Curriculum Vitae Anthony J. Durkin, Associate Professor in Residence

Curriculum Vitae Anthony J. Durkin, Associate Professor in Residence Office Address and Phone Number: Beckman Laser Institute and Medical Clinic email: adurkin@uci.edu 1002 Health Sciences Rd phone: 949-824-3284 Irvine, CA 92617-1475 mobile: 949-874-3637 Home Address: 22 Alcott Ct. Irvine, CA 92617 Place of Birth: South Bend, Indiana USA Citizenship: USA Education: University of Texas, Austin Ph.D. 1995 Biomedical Engineering University of North Texas M.S. 1988 Condensed Matter Physics Lamar University B.S. 1985 Physics Positions Held: 1/12- present Co-leader, Skin Cancer Disease Oriented Team, Chao Family Comprehensive Cancer Center, University of California, Irvine. 7/10-present Associate Professor in Residence, Beckman Laser Institute, University of California, Irvine 5/07-present Co-Director, Wide-field Functional Imaging, Laser Microbeam and Medical Program, an NIH P41 Center 8/03-6/10 Assistant Professor in Residence, Beckman Laser Institute, University of California, Irvine 2001-2003 Beckman Fellow, Beckman Laser Institute and Medical Clinic, University of California, Irvine 1998-2001 Director of Bioscience, Candela Corporation. 530 Boston Post Road Wayland, MA 01778 1997 Visiting Scientist, Electro-Optics Branch, GS-13, Center for Devices and Radiological Health/Food and Drug Administration, Rockville MD. 1995-1997 National Academy of Sciences/National Research Council (NRC) Research Fellow: Electro-Optics Branch, Center for Devices and Radiological Health/Food and Drug Administration, Rockville MD.

2 1995 Post-doctoral Researcher, Biomedical Engineering Optical Spectroscopy Group, University of Texas, Austin TX. 1991-1995 Research Assistant, Biomedical Engineering Optical Spectroscopy Group, University of Texas, Austin TX. 1991 Teaching Assistant, Optical Spectroscopy, Electrical and Computer Engineering Department, University of Texas, Austin TX. 1989-1990 Research Assistant, Electron Microscopy Group, Center for Materials Characterization (CMC), University of North Texas, Denton TX. 1988-1989 Research Assistant, Two Photon Magneto-Optical Characterization Group, Center for Applied Quantum Electronics (CAQE), University of North Texas, Denton TX. 1987-1990 Teaching Fellow/Lecturer, Undergraduate Physics Lecture and Recitation, Physics Department, University of North Texas, Denton TX. 1983-1985 Teaching Assistant, Undergraduate Physics Lab. Physics Department, Lamar University, Beaumont TX. Consulting: 2004-present Co-founder, Modulated Imaging Inc., Irvine, CA. (Co-founders: David Cuccia, Joon You, Anthony J. Durkin, Bruce. J. Tromberg, Frederic Bevilacqua). 2002-2010 Candela Corporation, 530 Boston Post Road Wayland, MA 01778. Laser based Acne treatment 2004-2007 EA Photonics, 2515 Fisk Lane Redondo Beach, CA 90278. 7/2006-10/2006 Masimo Corporation, 40 Parker Ln, Irvine, Ca 92618. Optical Properties for advanced pulse oximetry. 2004-2005 Canon Development Americas, Research Division, 15975 Alton Parkway, Irvine, CA. 2004-2005 Newport Corporation, 1791 Deere Avenue Irvine, California 92606. 2002-2003 NeurOptics Inc. 2600 Michelson, Suite 980, Irvine, CA 92612. 2000-2003 Inlight Solutions Inc. (Rio Grande Medical Technologies), 800 Bradbury SE, Albuquerque, NM 87106 Awards, Honors, and Biographical listings: August 2008 79 th place ranking (out of 489,232) by Editors of Blogged.com

3 Rated 7.5 (out of 10) Very Good http://www.blogged.com/blogs/tony-durkin-mailinglist.html May 2005 Second Place, UCI Paul Merage School of Business, Annual Business Plan Competition, OxImager Modulated Imaging Inc. 2001-2003 Arnold and Mabel Beckman Foundation Fellowship, Beckman Laser Institute and Medical Clinic, Irvine, CA 2002 Recipient, Air Force Office of Scientific Research Travel Grant to attend American Society of Lasers in Surgery and Medicine Annual Meeting, Atlanta, April 10-14, 2002. 2000 Nominee; American Society of Lasers in Surgery and Medicine Board of Directors; Industrial Research and Development 1996 Gordon Research Council Post-Doc/Graduate Student Award: Conference on Lasers in Medicine and Biology 1995-1997 National Academy of Sciences/National Research Council Research Fellowship, Electro-Optics Branch/Center for Devices and Radiological Health/Food and Drug Administration. 1993-96 Who's Who in Science and Engineering (Marquis) 1992 New Focus/Optical Society of America Student Travel Award: Conference on Lasers and Electro-Optics (CLEO) 1982-1985 Member, Sigma Pi Sigma, National Physics Honor Society 1982-1984 Physics Dept. Scholarship, Lamar University, Beaumont, TX. Professional Service: Editor for Peer-Reviewed Journals Sept 2010 - present Co-Editor (in Chief), Virtual Journal of Biomedical Optics (Optical Society of America) 2008- present Advisor, SPIE Newsroom; http://www.fac-media.com/ 2003 present Member, Editorial Board; SPIE Journal of Biomedical Optics. Scope: Assign reviewers, evaluate manuscripts and reviews, conduct author correspondence. 1999 2006 Topical Editor; Applied Optics: Optical Technology and Biomedical Optics. Optical Society of America, Second term; July 2002 Feb. 2006. Scope: Assign reviewers, evaluate manuscripts and reviews, conduct author correspondence. 43 manuscripts in the 2005 calendar year.

4 2002-2003 Co-Editor, Feature Issue on Biomedical Optics; Applied Optics: published June 2003. Professional Service: Leadership and Conference Organization Jan 2008- Jan. 2012 Moderator, Program Committee member Quality and Reliability of Spectroscopic Systems, SPIE: Photonics West Bios, Jan. San Francisco, CA. Jan 2008- Jan. 2012 Moderator, Program Committee member Photonics in Dermatology and Plastic Surgery, SPIE: Photonics West Bios, Jan. San Francisco, CA Sept. 2010-present Member, ASLMS/OSA Task force for Joint Conference in 2014. April 2007 Jan. 2007 Co-Director, Short Course, How Can We Use Diagnostic Information?, 27 th annual meeting, American Society of Lasers in Surgery and Medicine, Dallas, TX. Moderator, Quality and Reliability of Technologies for Medicine and Biomedical Devices, SPIE: Photonics West:Bios 2007, Jan. 20-25, San Jose, CA. 2006-2007 Program Committee member, Quality and Reliability of Technologies for Medicine and Biomedical Devices, SPIE: Photonics West:Bios 2007, San Jose, CA. May 2006 Oct. 2005 Session Chair; Fiber Optic Technologies, Conference on Lasers and Electro- Optics, (CLEO) Longbeach, CA May 21 26, 2006. Session Chair; Optical Methods in Diagnosis, Monitoring and Intervention, Frontiers in Optics 2005. Optical Society of America Annual Meeting, Tucson, AZ. Oct. 16-22. 2003-2005 Division Chair: Optics in Biology and Medicine, Optical Society of America. www.osa.org/join/techgroups/ bio/biology_and_medicine_presentation.ppt 2005 Program Committee member, Frontiers in Optics 2005. Optical Society of America Annual Meeting, Tucson, AZ. Division of Biology and Medicine Conference program design and organization. Peer review and scoring of submitted abstracts. 2003-2005 Member: Executive Committee of the Science and Engineering Council (ECSEC), Optical Society of America. http://www.osa.org/aboutosa/leaders/governing_bodies/councils.asp 2004 Program Committee member, Frontiers in Optics 2004, October 2004. Optical Society of America Annual Meeting, Rochester, NY. Division of Biology and Medicine Conference program design and organization. Peer review and scoring of submitted abstracts.

