ZHIQIANG CAO Department of Chemical Engineering and Materials Science Wayne State University 5050 Anthony Wayne Drive, ENG 1123, Detroit, MI 48202 Office: 313-577-3121; Fax: 313-577-3810 Email: zcao@wayne.edu EDUCATION David H. Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, and Boston Children s Hospital Research Fellow. 12/2011-12/2012 Advisor: Prof. Robert Langer University of Washington Ph.D., Chemical Engineering, 2011 Advisor: Prof. Shaoyi Jiang Thesis: Development of Zwitterionic/Mixed Charge Materials for Biological Applications M.Sc., Chemical Engineering, 2009 Tianjin University, China M.Engn., Biomedical Engineering, 2007 B.Engn., Polymer Materials & Engineering, 2004 B.A., English, 2004 ACADEMIC POSITIONS Wayne State University Assistant Professor, Department of Chemical Engineering and Materials Science, 1/2013- present. AWARDS AND HONORS Community of Innovators Award, 2011 (One faculty and one student from ten departments in the College of Engineering will receive the award for their innovation in research. Univ. of Washington) Chinese Government Award for Outstanding PhD Students Abroad, 2010 (A prestigious national award recognizing top Chinese Ph.D. students across all fields of study in the world) GSFEI Graduate Student Travel Award, 2009 (GSFEI: The Graduate School Fund for Excellence and Innovation. Univ. of Washington) 1
D.D. and Sylvia M. Drowley Endowed Fellowship, 2007-2008 (The Dep. of Chemical Engineering, Univ. of Washington) Student Science Award, 2006 (15 out of all undergraduate and graduate students in Tianjin Univ. awarded for their great scientific contributions) Rong Zhijian Fellowship, 2006 (12 out of approx. 7000 graduate students in Tianjin Univ. awarded for their excellence in research work) First prize for academic paper in Annual Academic Day held by Nankai Univ. and Tianjin Univ., 2006 (10 were awarded among papers in all disciplines) Three A s Student award (2006, 2002), Tianjin Univ. Three A s Student award (2005), School of Material Sci. & Eng., Tianjin Univ. Model of Three A s Student award (2001), Tianjin Univ. (14 were awarded among all undergraduate students for their excellence in undergraduate study) Excellent Student award (2001), School of Material Sci. & Eng., Tianjin Univ. ADDITIONAL EXPERIENCE David H. Koch Institute of Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA, and Children s Hospital of Boston at Harvard Medical School, Boston, MA Research Fellow. 2011-2012. Postdoc Advisor: Prof. Robert Langer Performed extensive research in drug delivery and tissue engineering for the treatment of cancer and diabetes. Department of Chemical Engineering, University of Washington, Seattle, MA Research Assistant. 2007-2011. Ph.D. Advisor: Prof. Shaoyi Jiang. Other Committee Member: Prof. Buddy Ratner, Prof. Allan Hoffman and Prof. Thomas Horbett. Performed extensive research in biomaterials, surface science, and nanomedicine. Designed and synthesized zwitterionic or mixed charged polymers and natural peptides with ultra-low fouling properties. Developed antifouling and functional coatings for medical or marine devices, protein arrays and biomarker diagnostics through Surface Plasmon Resonance (SPR) sensor, long-circulating and functional nano-medicines (i.e., biodegradable polymer nanoparticles, liposomes and quantum dots) for drug/gene delivery and tumor therapeutics in vivo, hydrogels for ophthalmic practice and tissue engineering. Developed smart materials, switching between non-sticky mode (ultra-low fouling) and sticky mode (chemically reactive), or antimicrobial mode (killing bacteria) and biocompatible mode (releasing dead bacteria). Polymer Materials & Engineering, and Biomedical Engineering, Tianjin University, China 2
