Complete starter packs for accelerated results

Solutions Complete starter packs for accelerated results Clinical Research imethod Tests Software Food Testing Environmental Analysis Service Network Forensic Toxicology Worldwide Support imethod Store

Testing laboratories worldwide are turning to the analytical power of to help them improve data accuracy, streamline process efficiencies, and increase throughput all at significant savings. It s no wonder that methods are replacing conventional techniques for the analysis of drugs, toxic compounds, and contaminants. 1973 1980 1989 1998 SCIEX Founded TAGA 6000 The Mobile TAGA 6000 EM API III System API 100 and 300 Systems API 3000 System

The voice of experience Innovative technology from Applied Biosystems/MDS Analytical Technologies opens the door to opportunity for testing labs specializing in food and beverage analysis, environmental analysis, clinical research, and forensic toxicology. For more than 25 years, we ve set the benchmarks for performance and dependability, holding over 630 patents that include some of the most important advances in mass spectrometry. With an installed base of over 12,000 instruments worldwide, the experience we bring to your lab speaks volumes. 2000 2001 2002 2005 2008 API 2000 System API 4000 System QTRAP Technology API 5000 System AB SCIEX QTRAP 5500 and Triple Quad 5500

Applied Biosystems/MDS Analytical Technologies offers a complete portfolio of affordable, high performance starter packs to help ease the adoption of technology in your lab. We ve taken and made it simple, delivering starter packs that combine performance and ease of use to help breakdown the perceived barriers to implementing technology in your lab.

A complete portfolio of application-specific starter packs Custom build starter packs that deliver advanced capabilities, while significantly reducing your time to results. Using best in class technologies you can tailor a complete solution or optimize your existing laboratory setup to simplify routine testing. Accurate analyses become easy to manage for even the novice user. Expert users can access comprehensive MS/MS libraries and use the data to create new or customized methods, which they can then easily share with colleagues. It also means more time available to manage the lab or other priorities. Choose one of our complete starter packs for food, environmental, clinical research, or forensic toxicology for a total application solution. Each complete starter pack combines the best mass spectrometry instrument, HPLC, and ion source to optimize your application. Add Cliquid application-specific software that virtually walks you through analyses, a downloadable, lab proven imethod Test and worldwide service and training, and it s like having an expert scientist on staff 24 hours a day. Each instrument system in our complete starter packs has been chosen to exceed the sensitivity required to perform a range of common industry tests. With the option to purchase additional imethod Tests, our complete application starter packs meet both your immediate requirements and provide scope for the future, should your laboratories needs grow. Discover what leading labs throughout the food, environmental, forensic and clinical research community already know. Applied Biosystems/MDS Analytical Technologies starter packs provide the easiest way to deploy new methods to generate, high-quality results, in weeks instead of months. Starter Pack Components AB SCIEX Triple Quad or QTRAP System Industry-leading front-end HPLC system Analyst Software Version 1.5, with Scheduled MRM Algorithm Cliquid Software, with fast and easy, 4-step workflow Pre-configured, application-specific imethod Tests Access to a portfolio of downloadable imethod Tests Expert training to speed implementation Dedicated worldwide service and support network

