Food and Energy Security through Sustainable Life Sciences. BIO Pacific Rim 2014 December 8, 2014

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Food and Energy Security through Sustainable Life Sciences TM BIO Pacific Rim 2014 December 8, 2014

What is Sustainability? Sustainability is something that improves the quality of human life while living within the carrying capacity of supporting eco-systems (IUCN/UNEP/WWF (1991)) We are also working to reduce humanity's ecological footprint the amount of land and natural resources needed to supply our food, water, fibre and timber, and to absorb our CO2 emissions. It's not about keeping people out of nature. Or turning back the clock. Or preventing countries or communities from developing. It is about finding practical solutions for a healthy planet. A planet where people and nature can thrive together, in a stable environment, now, and for generations to come. (WWF website 2014, emphasis added) 2

Our Mission Building a highly profitable company producing food, chemicals, and fuels from methane: a sustainable, abundant resource that does not compete with the human food chain 3

Methane is an Advantaged Feedstock Homogeneous methane doesn t vary due to weather or growing conditions Infrastructure the US has the world s most extensive methane distribution network Low Impact Methane is the lowest impact fossil fuel with up to 50% lower emissions than coal Climate Every ton of methane captured is equivalent to ~30 tons of carbon dioxide in GHG equiv. Sustainable methane does not compete with the human food supply, can be sourced from waste and renewables, and has minimal impacts on land and water usage

Anaerobic Digestion = Cellulosic Carbon Anaerobic digestion is the original treatment for cellulosic biomass Almost all organic matter will emit methane through natural decomposition Renewable Fuel Standard now recognizes biogas as a cellulosic and advanced fuel pathway 5

Calysta s Integrated Bioplatform? Methane (Nat Gas or Renewable) Proprietary Tools/ Algorithms High Mass Transfer Gas Reactors Industrial Partnerships 6

CHEMICALS/ENERGY NUTRITION Platform Tech Supports Multiple Products Methane Oxygen Ammonia Minerals Methanotrophs & CALYSTA Energy Technology Protein Carbohydrates Fatty acids Nutraceuticals Lactic Acid Butanediol Fatty alcohols Isoprene N-Butanol Succinic Acid and more 7

Food Security is the Issue of the Future By 2050, 9.6B people will demand 75% more protein than currently available Our research shows people will spend one-third of any increase in incomes on a more varied high-protein diet. - Greg Page, CEO of Cargill 100 80 60 40 20 0 Per Capita Protein Consumption (kg per year) 55% growth East Asia Industrialized countries 1997-1999 2030 Source: UN World Population Prospects: The 2012 Revision. World agriculture: towards 2015/2030. Food and Agriculture Organization of the United Nations, 2002. World agriculture: towards 2030/2050. Food and Agriculture Organization of the United Nations, 2012. 8

Increased Protein Consumption is Currently Unsustainable More than two-thirds of all agricultural land is devoted to growing feed for livestock, while only 8 percent is used to grow food for direct human consumption. If the entire world population were to consume as much meat as the Western world does-176 pounds of meat per capita per year- the global land required would be two-thirds more than what is presently used. Calysta s single cell protein product provides comparable protein content to high-quality fish meal minimal impacts on land and water usage a source of protein orthogonal to the human food chain a safe, validated product already approved for sale Source: UN Livestock, Environment, and Development (LEAD) Initiative, 2012. 9

IP and Know-how from the World s Only Commercially Validated Gas Fermenter Proprietary design and technology owned by Calysta Built and operated 300,000 liter fermenter Successfully produced over 10,000 tons of single cell protein from methane Successfully marketed and sold protein into the aquaculture and animal feed industries in Norway 10

Calysta is Active in Two Industry Verticals Nutrition Build, own and operate facilities producing approved microbial protein product using validated technology Pipeline of value-added feed ingredients that can drop in to validated production process Energy Licensing model with partnerfunded product development Calysta provides core technical capabilities Chemicals and Energy >$1,000B Partner provides path-tomarket knowledge Enables feedstock diversification for existing products 11

Joint Development in Energy Ongoing Menlo Park, CA June 16, 2014 Calysta, Inc. (www.calysta.com) today announced it has successfully fermented methane into lactic acid, under a research collaboration with NatureWorks. Lactic acid is the building block for NatureWorks Ingeo lactide intermediates and polymers used in consumer and industrial products worldwide. The joint development program, started in June 2013 between Calysta and NatureWorks, is focused on creation of a commercially viable methaneto-lactic-acid process. The key aims are providing a structurally simplified, lower cost Ingeo production platform and diversifying NatureWorks feedstock portfolio. 12

With New Developments! DOE AWARDS $2.5 MILLION TO NATUREWORKS TO TRANSFORM BIOGAS INTO THE LACTIC ACID BUILDING BLOCK FOR INGEO MINNETONKA, Minn., October 30, 2014 -- The U.S. Energy Department s Office of Energy Efficiency and Renewable Energy, Bioenergy Technologies announced a grant of up to $2.5 million to NatureWorks, one of the world s leading suppliers of bioplastics, in support of an ongoing program that aims to sequester and use methane, a potent greenhouse gas, as a feedstock for the company s Ingeo biopolymers and intermediates. 13

Chemical JDAs Grow the Tech Platform Innovation Pipeline Improvements in genetic tools Strain development & Exclusive licenses for commercialization Patents, knowhow, and expertise Short Chain Acids Lactic acid 3HP Etc. Fatty Acids and Alcohols Lauryl Alcohol Palmitic Acid Etc. Alkenes and Dienes Isoprene Butadiene Etc. 14

Calysta Continues to Lead with Innovative Uses for Methane Calysta s progress in the last year has changed the face of the company Fully integrated lab-to-commercial platform Commercial plant siting is underway; construction to begin next year Building a sustainable platform to food, fuels, and chemicals from an abundant resource that represents a practical solution 15

Contact Information CALYSTA, Inc. 1140 O'Brien Drive Menlo Park, CA 94025 (888) 265-6314 Alan Shaw, PhD - President & CEO 650.492.6880/Ext 102 ashaw@calysta.com Josh Silverman, PhD - CTO 650.492.6880/Ext 101 jsilverman@calysta.com Calysta, Calysta Energy, Calysta Nutrition, BioGTL, Biological Gas-to-Liquids, BGTL, BioGTC, Biological Gas-to-Chemicals, Biological Gas-to-Feed, Biological Gas-to-Fuel, BioGPS and PhyloGPS are trademarks of Calysta Energy, Inc. 16

Food and Energy Security through Sustainable Life Sciences TM BIO Pacific Rim 2014 December 8, 2014