I Jornada: Oportunidades de negocio en nanotecnología

I Jornada: Oportunidades de negocio en nanotecnología

NanoBioTer Maximizing polymer potential through flexible nanotechnology

Contents About Us Technology Selected Data Production process and Products Commercial Products Products in Development Customer Development NanoBioTer - Material potential. Maximized.

About Us Mission To maximize plastics and bioplastics properties through unique, green and cost effective nanotechnology. NanoBioTer products Nano-additives & concentrates for resin improvements (transparency, barrier, mechanical, thermal, rheological and active properties) Green Values and Technology Food contact approved (Complies with most stringent EU legislations) Safe handling - nanoscale in only 1 dimension (after dispersion) Naturally sourced raw materials (Nanoclays) Focus on sustainable and biodegradable resins Recyclable (and compostable) product NanoBioTer - Material potential. Maximized.

About Us Origin - Need for Combined Technologies Founded in 2004 by Prof. Dr. Jose Maria Lagaron, Scientist with the CSIC, combining technologies from the fields of nanotechnology, food packaging, plastics reinforcement and biobased materials. 2008 - High Growth Company Unique patented technology Unique applications Group of shareholders composed by venture capital groups, scientists and business angels. High academic level International workforce NanoBioTer - Material potential. Maximized.

Structure Medium Sized International Business Commercial Additive Plant - Vall D Uixo, Spain Capacity 2,500t/year ( 50,000-150,000t resin/year) Commercial extrusion plant Valencia, Spain (Under Construction / 2 months) Pilot Plants and Laboratory Valencia, Spain (Nanotechnology, plastics compounding, microbiology, barrier properties, food contact testing, thermal and mechanical plastics properties) Commercial offices: Spain (Valencia) and USA (Boston) NanoBioTer - Material potential. Maximized.

Overview - Nanotechnology

Nanotechnology nm µm mm m DNA Bacteria Bee Humans Definition Manufacturing of particles, products or devices with controlled particle size, with at least 1 dimension below 0.1 microns (= 100 nanometers).

Properties Property Microcomposite Nanocomposite Young Modulus Toughness or neutral Barrier properties Temperature resistance Transparency Cost or neutral Common loading 20-50% 2-5% Nanocomposites Composite materials that incorporate nanofillers, typically below 10 wt.-%. The purpose of a nanofiller is to enhance target properties while retaining most inherent characteristics of the original matrix, such as transparency, toughness etc.

Nanoclay Modification Mineral: Natural clay tactoid (stack) Modified Nanoclay Surface Modification Nanoclay Platelet Surface modifier

Nanoclay Dispersion Intercalated Nanoclay Exfoliated Nanoclay Nanoclay Platelet Surface modifier Polymer Chain

Physical Improvement & Active Solutions Physical Improvement Active Functionality Passive Barrier Properties, UV Blocking, Thermal Properties, Mechanical Properties. Antimicrobial, Antioxidant and Scavengers, Drug Control Release, etc. Nanoclay Platelet Matrix: Polymers, Ceramics, Solvents, Other Substrates Nanoclay Matrix compatibilizer Active Species

Physical Properties Improvement Tortuous Path Principle: Passive Barrier Enhancement Without NanoBioTer With NanoBioTer O 2 O 2 Typical Barrier Improvement: Up to 1 order of magnitude

Active Properties Novel properties through functionalization of the nanoadditives Without NanoBioTer+ With NanoBioTer+ Higher efficiency than standard additives due to the exfoliated nano-system Durability is ensured through permanent modification or controlled release mechanisms.

Selected Data Conventional Polymers and Biopolymers

Oxygen Barrier: EVOH + NanoBioTer Oxygen Permeability 1,2 1 EVOH 32 EVOH 32 + NanoBioTer (m 3 m)/(m 2 s Pa) 10-20 0,8 0,6 0,4 0,2 O 2 Barrier NanoBioTer decreases oxygen permeability approx. 70% at elevated humidity conditions 0 0,9 0,8 Water activity (humidity) JM Lagaron et al., Food Additives and Contaminants, 22 (10), pp. 994-998, 2005

Transparency: EVOH + NanoBioTer EVOH + 4% NanoBioTer EVOH neat NanoBioTer : High transparency

P(m 3 m/m 1 1 Oxygen Barrier: PET + NanoBioTer Oxigen Permeability 2 s Pa) 10-19 4 3 2 PET NanoPET O 2 Barrier 1 0 PET is generally regarded as highly sensitive to process conditions and humidity. LTR (Kg m/s m 2 ) 10-16 5 4 3 2 1 0 Limonene Permeability PET NanoPET NanoBioTer products enable enhanced barrier properties, when combining optimum surface modification and process parameters. JM Lagaron et al., Journal of Plastic & Film Sheeting 23 (2) 133-148, 2007

Biopolymers Definition Biopolymers (sustainable) Biopolymers are materials obtained from renewable biomass feedstocks, such as corn, potato, etc., and therefore have a reduced impact in the accumulation of greenhouse gases and on the well-known carbon footprint. Examples of Biopolymers: PLA, PHB, Chitosan, etc. Biodegradable polymers Biodegradable polymers are materials designed to biodegrade into carbon dioxide and water upon disposal by the action of soil microorganisms and water. The degradation must take place in a limited timeframe.

