Doing Life Science Business in Germany Illinois Life Sciences & Technology Park Skokie, Illinois June 1, 2012

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Chris Schmidt - istockphoto Illinois Life Sciences & Technology Park Skokie, Illinois June 1, 2012

Media Acclaim for a Flourishing Economy Strong economic performance Sound financial management The Economist, April 14, 2012 Modell Deutschland über alles www.gtai.com 2

Leading Economy After two years of strong growth, the federal government expects a 1.6% boost in GDP growth in 2013, after a brief slowdown in 2012. Share of Total GDP and Population in the European Union (2011) GDP (in EUR bn) Share of total GDP (EU 27) Population (in m) Source: Eurostat 2011, US Census Bureau 2011, Japanese Statistics Bureau 2011; Note: France GDP 2011 forecast Share of total Population (EU27) Germany 2,571 20% 82 16% France 1,988 16% 65 13% UK 1,737 14% 62 12% Italy 1,580 13% 61 12% Spain 1,073 8% 46 9% Netherlands 602 5% 17 3% Poland 370 3% 38 8% Sweden 387 3% 9 2% Czech Republic 155 1% 11 2% Hungary 101 1% 10 2% Slovak Republic 69 1% 5 1% USA 10,843 313 Japan 4,222 128 EU 27 12,629 502 Eurozone 9,414 75% 332 66% 5/31/2012 www.gtai.com 3

Top Sectors for Trade and Investment (US DOC) The Germany is a receptive market for innovative, high quality medical devices and pharmaceutical products from the U.S.A. Drugs and Pharmaceuticals Medical Equipment Scientific & Laboratory Instruments Industrial Chemicals Renewable Energies Automotive Parts and Services Telecommunications Equipment IT Hardware, Software & Services Sporting Goods Travel & Tourism Agricultural Sector Source: Country Commercial Guide Germany 2011, US DOC www.gtai.com 4

Global Healthcare Expenditures The USA and Europe account for 72% of global healthcare expenditures. www.gtai.com 5

European Healthcare Expenditures Germany ranks first in European healthcare expenditures. www.gtai.com 6

The German Health Care System: Market Demand Health Care Spending in Germany accounts for 11.6% of GDP Germany s Population - Health Insurance Status (2011) German population: 81.8 mln (2011) 20.6 % of population over 65 Private Health Insurance 9% Other Health Insurance 4% Public Health Insurance 87% Family insurance 27% Retired 24% Regular 49% About 70.3 mln people in Germany have public health insurance 153 public health insurance companies with 164 bln health care spent in 2011 35% spent on hospital treatment 2064 hospitals with 502,749 beds in Germany (2010) Insurance system is currently generating a surplus: 2010: 6 bln 2011: 4 bln PHIC: Public Health Insurance Company Source: DESTATIS: Grunddaten der Krankenhäuser 2011; BVMED Branchenbericht 2011 www.gtai.com 7

The Medical Biotechnology Industry in Germany In 2011 the 400 medical biotechnology companies in Germany generated 6,4 bln. Revenue in mln 2007-2011 Employee structure 7000 6000 5000 6% 6% 1,5% 44% 1-9 4000 10-49 3000 50-99 2000 100-249 1000 more than 250 0 2007 2008 2009 2010 2011 42,5% Medical biotech company revenue increased by nearly 50% for the period 2006 through 2011. This is equivalent to an annual growth rate of 9%. The German medical biotech market is mainly made up of small but innovative companies generally 1 to 9 employees in size. Source: BCG and vfa Report, Deutsche Biotechnologie 2006-2011 & Biotechnologie.de 2011 www.gtai.com 8

The Medical Biotechnology Industry in Germany In spite of the financial crisis, the biopharmaceutical pipeline continued to grow in 2011. Biopharmaceutical pipeline 2007-2011 600 Biopharmaceuticals 556 biopharmaceuticals in clinical development in 2011 500 400 300 200 100 0 117 99 89 91 213 231 92 182 159 130 197 204 208 169 132 2007 2008 2009 2010 2011 Phase I Phase II Phase III Main focus: monoclonal antibodies 8% growth of clinical development pipeline on 2010 levels 10 drug candidates approved for marketing since 2010 Diagnostics 10% share of the 2 bln German diagnostics market CAGR: 12% Regenerative Medicine Market volume: 150 mln Source: BCG and vfa Report 2011 www.gtai.com 9