5 2004 Conference General co-chair, Biomedical Optics Topical Meeting, Optical Society of America. April 14-17 2004, Miami, FL. Overall conference organization and fundraising. 2003 Program Committee member, Frontiers in Optics 2003, Optical Society of America Annual Meeting, Tucson, AZ. Division of Biology and Medicine Conference program design and organization. Peer review and scoring of submitted abstracts. 2002-2003 Chair-Elect: Division of Optics in Biology and Medicine. Optical Society of America. Training for term as Chair of Division of Optics in Biology and Medicine. 2002 Organizer and Moderator, Industry Forum, Gordon Research Conference, Lasers in Biology and Medicine, July 14-19, 2002 Meriden NH. Participants; Infraredx, Lucid Technologies, Mauna Kea Technologies, Alcon Labs. 2002 Program Chair; Biomedical Optical Spectroscopy and Diagnostics (BOSD), OSA topical meeting on Biomedical Optical Spectroscopy and Diagnostics (BOSD) and Advances in Optical Imaging and Photon Migration (AOIPM) April 7-10, Miami. Responsible for BOSD scientific program organization and content. Chair of BOSD committee (20 members); lead peer review and scoring of submitted abstracts and sessioning of conference talks in collaboration with AOIPM program chair. 2002 Co-Chair; Biomedical Optics Industry Roll-Out. Optical Society of America Topical Meetings on Biomedical Optical Spectroscopy and Diagnostics (BOSD) and Advances in Optical Imaging and Photon Migration (AOIPM) April 7-10, Miami. Participants; Infraredx, Xillix, SpectRx, NIRx, Xenogen. 2001-2008 Member, Biomedical Optics Ad Hoc Advisory Committee, Optical Society of America 2000 Organizer and Moderator; Biomedical Optics Industry Roll-Out; Optical Society of America Topical Meetings on Biomedical Optical Spectroscopy and Diagnostics (BOSD) and Advances in Optical Imaging and Photon Migration (AOIPM) April 2-5, Miami. Participants; SpectRx, Imaging Diagnostic Systems, RioGrande Medical Technologies, Xenogen. 2000 Program Committee member; Biomedical Optical Spectroscopy and Diagnostics (BOSD) Committee, Optical Society of America Topical Meetings on Biomedical Optics, April 2-5, 2000. Miami. 1999-2004 Member; SPIE International Technical Working Group on Biomedical Optics.

6 1998-Present Co-Founder, Moderator, Opt-dx, email list-serve, implemented through Yahoo Groups for disseminating Biomedical Optics oriented news, journal abstracts, and intellectual property announcements. 1998 Program Committee Member; Therapeutic Laser Applications in Biomedicine, Optical Society of America Topical Meetings on Biomedical Optics, Orlando, FL. 1997 Session Moderator, Clinical and Research Applications of Raman Spectroscopy I and II. Advances in Fluorescence Sensing Technology III. SPIE: Photonics West:Bios'97, San Jose, CA. Study Sections: June 2012 Dutch Burns Foundation. Critique of burn related proposals involving translational technologies. Fall 2003 NIH ZRG1-SSS-7(11): National Institutes of Health Special Emphasis Panel, Medical Imaging Technologies: Optics II (October 27 2003). 1998 U.S. Food and Drug Administration, Office of Women s Health, External Review of Scientific Proposals. Reviewer: Professional Journals: Applied Optics (Optical Society of America) Optics Express (Optical Society of America) Optics Letters (Optical Society of America) Journal of Biomedical Optics (SPIE) Journal of Quantum Electronics (IEEE) Photobiology and Photochemistry Journal of Lasers in Surgery and Medicine Professional Association Membership: 2011 present UCI Cancer Center Full Member 2011- present UCI Skin Disease Oriented Team Member (Co-Leader) 1998- present American Society of Lasers in Surgery and Medicine (ASLMS) Member American Physical Society (APS) Member Optical Society of America (OSA) Member Society of Photographic and Instrumentation Engineers (SPIE) Member Society for Applied Spectroscopy (SAS) Member Sigma Pi Sigma (Physics honor Society) Associate Member of Sigma Xi, the Scientific Research Society Other Service: 2007- present Chair, Information Technologies Committee, Beckman Laser Institute and Medical Clinic, University of California, Irvine

7 2003- present Member, Technology Transfer Committee, Beckman Laser Institute and Medical Clinic, University of California, Irvine. 2003- present Member, Space Committee, Beckman Laser Institute and Medical Clinic, University of California, Irvine. 2003- present Ad-hoc Member, Beckman Laser Institute Shared Resources Committee, Beckman Laser Institute and Medical Clinic, University of California, Irvine. 2001-2003 Member, Beckman Laser Institute Computer Resources Committee. Beckman Laser Institute Technology Transfer Committee, Beckman Laser Institute and Medical Clinic, University of California, Irvine. 1995-1997 Seminar Coordinator: Seminars in Biomedical Optics: Identified and Contacted speakers and organized seminars oriented toward Biomedical Optics Technology for Division of Physical Sciences/Electro-optics/FDA. 1984-1985 Vice President, Society of Physics Students, Lamar University, Beaumont TX. Dissertation: Quantitative Fluorescence Spectroscopy of Turbid Samples, Durkin, Anthony J, May 1995. University of Texas, Austin, TX. IACUC Protocols: IACUC Protocol #: 2006-2693-0 Impact of Hypertonic-Hyperoncotic Saline Solutions on Ischemia-Reperfusion Injury in Free Flaps in Rats, Lead Researcher: Evans, Gregory, A.J. Durkin Co-Investigator, Technology Lead. IACUC approved Protocol #2006-2645-0: Pre-Clinical Feasibility Study of Tissue Oxygenation Imager, A.J. Durkin, PI (closed June 2009) IRB Protocols: IRB Protocol HS# 2012-8868: Assessment of the Potential for Pressure Ulcer Formation using a new optical imaging technology: Spatial Frequency Domain Imaging (SFDI) AJ Durkin PI. IRB Protocol HS# 2011-8370: "A Pilot Study to Evaluate Multi-Spectral Imaging (MI) and Laser Speckle Imaging (LSI) and Multiphoton Microscopy (MPM) During Vascular Occlusion," AJ Durkin PI. IRB approved Protocol HS# 2009-7322: Ability of Modulated Imaging and Laser Speckle Imaging to Determine Burn Wound Severity and Healing Potential, AJ Durkin PI. IRB approved Protocol HS# 2008-6439: Optimizing Photodynamic Therapy (PDT) for skin cancer via structured illumination and real-time dosimetry, Kristen M. Kelly Lead Researcher, AJ Durkin Co-investigator.