P(m 3 m/m 1 Biopolymers + NanoBioTer Oxygen Permeability O 2 Barrier 2 s Pa) 10-18 2,5 2 1,5 1 0,5 0 PHB PLA PET PHB NanoPHB PLA NanoPLA PET NanoPET PLA NanoBioTer enables reduction of oxygen permeability in the range of 40-90%. Typical value 50% improvement. PHB NanoBioTer enables reduction of oxygen permeability in the range of 40-90%. Typical value 50% improvement. PHB + NanoBioTer exhibit barrier properties that are comparable to PET. JM Lagaron et al., Journal of Plastic & Film Sheeting, 23 (2) 133-148, 2007 JM Lagaron et al., Journal of Plastic & Film Sheeting, 22 (4), pp. 265-274, 2006

Transparency: PLA + NanoBioTer PLA + 5% NanoBioTer PLA neat NanoBioTer : High Transparency

Thermal properties 2D Graph 6 Loss Modulus (Pa) Bioresin Bioresin 5% NanoBioTer 1 Bioresin 5% NanoBioTer 2 DMA Pérdida Masa (%) 100 TGA 90 80 70 250 275 300 325 350 375 Temperature (ºC) Temperatura (ºC) Temperature (ºC) NanoBioTer enables increased HDT (Heat Deflection Temperature) performance in biopolymers such as PLA*. This is an important characteristic for these materials with generally limited thermal resistance (softening begins above 40ºC.) NanoBioTer delays the onset of thermal degradation, as illustrated by the TGA curve (Thermal Gravimetric Analysis). * The exact conditions and improvement is protected under customer confidentiality agreement

Process Stability PHB blend + 4% market nanoclay PHB blend + 4%NanoBioTer PHB blend NanoBioTer has a very low impact on the processing degradation of the polymer. The polymer structure, as reflected by the melting point, is largely retained (this is not the case for other traditional nanoclays offered on the market) JM Lagaron et al., Journal of Applied Polymer Science, 108 (5), 2787-2801, 2008

Transmittance at 300nm ( %) UV Protection: PLA + NanoBioTer Transmittance at 300nm (30 microns Film)* 100 90 80 70 60 50 40 30 20 10 0 PLA Original Increasing Content NanoBioTer UV Protection NanoBioTer has unique, UV blocking properties. This technology allows protection of packaging contents while maintaining transparency. * Patent pending

WVTR (g m / s m 2 ) 1 2 Barrier Coatings Water Vapour Transmision Rate 1,6E-07 Biopolymer standard coating 1,4E-07 1,2E-07 1,0E-07 8,0E-08 6,0E-08 4,0E-08 Biopolymer with NanoBioTer coating H 2 O Barrier NanoBioTer is a highly efficient coating additive. Example: Water sensitive protein film. 2,0E-08 0,0E+00 JM Lagaron et al., SPE Antec 2008 Conference Proceedings, USA, 2008

Active Properties Antimicrobial additives High efficiency and duration through controlled release mechanism S.Aureus bacteria Gelatin film with chlorophyllin E-140 NanoBioTer+ antimicrobial additive Without antimicrobial additive NanoBioTer+ Antimicrobial activity tested as per specification in JIS Z 2801 and ISO 22196:2007 norms.

NanoBioTer - Process and Products

NanoBioTer Process Purification Process Surface Modification Raw Clay Nano Clay NanoBioTer + Extrusion Process NanoBioTer Resin NanoBioTer Concentrates

Products NanoBioTer Barrier Additives Gases O 2, CO 2 Water Vapor Aromas Migrants UV light Chemical Oil and Grease - Up to 1 order of magnitude improvement Focus systems Packaging (Food) Increasing shelf-life High barrier / multilayer systems (e.g.. EVOH). Biodegradable / Sustainable resins (e.g.. PCL, PHB) Coatings (Casting, extrusion coating, lamination) Transparent packaging materials (e.g.. PET) Development Partnership Efficiency is highly dependent on processing conditions, so materials should always be tested in the industrial application. NanoBioTer - Material potential. Maximized.

Products - Active + NanoBioTer+ Active Antimicrobial Properties combined with barrier performance for a wide range of applications Water and solvent based coatings Powder coatings Gel coats Paints Packaging Surfaces Norm Compliant: JIS Z 2801 and ISO 22196:2007 NanoBioTer - Material potential. Maximized.

Products Next Generation NanoBioTer Developments Short term Additional active additives NanoBioTer+ (e.g. antioxidants and other active/bioactive components) Additives for a wider range of resins through unique patent-pending modification techniques Increased product efficiency through unique patent-pending production steps. Medium Term Reinforcing nanoadditives for resorbable and permanent plastic implants in biomedical applications Controlled/accelerated biodegradability NanoBioTer - Material potential. Maximized.

Customer Projects and Developments Flexible NanoBioTer technology Improvements in an extremely wide range of applications, resins and properties: Targeting specific properties for a customer application Physical and chemical modification to obtain maximum dispersion in nearly any polymeric system Extensive lab and pilot plant equipment for development and testing purposes Your partner for project management We work actively with your team to cover all aspects of a successful development: Determine objectives and regulatory needs according to application Set timing for development steps and milestones Identify what to measure and how Determine ownership rights for the developed properties and products Finalize project plan and costs Create synergies for product marketing and launch NanoBioTer - Material potential. Maximized.

Contact Business Development Director Ole Faarbaek Jensen ofaarbaek@nanobiomatters.com Research & Development Director Prof. Dr. Jose Maria Lagaron lagaron@nanobiomatters.com Phone: +34 961 31 86 28 NanoBioTer - Material potential. Maximized.

Thank you for your attention NanoBioTer - Tomorrows Technologies, Combined Today