The following lists of designated substances and carcinogens have been extracted from the Occupational Health and Safety Act, International Agency for Research on Cancer (IARC), and American Conference of Governmental Industrial Hygienists (ACGIH). For a complete and current listing, refer to their original sources, as noted in each category heading. When purchasing products that fall within these lists, consider the amount, concentration, route of exposure, form or state of the substance, and other factors (e.g. use of the product) that may impact its carcinogenic properties. Designated Substances As designated under the Ontario Occupational Health and Safety Act (For a current and accurate listing, refer to Ontario Regulation 490/09 Designated Substances) Acrylonitrile Arsenic Asbestos Benzene Coke oven emissions Ethylene oxide Isocyanates Lead Mercury Silica Vinyl chloride Group 1: Carcinogenic to Humans As established by the IARC (For a complete and current listing, refer to the IARC website at: http://monographs.iarc.fr/eng/classification/index.php) Acid mists, strong inorganic Aflatoxins [1402-68-2] 4-Aminobiphenyl [92-67-1] Aristolochic acid [313-67-7] Arsenic and inorganic arsenic compounds [7440-38-2; 1303-00-0] Asbestos, all forms [1332-21-4; 77536-67-5; 12172-73; 77536-66-4; 12001-29-5; 12001-28-4; 77536-68-6], including mineral substances (e.g. talc, vermiculite) that contain asbestos Azathioprine [446-86-6] Benzene [71-43-2] Benzidine [92-87-5] and dyes metabolized to benzidine Benzo[a]pyrene [50-32-8] Beryllium [7440-41-7] and beryllium compounds Busulfan [55-98-1] 1,3 Butadiene [106-99-0] Bis(chloromethyl)ether [542-88-1]; chloromethyl methyl ether (technical-grade) [107-30-2] Cadmium and cadmium compounds [7440-43-9] Chlorambucil [305-03-3] Chlornaphazine [494-03-1] Last Revised: November 2016 Page 1 of 5
Chromium (VI) compounds [18540-29-9] Coal-tar pitch [65996-93-2] Cyclosporin [59865-13-3; 79217-60-0] Cyclophosphamide [50-18-0; 6055-19-2] 1,2-Dichloropropane [78-87-5] Diethylstilboestrol [56-53-1] Erionite [66733-21-9] Ethylene oxide [75-21-8] Etoposide [33419-42-0; 15663-27-1; 11056-06-7] Formaldehyde [50-00-0] Lindane [58-89-9] Melphalan [148-82-3] 4-4'-Methylene bis(2-chloroaniline) (MOCA) [101-14-4] Mineral oils, untreated or mildly treated 2-Naphthylamine [91-59-8] N-Nitrosonornicotine (NNN) and 4-N-Nitrosomethylamino-1-(3-pyridyl)-1-butanone (NNK) [16543-55-8; 64091-91-4] Nickel compounds 3,4,5,3',4'-Pentachlorobiphenyl (PCB-126) [57465-28-8] 2,3,4,7,8-Pentachlorodibenzofuran [57117-31-4] Pentachlorophenol [87-86-5] Phenacetin [62-44-2] Plutonium [7440-07-5] Phosphorus-32, as phosphate [14596-37-3] Polychlorinated biphenyls [1336-36-3] Semustine [1-(2-Chloroethyl)-3-(4-methylcycohexyl)-1-nitrosourea Methyl-CCNU] [13909-09-6] Shale-oils [68308-34-9] Silica dust [14808-60-7], crystalline, in the form of quartz or cristobalite Sulfur mustard [505-60-2] Talc containing asbestiform fibres Tamoxifen [10540-29-1] 2,3,7,8-Tetrachlorodibenzo-para-dioxin [1746-01-6] Thiotepa [52-24-4] Ortho-Toluidine [95-53-4] Treosulfan [299-75-2] Trichloroethylene [79-01-6] Vinyl chloride [75-01-4] Category A1-Confirmed Human Carcinogens As listed by the ACGIH (For a complete and current listing, refer to the latest edition of TLVs and BEIs, published by the ACGIH) 4-Aminodiphenyl [92-67-1] Arsenic [7440-38-2] and inorganic compounds, as As Asbestos, all forms [1332-21-4] Benzene [71-43-2] Benzidine [92-87-5] Last Revised: November 2016 Page 2 of 5
Beryllium [7440-41-7] and compounds, as Be Bis(Chloromethyl) ether [542-88-1] Chromite ore processing (Chromate), as Cr Chromium [7440-47-3] Water-soluble Cr VI compounds and insoluble Cr VI compounds Coal tar pitch volatiles [65996-93-2], as benzene soluble aerosol β-naphthylamine [91-59-8] Nickel [7440-02-0], as Ni including insoluble inorganic compounds (NOS) and Nickel subsulfide [12035-72-2] Talc [14807-96-6], containing asbestos fibres Uranium (natural) [7440-61-1], soluble and insoluble compounds, as U Vinyl chloride [75-01-4] Wood dusts, oak and beech Zinc chromates [11103-86-9; 13530-65-9; 37300-23-5], as Cr Group 2A: Probably Carcinogenic to Humans As