8 IRB approved Protocol HS# 2008-6307: Skin Imaging with Technologies in Development, Kristen M. Kelly Lead Investigator, A.J. Durkin Co-Investigator Modulated Imaging, Diffuse Optical Spectroscopy of Superficial Skin. IRB approved Protocol HS# 2008-6099: A Pilot Study to Evaluate the Correlation between Modified Two Layer Diffuse Optical Spectroscopy and SIAscopy with the Clinical and Histological Examinations of Pigmented Skin Lesions based on Physiological Parameters Lead Researcher: David Hsiang, A.J. Durkin Co-Investigator, Technology Lead. IRB approved Protocol HS# 2007-5891: Monitoring of Tissue Transfer Flaps by Modulated Imaging (MI) Spectroscopy, Greg Evans, MD, Lead Researcher, A.J. Durkin Co-Investigator, Technology Lead, Spatial Frequency Domain Imaging. IRB approved Protocol #1996-200: Optical Biopsy of Human Skin ; J. Stuart Nelson Lead Investigator, A.J. Durkin Co-Investigator Modulated Imaging, Diffuse Optical Spectroscopy of Superficial Skin (protocol closed, Aug 2008) Interviews/Articles: Photonics for dermatology applications: a video interview with Anthony Durkin 20 March 2009, SPIE Newsroom. DOI: 10.1117/2.3200902.0008 http://mfile.akamai.com/65904/mov/spiestorage.download.akamai.com/65904/durkinfinal.mov Online Resources: The Tony Durkin Mailing List features news and journal articles focused on diagnostic technologies in biomedical optics: http://www.bli.uci.edu/~blog/td/tonydurkinmailinglist.html And http://tdmailinglist.blogspot.com/ 2/2010 Present, AJ Durkin Founder, Opt-dx on Linked In. A networking group/resource for professionals engaged in biomedical optics, particularly from the imaging and diagnosis perspective. Currently 129 members. http://www.linkedin.com/groups?gid=2724980&trk=myg_ugrp_ovr Refereed journal articles: J1. "New Laser Based Magneto-Optical Studies of Hg1-xCdxTe Alloys", D.G. Seiler, M.R. Loloee, S.A. Milazzo, A.J. Durkin, Center for Applied Quantum Electronics, University of North Texas, C.L. Littler, Central Research Labs, Texas Instruments, Solid State Communications, March 1989. J2. "Optically Dilute, Absorbing and Turbid Phantoms for Fluorescence Spectroscopy of Homogeneous and Inhomogeneous Samples", A.J. Durkin, S. Jaikumar, R. Richards-Kortum, Applied Spectroscopy Vol.47, No. 12 (December 1993) pp.2114-2121. J3. "Relation Between Fluorescence Spectra of Dilute and Turbid Samples", A.J. Durkin, S. Jaikumar, N. Ramanujam, R. Richards-Kortum, Applied Optics Vol.33, No.3 (January 1994) pp. 414-423.

9 J4. "A Fiber Optic Based Confocal Spectrofluorimeter", R. Richards-Kortum, A.J. Durkin, J. Zeng, Applied Spectroscopy Vol. 48 No. 3 (March 1994) pp. 350-355. J5. "A Comparison of Methods to Determine Chromophore Concentrations from Fluorescence Spectra of Turbid Samples, A.J. Durkin, Rebecca Richards-Kortum, Lasers in Surgery and Medicine, Vol 19, No.1, 1996 pp 75-89. J6. "Quantification of Polydimethylsiloxane Concentration in Turbid Samples Using Raman Spectroscopy and Method of Partial Least Squares,", A.J. Durkin, M.N. Ediger, G.H.Pettit, Lasers Med. Sci. 1998, 13:32-42. J7. "Fluorescence Excitation-Emission Matrices of Human Tissue: A system for in-vivo measurement and method of data analysis, A.F. Zuluaga, Urs Utzinger, A.J. Durkin, Holger Fuchs, J. J. Fan, Ann Gillenwater, R. Richards-Kortum, Applied Spectroscopy, Vol. 53, No. 3 pp 302-311 (March 1999). J8. Chemometric Analysis of Frequency-Domain Photon Migration Data: Quantitative Measurements of Optical Properties and Chromophore Concentrations in Multicomponent Turbid Media, Andrew J. Berger, Vasan Venugopalan, Anthony J. Durkin, Tuan Pham, and Bruce J. Tromberg, Applied Optics; Optical Technology and Biomedical Optics, Vol. 39 No. 10 pp. 1659-1667 (April 2000) J9. Quantifying the optical properties and chromophore concentrations of turbid media by chemometric analysis of hyperspectral, diffuse reflectance data collected using a Fourier interferometric imaging system, Tuan H. Pham, Charlotta Eker, Anthony Durkin, Bruce J. Tromberg, Stefan Andersson-Engels, Applied Spectroscopy 55, no. 8 (2001): 1035-1045. J10. In-vivo fluorescence spectroscopy of Non-Melanoma Skin Cancer, Lorenzo Brancaleon, Anthony J. Durkin, John H. Tu, Gregg Menaker, Jerome D. Fallon, Nikiforos Kollias, Photochemistry and Photobiology 2001 73(2): 178-183. J11. Congruent MRI and Near-infrared spectroscopy for Functional and Structural Imaging of Tumors, Gultekin Gulsen,Hon Yu, Jun Wang, Orhan Nalcioglu, Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning, Bruce J. Tromberg, J. Technology in Cancer Research & Treatment 1: 497-505, Dec. 2002. J12. Reflectance-based Determination of Optical Properties in Highly Attenuating Tissue, T. Joshua Pfefer, L. Stephanie Matchette, Carrie L. Bennett, Jessica A. Gall, Joy N. Wilke, Anthony J. Durkin, Marwood N. Ediger, 206-215, Vol 8, No. 2, April 2003, Journal of Biomedical Optics. J13. Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model, Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning, Gultekin Gulsen, Hon Yu, Jun Wang, Orhan Nalcioglu, Bruce J. Tromberg, Appl Opt. 2003 Jun 1;42(16):2951-9.

10 J14. In vivo Quantification of Optical Contrast Agent Dynamics in Rat Tumors by Use of Diffuse Optical Spectroscopy with Magnetic Resonance Imaging Coregistration, David J. Cuccia, Frederic Bevilacqua, Anthony J. Durkin, Sean Merritt, Gultekin Gulsen, Hon Yu, Jun Wang, Orhan Nalcioglu, Bruce J. Tromberg, Appl Opt. 2003 Jun 1;42(16):2940-50. J15. "Topics in biomedical optics: introduction," J. C. Hebden, D. A. Boas, J. S. George, and A. J. Durkin, Applied Optics, 42, 2869-2870. June 2003. J16. Comparison of Water and Lipid Content Measurements Using Diffuse Optical Spectroscopy and MRI in Emulsion Phantoms. Sean Merritt, Gultekin Gulsen, George Chiou, Yong Chu, Chengwu Deng, Albert E. Cerussi, Anthony J Durkin, Bruce J. Tromberg, Orhan Nalcioglu, Technol Cancer Res Treat. 2003 Dec; 2(6): 563-9. J17. Characterization of Port Wine Stain Skin Color Using Cross-Polarized Diffuse Reflectance Imaging Byungjo Jung, Bernard Choi, Anthony J. Durkin, Kristen M. Kelly, J. Stuart Nelson, Lasers Surg Med. March 2004;34(2):174-81. J18. DETERMINATION OF OPTIMAL VIEW ANGLES FOR QUANTITATIVE FACIAL IMAGE ANALYSIS, Byungjo Jung,* Bernard Choi,* Yongjin Shin,*Anthony J. Durkin,* J. Stuart Nelson*, Journal of Biomedical Optics, March/April 2005, Volume 10, Issue 2. [Epub ahead of print]. J19. Modulated Imaging: Quantitative Analysis and Tomography of Turbid Media in the Spatial Frequency Domain. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, B. J. Tromberg, Opt. Lett. 2005 Jun;30 (11). J20. Quantitative Spectroscopy of Superficial Turbid Media, Sheng-Hao Tseng, Carole Hayakawa, Bruce J. Tromberg, Jerome Spanier, Anthony J. Durkin, Opt. Lett. 30, 3165-3167 (2005). J21. Determination of Optical Properties of Superficial Volumes of Layered Tissue Phantoms, Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, Anthony J. Durkin, IEEE Trans Biomed Eng. 2008 Jan;55(1):335-9. J22. In-vivo Determination of Skin Optical Properties using Diffuse Optical Spectroscopy, Sheng-Hao Tseng, Alexander Grant, Anthony J. Durkin, J. Biomed. Opt. Vol. 13, 014016 (Jan. 14, 2008) J23. Spatial shift of spatially modulated light projected on turbid media, Andrea Bassi, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg, JOSA A, Vol. 25, Issue 11, pp. 2833-2839. 2008. J24. Quantitative Mapping of Turbid Media Optical Properties using Modulated Imaging. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. Ayers, B. J. Tromberg, Journal of Biomedical Optics, Vol. 14, 024012 (2009); DOI:10.1117/1.3088140 Published 3 April 2009

