Nikolaos A. Gkanatsios, Ph.D.

CURRICULUM VITAE Nikolaos A. Gkanatsios, Ph.D. NAME ADDRESS (Home) ADDRESS (Work). 504 Larson Drive Danbury, CT 06810 USA Phone: +1 203 778 9196 Fax: +1 206 984 4248 Cellular:+1 203 512 7789 LORAD, A Hologic Company 36 Apple Ridge Road Danbury, CT 06810 USA Phone: +1 203 731 8432 Fax: +1 203 731 8459 e-mail: nikos@exodose.com URL: http://www.exodose.com BIRTH PLACE BIRTH DATE NATIONALITY Thessaloniki, GREECE April 6, 1970 Greek 1995-1998 1992-1995 1988-1992 Education University of Florida, College of Engineering Gainesville, FL Ph.D. in Diagnostic Medical Physics Dissertation: Patient Doses And Image Quality In Interventional Neuroradiology University of Florida, College of Engineering Gainesville, FL Master of Science in Medical Physics Thesis: Computation Of Energy Imparted In Diagnostic Radiology Worcester Polytechnic Institute Worcester, MA Bachelor of Science in Nuclear Engineering Major Qualifying Project: A Camac LabView Macintosh Nuclear Medicine Imaging System Interactive Qualifying Program: A Revealing Look Into The Department Of Defense s Use Of Military Specifications Sufficiency: The Republic Of Plato i

1988 1992 Since 1993 1994 1998 Professional memberships American Nuclear Society (ANS) American Association of Physicists in Medicine (AAPM) Health Physics Society (HPS) Since 1992 Other memberships American Hellenic Educational Progressive Association (AHEPA) Apr 2001 Present Employment LORAD, A Hologic Company Medical Physicist R&D Scientist: hired as a member of the scientific research team to assist in the development of next generation mammography and breast biopsy systems. Responsibilities: Contribute to the development of new x-ray imaging systems for mammography and breast cancer biopsy Develop image processing algorithms for full field digital mammography. Steer the development of softcopy diagnostic review workstation for full field digital mammography. Participate in the development of novel PACS solutions for full field digital mammography. Create and review design requirement documents for the full field digital mammography systems. Develop QA and QC procedures for full field digital mammography. Other activities: Educate radiologists and mammography technologists on full field digital mammography technologies and practices. Participate and provide scientific support at the Radiological Society of North America (RSNA) show and other similar medical shows in North America and abroad. Give full field digital mammography presentations at trade shows and to customers. Research and Development: Image processing in digital imaging. Digital x-ray detectors. Direct capture of x rays. Advanced application in full field digital mammography. July 2000 Mar 2001 Baylor University Medical Center, Dallas, TX Medical Physicist Clinical: hired as a clinical Medical Physicist in Diagnostic Radiology and Nuclear Medicine ii

Responsibilities in Radiology: Develop protocols for testing film-based and digital imaging systems for commissioning, verification of regulatory compliance and image quality assurance. Perform acceptance and routine quality control testing for radiographic, tomographic, fluoroscopic, angiographic, cardiac catheterization, mammographic, computed radiography and computed tomography imaging modalities. Establish image quality standards for film-based and digital imaging systems. Troubleshoot image quality issues. Consult in developing imaging protocols for computed radiography systems. Responsibilities in Nuclear Medicine: Develop quality control programs to follow the performance of nuclear medicine imaging cameras. Perform monthly quality management and quarterly audits of nuclear medicine departments. Perform acceptance testing and routine evaluation of nuclear medicine imaging cameras. Evaluate the performance of SPECT imaging nuclear medicine cameras. Evaluate data analysis algorithms for nuclear medicine processing software. Evaluate the performance of a multiline attenuation correction source for SPECT imaging. Troubleshoot image quality issues with nuclear medicine imaging cameras. Troubleshoot hardware issues with nuclear medicine instrumentation. Consult patients regarding radiation safety after the administration of therapeutic doses of radionuclides. Perform dosimetry calculations for patients and the public from nuclear medicine diagnostic and therapeutic procedures. Act as a liaison between service personnel and the department of nuclear medicine. Assist with the accreditation of the nuclear medicine department. Other Responsibilities: Educate other medical physicists on image quality standards and controls. Assist in teaching medical physics to radiology residents and technologists. Assist with the hospital in-service program regarding radiation safety. Assist in personnel training for handling radioactive materials. Perform radiation surveys. Perform dosimetry calculations for patients undergoing radiologic procedures. Compute fetal doses. Calculate shielding requirements for radiographic, fluoroscopic, computed tomography and nuclear medicine rooms. Evaluate and consult on different patient exposure meters for use during high exposure radiologic and cardiac procedures. Consult on image quality and patient dosimetry issues. Review IRB protocols regarding radiation safety. iii