Research Assistant. 2003-2007. Advisor: Prof. Wenguang Liu Performed research in the areas of gene delivery and hydrogels. Designed and synthesized cationic, and hydrogen-bonding polymers (i.e., chitosan, polyarginine, and polyvinyldiaminotriazine) for gene delivery. Designed and synthesized block copolymers with varied architectures via atom transfer radical polymerization. Designed and synthesized PNIPAAm based thermo-responsive polymers and hydrogels. RESEARCH INTERESTS Material/Surface Chemistry; Biomaterials by Design; Antifouling/Antimicrobial Coatings; Biosensors; Nanomedicines (drug/gene delivery) and Tissue Engineering for cancers and diabetes. PUBLICATIONS 1. L. Zhang, Z.Q. Cao, T. Bai, L. Carr, J.-R., Ella-Menye, C. Irvin, B. Ratner, S.Y. Jiang*, Zwitterionic hydrogels implanted in mice resist the foreign-body reaction. Nature Biotechnology, (2013) DOI:10.1038/nbt.2580 2. L. Zhang, A. Sinclair, Z.Q. Cao, J.-R. Ella-Menye, X. Xu, L. Carr, S. H. Pun, S.Y. Jiang*, Hydrolytic Cationic Ester Microparticles for Highly Efficient DNA Vaccine Delivery, Small, (2013) DOI: 10.1002/smll.201202727 3. Z.Q. Cao, L. Zhang, S.Y. Jiang*, Superhydrophilic Zwitterionic Polymers Stabilize Liposomes, Langmuir, 28, 11625 (2012) 4. Z.Q. Cao, S.Y. Jiang*, Super-hydrophilic Zwitterionic Poly(carboxybetaine) and Amphiphilic Non-ionic Poly(ethylene Glycol) for Stealth Nanoparticles. Nano Today, 7, 404 (2012) 5. L. Zhang, Z.Q. Cao, Y.T. Li, J.-R. Ella-Menye, T. Bai, S.Y. Jiang*, Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation. ACS Nano, 6, 6681 (2012) 6. Z.Q. Cao, L. Mi, J. Mendiola, J.-R. Ella-Menye, L. Zhang, H. Xue, S.Y. Jiang*, Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria. Angewandte Chemie International Edition, 51, 2602 (2012) (Highlighted as a Frontispiece & Hot Paper) 7. Z.Q. Cao, N. Brault, H. Xue, A. Keefe, S.Y. Jiang*, Manipulating Sticky and Non-Sticky Properties in a Single Material, Angewandte Chemie International Edition, 50, 6102 (2011) 8. Z.Q. Cao, Q.M. Yu, H. Xue, G. Cheng, S.Y. Jiang*, Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA-Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks, Angewandte Chemie International Edition, 49, 3771 (2010) 9. S.Y. Jiang*, Z.Q. Cao, Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic 3
Materials and Their Derivatives for Biological Applications, Advanced Materials, 22, 920 (2010) 10. S.F. Chen, Z.Q. Cao (co-first author), S.Y. Jiang*, Ultra-low Fouling Peptide Surfaces Derived from Natural Amino Acids, Biomaterials, 30, 5892 (2009) 11. G.W. Jia, Z.Q. Cao, H. Xue, Y.S. Xu, S.Y. Jiang*, Novel Zwitterionic-Polymer- Coated Silica Nanoparticles, Langmuir, 25, 3196 (2009) 12. L. Zhang, H. Xue, Z.Q. Cao, A. Keefe, J. Wang, S.Y. Jiang*, Multifunctional and Degradable Zwitterionic Nanogels for Targeted Delivery, Enhanced MR Imaging, Reduction-Sensitive Drug Release, and Renal Clearance, Biomaterials, 32, 4604 (2011) 13. G. Cheng, L. Mi, Z.Q. Cao, H. Xue, Q.M. Yu, L. Carr, S.Y. Jiang*, Functionalizable and Ultrastable Zwitterionic Nanogels, Langmuir, 26, 6883 (2010) 14. H. Vaisocherova, Z. Zhang, W. Yang, Z.Q. Cao, G. Cheng, A.D. Taylor, M. Piliarik, J. Homola, S.Y. Jiang*, Functionalizable Surface Platform with Reduced Nonspecific Protein Adsorption from Full Blood Plasma - Material Selection and Protein Immobilization Optimization, Biosensors and Bioelectronics, 24, 1924 (2009) 15. H. Vaisocherova, W. Yang, Z. Zhang, Z.Q. Cao, G. Cheng, M. Piliarik, J. Homola, S.Y. Jiang*, Ultra-low Fouling and Functionalizable Surface Chemistry Based on a Zwitterionic Polymer Enabling Sensitive and Specific Protein Detection in Undiluted Blood Plasma, Analytical Chemistry. 