imethod Store The imethod Store provides access to an entire portfolio of preconfigured methods which you can purchase and download directly into Cliquid Software. imethod Tests are available for a broad range of compounds, each optimized for your system, so you can skip method development and begin analysis immediately. The result is significant time, effort, and cost savings when deploying new tests. The imethod Tests portfolio is continually updated with the latest lab-proven methods, as well as methods contributed by labs from around the world. Visit info.appliedbiosystems.com/imethods imethod Tests Lab-proven imethod Tests are the easiest way yet to access the power of, and the fastest way to help generate accurate results. imethod Tests eliminate the need for method development, simply download from the Web or a CD into Cliquid Software and start running samples. Example imethod tests available: Clinical Research Immunosuppressants Mycophenolic Acid Vitamin D Inborn Errors of Metabolism Research Amino Acid Analysis Forensic Toxicology Drugs of abuse Drug Library (1250 compounds) Benzodiazepines Opiates Food Testing Pesticides Acrylamide Azo Dyes Chloramphenicol Nitrofurans Fluoroquinolones Melamine Malachite green Water Testing Pharmaceutical Personal Care Products Pesticides in Water Fluorinated Surfactants With imethod Tests you can easily run samples, create new tests, or customize existing methods. Worldwide Support Application support We provide the world s most extensive application support network, with more than 170 dedicated mass spectrometry specialists in 13 global customer support labs. We ensure you achieve the best possible results and help you optimize your applications and workflows via phone, email, online or through onsite visits. Training We offer comprehensive, hands-on instrument training via self-paced learning, live e-learning training sessions and applications-based courses across a wide range of methods and compounds. Tests imethod imethod Store More o you need starte Analysis made simple. W or a newcomer to food an clinical research, or forens leading star to deploy new meth immediately begin re of for Worldwide Support

Software Software f what in every r pack hether you re an expert d environmental analysis, ic toxicology, our industryter packs make it easy ods in your lab, and alizing the benefits routine testing. Service Network Cliquid Software An essential tool for simplifying routine analyses without compromising the quality of results. The point-and-click operation and 4-step workflow greatly simplify even complex analysis. Flexible data analysis and extensive reporting tools provide further in-depth review of your results. Analyst 1.5 Software Get enhanced performance and state-of-the-art functionality for instrument control, data analysis, and reporting. The Scheduled MRM Algorithm makes it easy to schedule overlapping MRM monitoring periods, allowing you to maximize quantitative performance, accuracy and throughput. ChemoView Software Clinical researchers now have the ability to process and review large data sets based on compound response, concentration, and calculated results while highlighting results that fall outside of predetermined limits set by the user. Mass Spectrometry Our industry leading triple quadrupole systems deliver quantitative performance and robustness, ranging from the API 2000 entry-level system for routine analysis to today s most sensitive triple quadrupole, the AB SCIEX Triple Quad 5500 System. Innovative QTRAP System Technology combines industry leading triple quadrupole technology with high performance linear ion trap capability. We offer a range of QTRAP Technology to suit every budget, from the economical 3200 QTRAP System that delivers superior performance and productivity, to the ultra-performance AB SCIEX QTRAP 5500 System, an extraordinary system with no sacrifice in qualitative or quantitative performance. HPLC Our flexibility to offer the best front-end HPLC system available helps your applications achieve optimum performance, creating systems that deliver maximum throughput and productivity. Ion sources Systems are supplied with the industry leading plug-and-play Turbo V Source, long considered the gold standard for unmatched robustness, performance, ease of maintenance, and ease of use. Service Network Our application-specific starter packs are backed by the world s most extensive mass spectrometry service network, with more than 300 dedicated mass spectrometry service specialists worldwide. From business consulting and protocol development to instrument repair, optimization and application integration, our service specialists can help your lab increase productivity and efficiency.

More ways to help your laboratory excel Realize the benefits of technology with any of Applied Biosystems/MDS Analytical Technologies Starter Packs Run more samples per analysis per day Our best in class technology significantly reduces sample preparation and LC run times to dramatically increase throughput. You ll also be able to increase the type and variety of tests you can perform with a single instrument. Be up and running quicker Applied Biosystems/MDS Analytical Technologies Starter Packs make implementing in your laboratory as easy as combining the superior performance of our technology, the 4-step workflow of Cliquid Software, and preconfigured imethod Tests. You can be up and running in just a matter of hours, significantly reducing the time from sample to result. Easy-to-use applications Our starter packs virtually walk you through each analysis. Cliquid Software allows you to select a test, build a sample list, run the sample, and report results with push-button ease. Even laboratories without mass spectrometry experience can successfully run complex analyses.

