the transaction. On August 7, 2015, the Company and TNK also entered into a Stock Purchase Agreement (the Stock Purchase Agreement ) with BDL Products, Inc. ( BDL ) and the stockholders of BDL Products, Inc. ( Stockholders ) pursuant to which the Stockholders sold all of their shares of capital stock in BDL to TNK for: (1) a cash payment of $100, and (2) such number of shares of Class A common stock of TNK equal to $6,000,000 worth of TNK Class A common stock, subject to adjustment in certain circumstances, to be issued to the Stockholders upon a Qualified Financing. In the event a Qualified Financing does not occur by March 15, 2016 or TNK does not complete an initial public offering of shares of its capital stock by March 31, 2016, the Stockholders shall receive an aggregate of 309,917 shares of common stock of the Company, subject to adjustment in certain circumstances. The Stock Purchase Agreement further provides that 20% of the shares of TNK or the Company, as applicable, issuable to the Stockholders shall be held in escrow to secure certain post-closing adjustment and indemnification rights of TNK for a period of 12 months following the closing of the transaction. The foregoing summary is qualified in its entirety by the full text of the agreements described above, copies of which will be attached as exhibits to the Company s Quarterly Report on Form 10-Q for the quarter ending September 30, 2015. Item 2.01 Completion of Acquisition or Disposition of Assets. The information set forth in response to Item 1.01 of this Current Report on form 8-K is incorporated by reference in this Item 2.01. The closing of the transactions contemplated by the Membership Interest Purchase Agreement and the Stock Purchase Agreement occurred on August 7, 2015. Item 9.01 Financial Statements and Exhibits. Exhibit No. Description 99.1 Press release dated August 10, 2015.

SIGNATURE Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Dated: August 10, 2015 SORRENTO THERAPEUTICS, INC. By: /s/ Henry Ji Name: Henry Ji Title: President and Chief Executive Officer

Exhibit 99.1 SORRENTO S TNK THERAPEUTICS SUBSIDIARY ACQUIRES MULTIPLE CLINICAL STAGE CAR-T IMMUNOTHERAPY PROGRAMS San Diego, CA August 10, 2015 Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) announced today that its wholly-owned subsidiary, TNK Therapeutics, Inc., has acquired multiple preclinical and clinical stage chimeric antigen receptor (CAR)-T immunotherapy programs as well as underlying CAR-T technology through the acquisition of two privately-held biotechnology companies. The CAR-T programs focus on targeting solid tumors as well as infectious diseases. We are very pleased to enter the dynamic CAR-T immunotherapy field with these clinical stage assets targeting solid tumors, an area of great unmet medical need, said Dr. Henry Ji, President and CEO of Sorrento. Especially exciting is the potential of combining the CAR-T therapies with Sorrento s immune-oncology programs, such as anti-pd1 and anti-ctla4 monoclonal antibodies (mabs). We recently in-licensed late clinical stage biobetter mabs of the marketed antibodies infliximab, cetuximab, and basiliximab, as well as a biosimilar mab of omalizumab. Utilizing these assets, combination therapies of our biobetter mab of basiliximab, an anti-cd25 mab that has been used to target and deplete immunosuppressive regulatory T cells 1, or cetuximab, an anti-egfr (epithelial growth factor receptor) mab, may work synergistically with our CAR-T and CAR.TNK programs for the treatment of solid tumors. With these acquisitions of clinical and pre-clinical CAR constructs, TNK Therapeutics is now positioned to accelerate the development of in-house adoptive immunotherapies, including the off-the-shelf CAR.TNK programs in our exclusive partnership with NantKwest. This breadth of complementary clinical programs and enabling technologies truly positions TNK Therapeutics to be a leader in the field of adoptive immunotherapies. Information about these CAR-T programs, underlying technologies as well as the biosimilar/biobetter antibodies will be detailed in Sorrento s updated corporate presentation later this month. About Sorrento Therapeutics, Inc. Sorrento is a clinical stage biopharmaceutical company developing new treatments for cancer and associated pain and inflammation and autoimmune diseases. Sorrento recently licensed multiple late-stage biosimilar and biobetter antibodies for oncology and inflammation diseases for the US, European and Japanese markets. Sorrento recently sold the rights to Cynviloq, which successfully completed the TRIBECA study, to NantPharma. The company is also developing resiniferatoxin (RTX), a non-opiate TRPV1 agonist to treat terminal cancer patients suffering from intractable pain. 1 Int J Oncol. 2009 Feb;34(2):563-72

In December 2014, Sorrento and NantWorks formed a global joint venture, now called Immunotherapy NANTiBody, LLC, to focus on immunotherapies for cancer. Also in December 2014, Sorrento and Conkwest, Inc., now renamed as NantKwest, Inc., an immunooncology company developing proprietary Neukoplast, a Natural Killer (NK) cell-line based therapy, entered into an agreement to jointly develop CAR.TNK (Chimeric Antigen Receptor Tumor-attacking Neukoplast) immunotherapies for the treatment of cancer and infectious diseases. In March 2015, Sorrento entered into a global collaboration with NantCell, a NantWorks company, to discover and develop immunotherapies against tumor neo-epitopes. In July 2015, Sorrento and NantBioScience, Inc., a subsidiary of NantWorks, established a joint venture, called NantCancerStemCell, LLC to focus on the development of first-in-class small molecules against targets which may address important drivers of cancer growth including cancer stem cells. Forward-Looking Statements This press release contains forward-looking statements related to Sorrento Therapeutics, Inc. under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995 and subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward-looking statements include statements about Sorrento s prospects, including, but not limited to any statements about the chimeric antigen receptor (CAR) T cell programs; potential combination therapies, Sorrento s expectations for adoptive cellular immunotherapies, Sorrento s collaborations with NantKwest, NantCell, NantPharma and NantBioScience, and the development of adoptive immunotherapies and the biosimilar/biobetter programs; Sorrento s ability to leverage the expertise of its employees and partners to assist the company in the execution of its strategies; Sorrento s advances made in developing RTX, CAR.TNKs and human monoclonal antibodies using its proprietary G-MAB fully human antibody technology, if any; and other matters that are described in Sorrento s Annual Report on Form 10-K for the year ended December 31, 2014, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission, including the risk factors set forth in those filings. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release and we undertake no obligation to update any forward-looking statement in this press release except as required by law. Sorrento, G-MAB, CAR.TNK, TNK Therapeutics, and the Sorrento logo are trademarks owned by Sorrento Therapeutics, Inc. All other trademarks and trade names are the property of their respective owners. Logo - http://photos.prnewswire.com/prnh/20150105/167173logo SOURCE: Sorrento Therapeutics, Inc.

Contact: Henry Ji, Ph.D. President & Chief Executive Officer Tel: (858) 668-6923 hji@sorrentotherapeutics.com