11 J25. Wide-field Spatial Mapping of in-vivo Tattoo Skin Optical Properties using Modulated Imaging, Frederick Ayers, David J. Cuccia, Kristen Kelly, Anthony J. Durkin, Journal of Lasers in Surgery and Medicine. 2009;41(6):442-53. J26. Non-contact imaging of absorption and scattering in layered tissue using spatiallymodulated structured light, Jessie R. Weber, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg, J. Appl. Phys. 105, 102028 (2009); DOI:10.1063/1.3116135 J27. Three-dimensional surface profile intensity correction for spatially modulated imaging, Sylvain Gioux, Amaan Mazhar, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg, John V. Frangioni, J. Biomed. Opt., Vol. 14, 034045 (2009); doi:10.1117/1.3156840, Published 24 June 2009. J28. Chromophore Concentrations, Absorption and Scattering Properties of Human Skin Invivo Sheng-Hao Tseng, Paulo Bargo, Anthony Durkin, Nikiforos Kollias, Optics Express, Vol. 17, Issue 17, pp. 14599-14617 doi:10.1364/oe.17.014599, August 2009. J29. Investigation of a probe design for facilitating the uses of the standard photon diffusion equation at short source-detector separations: Monte Carlo simulations. Tseng SH, Hayakawa C, Spanier J, Durkin AJ. J Biomed Opt. 2009 Sep-Oct;14(5):054043. J30. Determination of optical properties of turbid media spanning visible and near infrared regimes via Spatially Modulated Quantitative Spectroscopy (SMoQS), Rolf B Saager, David J Cuccia, Anthony J Durkin, J. Biomed. Opt., Vol. 15, 017012 (2010); doi:10.1117/1.3299322 J31. Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light. Konecky SD, Mazhar A, Cuccia D, Durkin AJ, Schotland JC, Tromberg BJ. Opt Express. 2009 17;17(17):14780-90. J32. Structured Illumination Enhances Resolution and Contrast in Thick Tissue Fluorescence Imaging. J A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, B. J. Tromberg, J. Biomed. Opt. 15(01), 010506 (Jan. 2010) J33. A Lookup-Table Method for Imaging Optical Properties with Structured Illumination Beyond the Diffusion Theory Regime, Tim A. Erickson, Amaan Mazhar, David Cuccia, Anthony Durkin, James W. Tunnell, J. Biomed. Opt., Vol. 15, 036013 (2010); doi:10.1117/1.3431728 J34. Early Detection of Complete Vascular Occlusion in a Pedicle Flap Model using Quantitative Spectral Imaging. Michael R. Pharaon, MD, Thomas Scholz, MD, Scott Bogdanoff, David Cuccia, PhD, Anthony J. Durkin, PhD, David D Hoyt, MD, FACS, Gregory R.D. Evans, MD, FACS, Plastic & Reconstructive Surgery. 126(6):1924-1935, December 2010. doi: 10.1097/PRS.0b013e3181f447ac J35. Wavelength Optimization for Rapid Chromophore Mapping using Spatial Frequency Domain Imaging (SFDI), Amaan Mazhar, Steven Dell, David Cuccia, Sylvain Gioux,

12 Anthony Durkin, John Frangioni, Bruce Tromberg, J Biomed Opt. 2010 Nov- Dec;15(6):061716. J36. Postoperative Quantitative Assessment of Reconstructive Tissue Status in Cutaneous Flap Model using Spatial Frequency Domain Imaging. Amr Yafi, Thomas S Vetter, Michael R Pharaon, Thomas Scholz, Sarin Patel, Rolf B Saager, David J Cuccia, Gregory R Evans, Anthony J Durkin, Plastic & Reconstructive Surgery. 127(1):117-130, January 2011. doi: 10.1097/PRS.0b013e3181f959cc PMID: 21200206 J37. Noninvasive Assessment of Burn Wound Severity Using Optical Technology: A Review of Current and Future Modalities, Meghann Kaiser, Amr Yafi, Marianne Cinat, Bernard Choi, Anthony J Durkin, Burns. 2011 May;37(3):377-86. doi:10.1016/j.burns.2010.11.012 PMID: 21185123 J38. Multispectral imaging of tissue absorption and scattering using spatial frequency domain imaging and a computed-tomography imaging spectrometer. Weber JR, Cuccia DJ, Johnson WR, Bearman GH, Durkin AJ, Hsu M, Lin A, Binder DK, Wilson D, Tromberg BJ. J Biomed Opt. 2011 Jan-Feb;16(1):011015. PMCID: PMC3055588 J39. Laser speckle imaging in the spatial frequency domain, Amaan Mazhar, David J. Cuccia, Tyler B. Rice, Stefan A. Carp, Anthony J. Durkin, David A. Boas, Bernard Choi, and Bruce J. Tromberg, Biomedical Optics Express, Vol. 2, Issue 6, pp. 1553-1563 (2011) doi:10.1364/boe.2.001553 PMID: 21698018 J40. Method for depth-resolved quantitation of optical properties in layered media using Spatially Modulated Quantitative Spectroscopy (SMoQS), Rolf B Saager, Alex Truong, David J Cuccia, Anthony J. Durkin, SPIE Journal of Biomedical Optics, 16, 077002 (Jul 07, 2011); doi:10.1117/1.3597621 PMID: 21806282, PMC3146548 J41. Hybrid Diffusion and Two-Flux Approximation for Multi-Layered Tissue Light Propagation Modeling Optical Society of America, Applied Optics, Yudovsky, D., Durkin AJ. Applied Optics, Vol. 50, Issue 21, pp. 4237-4245 (2011) doi:10.1364/ao.50.004237 PMID: 21772413 J42. First-in-Human Pilot Study of a Spatial Frequency Domain Oxygenation Imaging System, Sylvain Gioux, Amaan Mazhar, Bernard T. Lee, David J Cuccia, Alan Stockdale, Rafiou Oketokoun, Yoshimoto Ashitate, Edward Kelly, Maxwell Weinmann, Nicholas James Durr, Lorissa A. Moffitt, Anthony J Durkin, Bruce J. Tromberg, John V. Frangioni, SPIE Journal of Biomedical Optics, 2011 Aug;16(8):086015. PMID:21895327 J43. Spatial Frequency Domain Spectroscopy of Two Layer Media, Dmitry Yudovsky, Anthony J. Durkin, SPIE Journal of Biomedical Optics, J. Biomed. Opt. 16, 107005 (2011) ; doi:10.1117/1.3640814 PMID: 22029367 J44. Quantitative Determination of Dynamical Properties using Coherent Spatial Frequency Domain, T. Rice, A. Mazhar, S. D. Konecky, B. Choi, A. J. Durkin, B. J. Tromberg Optical