Downloading imethod Tests directly into Cliquid Software gives you instant access to lab-proven methods. Because all imethod Tests are lab-proven and optimized for your system, you can begin analysis immediately. Best-in-class performance Offering unsurpassed performance our starter packs combine industry-leading API Triple Quadrupole and QTRAP Systems, front-end HPLC, Cliquid Software s 4-step workflow, lab-proven imethod Tests, and the world s most extensive training, service, and support network. At every turn, we re committed to helping deliver optimum results. Faster return on investment See a faster return on your investment with starter packs that deliver more results, at higher confidence, in less time. Applied Biosystems/MDS Analytical Technologies API Triple Quadrupole and QTRAP System technologies provide increased throughput, enabling you to quantify more compounds in a set period of time, with less sample preparation and greater sensitivity, reducing the cost per analysis and the need for re-analysis. Cliquid Software s 4-step workflow provides the ability to analyze even more compounds per test, and perform more tests per day. And starting with an imethod Test can save you not only months of time and effort, but thousands of dollars in the deployment of a new test. Worldwide service and support All our starter packs are backed by one of the industry s most extensive worldwide training, service and support networks dedicated to mass spectrometry more than 170 chemists in 13 global customer support labs and over 300 service imethod Tests vs. traditional in house method development Activity Create Test Protocol Documentation Create Sample Prep Method Optimized MS/MS Acquisition Parameters Create LC Instrument Parameters with Retention Times imethod Test Included specialists, plus e-mail, phone, and online contact. Our comprehensive, hands-on training further ensures that you get the most from every application. Included, with examples and references Included Included Create Integration Parameters Included Days Create Reporting Templates Included Days Create Library Spectra Staff Training on Method Perform Method Validation Complete Test Development and Deployment Realize your full analytical potential Applied Biosystems/MDS Analytical Technologies stands ready to help you develop best-in-class solutions that meet both your immediate needs and May be included. Stand-alone libraries are also available Simple Cliquid Software interface, no additional training Weeks. Validation templates and support available Weeks Traditional Methods Development Weeks - Months Weeks - Months Weeks - Months Days - Weeks Weeks - Months Days - Traditional MS Software and review procedures Weeks - Months 6-12 months provides a viable path for future growth. Whether you re new to or are looking for ways to accelerate method deployment, we have a starter pack that helps you get up and running quickly generating results.

.06 2.08 2.10 2.1 2 2.1 4 2.16 2.18 2.20 2.22 2. Conduct research with complete confidence Applied Biosystems/MDS Analytical Technologies leads the way in, working closely with clinical research and forensic toxicology laboratories worldwide to develop fast, sensitive, and easy-to-use solutions that meet your specific needs. Clinical Research XIC of +MRM (3 pairs): 383.4/211.1 amu from Sample 29 (QC 1 (10 ng/ml)) of samples-set 1.wiff (Heated Nebulizer) Max. 7600.0 cps. Forensic Toxicology 7500 7000 6500 6000 5500 5000 4500 4000 3500 3000 2500 2000 1500 ISTD 25-OH-Vit D3 25-OH-Vit D2 1000 500 0 1.49 1.69 1.83 1.95 2.07 2.172.29 2.38 2.58 0.65 2.81 2.8 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 2.68 The advantages of versus traditional clinical research tools, are significant: faster time to results, lower cost per sample, increased accuracy and sensitivity, and the ability to detect multiple analytes in a single analysis. Now you can quickly and accurately identify and quantify minute amounts of compounds in complex sample matrices such as blood, urine, and oral fluid. Whether you need a cost-effective solution for investigating high-throughput therapeutic drug monitoring, the utmost in accuracy and sensitivity to study panels of steroids, or the speed and versatility to identify and quantify hundreds of targeted drugs simultaneously, Applied Biosystems/MDS Analytical Technologies Starter Packs deliver the technology required to quickly generate high quality results. Clinical Research: Extracted ion chromatograms for a 10 ng/ml extracted calibrator for Vitamin D analysis. Forensic Toxicology: Screening and identification of more than 300 drugs of abuse compounds using an imethod Test. The use of for forensic toxicology has increased dramatically over the last 10 years and is now widely used for both qualitative and quantitative analysis. provides the ability to analyze a wider molecular weight and polarity range of compounds with better sensitivity, reduced sample preparation, and no derivitization, in less time. Applied Biosystems/MDS Analytical Technologies Starter Packs for forensic toxicology deliver the most powerful combination available for drugs of abuse screening enabling you to screen for, identify and confirm, hundreds of drugs in a single run, as well as quantitate them once found. Now analyze more compounds per analysis, and more analyses per day.