Participate in Radiation Safety Committee meetings. Dec 1998 June 2000 Imaging Diagnostic Systems, Inc., Plantation, FL Medical Physicist R&D Scientist: hired as a member of the development efforts of the patented computed tomography laser mammography scanner (CTLM TM ). Responsibilities: Act as a member of the research and development team for the computed tomography laser mammography (CTLM ) scanner. Act as a member of the research and development team for fluorescence optical imaging tomography. Act as a consultant to management and other entities within the organization. Collect and analyze experimental data to aid in the advancement of the optical tomography scanner. Create theoretical models of optical processes to validate experimental results. Develop and implement testing protocols and necessary test fixtures to fully characterize optical tomography scanners. Calibrate optical tomography scanners. Develop criteria for acceptance testing of optical tomography scanners. Design and perform experiments to study principles of optical imaging. Design and make optical imaging phantoms. Research, recommend and evaluate new imaging detectors and support electronics for optical imaging. Develop requirements for laser light sources and evaluate same. Teach principles of medical physics and optical imaging to engineers, scientists and technologists. Evaluate and interpret first clinical images acquired using optical computed tomography and optical computed fluorescence tomography. Teach the science of optical computed tomography image interpretation to radiologists and radiology residents. Other activities: Consult on clinical trials of the computed tomography laser mammography (CTLM ). Compile results from clinical trials of optical imaging tomography. Contribute to the Food and Drug Administration (FDA) submission of case studies in optical computed tomography. Contribute to the development of calibration, acquisition and image reconstruction software. Evaluate and suggest improvements to new software. Write software specifications. Develop database software. Design security schemes for software and hardware implementation and consult on same. Participate and provide scientific support at the Radiological Society of North America (RSNA) show and other similar medical shows. iv

Research: Optical imaging. Optical detectors. Light interaction with matter. Perturbation extraction in optical imaging using analytic models. Perturbation extraction in optical imaging using finite elements method (FEM). Use of optical contrast agents in optical imaging. 3-D optical imaging using fluorescent contrast agents. Fall 1992 Fall 1998 Department of Radiology, University of Florida, Gainesville, FL Graduate Assistant / Medical Physicist: hired as part time graduate assistant to help the Department of Radiology to perform daily quality assurance and control tasks. Evolved to a part time Medical Physicist with research and clinical responsibilities under supervision. Quality Control and Quality Assurance in Radiology: Develop protocols for testing film-based and digital imaging systems for commissioning, verification of regulatory compliance and image quality assurance. Perform acceptance and routine quality control testing for radiographic, tomographic, fluoroscopic, angiographic, cardiac catheterization, mammographic, computed radiography and computed tomography imaging modalities. Develop an image quality assurance program for fluoroscopic and digital angiographic equipment. Assist in developing a computed tomography quality assurance program. Troubleshoot image quality problems. Other Responsibilities: Configure, calibrate, troubleshoot, maintain and upgrade a patient dosimetry network in neuroradiology. Act as a consultant to department of radiology on the acquisition of new diagnostic x-ray equipment. Participate in reliability testing of computed radiography systems. Perform shielding design for radiographic, fluoroscopic and computed tomography rooms. Compute fetal and patient doses from x-ray imaging procedures. Create exposure chart for x-ray equipment. Develop database programs for quality assurance and patient doses. Maintain quality control of testing equipment. Act as a liaison between service engineers and the Department of Radiology. Clinical Research: Optimization of imaging parameters for the use of CO 2 in intra-arterial, digital subtraction angiography. v