13 Society of America, JOSA A, J Opt Soc Am A Opt Image Sci Vis. 2011 Oct 1;28(10):2108-14. doi: 10.1364/JOSAA.28.002108. PMID: 21979516 J45. Effects of Motion on Optical Properties in the Spatial Frequency Domain John Nguyen, Rolf B Saager, David J Cuccia, David Hsiang, Kristen M Kelly, Anthony J Durkin, J Biomed Opt. 2011 Dec;16(12):126009. PMID: 22191926 J46. Quantitative fluorescence imaging of Protoporphyrin IX though determination of tissue optical properties in the Spatial Frequency Domain, Rolf B Saager, David J Cuccia, Steve Saggese, Kristen M Kelly, Anthony J Durkin, J Biomed Opt. 2011 Dec;16(12):126013. PMID: 22191930 J47. Imaging Scattering Orientation with Spatial Frequency Domain Imaging, Soren D Konecky, Tyler Bywaters Rice, Anthony J Durkin, Bruce J. Tromberg, SPIE Journal of Biomedical Optics, J. Biomed. Opt. 16, 126001 (2011), DOI:10.1117/1.3657823 PMID: 22191918 J48. Spatial Frequency Domain Imaging of Port Wine Stain Biochemical Composition in Response to Laser Therapy: A Pilot Study, Amaan Mazhar PhD, Seyed A. Sharif MD, David J. Cuccia PhD, J. Stuart Nelson MD,PhD, Kristen M. Kelly MD, and Anthony J. Durkin PhD, Laser in Surgery and Medicine. 2012 Aug 21. doi: 10.1002/lsm.22067. [Epub ahead of print] PMID: 22911574 J49. Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review A. Sharif, R. Rahimian, E. Taydas, A. Mazhar, B. Choi, KM Kelly, JS Nelson, AJ Durkin, Br J Dermatol. 2012 Jul 14. doi: 10.1111/j.1365-2133.2012.11139.x. PMID:22804872 J50. In Vivo Spatial Frequency Domain Spectroscopy of Two Layer Media, Dmitry Yudovsky, John Quan Minh Nguyen, Anthony J Durkin, J. Biomed. Opt. 17(10), 107006 (Oct 19, 2012). doi:10.1117/1.jbo.17.10.107006 J51. Quantitative Near Infrared Spectroscopic Analysis of Q Switched Nd:YAG Treatment of Generalized Argyria Rolf B Saager, PhD, Khaled M Hassan, MD, Clement Kondru, BS, Anthony J Durkin, PhD, Kristen M Kelly, MD, Lasers Surg Med. 2013 Jan 15. doi: 10.1002/lsm.22084. [Epub ahead of print] PMID: 23322674 J52. Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging, Adrien Ponticorvo, Eren Taydas, Amaan Mazhar, Thomas Scholz, Hak-Su Kim, Jonathan Rimler, Gregory R. D. Evans, David J. Cuccia, and Anthony J. Durkin, Biomedical Optics Express, Vol. 4, Issue 2, pp. 298-306 (2013) http://dx.doi.org/10.1364/boe.4.000298 J53. A Light Emitting Diode (LED) Based Spatial Frequency Domain Imaging System for Optimization of Photodynamic Therapy of Nonmelanoma Skin Cancer: Quantitative Reflectance Imaging, Rolf B. Saager, Steven Saggese, David J. Cuccia, Kristen M Kelly, Anthony J Durkin, 2013 Lasers In Surg. Med. Apr;45(4):207-15. doi: 10.1002/lsm.22139. PMID:23619900

14 J54. Spatial Frequency Domain Imaging of Burn Wounds in a Preclinical Model of Graded Burn Severity, John Quan Minh Nguyen, Christian Crouzet, Tuan Mai, Kathleen Riola, Daniel Uchitel, Lih-Huei L Liaw, Nicole Bernal, Adrien Ponticorvo, Bernard Choi, Anthony J Durkin, J Biomed Opt. 2013 Jun;18(6):66010. doi: 10.1117/1.JBO.18.6.066010.PMID: 23764696 J55. Visible spatial frequency domain imaging with a digital light microprojector, Alexander Lin, Adrien Ponticorvo, Soren Konecky, Haotian Cui, Tyler Rice, Bernard Choi, Anthony J Durkin, Bruce J. Tromberg, J Biomed Opt. 2013 Sep 1;18(9):96007. doi: 10.1117/1.JBO.18.9.096007. PMID: 24005154 J56. A Novel Pilot Study Using Spatial Frequency Domain Imaging to Assess Oxygenation of Perforator Flaps During Reconstructive Breast Surgery. Nguyen JT, Lin SJ, Tobias AM, Gioux S, Mazhar A, Cuccia DJ, Ashitate Y, Stockdale A, Oketokoun R, Durr NJ, Moffitt LA, Durkin AJ, Tromberg BJ, Frangioni JV, Lee BT. Ann Plast Surg. 2013 Sep;71(3):308-315. PMID: 23945533 J57. Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging, Kyle Nadeau, Hak Lee, Adrien Ponticorvo, Anthony J. Durkin, Bruce J. Tromberg, Optics Letters, Vol. 38, Issue 18, pp. 3566-3569 (2013) http://dx.doi.org/10.1364/ol.38.003566, PMID:24104815 [PubMed - in process] J58. Quantitative, depth-resolved determination of particle motion using multi-exposure, spatial frequency domain laser speckle imaging, Tyler Rice, Bernard Choi, Anthony J. Durkin, Bruce J. Tromberg, Biomedical Optics Express, Biomedical Optics Express Vol. 4, Iss. 12, pp. 2880 2892 (2013). J59. In-vivo optical signature of neuronal death in a mouse model of Alzheimer s disease. Alexander J. Lin, Nicholas A. Castello, Grace Lee, Kim N. Green, Anthony J. Durkin, Bernard Choi, Bruce J. Tromberg, Lasers in Surgery and Medicine (Accepted for publication/in Press) Manuscripts in Submission: Assessing reconstructive flaps: a comparison between visual perception and spatial frequency domain imaging, Adrien Ponticorvo, Eren Taydas, Amaan Mazhar, Jonathan Rimler, Hak-Su Kim, Thomas Scholz, Christopher L. Ellstrom, June Tong, Gregory R.D. Evans, David J. Cuccia, Anthony J. Durkin, (Submitted) Plastic & Reconstructive Surgery. Distinguishing between benign and malignant melanocytic nevi by in vivo multiphoton microscopy Mihaela Balu, Kristen Kelly, Christopher Zachary, Ronald Harris, Tatiana Krasieva, Karsten König, Anthony J. Durkin, and Bruce Tromberg, Cancer Research, in revision, Manuscript # CAN-13-2582 Polarization Sensitive Hyperspectral Imaging in-vivo: A Multimode Dermscope for Skin Analysis, Fartash Vasefi, Nicholas MacKinnon, Rolf B. Saager, Anthony J. Durkin, Robert Chave, Erik H. Lindsley, Daniel L. Farkas, Submitted to Scientific Reports, Sept 2013.

