Application of Proteomics and Transcriptomics in EMF Research

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Workshop Application of Proteomics and Transcriptomics in EMF Research October 30 - November 1, 2005 STUK- Radiation and Nuclear Safety Authority Laippatie 4, 00880 Helsinki, Finland http://www.who.int/peh-emf/meetings/proteomics_helsinki05/en/ Scientific Committee Dariusz Leszczynski - Chair STUK, Finland Mike Repacholi WHO Norbert Leitgeb EU Cost281 Gerd Friedrich FGF Frank Prato URSI Commission K Marty Meltz ICES Franz Adlkofer VerUm Foundation Sponsoring Organizations WHO EMF Project, Geneva, Switzerland STUK - Radiation and Nuclear Safety Authority, Helsinki, Finland EU Action Cost281 Forschungsgemeinschaft Funk (FGF), Germany URSI Commission K International Committee on Electromagnetic Safety (ICES), USA VerUm Foundation, Munich, Germany

Scientific Program of the Workshop Day 1: Presentations by Experts in High-Throughput Screening Techniques October 30, 2005, Sunday 8:50-9:00 Opening Mike Repacholi & Dariusz Leszczynski 9:00-9:40 Keynote talk Towards system level analysis of biological questions Risto Renkonen, Biomedicum, University of Helsinki, Finland 9:40-10:00 discussion 10:00-10:40 Proteomics - HPLC & MS Timothy Griffin Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, USA 10:40-11:00 discussion 11:00-11:30 Coffee & Tea 11:30-12:10 2DE as tool for proteomics studies and protein identification by mass spectrometry Brigitte Wittmann-Liebold WITA GmbH, Teltow/Berlin, Germany 12:10-12:30 discussion 12:30-13:10 Protein chips Thomas Joos (D. Stoll; M. Templin) Department of Biochemistry, NMI - Natural & Medical Sciences Institute, University of Tübingen, Reutlingen, Germany 13:10-13:30 discussion 13:30-14:30 Lunch 14:30-15:10 Gene expression - DNA chip/arrays Dirk Koczan Proteome Center, University of Rostock, Germany 15:10-15:30 discussion 14:30-16:10 Understanding complex biological systems with metabolomics: An overview Roy Goodacre School of Chemistry, University of Manchester, UK 16:10-16:30 discussion 16:30-17:00 Coffee & Tea

17:00-17:40 Protein networks J. Douglas Armstrong, Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Scotland, UK 17:40-18:00 discussion 18:00-18:40 Bioinformatics and data mining Juha Saharinen Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland 18:40-19:00 discussion 23:00-23:00 Dinner for invited speakers (sponsored by NOKIA) Day 2: Presentations by EMF Researchers using High-Throughput Screening Techniques October 31, 2005, Monday 9:00-9:30 Use of transcriptomics and proteomics in EMF research: Present status and future needs Dariusz Leszczynski Functional Proteomics Group, Radiation Biology Laboratory, STUK, Finland 9:30-9:45 discussion 9:45-10:15 2D gel-based proteomics: Application in EMF-treated human glioma cells and future directions Frank Witzmann Department of Cellular and Integrative Physiology, Indiana University Med. Sch., Indianapolis, IN, USA 10:15-10:30 discussion 10:30-11:00 Title: TBA Jim Metcalfe, Department of Biochemistry, University of Cambridge, Cambridge UK 11:00-11:15 discussion 11:15-11:45 Coffee & Tea 11:45-12:15 Application of genomic and proteomic approaches in studying bioeffects of EMF Zhengping Xu Bioelectromagnetics Laboratory, Zhejiang University Med. Sch., Hanghzou, China 12:15-12:30 discussion

12:30-13:00 Title: TBA Martin Meltz University of Texas Health Science Center, San Antonio, TX, USA 13:00-13:15 discussion 13:15-14:15 Lunch 14:15-14:45 Title: TBA Joseph Roti Roti Division of Biology &Biomedical Sciences, Washington University Med. Sch., St. Louis, MO, USA 14:45-15:00 discussion 15:00-15:30 In vitro gene expression studies and their impact on high content screening assays in EMF research Christian Maercker Mannheim University of Applied Sciences, Mannheim/Heidelberg, Germany 15:30-15:45 discussion 15:45-16:15 The proteomic analysis of human endothelial cells exposed to mobile phone radiation Reetta Nylund Functional Proteomics Group, Radiation Biology Laboratory, STUK, Finland 16:15-16:30 discussion 16:30-17:00 The proteomic response of S. pombe to static and oscillating low-field strength EMFs John Timms Ludwig Institute for Cancer Research, Proteomics Unit, London, UK 17:00-17:15 discussion 17:15-18:30 Brief 10 min. presentations from the submitted abstracts 18:30-20:00 Working groups preparing summary statements Coffee & Tea will be served in the working rooms 20:00-23:00 Get-together event with snacks and wine Day 3: Summaries & rapporteurs reports November 1, 2005, Tuesday 9:00-9:30 Statement proposals 9:30-11:00 Discussion on statements (Moderator: TBA) 11:00-11:30 Coffee & Tea

11:30-12:00 The first draft of the workshop rapporteurs report (Leszczynski & Meltz) 12:00-13:00 General discussion (Moderator: Michael Repacholi) 13:00 - departure (on your own)