80, 7894 (2008) 16. G.X. Ye, Z.Q. Cao, L. Lin, D.Y. Chen, W.G. Liu*, Study on cellular internalization of poly(vinyldiaminotriazine)-based hydrogen bonding type non-viral transgene vector, Chinese Science Bulletin, 53, 2307 (2008) 17. Z.Q. Cao, W.G. Liu*, et al., Design of Novel Poly(vinyldiaminotriazine)-based Non-viral Vectors via Specific Hydrogen Bonding with Nucleic Acid Base Pairs, Advanced Functional Materials, 17, 246 (2007) 18. Z.Q. Cao, W.G. Liu*, G.X. Ye, et al., N-isopropylacrylamide/2-hydroxyethyl methacrylate star diblock copolymer-synthesis and Thermoresponsive behavior study, Macromolecular Chemistry and Physics, 207, 2329 (2006) 19. N. Cheng, W.G. Liu*, Z.Q. Cao, et al., A study of thermoresponsive poly(n-isopropylacrylamide)/polyarginine bioconjugate non-viral transgene vectors, Biomaterials 27, 4984 (2006) 20. Z.Q. Cao, W.G. Liu*, P. Gao, et al., Towards an understanding of thermoresponsive transition behavior of hydrophobically modified N-isopropylacrylamide copolymer solution, Polymer 46, 5268 (2005) 21. W.G. Liu*, S.J. Sun, Z.Q. Cao, et al., An investigation on the physicochemical properties of chitosan/dna polyelectrolyte complexes, Biomaterials 26, 2705 (2005) 22. S.J. Sun, W.G. Liu*, N. Cheng, B.Q. Zhang, Z.Q. Cao, et al., A thermoresponsive chitosan-nipaam/vinyl laurate copolymer vector for gene transfection, Bioconjugate Chemistry 16, 972 (2005) 23. W.G. Liu*, J.R. Zhang, Z.Q. Cao, et al., A chitosan-arginine conjugate as a novel 4
anticoagulation biomaterial, Journal of Materials Science-Materials in Medicine 15, 1199 (2004) 24. W.G. Liu*, J.R. Zhang, N. Cheng, Z.Q. Cao, et al., Anticoagulation activity of crosslinked N-sulfofurfuryl chitosan membranes, Journal of Applied Polymer Science 94, 53 (2004) PATENTS 1. Self-assembled Particles from Zwitterionic Polymers and Related Matters. International Application No.: PCT/US2010/055887; Pub. No.: WO/2011/057225; US Patent Application No.: 13/463,662 2. Switchable Polymers and Surfaces with Reversibly Switchable Properties, US Patent Application No.: 13/453,809 INVITED SEMINARS & CONFERENCE TALKS 1. Zwitterionic and Mixed-Charge Materials for Biomedical Applications, Department of Chemical and Biological Engineering, Missouri University of Science and Technology, Rolla, MO, May 2, 2011. 2. Zwitterionic and Mixed-Charge Materials for Biomedical Applications, Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, Feb 15, 2011. 3. Multifunctional, biodegradable, magnetic nanoparticles based on zwitterionic polymers, 2010 AIChE Annual Meeting, Salt Lake City, UT, Nov 10, 2010. 4. Towards stealth liposomes: zwitterionic polymers v.s. non-ionic polyethylene glycol (PEG), 2010 AIChE Annual Meeting, Salt Lake City, UT, Nov 9, 2010. 5. Ultra-low fouling ph-dependent peptide surface derived from natural amino acids, 2010 AIChE Annual Meeting, Salt Lake City, UT, Nov 9, 2010. 6. Degradable drug delivery nanoparticles assembled from zwitterionic sharp contrast amphiphilic polymers, 2010 AIChE Annual Meeting, Salt Lake City, UT, Nov 9, 2010. 7. Drug delivery nanoparticles from amphiphilic polymers with sharp hydrophobic/ hydrophilic contrast, 240 th American Chemical Society National Meeting, Boston, MA, Aug 24, 2010. 8. Stealth and functionalizable zwitterionic magnetic nanoparticles prepared by a one-step method for image-guided targeting drug delivery, 240 th American Chemical Society National Meeting, Boston, MA, Aug 23, 2010. 9. Nonfouling materials from mixed charged groups, 2009 AIChE Annual Meeting, Nashville, TN, Nov 13, 2009. 10. PLGA-zwitterionic block copolymers: synthesis, characterization, and application for drug delivery, 2009 AIChE Annual Meeting, Nashville, TN, Nov 10, 2009. 11. PLGA-zwitterionic polymers core-shell nanoparticles: a stealthy and multifunctional drug delivery platform, 238 th American Chemical Society National Meeting, Washington DC, 5
Aug 20, 2009. TEACHING AND MENTORING Course Winter 2013 MSE 5650 Surface Science/ BME 7370 Biomaterial Interfaces JOURNALS REFEREE Peer-reviewed journals: Advanced Materials Advanced Healthcare Materials Biomaterials Biomaterials Science Tissue Engineering Chemical Communications Journal of Materials Chemistry Journal of Materials Chemistry B Macromolecules RSC Advances New Journal of Chemistry Polymer Chemistry Journal of Biomedical Nanotechnology Photochemistry and Photobiology Carbohydrate Research Journal of Applied Polymer Science. PROFESSIONAL MEMBERSHIPS American Institute of Chemical Engineers American Chemical Society 6