Opportunities for U.S. Drug & Pharma Exporters The German market is receptive to U.S. drug and pharma products. Diagnostic and therapeutic drugs for Dementia Auto immune diseases Inflammation Oncology Painmanagement Vaccines and cell- and bio-therapeutics Biosimilars Orphan drugs Source: US Commercial Service, Country Guide 2012 www.gtai.com 10

The European Medtech Industry Germany has the #1 Medtech industry in Europe measured by employment and number of companies. www.gtai.com 11

The European Medtech Industry Medtech sales in Europe 2009 Germany is Europe s leading market, and USA is the leading source of medtech product imports. The US is the leading supplier of medical devices to Germany, accounting for 28-30% of imports 22% of imports in F, 18% UK, 10% in IT Germany accounts for 18% of US medtech imports www.gtai.com 12

Opportunities for U.S. Medical Device Exporters Sub-sector best prospects according to the US Commercial Service: High quality advanced diagnostic and therapeutic equipment Innovative technologies and minimally invasive equipment, such as laser-optics in vascular surgery, urology, gastrology, dermatology, and neuro-surgery New diagnostic and imaging devices Specialized wound care and easy-to-use home care products Trend: demand for miniaturized electro-med. equipment + nano-technology products Preventive diagnostics and medical products Innovative orthopedic and physiotherapy devices Biomaterial, cardiovascular and endoscopy products Natural orifice surgery, novel imaging technologies, e-health and e-care, mobile medical products Source: US Commercial Service, Country Guide 2011 www.gtai.com 13

The Medical Technology Industry In Germany Germany is the largest innovation center for medical technology in Europe with 1244 patent applications in 2010. German Medical Technology Clusters Medical Technology Patent Applications 2008 Kiel United States 4825 Rostock Schwerin Hamburg Germany 1244 Bremen Hanover Düsseldorf Erfurt Berlin Potsdam Magdeburg Leipzig Dresden Jena Companies with more than 27.5 mln Companies with sales between 10.5 and 27.5 mln Japan Switzerland France 346 595 801 Mainz Saarbrücken Stuttgart Munich Companies with sales between 5 and 10.5 mln United Kingdom Sweden Israel 261 158 343 52 % of new ideas for medical devices are produced by clinical users 0 2000 4000 6000 Sources: Handelsblatt 2007, GTAI 2010 & European Patent Office Munich 2010 www.gtai.com 14

Research Performing Organizations A rich and varied research landscape drives innovation in Germany. Basic Research Applied Research Industrial Research Ass. s (AiF) Companies/ Industrial Research Länder Networks/Clusters Institutions Fraunhofer Gesellschaft Federal Institutions Heimholz Association Leibnitz Association Max Planck Society Universities Academics Research Infrastructures Public Funding Private Funding Source: BMBF, www.research-in-germany.de www.gtai.com 15

Germany Trade & Invest the Agency A two-fold mandate: assisting foreign investors and German exporters Germany Trade & Invest is the foreign trade and inward investment promotion agency of the Federal Republic of Germany. The agency is promoted by the Federal Ministry of Economics and Technology and the Federal Government Commissioner for the New Federal States Germany Trade & Invest Promotes Germany abroad as an investment location Provides consulting services to foreign companies wishing to set up in Germany Supports German exporters with reports on global markets www.gtai.com 16

Germany Trade & Invest the Agency Germany Trade & Invest has an extensive global network. Chicago New York San Francisco Toronto Washington Buenos Aires Caracas Mexico City Santiago de Chile Sao Paulo Berlin Bonn Athens Brussels London Madrid Milan Paris Stockholm Tel Aviv Johannesburg Cairo Nairobi Tunis Dubai Istanbul Belgrade Budapest Bucharest Kiev Moscow Prague Riga Warsaw Zagreb Bangkok Beijing Hanoi Hong Kong Jakarta Kuala Lumpur Mumbai NewDelhi Seoul Shanghai Taipeh Tokyo Sydney Two Headquarters in Germany - 46 Locations Worldwide www.gtai.com 17

Germany Trade & Invest the Agency Germany Trade & Invest partners with other organizations and institutions to promote international trade and investment. 120 offices in 80 countries Provides information about business opportunities in Germany Foreign Chamber Network Industry Associations, Multipliers 46 offices in all continents Supports and consults foreign investors with investment projects in Germany 212 embassies and consulates in nearly all countries Analysis of political and economic conditions Consular services, e.g. visa questions State EDCs Embassies and consulates www.gtai.com 18

Have a look at our homepage! The GTAI website offers a wealth of useful business and contact information to help you take the next step in Germany. www.gtai.com 19