Vascular. Improvement of Functions Supporting Neuro-IVR. 1. Introduction. 2. Current State of Functions Supporting Neuro-IVR

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Vascular Improvement of Functions Supporting Neuro-IVR Medical Systems Division, Shimadzu Corporation Yoshiaki Miura 1. Introduction The use of techniques in which intravascular treatment is performed with the aid of angiography systems (i.e., interventional radiology, hereafter referred to as IVR ) has spread widely, and the relevant technology is advancing at an everincreasing rate. At the same time, functions that can support the advanced techniques used in treatments are required of angiography systems. We have developed a function for supporting the precise device operations used in IVR procedures performed in the neuroendovascular treatment. Here, I will describe the purpose and operating principle of this function, and present some examples of its use. 2. Current State of Functions Supporting Neuro-IVR For some time, angiography systems have incorporated a MAP mode as a function for supporting IVR. By superimposing fluoroscopic images and angiographic images obtained by performing radiography after the injection of a contrast medium that absorbs X-rays, this function indicates the positional relationship between blood vessels and devices being manipulated (Fig. 1). (a) (b) Fig. 1 Examples of Fluoroscopic Image and MAP Image (a) Fluoroscopic Image, (b) MAP Image This function makes it possible for the operator to more accurately grasp the position and state of the devices being manipulated and is an effective support function for procedures. A function that provides a 3-dimensional sense of the shape of blood vessels using angiography systems has also been developed. This function obtains information from X-ray images taken of the subject from various directions by rotating the C-arm and performs 3D reconstruction to produce a steric display of blood vessel images. Our BRANSIST safire angiography system is equipped with this function. The observation of 3D images facilitates simulations for investigating the direction from which the region of interest should be observed in order to obtain images that are effective for treatment. This function has become indispensable for treatment. 3. Problems with Standard MAP Function As described in the previous section, the MAP function is an extremely effective tool for intravascular treatments, and there is no doubt that it supports the operator. One problem with this function, however, is that it does not work if the fluoroscopy position and the position used to obtain the mask image (i.e., the other component of the MAP image) do not coincide. This means that MAP mode can be used only if the position of the C-arm acquiring the X-ray image is not changed and images are not enlarged. In the manipulation of devices, it is normal to try to identify locations and image sizes that give greater visibility, and refraining from changing the size or position is out of the question. Normally, DSA is performed frequently in response to a change in size or position in order to create mask images (Fig. 2). This gives rise to the two secondary problems: increased X-ray exposure to the patient and contrast medium consumption and the necessity of interrupting device manipulation.

Flow of procedure Interruption Interruption Interruption Operation State size Fig. 2 Example of Flow of IVR Procedure Highlighting Creation of Mask Images 4. Concept of 3D-MAP Function The 3D-MAP function is based on the idea of solving the problem faced with the standard MAP function by using a 3D image as the mask image. (Hereafter, in order to compare it with the 3D-MAP function, I will refer to the standard MAP function as the 2D-MAP function.) With a 3D image, changing the from which reconstructed images are observed allows the observation of blood vessel images from various angles. Therefore, using a 3D image expressed in accordance with the position and size of the desired fluoroscopic image makes it possible for a single set of image data to replace the multiple mask images that would have been created for each new state in the past. 4.1. Acquisition of Mask Images It is possible to acquire 3D-MAP mask images using the 3D-Angio function that, for some time, has been provided as an option for BRANSIST safire. In IVR procedures where 3D-MAP is used, 3D-Angio imaging is nearly always performed in order to ascertain the form of the blood vessels. For this reason, there are probably only a very small number of cases in which additional imaging is performed for 3D-MAP (Fig. 3). Fig. 4 Example of Mask Image Display on 3D-MAP 4.2. Display of 3D-MAP Images First, the 3D image data acquired with 3D-Angio is transferred to the 3D-MAP Work Station (hereafter referred to as WS ), and on the 3D-MAP WS, the 3D image to be used for 3D-MAP is specified and the transfer operation is performed using the menus. Approximately 10 sec after transfer starts, a reconstructed image of the blood vessels is displayed on the 3D-MAP screen (Fig. 4). On comparison with Fig. 3, it can be observed that the front-back relationship is reversed. This is due to consideration of the fact that, whereas the blood vessels are visualized from the frontal perspective in the 3D-Angio image, the fluoroscopic image used for 3D-MAP is a projected image originating from the X-ray source, which is situated on the opposite side from the flat panel detector on which it is formed, and so the front-back size relationship is reversed. 4.3. Tracking Capability and Effect of 3D-MAP Images Real-time information on the positions and sizes of images is provided to the rendering engine for the 3D images used for mask images, and mask images that track the movement of the C-arm are displayed (Fig. 5). This eliminates the need for the DSA images that were obtained whenever the C-arm was moved in order to create mask images, and allows procedures to be performed without interruptions (Fig. 6). A clinical example is shown in Fig. 7. Fig. 3 Example of 3D-Angio Image

