Accelerating our strategy: GSK to acquire full ownership of Consumer Healthcare Business

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Accelerating our strategy: GSK to acquire full ownership of Consumer Healthcare Business Buyout of Novartis stake Strategic review of Horlicks and other Consumer Healthcare Nutrition products

Cautionary statement regarding forward-looking statements This presentation may contain forward-looking statements. Forward-looking statements give the Group s current expectations or forecasts of future events. An investor can identify these statements by the fact that they do not relate strictly to historical or current facts. They use words such as anticipate, estimate, expect, intend, will, project, plan, believe, target and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. In particular, these include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, the outcome of contingencies such as legal proceedings, and financial results. Other than in accordance with its legal or regulatory obligations (including under the Market Abuse Regulations, UK Listing Rules and the Disclosure Guidance and Transparency Rules of the Financial Conduct Authority), the Group undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. Investors should, however, consult any additional disclosures that the Group may make in any documents which it publishes and/or files with the US Securities and Exchange Commission (SEC). All investors, wherever located, should take note of these disclosures. Accordingly, no assurance can be given that any particular expectation will be met and investors are cautioned not to place undue reliance on the forward-looking statements. Forward-looking statements are subject to assumptions, inherent risks and uncertainties, many of which relate to factors that are beyond the Group s control or precise estimate. The Group cautions investors that a number of important factors, including those in this presentation, could cause actual results to differ materially from those expressed or implied in any forward-looking statement. Such factors include, but are not limited to, those discussed under Item 3.D Risk factors in the Group s Annual Report on Form 20-F for 2017. Any forward-looking statements made by or on behalf of the Group speak only as of the date they are made and are based upon the knowledge and information available to the Directors on the date of this presentation. A number of adjusted measures are used to report the performance of our business. These measures are defined in our Q4/FY 2017 earnings release and Annual Report on Form 20-F for 2017. All expectations and targets regarding future performance should be read together with Assumptions related to 2018 guidance and 2016-2020 outlook on page 40 of our full year and fourth quarter 2017 earnings release. 2

Agenda Strategic overview Emma Walmsley, Chief Executive Officer Financial highlights Simon Dingemans, Chief Financial Officer Winning in Consumer Healthcare Brian McNamara, CEO, Consumer Healthcare Summary & Q&A Emma Walmsley, Chief Executive Officer 3

Emma Walmsley, CEO Strategic overview

Balanced business to deliver growth and returns to shareholders Pharmaceuticals Leading positions in HIV and Respiratory Vaccines Broadest portfolio with leading position in meningitis and opportunity in shingles Consumer Healthcare Category leadership in Respiratory, Pain Relief and Oral Health Common goal to improve health, from prevention to treatment Therapeutic and category leadership Global opportunities Strategic and operational synergies Balanced set of cash flows and returns 5

Advancing our priorities Key priorities for capital Innovation Invest in the business 1. Pharma pipeline including BD 2. Consumer put 3. Vaccines capacity Performance Improved cash generation Shareholder returns 80p per share expected for 2018 Focus on rebuilding free cash flow cover over time Target 1.25x to 1.5x FCF cover before returning to dividend growth Trust Other BD/ M&A Strict discipline on returns 6

Two important milestones for Consumer Healthcare Buyout of Novartis stake Full ownership of Consumer Healthcare business Strategic review Horlicks and Consumer Nutrition products Shareholders capture full value of world-leading Consumer Healthcare business Benefits adjusted earnings and cash flows helping accelerate performance Removes uncertainty and supports capital planning for Group s other priorities 7

Simon Dingemans, CFO Financial Highlights

Financial Highlights Consideration $13 billion ( 9.2 billion 1 ) Returns on JV 2 Financial effects Consumer Healthcare Pharma & Vaccines Outlooks +10% IRR CFROI targets met Expected to be accretive to adjusted earnings in 2018 and thereafter Expected to strengthen cashflow generation Supportive of target credit profile Continue to expect operating margin of more than 20% by 2020 (at 2015 rates) Targeting operating margins in mid-20s percentages by 2022 (at 2017 rates) Incremental earnings and cashflows to invest in Pharma R&D and other growth drivers Flexibility retained to invest capital in R&D and other capital allocation priorities Increased confidence in delivering outlooks for 2020 Group sales and adjusted EPS Continue to expect to pay a dividend of 80p in 2018 1. $1.42/ as at close 26 March 2018 2. Since formation of Novartis JV in 2015 9

Timing and considerations Novartis buy-out Review of Horlicks & Nutrition products Shareholder approval required Review to conclude around end of 2018 Vote anticipated in 1H 2018 10

Brian McNamara CEO Consumer Healthcare Winning in Consumer Healthcare

Global leader in Consumer Healthcare 1 1 Competitive geographic 7.8 billion net sales footprint Attractive returns Proven track record of delivery Strong portfolio Strong and increasing capabilities 1. 12 month net sales year ending 31 December 2017. 12

Industry dynamics Positive long term drivers Increasing health awareness and self care 1 77% of consumers want to take more control over decisions about their health Ageing population 2 1.4 billion aged 60+ by 2030, an increase of 0.5 billion vs 2015 Emerging middle class Almost 2.4 billion more emerging middle class consumers by 2030 vs 2015 3 Innovation Unmet consumer needs (switches, products, formats, channels, devices) 1. IPSOS Trend Survey Sept-Oct 2016. 2. UN DESA. 3. Brookings Institution. 13