Meet and exceed regulatory demands Applied Biosystems/MDS Analytical Technologies leads the way in bringing confidence, certainty, and capabilities to contaminant testing with industry-leading starter packs, making it easier to get reliable answers, as well as fast, accurate results when you need them. Food Testing Water Testing Concern about food quality and safety is on the rise. To ensure food supplies remain safe for consumption, producers, manufacturers and regulatory agencies are being required to test more products, more accurately, and in less time. Applied Biosystems/MDS Analytical Technologies Starter Packs for food testing are your assurance that you can identify food contaminants in raw materials and finished products before they become an issue. Whether you re analyzing drugs, pesticides, toxins, or potential adulterants, our starter packs deliver easy-to-use solutions that speed the adoption of in your lab. The ability to accurately detect more contaminants at lower levels in a single analysis will enable you to make faster, more informed decisions about next steps. Food Testing: Detection of pesticides (Thiabendazole, Imazalil and Spiroxamine) in food. Intensity, cps Intensity, cps Intensity, cps XIC of +MRM (24 pairs): EXP 2, 294.0/249.9 amu from Sample 8 (100 pp...) Max: 1.9e6 cps. XIC of +MRM (24 pairs): EXP 2, 307.0/161.0 amu from Sample 8 (100 pp...) Max: 2.9e6 cps. 36.03 34.37 1.9 e6 2.9 e6 1.5 e6 2.5 e6 1.4 e6 1.2 e6 2.0 e6 Diclofenac Warfarin 1.0 e6 1.5 e6 8.0 e5 6.0 e5 1.0 e6 4.0 e5 6.0 e5 2.0 e5 0.0 0.0 34.5 35.0 35.2 35.4 35.8 35.8 36.0 36.2 36.4 36.6 36.8 37.0 37.2 37.4 33.5 34.0 34.5 35.0 35.5 36.0 36.5 Time, min Time, min XIC of +MRM (24 pairs): EXP 2, 213.0/126.9 amu from Sample 8 (100 pp...) Max: 2.7e6 cps. 33.17 2.5 e6 2.0 e6 1.5 e6 Clofibric 1.0 e6 Acid 6.0 e5 0.0 32.0 32.5 33.0 33.5 34.0 34.5 35.0 35.5 36.0 Time, min XIC of +MRM (24 pairs): EXP 2, 205.0/161.0 amu from Sample 8 (100 pp...) Max: 1.8e5 cps. 36.65 1.9 e5 1.5 e5 1.4 e5 1.2 e5 1.0 e5 Ibuprofen 8.0 e4 6.0 e4 4.0 e4 2.0 e4 0.0 35.0 36.0 36.2 36.4 36.6 36.8 37.0 37.2 37.4 37.6 37.8 38.0 38.2 38.4 38.6 Time, min XIC of +MRM (24 pairs): EXP 2, 178.8/136.0 amu from Sample 8 (100 pp...) Max: 8.1e4 cps. XIC of +MRM (24 pairs): EXP 2, 322.0/153.0 amu from Sample 8 (100 pp...) Max: 3.4e4 cps. 23.05 24.55 8.0 e4 3.4 e4 7.0 e4 3.0 e4 6.0 e4 2.5 e4 5.0 e4 2.0 e4 Acetylsalicylic Chloramphenicol 4.0 e4 1.5 e4 3.0 e4 1.0 e4 2.0 e4 Acid 1.0 e4 5000.0 0.0 0.0 22.0 22.5 23.0 23.5 24.0 24.5 25.0 24.0 24.5 25.0 25.5 26.0 26.5 27.0 Time, min Time, min Water Testing: Pharmaceuticals detected in river influent. Intensity, cps Intensity, cps Intensity, cps Damage to human health caused by water contaminants is well documented, and laboratories face a constant battle to find new technologies to detect contaminants at increasingly lower levels. Applied Biosystems/MDS Analytical Technologies Starter Packs meet or exceed today s challenging and ever-changing regulatory guidelines. From pharmaceuticals and pesticides, to algal toxins and other emerging contaminants, our Starter Packs allow you to analyze more compounds in less time, with greater confidence, as well as improve your ability to respond to environmental regulatory changes as they happen.