15 "Optical imaging biomarkers of cerebrovascular impairment in normal aging and 3xTg Alzheimer s mouse model" Alexander J. Lin, Nick Castello, James J. Yeh, Rombod Rahimian, Grace Lee, Bernard Choi, Anthony J. Durkin, Frank M. LaFerla, Kim N. Green, Bruce J. Tromberg. (in submission). Manuscripts in Preparation: Review of Approaches to Scar Assessment/Wound Healing (Review Paper), Ata Sharif, Adrien Ponticorvo, Kristen Kelly, Nicole Bernal, Anthony J. Durkin, Burns Short-Wave wave Infrared (SWIR) multispectral wide-field imaging for quantitative optical characterization of burns, Robert H. Wilson, Kyle P. Nadeau, Frank B. Jaworski, Rebecca Rowland, John Q. Nguyen, Christian Crouzet, Rolf B. Saager, Bruce J. Tromberg, and Anthony J. Durkin, JBO Letters Methods for in-vivo Assessment of Pigmentation in Human Skin (Review Paper), Viera Cosignani, Ata Sharif, Rolf Saager, Adrien Ponticorvo, Anthony J. Durkin. Preclinical assessment of burn-wound severity using laser speckle imaging Crouzet C, Nguyen JQ, Ponticorvo A, Durkin AJ, Choi B. Measurement of blood volume and tissue oxygen saturation with a clinical Spatial Frequency Domain Imaging (SFDI) system, A. Mazhar, RB Saager, AJ Durkin Monitoring and mapping seizure in the brain using spatially-modulated structured light, J.R. Weber, C.M. Owen, D. Lee, D.J. Cuccia, D.K. Binder, W.R. Johnson, G.H. Bearman, A.J. Durkin, B.J. Tromberg. To be submitted to Journal of Biomedical Optics. Early Detection of Complete Venous Occlusion using a Novel Multi-Spectral Imaging Technique in Swine Myocutaneous Pedicle Flap Model, Michael R. Pharaon, MD, Thomas Scholz, MD, David Cuccia, PhD, Anthony J. Durkin, PhD, David D Hoyt, MD, FACS, Gregory R.D. Evans, MD, FACS Optical Technologies for Assessment of Reconstructive Tissue Status (Review Paper), Eren Taydas. Amr Al Yafi MD, Rolf Saager PhD, Anthony J. Durkin PhD Pre-clinical Feasibility of Tissue Oxygenation Imager in a Dorsal Pedicle Flap Model, Anthony J. Durkin, Jae G. Kim, David J. Cuccia, Journal of Biomedical Optics In-vivo, Broadband Optical Properties of Melanocytic Lesions in the Near Infrared (650-1000nm), Kelly Sry, Rolf Saager, Clement Khondru, Anthony J. Durkin Conference Presentations and Proceedings: P1. "Simultaneous Measurement of the Energy Gap and Conduction Band Edge Effective Mass in n-insb", D.G. Seiler, S.A. Milazzo, A.J. Durkin, M.R. Loloee, Center for Applied Quantum Electronics, University of North Texas, C.L. Littler, Central Research Labs, Texas

16 Instruments, Proceedings of the 19th International Conference on the Physics of Semiconductors, ed. W. Zawadzki, Vol. 1, Institute of Physics Polish Academy of Sciences Warsaw, Poland, 1988. P2. "Remote Monitoring of Fluorescent Molecules in Turbid Media", A.J. Durkin, S. Jaikumar, R. Richards-Kortum, Conference on Lasers and Electro-Optics, 1992 OSA Technical Digest Series (Optical Society of America, Washington, D.C.) Vol 12. p 398, Anaheim CA. (See also under Public Lectures: PM 1). P3. "Phantoms for Fluorescence Spectroscopy", A.J. Durkin, S. Jaikumar, R. Richards- Kortum. International Conference on Lasers '92, Society for Optical and Quantum Electronics, 1992. Houston, TX. (See also under Public Lectures: PM 2) P4. "Evaluation of a Model to Remove Reabsorption and Scattering Effects from Turbid Sample Fluorescence", N. Ramanujam, A.J. Durkin, S. Jaikumar, R. Richards-Kortum, Proceedings from International Conference on Lasers '92, Society for Optical and Quantum Electronics, December 1992. P5. "Confocal Fluorescence Spectroscopy of Turbid Media", J Zeng, A J Durkin, R Richards-Kortum, Conference on Lasers and Electro-optics, OSA Technical Digest Series (Optical Society of America, Washington, D.C.) Baltimore MD. 1993 P6. "Evaluation of Fluorescence from Turbid Samples using the Kubelka-Munk Transfer Function", N. Ramanujam, A.J. Durkin, S.Jaikumar, R. Richards-Kortum, Conference paper, American Society of Lasers in Medicine and Surgery, April 1993. P7. "Comparison of Methods for Determining Fluorophore Concentrations from Turbid Samples", A.J. Durkin, C.M. Gardner, R. Richards-Kortum, Conference on Lasers and Electro- Optics, 1994, Anaheim, CA. Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting. Publ by IEEE, IEEE Service Center, Piscataway, NJ, USA,94CH3463-7. v 8 1994. p.71 (See also under Public Lectures: PM 3) P8. "A Comparison of Methods to Determine Chromophore Concentrations from Fluorescence Spectra of Turbid Samples", A.J. Durkin, Rebecca Richards-Kortum, Conference on Lasers and Electro-Optics, 1995 OSA Technical Digest Series (Optical Society of America, Washington, D.C.) Baltimore, MD. (See also under Public Lectures: PM 4). P9. "Application of the Method of Partial Least Squares to Determine Chromophore Concentrations from Fluorescence Spectra of Turbid Samples", A.J. Durkin, Rebecca Richards- Kortum, Proc. SPIE BiOS 96, Proc. SPIE Vol. 2678, p. 475-484, Optical Diagnostics of Living Cells and Biofluids, Daniel L. Farkas; Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Bruce J. Tromberg; Eds. Publication Date: 5/1996 (See also under Public Lectures: PM 5). P10. Chromophore Quantification in Turbid Samples using Fluorescence and Raman Spectroscopies, Anthony J. Durkin, Marwood N. Ediger, Rebecca Richards-Kortum,

17 Proceedings of the 1996 ERDEC Scientific Conference on Obscuration and Aerosol Research. Research and Technology Directorate, Aberdeen Proving Ground, MD: Edgewood Research, Development, and Engineering Center. (See also under Public Lectures: PM 7). P11. "Determination of Polydimethylsiloxane (Silicone) Concentration in Turbid Samples from Raman Spectra" Anthony J. Durkin, Marwood N. Ediger, George H. Pettit, Conference on Lasers and Electro-Optics, Vol. 9, 1996 OSA Technical Digest Series (Optical Society of America, Washington, D.C.), pp74-75. Also Viewable as an electronic poster: http://www.fda.gov/cdrh/intro.html (See also under Public Lectures: PM 6). P12. Invited: "Silicone Quantification in Turbid Samples by Raman Spectroscopy and the method of Partial Least Squares", Anthony J. Durkin, Marwood N. Ediger, Stephanie Matchette, George H. Pettit, Photonics West/Bios'97, Advances in Fluorescence Sensing Technology III, Feb. 97, San Jose Ca. Proc. SPIE Vol. 2980, p. 217-226, Advances in Fluorescence Sensing Technology III, Richard B. Thompson; Ed. Publication Date: 5/1997 (See also under Public Lectures: PM 9). P13. Evaluation of ultraviolet ellipsometry as a potential method for determination of corneal absorption coefficient, Ediger, M N. Durkin, A J. Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-CLEO. v11 1997. IEEE, Piscataway, NJ, USA, 97CH36110. p 152-153. P14. "Determination of silicone concentrations from Raman spectra using the method of partial least squares", Anthony Durkin, L.S. Matchette, M.N. Ediger, OSA Trends in Optics and Photonics, Vol. XXII, Biomedical Optical Spectroscopy and Diagnostics/ Therapeutic Laser Applications, Eva M. Sevick-Muraca, Joseph A. Izatt, and Marwood N. Ediger eds. (Optical Society of America, Washington, DC 1998) pp 164-167. (See also under Public Lectures: PM 11). P15. "Ultraviolet ellipsometric measurement of corneal absorption coefficient", M.N. Ediger, A.J. Durkin OSA Trends in Optics and Photonics, Vol. XXII, Biomedical Optical Spectroscopy and Diagnostics/ Therapeutic Laser Applications, Eva M. Sevick-Muraca, Joseph A. Izatt, and Marwood N. Ediger eds. Optical Society of America, Washington, DC 1998, pp 308-311. (See also under Posters: PO 5). P16. A system for rapid acquisition of excitation emission matrices in vivo: instrumentation and studies, Urs Utzinger, Andres Zuluaga, Holger Fuchs, Rebecca Richards-Kortum, Anthony Durkin, Molly Brewer, Lezlee Coghlan, Ann Gillenwater, Optical Society of America, Topical meeting on Biomedical Spectroscopy and Diagnostics, March 1998. P17. In Vivo Fluorescence EEM Collection of Normal and Cancerous Epithelial Tissue in the Hamster Pouch Model. Michele Follen Mitchell, Andres F. Zuluaga, Anthony Durkin, Carrie Kazinoff Brookner, Dale Weiss, Irma Gimenez-Conti, Lezlee Coghlan, and Rebecca Richards- Kortum. Proceedings of the Twenty-Ninth Annual Meeting of the Society of Gynecologic Oncologists, 1998, Page 84.