Industry dynamics Sources of short-term variability Seasonal Switches Emerging market dynamics Timing and strength of allergy and cough/cold season Growth followed by private label entry Economic variability (e.g. Brazil, Saudi Arabia) Government regulatory changes (e.g. Indian GST and demonetisation) Emerging trends Phenomenal digital opportunity 100 billion Google healthcare searches each year e-commerce A challenge and an opportunity Emergence of local brands Increased quality of local competition 14

Leadership in key categories and segments OTC: 99 billion market Oral Health: 22 billion market 1 4 Pain Relief Respiratory Digestive Health Sensitivity Gum Health Denture Care #1 in global pain market #1 in global respiratory market 1 1 #3 in global digestive health market 1 #1 in global sensitivity 2 #1 in gum health 3 #1 in global 4 denture 1. OTC 2016 Nicholas Hall DB6 Data 2. Nielsen Data via Compass 3. GSK Internal Estimate for Stand-alone Gum Health Products 4. Oral Health Euromonitor 2016 15

Our Consumer Healthcare priorities Our purpose: to help people do more, feel better, live longer Our strategy: meet the everyday healthcare needs of consumers by building consumer preferred and expert recommended brands, differentiated by science and insight-driven innovation Our priorities: Innovation Performance Trust Brilliant execution of launches Strong, differentiated pipeline of consumer-led, science-based innovation and claims Sustained above market growth Competitive cost structure, margin and cash flow. Reliable supply Improved reputation Highly engaged employees 16

Building a competitive advantage through consumer-led, science-based innovation Performance Innovation Integrated category and R&D innovation hubs Scientific and technical excellence Novel packaging, sensorials and claims Emerging markets and digital innovation External innovation and partnerships 17

This focus is driving a pipeline transformation Major focus of spend and capability on Power and Core brands Key launches in past 12 months: Halved the number of projects whilst increasing overall pipeline value (vs. 15) Top 10 projects (by value) have doubled in size (vs. 16) Flonase Sensimist Gentle mist, powerful relief parodontax US launch Leave bleeding gums behind Voltaren No Mess Applicator Triple effect pain relief, now with clean hands! 5-fold increase in external innovation pipeline value A strong set of launches across categories in 2018 Sensodyne Rapid Clinically proven relief in just 60 seconds Tums Chewy Bites Fast relief in every bite Polident Max Seal All day hold and maximum food seal protection 18

A winning strategy for growth Sustained above market growth and strong operating margin progression Performance Building consumer preferred and expert recommended brands Winning with shoppers, customers and experts Seizing the digital opportunity Drive gross margin improvement, operational efficiencies & cash discipline 19

Building consumer preferred and expert recommended brands Sensodyne: > 1 billion net sales and over ten years of double digit growth Sensodyne vs Toothpaste market 1 Sales indexed to 2007 Sensodyne Toothpaste Market ex Sensodyne +11% CAGR +4% CAGR 2004 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 Dentist Testimonial campaign Pronamel US launch India and China launch Repair & Protect launch Complete launch True White launch Rapid launch 1. Euromonitor Data, CER 20

Building consumer preferred and expert recommended brands Voltaren: creating the world s leading topical analgesic, > 600 million net sales Voltaren vs Pain market Sales indexed to 2007 1 Voltaren Pain Market ex. Voltaren +11% CAGR +4% CAGR 1999 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 1st Rx to OTC switch 2004 2005 1 st systemic launch 1 st patch launch 1 st 12 hour launch Launch of Global Pain Index Voltaren and Panadol regimen No mess launch 1. Nicholas Hall DB6 CER 21

Seizing the digital opportunity Digital is half of all media consumption 1 When consumers go online, they consider 2 40% more brands 3 Almost half of offline sales are influenced by online information 4 4.6% total FMCG sales via e-commerce (~2% for OTC) 1. Global Web Index 2. McKinsey 3.Forrester Research, Deloitte and GSK analysis 4: Kantar World Panel 22

Investing in digital capability to win Chief Digital Officer Chief Insights & Analytics Officer Head of Digital Innovation Hub Tech stack deal: owning our data and providing deeper consumer insights Optimising digital spend: currently >29% of A&P More efficient search Improving ROI Leadership Capability Data Growth Efficiency Created Digital Advisory Board Launched new marketing capability program Data driven precision marketing New sales channels Digital innovation pipeline hub 31 projects live 23

Drive gross margin improvement, operational efficiencies and cash discipline Expected 20%+ operating margin by 2020 at 2015 CER, expect operating margin to approach mid-20 s by 2022 at 2017 CER 20% 1 Approaching Mid 20% 2 By 2022 17.7% Power brand mix 15.5% Supply chain A&P efficiencies Cost discipline FY 2015 FY 2016 FY 2017 2020 2022 1.At constant, 2015 exchange rates 2 At 2017 exchange rates 24

Fundamentals in place to lead Consumer Healthcare Sustained above market growth and strong operating margin progression Category leadership Strong and increasing capability Strong pipeline Seizing digital opportunities Proven track record of delivery Clear margin progression roadmap 25

Emma Walmsley, CEO Summary

Accelerating our strategy Shareholders capture full value of world-leading Consumer Healthcare business Innovation Benefits adjusted earnings and cash flows helping accelerate performance Performance Removes uncertainty and supports capital planning for Group s other priorities Trust

Q&A