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Supplement to Siegfried s Annual Report 2017 GRI Content Index GRI Standard Disclosure Page Comments GRI 101 101 Foundation (2016) Organizational Profile GRI 102 General Disclosures (2016) 102-1 Name of the organization 75 102-2 Activities, brands, products, and services 8 11 102-3 Location of headquarters 73 102-4 Location of operations 73 102-5 Ownership and legal form 67 68 102-6 Markets served 15 102-7 Scale of the organization 3, 8 102-8 Information on employees and other workers 51 102-9 Supply chain 45 102-10 Significant changes to the organization and its supply chain 59 102-11 Precautionary Principle or approach 45 46 102-12 External initiatives 45 46 102-13 Membership of associations 52 Strategy 102-14 Statement from senior decision-maker 2 3 Ethics and integrity 102-16 Values, principles, standards, and norms of behavior 41, 43 Governance 102-18 Governance structure 2 3, 25, 41, 43 01

GRI Standard Disclosure Page Comments Stakeholder engagement 102-40 List of stakeholder groups 42 102-41 Collective bargaining agreements 51 102-42 Identifying and selecting stakeholders 41 42 102-43 Approach to stakeholder engagement 42 102-44 Key topics and concerns raised 42 Reporting practice 102-45 Entities included in the consolidated financial statements 59 102-46 Defining report content and topic boundaries 41, GRI Index p. 6 102-47 List of material topics 41, 43 102-48 Restatements of information No reformulations were required. 102-49 Changes in reporting There were no changes to the material topics and topic boundaries. 102-50 Reporting period 75 102-51 Date of most recent report 75 102-52 Reporting cycle 75 102-53 Contact point for questions regarding the report 75 102-54 Claims of reporting in accordance with the GRI Standards 75 102-55 GRI content index The GRI content index is available on the Internet at report.siegfried.ch 102-56 External assurance We did not have an independent external validation of the Sustainability Report drawn up by a third party. 02

Material Topics GRI Standard Disclosure Page Further information and omissions Corruption and Anti-Competitive Behavior 103-1 Explanation of the material topic and its boundary 43 103-2 The management approach and its components 43 103-3 Evaluation of the management approach 43 GRI 205 Anti-corruption (2016) 205-1 Operations assessed for risks related to corruption GRI 206 Anti-competitive behavior (2016) 206-1 Legal actions for anti-competitive behavior, anti-trust, and monopoly practices 43 43 Product Safety 103-1 Explanation of the material topic and its boundary 44 45 103-2 The management approach and its components 44 45 103-3 Evaluation of the management approach 44 45 GRI 416 Customer Health and Safety (2016) 416-1 Assessment of the health and safety impacts of product and service categories 44 45 Supplier Environmental Assessment 103-1 Explanation of the material topic and its boundary 45 103-2 The management approach and its components 45 103-3 Evaluation of the management approach 45 GRI 308 Supplier Environmental Assessment (2016) 308-1 New suppliers that were screened using environmental criteria GRI 414 Supplier Social Assessment (2016) 414-1 New suppliers that were screened using social criteria For the present, no data is available concerning the systematic examination of new suppliers social and environmental criteria. Siegfried will examine the establishment of the required processes and data collection systems in 2018. For the present, no data is available concerning the systematic examination of new suppliers social and environmental criteria. Siegfried will examine the establishment of the required processes and data collection systems in 2018. 03

GRI Standard Disclosure Page Further information and omissions Energy and Climate Change 103-1 Explanation of the material topic and its boundary 45 47 103-2 The management approach and its components 45 47 103-3 Evaluation of the management approach 45 47 GRI 302 Energy (2016) 302-1 Energy consumption within the organization 45 47 GRI 305 Emissions (2016) 305-1 Direct (Scope 1) GHG emissions 45 47 Waste and Pollution 103-1 Explanation of the material topic and its boundary 47 48 103-2 The management approach and its components 47 48 103-3 Evaluation of the management approach 47 48 GRI 306 Effluents and Waste (2016) 306-2 Waste by type and disposal method 47 48 Occupational Health and Safety 103-1 Explanation of the material topic and its boundary 48 50 103-2 The management approach and its components 48 50 103-3 Evaluation of the management approach 48 50 GRI 403 Occupational Health and Safety (2016) 403-2 Types of injury and rates of injury, occupational diseases, lost days, and absenteeism, and number of work-related fatalities 49 Data concerning the injury rate and the days lost rate are not available for 2017 and will be collected from 2018. Fair Working Conditions 103-1 Explanation of the material topic and its boundary 50 51 103-2 The management approach and its components 50 51 103-3 Evaluation of the management approach 50 51 GRI 401 Employment (2016) 401-2 Benefits provided to full-time employees that are not provided to temporary or part-time employee 51 04

GRI Standard Disclosure Page Further information and omissions Local Communities 103-1 Explanation of the material topic and its boundary 52 103-2 The management approach and its components 52 103-3 Evaluation of the management approach 52 GRI 413 Local Communities (2016) 413-1 Operations with local community engagement, impact assessments, and development programs 52 Public Policy 103-1 Explanation of the material topic and its boundary 52 103-2 The management approach and its components 52 103-3 Evaluation of the management approach 52 GRI 415 Public Policy (2016) 415-1 Political contributions 52 05

GRI Standards Material Topics and Topic Boundaries GRI 102-46 Siegfried s Value Chain Material Topics Supply Chain Siegfried Products Corruption and Anti-competitive Conduct Product Safety Sustainability in the Supply Chain Energy and Climate Change Waste and Contamination Occupational Health and Safety Fair Working Conditions Local Population Political Representation of Interest Siegfried Topic Boundaries 06

The Siegfried Group is a leading supplier in the global CMO market with production facilities in Switzerland, the USA, Malta, China, Germany, and France. Siegfried employs a workforce of about 2300 employees (FTE) at nine sites in six countries. The Siegfried Holding AG, headquartered in Zofingen (Switzerland), is listed on the Swiss Exchange (SIX:SFZN). We offer customized solutions for services in the development and production of active pharmaceutical ingredients, intermediates, and complex dosage forms (including sterile filling) as well as products from our portfolio. Siegfried Holding AG Untere Bruehlstrasse 4 CH-4800 Zofingen www.siegfried.ch 07