Accelerate your time to results with leading edge starter packs Research laboratories worldwide are turning to Applied Biosystems/MDS Analytical Technologies technology for increased specificity, sensitivity, and robustness, qualities often lacking in conventional techniques such as GC/MS, LC/UV, and immunoassay. The right answer, the first time Superior sensitivity and low detection limits together with high specificity lead to better data and greater confidence in your results. Faster time to results significantly reduces sample preparation and LC run times, and dramatically increases throughput to give results in minutes, not hours. Easy-to-use methods methods can be implemented quickly and easily, even in laboratories without extensive mass spectrometry experience. Broader application coverage The flexibility and versatility of detection increase the type and variety of testing you can perform with a single instrument. Fast and easy updates for analytes allows you to modify methods and incorporate new analytes quickly and easily, without extensive redevelopment. More compounds per analysis, more analysis per day Significantly improve throughput with the ability to screen for hundreds of compounds in the same run. Maximum instrument uptime Rugged and robust instrumentation allows you to run thousands of samples with minimal downtime. Lower operating costs Lower running costs and increased throughput of technology add up to significant savings, and a faster return on investment. Applied Biosystems/MDS Analytical Technologies is committed to keeping you at the forefront of life science research by providing you with the tools you need to turn opportunities into achievements. For Research Use Only. Not for use in diagnostic procedures. The imethod Tests described have been designed by Applied Biosystems to provide the sample prep and instrument parameters required to accelerate the adoption of these methods for routine testing. These methods are provided for information purposes only. Applied Biosystems provides no warranty of performance. The performance of these methods are not guaranteed due to many different potential variations, including instrument performance, tuning, and maintenance, chemical variability and procedures used, technical experience, sample matrices, and environmental conditions. It us up to the end user to make adjustments to the method to account for slight differences in equipment and/or materials from lab to lab as well as to determine and validate the performance of this method for a given instrument and sample type. Please note that a working knowledge of Analyst Software may be required to do so. The information included in this product is intended for reference and research purposes only. Applied Biosystems offers no guarantee as to the quality or suitability of this data and suitability of the information included in this (Library, database, etc.) for use with your specific application. Applied Biosystems and AB (design) are registered trademarks of Applied Biosystems or its subsidiaries in the US and/or certain other countries. API 2000, AB SCIEX Triple Quad, imethod, Scheduled MRM Algorithm and Turbo V are trademarks and AB SCIEX QTRAP, Analyst, Cliquid, itraq and QTRAP are registered trademarks of Applied Biosystems/MDS Analytical Technologies, a joint venture between Applied Biosystems and MDS Inc. All other trademarks are the sole property of their respective owners. 2008 Applied Biosystems and MDS Inc. Joint Owners. All Rights Reserved. Information subject to change without notice. Printed in the USA, 12/2008 Publication 114BR28-01 Headquarters 850 Lincoln Centre Drive Foster City, CA 94404 USA Phone 650.638.5800 Toll Free 800.345.5224 www.appliedbiosystems.com International Sales For our office locations please call the division headquarters or refer to our Web site at www.appliedbiosystems.com/about/offices.cfm