Optimization of imaging techniques with respect to image quality and patient dose for neonatal and pediatric patients. Comparison of image quality and patient dose between a dedicated chest unit and a computed radiography chest unit. Study of the effects of viewbox luminance and conditions on reader performance. Patient doses in neuroradiology. Pediatric dosimetry. Dosimetry in computed tomography. Evaluation of radiation protective devices. Evaluation of film-screen combinations. X-ray beam characteristics. Teaching: Teach new medical physics graduate students during their clinical rotations. Train medical physics graduate assistants to perform acceptance testing, routine quality control and image quality assurance testing on most diagnostic imaging modalities. Teach instrumentation principles and design as well as testing procedures to medical physics graduate assistants. Assist in teaching imaging physics to radiology residents. Fall 1991 - Spring 1992 Department of Nuclear Medicine, University of Massachusetts Medical Center, Worcester, MA Research Engineer: worked on the development of a novel intraoperative nuclear gamma camera under the Major Qualifying Project (MQP) program at Worcester Polytechnic Institute. Research and Development: Built modular image acquisition hardware for a novel, 3-inch, position sensitive intraoperative nuclear gamma camera. Interface the image acquisition hardware to a Macintosh computer and develop the software to configure and control image acquisition, image process and display. Evaluate the imaging characteristics of the position sensitive intraoperative gamma camera. Fall 1990 - Spring 1991 Department of Mechanical Engineering, Nuclear Reactor, Worcester Polytechnic Institute, Worcester, MA Nuclear Reactor Operator: participated in the nuclear reactor operator training. Experience: Operate a 10KW open-pool experimental nuclear reactor. Fall 1990 Manufacturing Studies Board, Commission on Engineering and Technical Systems, National Research Council, Washington, DC vi

Co-op: worked with the Manufacturing Studies Board at the National Research Council examining the use of military specifications within the Defense Acquisition Process as part of the Interactive Qualifying Project (IQP) program at Worcester Polytechnic Institute. Responsibilities: Provide the Committee on Defense Manufacturing Strategy with an assessment of the use of military specifications within the Defense Acquisition Process. Evaluate the major problems associated with military specifications. Evaluate the use of commercial specifications in place of military specifications. Fall 1988 - Spring 1989 Department of Computer Sciences, Worcester Polytechnic Institute, Worcester, MA Student work: hired by the department of Computer Sciences to administer a network of UNIX PCs. Responsibilities: Administer a network of UNIX PCs. Establish network connectivity between the UNIX PCs and an IBM mainframe computer. Help users with the UNIX operating system. Computer Skills Programming in C/C++, IDL, Fortran, BASIC, Pascal, Graphic G, UNIX shells Algorithm evaluation Software design and specifications Commercial application development Database development Data network design and implementation Administration of UNIX and Windows NT systems Awards received April 21, 1995 March 23, 1996 1995 Annual Meeting of the Florida Chapter of the American Association of Physicists in Medicine (AAPM) Orlando, FL Best Paper Presentation: Computation of energy imparted in diagnostic radiology. American Nuclear Society (ANS) and Society of Health Physics (HPS) Eastern Regional Student Conference Gainesville, FL Best Paper Presentation in Radiation Dosimetry: Evaluation of an on-line patient exposure meter in neuroradiology. vii