(a) Fig. 7 Clinical Example of 3D-MAP (b) 4.4. Free-Layout MAP Display In order to provide a safer and more comfortable IVR environment, our roadmap function (Fig. 8) is equipped with the following features. Both 2D and 3D roadmap images can be produced. Standard fluoroscopic images and roadmap images can be arranged freely. During operation of the roadmap function, the optimal display layout is switched to automatically and so no special operations are required. Dual Roadmap There are two roadmap functions, which can be selected according to the procedure. Subtraction MAP When the contrast medium is flashed during fluoroscopy, a black peak hold operation is performed, and a blood vessel map is created. The next time fluoroscopy is performed, the blood vessels are displayed as white subtraction images, and the guide wires can be observed as black objects inside the white blood vessels. Note: Synthetic image Superimpose MAP This function superimposes a previously obtained DSA image and a fluoroscopic image. Because repeated imaging is not required, the burden on the patient can be reduced. (c) Map/Fluoroscopy Simultaneous Display Function During operation of the roadmap function, the display monitor can switch automatically to show both the fluoroscopic image and roadmap image simultaneously, thereby supporting safer interventions. Fig. 5 3D-MAP Mask Images Tracking the C-arm Angle (a) RAO20/CRA20, (b) RAO20/CAU20, (c) LAO45/CRA0 During standard fluoroscopy During roadmap operation (frontal fluoroscopy) Flow of procedure Operation During roadmap operation (lateral fluoroscopy) State size Fig. 8 Roadmap Fig. 6 Example of Flow of IVR Procedure Performed Using 3D-MAP (for Comparison with Fig. 2) It is also possible to view and interpret images while performing image acquisition processing for fluoroscopy or radiography. One example of an application that utilizes this ability is the dynamic reference function (Fig. 9). With this function, a reference image with the same angle as the fluoroscopy/radiography angle and the current fluoroscopic image are displayed on the same

monitor, alternating according to whether or not fluoroscopy is being executed. Previously, the operator had to switch his or her gaze between the fluoroscopy monitor and the reference monitor while performing catheter operations. The dynamic reference function eliminates this necessity and allows easy comparative operation of images. Reference monitor Dynamic Reference 1 All the displayed images can be displayed as moving images. 4.6. Intuitive, Stress-Free Operating Interface In order to realize operation that is more intuitive and stress-free with the BRANSIST safire HB9/VB9 bi-plane systems, we have developed the following interfaces. (1) X-Ray Control Console: System Display We have developed a system display (Fig. 11) that, as an X-ray control console for the control room, enables the unified management of system information (e.g., X-ray conditions and mechanical information). It has an extremely simple operating system that can be operated with a touch-screen. Fluoroscopy ON Live monitor Single plane Fluoroscopy OFF Dynamic Reference 2 The image changes when fluoroscopy starts. No need for the operator to switch gaze. Bi-plane Fig. 9 Dynamic Reference Function Fig. 11 X-Ray Control Console: System Display 4.5. CT-Like Imaging Function The CT-like imaging function is coming to be regarded as an indispensable tool for the IVR of various regions, and is already incorporated in the BRANSIST safire angiography system, which offers the largest field of view in the world with a 17 17-inch FPD. Details are given in issue number 64 of this magazine 1). We have developed this function in a way that is suitable for systems equipped with a 9 9-inch FPD. This has made it possible to use our CT-like imaging function with all fields of view, from small to large, and to apply it to the IVR of a wide range of regions. A clinical example is shown in Fig. 10. (2) Examination Room Display: Information Display We have developed an information display (Fig. 12) that shows, in an integrated way, information related to C-arms in the examination room. It efficiently organizes large amounts of information and makes it easy to acquire the necessary information instantly. Single plane Bi-plane Fig. 12 Examination Room Display: Information Display Fig. 10 Clinical Example of CT-Like Imaging Performed with 9 9-Inch FPD (3) Controller for Control Room: IVR Shuttle We have developed the IVR shuttle (Fig. 13) as a controller for the control room. This makes it possible for anyone to perform the various operations required in clinical facilities, such as the display, frame-by-frame playback, and contrast adjustment of acquired images, with simple operations and without a manual.

Fig. 13 Controller for Control Room: IVR Shuttle 5. Summary In pursuing the improvements to functions supporting neuro-ivr described here, we gave the highest priority to the opinions of users performing cutting-edge intravascular treatments in medical facilities and focused on ways of making the IVR performed in the treatment of blood vessels safer and more precise. In the future, we will continue to pursue functional improvements aimed at enhancing treatment, and focus on coordination with other modalities that affect the environment in which these functions are used as well as the development of new applications. Reference 1) Kazuyoshi Nishino: Development of CT-like Imaging Function for BRANSIST safire Angiography System VC17, MEDICAL NOW, No. 64, p. 25-27, 2008