18 P18. Chemometric analysis of FDPM data: Using training sets instead of diffusion theory, Andrew J. Berger, Vasan Venugopalan, Tuan Pham, Bruce J. Tromberg, Anthony J. Durkin, Biomedical Optical Spectroscopy, Imaging and Diagnostics (BOSD), Optical Society of America, April 2000, Miami. P19. Fiber optic probe-based determination of tissue optical properties with diffuse reflectance, T. Pfefer, L. S. Matchette, J. A. Wilke, U.S. Food and Drug Administration; A. J. Durkin, Beckman Laser Institute and Medical Clinic; M. N. Ediger, U.S. Food and Drug Administration, SPIE Photonics West/Bios 2002 Proceedings of SPIE Vol. #4613, Optical Biopsy IV [4613-40]. P20. Quantitative analysis and imaging of subsurface heterogeneities using spatially structured illumination, Frederic Bevilacqua, David J. Cuccia, Anthony J. Durkin, and Bruce J. Tromberg, Optical Society of America Biomedical Optics Topical Meeting, Miami, April 7-10, 2002. P21. In-vivo quantification of optical contrast agents using a combined frequency-domain and steady state technique, David J. Cuccia, Frederic Bevilacqua, Anthony Durkin, Sean Merritt, Bruce Tromberg, Gultekin Gulsen, Hon Yu, Jun Wang, Orhan Nalcioglu, Optical Society of America Biomedical Optics Topical Meeting, Miami, April 7-10, 2002. P22. Near-infrared spectroscopy and MRI co-registration of tumor tissue physiology, Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning and Bruce J. Tromberg, Gultekin Gulsen, Hon Yu, Jun Wang, Orhan Nalcioglu Optical Society of America Biomedical Optics Topical Meeting, Miami, April 7-10, 2002. P23. Combined MRI and NIR Spectroscopy for Functional and Structural Imaging of Tumors, Gultekin Gulsen, Hon Yu, Jun Wang, O. Nalcioglu, Frederic Bevilacqua, Anthony J. Durkin, David Cuccia, Sean Merritt and Bruce J. Tromberg, International Society for Magnetic Resonance in Medicine, Tenth Scientific Meeting and Exhibition, Honolulu Hawaii, May, 2002. P24. Quantitatitive Analysis of Chromophore Responses to Dermatologic Laser Treatments using Near infrared reflectance hyperspectral imaging. Zhihong Pan, Manish Prasad, Glenn Healey, Anthony Durkin, J.Stuart Nelson, Frederic Bevilacqua, Bruce Tromberg, Conference paper, Annual Meeting of the American Society of Lasers in Medicine and Surgery, April 2003. P25. Objective Assesement of Portwine Stain using Digital Imaging System and Color Analysis Method, Byungjo Jung, Bernard Choi, Anthony J. Durkin, Kristen M. Kelly, J. Stuart Nelson, Conference paper, Annual Meeting of the American Society of Lasers in Medicine and Surgery, April 2003. P26. Endogenous tissue autofluorescence accentuates nonmelanoma skin cancer margins. Tu J H [a]; Brancaleon L; Durkin A; Menaker G M; Kollias N. [Meeting] Journal of Investigative Dermatology. [print] 121(1). July 2003. P27. In-vivo optical contrast agent dynamics in tumors with MRI co-registration David J. Cuccia 1, Frederic Bevilacqua 1, Anthony Durkin 1, Bruce J. Tromberg 1, Gultekin

19 Gulsen 2, Hon Yu 2, Jun Wang 2, Orhan Nalcioglu 2 ; Frontiers in Optics, Sponsored by the Optical Society of America, Tucson, AZ, October 2003. P28. Depth-sectioned subsurface imaging in turbid media using spatially modulated illumination, Frederic Bevilacqua, David J. Cuccia, Anthony J. Durkin, Bruce J. Tromberg; Beckman Laser Institute, USA. Frontiers in Optics, Sponsored by the Optical Society of America, Tucson, AZ, October 2003. P29. Effects of curvature and view angle on quantitative imaging of erythema and melanin content in facial port wine stain skin, Byungjo Jung, Bernard Choi, Yongjin Shin, Anthony J. Durkin, J. S. Nelson, Proc. SPIE Int. Soc. Opt. Eng. 5312, 1 (2004) P30. In-vivo human skin optical properties and chromophore concentrations from nearinfrared-reflectance hyperspectral imaging, M. Prasad, Z. Pan, A. Durkin, F. Bevilacqua, G. Healey, B. Tromberg, [5326-14] Proceedings of SPIE Vol. #5326 OPTICAL BIOPSY V SPIE Photonics West Jan. 2004. P31. EFFICACY OF CROSS-POLARIZED DIGITAL IMAGING FOR EVALUATION OF LASER PORT WINE STAIN THERAPY, Byungjo Jung, Bernard Choi, Yongjin Shin, Anthony J. Durkin, J. Stuart Nelson, Conference paper, Annual Meeting of the American Society of Lasers in Medicine and Surgery, April 2004. P32. Water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms Sean Merritt, Albert E. Cerussi, Anthony J. Durkin, Bruce J. Tromberg, Gultekin Gulsen, George Chiou, Yong Chu, Chengwu Deng, Orhan Nalcioglu, Optical Society of America Biomedical Optics, Miami Florida, April 14-17, 2004. P33. Depth-sectioned imaging and quantitative analysis in turbid media using spatially modulated illumination David J. Cuccia, Frederic Bevilacqua, Anthony J. Durkin, Bruce J. Tromberg, Optical Society of America Biomedical Optics Topical Meeting, Miami, April 14-17, 2004. P34. A Diffusive Light Source for Quantification of Optical Properties of Superficial Layers, Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, Bruce J. Tromberg, Anthony J. Durkin, Optical Society of America Biomedical Optics Topical Meeting, Miami, April 14-17, 2004. P35. Monitoring Temperature Non-invasively using Broadband Diffuse Optical Spectroscopy, Sean Merritt, Ruka Sakurai, Albert Cerussi, Anthony J. Durkin, Jangwoen Lee and Bruce J. Tromberg, FiO 2004 Merritt Frontiers in Optics, Sponsored by the Optical Society of America, Rochester, NY, October 2004. P36. A Diffusive Light Source for Quantification of Optical Properties of Superficial Layers Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier, Bruce J. Tromberg, Anthony J. Durkin, Frontiers in Optics, Sponsored by the Optical Society of America, Rochester, NY, October 2004. P37. A Diffusive Probe with Adjustable Interrogation Depth for Determination of Optical Properties of Superficial Volumes, Sheng-Hao Tseng, Carole Hayakawa, Jerome Spanier,