December 6, 1996 82 nd Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) Chicago, IL Certificate of Merit: Viewbox luminance measurements and their effect on reader performance. In progress Books Huda W, Gkanatsios NA. Patient Effective Doses in Diagnostic Radiology. Medical Physics Publishing. Your Computer, UK RSNA 1997 -- AAPM 1998 Software Gkanatsios NA. "CASTLE: Arcade adventure for Amstrad CPC range computers." Your Computer 6(10): 74 (1986). Gkanatsios NA. "exodose: Computation of dosimetric parameters in computed tomography." Publications Physica Medica Medical Physics Medical Physics Radiology Medical Physics Health Physics Academic Radiology SPIE SPIE Medical Physics Peer Reviewed Journals Gkanatsios NA, Mardirossian G, Matsushita T, Karellas A, Rajeevan N, Garcia M, Redus R, Fogarty M, Bacharach S, Brill AB. A portable Camac LabView nuclear medicine imaging system. Physica Medica 9: 229-232 (1993). Geiser WR, Huda W, Gkanatsios NA. Effect of patient support pads on image quality and dose in fluoroscopy. Medical Physics 24: 377-382 (1997). Gkanatsios NA, Huda W. Computation of energy imparted in diagnostic radiology. Medical Physics 24: 571-579 (1997). Gkanatsios NA, Huda W, Peters KR, Freeman JA. Evaluation of an on-line patient exposure meter in neuroradiology. Radiology 203: 837-842 (1997). Huda W, Gkanatsios NA. Effective dose and energy imparted in diagnostic radiology. Medical Physics 24: 1311-1316 (1997). Huda W, Gkanatsios NA. Radiation dosimetry for extremity radiographs. Health Physics 75: 492-499 (1998). Rill LN, Huda W, Gkanatsios NA. Viewbox luminance measurements and their effect on reader performance. Academic Radiology 6: 521-525 (1999). Grable RJ, Ponder SL, Gkanatsios NA, Olivier P, Hall DJ, Zeng Y, Wake R. Optical computed tomography for imaging the breast: first look. Proceedings of SPIE Vol. 4082: 40-45 (2000). Gkanatsios NA, Huda W, Peters KR. How does magnification affect image quality and patient dose in digital subtraction angiography? Proceedings of SPIE Vol. 4320: 326-330 (2001). Gkanatsios NA, Huda W, Peters KR. Adult patient doses in interventional neuroradiology. Medical Physics 29: 717-723 (2002). viii

Medical Physics Gkanatsios NA, Huda W, Peters KR. Effect of radiographic techniques (kvp &mas) on image quality and patient doses in digital subtraction angiography. Medical Physics 29: 1643-1650 (2002). Pediatric Neuroradiology Publications in Preparation Gkanatsios NA, Huda W, Peters KR. Pediatric patient doses in interventional neuroradiology. To be submitted to Pediatric Neuroradiology. Worcester Polytechnic Institute National Research Council Worcester Polytechnic Institute University of Florida COMP COMP University of Florida Applied Radiology Other Publications Gkanatsios NA. Sufficiency: The Republic Of Plato. Worcester MA: Worcester Polytechnic Institute (1989). Gess D, Gkanatsios NA, Jones C. A Revealing Look Into The Department Of Defense s Use Of Military Specifications. Washington, DC: Manufacturing Studies Board, National Research Council (1990). Gkanatsios NA. Bachelor Thesis (MQP): A Camac LabView Macintosh Nuclear Medicine Imaging System. Worcester MA: Worcester Polytechnic Institute (1992). Gkanatsios NA. Master Thesis: Computation of Energy Imparted in Diagnostic Radiology. Gainesville, FL: University of Florida (1995). Gkanatsios NA, Huda W. Patient effective doses in diagnostic radiology. Conference Proceedings p.:28-30, 43 rd Annual Scientific Meeting (Canadian Organization of Medical Physicists), Charlottetown, PEI Canada (1997). Huda W, Gkanatsios NA, Botash RJ, Botash AS. Pediatric effective doses in diagnostic radiology. Conference Proceedings p.:114-116, 44 th Annual Scientific Meeting (Canadian Organization of Medical Physicists), London, Ontario Canada (1998). Gkanatsios NA. Doctoral Dissertation: Patient Doses and Image Quality in Interventional Neuroradiology. Gainesville, FL: University of Florida (1998). Grable R, Gkanatsios NA, Ponder SL. Optical mammography. Applied Radiology 29: 18-20 (2000). PMB 1992 AAPM 1994 RSNA 1994 Florida AAPM 1995 Presentations Gkanatsios NA, Mardirossian G, Matsushita T, Karellas A, Rajeevan N, Garcia M, Redus R, Fogarty M, Bacharach S, Brill AB. A portable Camac LabView nuclear medicine imaging system. [POSTER] Presented at the IV International Conference on Applications of Physics to Medicine and Biology, Miramare - Trieste, Italy (September 1992). Gkanatsios NA, Huda W, Tucker DM. Computation of energy imparted in diagnostic radiology. Medical Physics 21: 948. [ORAL/POSTER] Presented at the AAPM in Anaheim, CA (July 1994). Gkanatsios NA, Huda W, Tucker DM. Computation of energy imparted in diagnostic radiology. Radiology 193(P): 283. [POSTER] Presented at the RSNA in Chicago, IL (November 1994). Gkanatsios NA, Huda W. Computation of energy imparted in diagnostic radiology. [ORAL] Presented at the 1995 Annual Meeting of the Florida Chapter of the AAPM, Orlando, FL (April 1995). ix