established by the IARC (For a complete and current listing, refer to the IARC website at: http://monographs.iarc.fr/eng/classification/index.php) Acrylamide [79-06-1] Adriamycin [23214-92-8] Azacitidine [320-67-2] Bischloroethyl nitrosourea (BCNU) [154-93-8] Bitumens [64742-93-4] Captafol [2425-06-1] Chloral [75-87-6] Chloral hydrate [302-17-0] Chloramphenicol [56-75-7] a-chlorinated toluenes (benzal chloride, benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures) [98-87-3; 98-07-7; 100-44-7] 1-(2-Chloroetyl)-3-cyclohexyl-1-nitrosourea (CCNU) [13010-47-4] 4-Chloro-ortho-toluidine [95-69-2] Chlorozotocin [54749-90-5] Cisplatin [15663-27-1] Cobalt metal with tungsten carbide [7440-48-4; 12070-12-1] Creosotes [8001-58-9] Cytclopenta[cd]pyrene [27208-39-3] DDT (4,4'-Dichlorodiphenyltrichloroethane) [50-29-3] Diazinon [333-41-5] Dibenz[a,h]anthracene [53-70-3] Dibenz[a,j]acridine [224-42-0] Dibenzo[a,l]pyrene [191-30-0] Dichloromethane (Methylene chloride) [75-09-2] Dieldrin, and Aldrin metabolized to dieldrin [60-57-1; 309-00-2] Diethyl sulfate [64-67-5] 1,2 Dimethylhydrazine [540-73-8] Dimethyl sulfate [77-78-1] Dimethylcarbamoyl chloride [79-44-7] Last Revised: November 2016 Page 3 of 5
Dimethylformamide [68-12-2] Epichlorohydrin [106-89-8] Ethyl carbamate (Urethane) [51-79-6] Ethylene dibromide [106-93-4] N-Ethyl-N-nitrosourea [759-73-9] Etoposide [33419-42-0] Glycidol [556-52-5] Glyphosate [1071-83-6] Hydrazine [302-01-2] Indium phosphide [22398-80-7] IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) [76180-96-6] Lead compounds, inorganic Malathion [121-75-5] 2-Mercaptobenzothiazole [149-30-4] 5-Methoxypsoralen [484-20-8] Methyl methanesulfonate [66-27-3] N-Methyl-N -nitro-n-nitrosoguanidine(mnng) [70-25-7] N-Methyl-N-nitrosourea [684-93-5] Nitrate or nitrite (ingested) under conditions that result in endogenous nitrosation 6-Nitrochrysene [7496-02-8] Nitrogen mustard [51-75-2] 1-Nitropyrene [5522-43-0] N-Nitrosodiethylamine [55-18-5] N-Nitrosodimethylamine [62-75-9] 2-Nitrotoluene [88-72-2] Pioglitazone [111025-46-8] Polybrominated biphenyls [59536-65-1] Procarbazine hydrochloride [366-70-1] 1,3-Propane sultone [1120-71-4] Silicon carbide whiskers [409-21-2] Styrene-7,8-oxide [96-09-3] Teniposide [29767-20-2] Tetrabromobisphenol A [79-94-7] 3,3'4,4'-Tetrachloroazobenzene [14047-09-7] Tetrachloroethylene (Perchloroethylene) [127-18-4] Tetrachlorofluoroethylene [116-14-3] 1,2,3-Trichloropropane [96-18-4] Tris(2,3-dibromopropyl) phosphate [126-72-7] Vinyl bromide [593-60-2] Vinyl fluoride [75-02-5] Category A2 - Suspected Human Carcinogens As listed by the ACGIH (For a complete and current listing, refer to the latest edition of TLVs and BEIs, published by the ACGIH) Acetaldehyde [75-07-0] Last Revised: November 2016 Page 4 of 5
Antimony trioxide [1309-64-4] Benz[a]anthracene [56-55-3] Benzo[b]fluoranthene [205-99-2] Benzo[a]pyrene [50-32-8] Benzotrichloride [98-07-7] 1,3-Butadiene [106-99-0] Cadmium [7440-43-9] and compounds, as Cd Calcium chromate [13765-19-0], as Cr Carbon tetrachloride [56-23-5] Chloromethyl methyl ether [107-30-2] Β-Chloroprene [126-99-8] 2016 Notice of Intended Changes submitted to add this substance to Category A2 in the future Diazomethane [334-88-3] 1,4-Dichloro-2-butene [764-41-0] Dimethyl carbamoyl chloride [79-44-7] Ethylene Oxide [75-21-8] Formaldehyde [50-00-0] 2016 Notice of Intended Changes submitted to move this substance from Category A2 to A1 in the future Hard metals containing Cobalt [7440-48-4] and Tungsten carbide [12070-12-1], as Co Lead chromate [7758-97-6], as Pb or Cr 4,4 -Methylene bis(2-chloroaniline) [101-14-4] Mineral oil, excluding metal working fluids, poorly and mildly refined 4-Nitrodiphenyl [92-93-3] Silica, crystalline α-quartz [1317-95-9; 14808-60-7] and cristobalite [14464-46-1] Silicon carbide [409-21-2], fibrous (including whiskers) Strontium chromate [7789-06-2], as Cr Sulfuric acid [7664-93-9] Synthetic vitreous fibres, refractory ceramic fibres Trichloroethylene [79-01-6] 1,2,3-Trichloropropane [96-18-4] Vinyl bromide [593-60-2] Vinyl fluoride [75-02-5] Wood dusts, birch, mahogany, teak, walnut Last Revised: November 2016 Page 5 of 5