20 Bruce J. Tromberg, Anthony J. Durkin, SPIE Photonics West/Bios, San Jose Convention Center, San Jose, California, USA. Jan. 2005. P38. Modulated imaging with CTIS: high-speed, quantitative spectral imaging in turbid media, D. J. Cuccia, F. P. Bevilacqua, A. J. Durkin, B. J. Tromberg, W. R. Johnson, D. W. Wilson, G. H. Bearman, SPIE Photonics West/Bios, San Jose Convention Center, San Jose, California, USA. Jan. 2005 [5694-06] P39. Application of a novel technique, modulated imaging, toward wide-field, depth-resolved imaging and quantitative functional mapping of in-vivo rat brain, D. J. Cuccia, A. J. Durkin, F. Bevilacqua, R. D. Frostig, B. J. Tromberg, SPIE Photonics West/Bios, San Jose, CA. Jan. 2005 [5686-101] P40. Monitoring deep tissue temperature with broadband diffuse optical spectroscopy, S. I. Merritt, R. Sakurai, A. E. Cerussi, A. J. Durkin, J. Lee, S. H. Chung, B. J. Tromberg, Univ. of California/Irvine SPIE Photonics West/Bios, San Jose, CA. Jan. 2005 [5693-101] P41. Modulated Imaging: A new method for multi-resolution functional mapping of tissues. David J. Cuccia, Frederic Bevilacqua, Anthony Durkin, Bruce J. Tromberg. Tissue Ulcer Healing and Wound Repair, Paris, France, March 18-19, 2005. P42. Quantitative Recovery of Tissue Optical Properties in the Spatial Frequency Domain Using Modulated Imaging David J. Cuccia, Frederic Bevilacqua, Anthony J. Durkin, Bruce J. Tromberg, Frontiers in Optics, Sponsored by the Optical Society of America, Tucson, AZ, October 2005 [FTuN4]. P43. Modulated Imaging: Advancements in Diffuse Optical Tomography and Spectroscopy David J. Cuccia, Frederic Bevilacqua, Ang Li, Anthony J. Durkin, Ron D. Frostig, Bruce J. Tromberg; Optical Society of America Biomedical Optics Topical Meeting, Fort Lauderdale, FL, March 19-23, 2006 P44. Wide-Field Spatial Mapping of in-vivo Skin Optical Properties and Chromophores using Modulated Imaging David J. Cuccia, Anthony J. Durkin, Frederic Bevilacqua, Bruce J. Tromberg, Conference paper, Annual Meeting of the American Society of Lasers in Medicine and Surgery, Boston, MA April 6-9, 2006. P45. In-vivo Determination of Skin Optical Properties using Diffuse Optical Spectroscopy, Sheng-Hao Tseng_, Carole Hayakawa, Jerome Spanier, Anthony J. Durkin, Conference paper, Annual Meeting of the American Society of Lasers in Medicine and Surgery, Boston, MA April 6-9, 2006. P46. Spatial-Frequency-Domain Imaging for Quality Assessment of Apples, Eric R. Anderson, Joon S. You, David J. Cuccia, and Anthony J. Durkin, Conference Proceedings Conference on Lasers and Electro-optics (CLEO), Long Beach, CA May 21 26 2006.

21 P47. Quantitative Near Infrared Spectroscopy of Vulnerable Plaque in ex-vivo Human Coronary Artery Tissue: Feasibility, Kasra Maasumi, Sheng Hao Tseng, Anthony J. Durkin, American Heart Association, Western Division Roundtable, Irvine, CA August 15, 2006. P48. Absorption and Fluorescence Diffuse Optical Tomography in the Spatial Frequency Domain Using Modulated Imaging David J. Cuccia, Frederic Bevilacqua, Ang Li, Anthony J. Durkin, Bruce J. Tromberg, 28th IEEE EMBS Annual International Conference, New York, Aug 30 Sept 3 2006. P49. Detection of Bruises on Apples Using Spatial-Frequency-Domain Imaging, Eric R. Anderson, Joon S. You, David J. Cuccia, and Anthony J. Durkin, SPIE Photonics West/Bios, San Jose, CA. Jan. 2007. 6430B-55 P50. In-vivo quantitative mapping of blood volume and oxygen saturation using modulated imaging: experimental results in a rat dorsal pedicle skin flap model, David J. Cuccia, Jae G. Kim, Joon S. You, Anthony J. Durkin,, SPIE Photonics West/Bios, San Jose, CA. Jan. 2007., 6424A-16 P51. Monitoring of chemotherapy effects on rat breast tumors: a correlation between optical signals and histology. Jae-Gwan Kim, David J. Cuccia, Jangwoen Lee, Albert E. Cerussi, Anthony J. Durkin, Bruce J. Tromberg,. SPIE Photonics West/Bios, San Jose, CA. Jan. 2007. 6434-58 P52. OPTICAL MONITORING OF TUMOR ANGIOGENESIS BY MODULATED IMAGING: PRELIMINARY RESULTS FROM IN VIVO RAT TUMOR MODEL. JG Kim 1, J Lee 1, EL Nelson 2, DJ Cuccia 1, A Cerussi 1, AJ Durkin 1, M Brenner 3, BJ Tromberg 1, 35 th Annual Western Student Medical Research Forum, Jan 31 Feb 3, 2007, Carmel CA. P53. DIFFUSE NEAR INFRARED SPECTROSCOPY OF VULNERABLE PLAQUE IN EX- VIVO HUMAN CORONARY ARTERY TISSUE: FEASABLILTY, Kasra Maasumi, Sheng-Hao Tseng, A.J. Durkin, 35 th Annual Western Student Medical Research Forum, Jan 31 Feb 3, 2007, Carmel CA. P54. QUANTITATIVE CHARACTERIZATION OF INTACT ORGANS IN A LIVE ANIMAL MODEL USING BROADBAND DIFFUSE OPTICAL SPECTROSCOPY Clifford Hom, Jae G. Kim, Sheng-Hao Tseng, Alexander Grant, Albert Cerussi, Anthony J. Durkin, Annual Meeting of the American Society of Lasers in Medicine and Surgery, Dallas, TX April 11-15, 2007. P55. WIDE-FIELD SPATIAL MAPPING OF IN-VIVO TATTOO SKIN OPTICAL PROPERTIES USING MODULATED IMAGING, Frederic Ayers, David J. Cuccia, Alexander Grant, Kristen Kelly, Anthony J. Durkin, Annual Meeting of the American Society of Lasers in Medicine and Surgery, Dallas, TX April 11-15, 2007. P56. OPTICAL MONITORING OF TUMOR ANGIOGENESIS BY MODULATED IMAGING:PRELIMINARY RESULTS FROM IN VIVO RAT TUMOR MODEL, Jae G. Kim, Clifford Hom, Edward L. Nelson, David J. Cuccia1, Albert E. Cerussi, Anthony J. Durkin1,