AAPM 1995 AAPM 1995 RSNA 1995 Student ANS/HPS 1996 AAPM 1996 RSNA 1996 RSNA 1996 COMP 1997 COMP 1998 AAPM 1998 RSNA 1998 RSNA 1998 RSNA 1999 SPIE 2000: Photonics Taiwan AAPM WC2000 AAPM WC2000 Gkanatsios NA, Huda W. Can water phantoms simulate real patients for estimating energy imparted? Medical Physics 22: 946. [ORAL/POSTER] Presented at the AAPM in Boston, MA (July 1995). Geiser WR, Gkanatsios NA, Huda W. Image quality and patient dose in pediatric fluoroscopy. Medical Physics 22: 972. [ORAL/POSTER] Presented at the AAPM in Boston, MA (July 1995). Gkanatsios NA, Huda W, Peters KR, Freeman JA. Evaluation of an on-line patient exposure meter in neuroradiology. Radiology 197(P): 359. [ORAL] Presented at the RSNA in Chicago, IL (November 1995). Gkanatsios NA, Huda W, Peters KR, Freeman JA. Evaluation of an on-line patient exposure meter in neuroradiology. [ORAL] Presented at the ANS/HPS Eastern Regional Student Conference in Gainesville, FL (March 1996). Huda W, Gkanatsios NA. Effective dose and energy imparted in radiology. Medical Physics 23: 1181. [POSTER] Presented at the AAPM in Philadelphia, PA (July 1996). Huda W, Gkanatsios NA, Cumming WA. Effective doses to pediatric patients in abdominal radiography. Radiology 201(P): 150. [ORAL] Presented at the RSNA in Chicago, IL (December 1996). Rill L, Huda W, Geiser WR, Gkanatsios NA. Viewbox luminance measurements and their effect on reader performance. Radiology 201(P): 529. [SCIENTIFIC EXHIBIT] Presented at the RSNA in Chicago, IL (December 1996). Gkanatsios NA, Huda W. Patient effective doses in diagnostic radiology. Medical Physics 24: 1196. [POSTER] Presented at COMP in Charlottetown, PEI Canada (July 1997). Huda W, Gkanatsios NA, Botash RJ, Botash A. Pediatric effective doses in diagnostic radiology. Medical Physics 25: 1080. [POSTER] Presented at COMP in London, Ontario Canada (June 1998). Gkanatsios NA, Huda W, Peters KR. Patient doses in interventional neuroradiology. Medical Physics 25: A166. [ORAL/POSTER] Presented at the AAPM in San Antonio, TX (August 1998). Gkanatsios NA, Huda W, Peters KR. How does magnification affect patient dose and image quality in neuroradiologic Digital Subtraction Angiography? Radiology. [ORAL/POSTER] Presented at the RSNA in Chicago, IL (December 1998). Klioze S, Huda W, Mergo P, Gkanatsios NA. Patient specific mas values in chest biopsy CT imaging. Radiology. [ORAL/POSTER] Presented at the RSNA in Chicago, IL (December 1998). Gkanatsios NA, Huda W, Peters KR. Adult patient doses in interventional neuroradiology. Radiology. [ORAL] Presented at the RSNA in Chicago, IL (December 1999). Grable RJ, Ponder SL, Gkanatsios NA, Olivier P, Hadd DJ, Zeng Y, Wake R. Optical computed tomography for imaging the breast: first look. SPIE: Photonics Taivan. [ORAL] Presented at the SPIE International Optoelectronics Symposium, Taipei, Taiwan (July 2000). Gkanatsios NA, Huda W, Peters KR. The effect of x-ray tube voltage on patient dose and image quality in digital subtraction angiography. Medical Physics 27: *** [ORAL/POSTER] Presented at the AAPM WC2000 in Chicago, IL (July 2000). Gkanatsios NA, Huda W, Peters KR. Radiation doses to pediatric patients undergoing interventional neuroradiologic procedures. Medical Physics 27: *** [ORAL/POSTER] Presented at the AAPM WC2000 in Chicago, IL (July 2000). x

References Available upon request xi