NANO-COMMUNICATIONS: AN OVERVIEW

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NANO-COMMUNICATIONS: AN OVERVIEW I. F. AKYILDIZ Georgia Institute of Technology BWN (Broadband Wireless Networking) Lab & Universitat Politecnica de Catalunya EntriCAT (Center for NaNoNetworking in Catalunya)

REFERENCES I.F. Akyildiz, F. Brunetti, and C. Blazquez, "NanoNetworking: A New Communication Paradigm", Computer Networks Journal, (Elsevier), June 2008. http://www.ece.gatech.edu/research/labs/bwn/nanos/ IFA 09 BARCELONA 2

Development of Nano-Machines IFA 09 BARCELONA 3

Nano-Machine Networking Nano-machines can be interconnected to execute more complex tasks in a distributed manner Resulting nano-networks are envisaged to expand the capabilities and applications of single nanomachines, both in terms of complexity and IFA 09 BARCELONA 4

Why can t we use traditional communication mechanisms for Nanonetworks? Communication Paradigms Electromagnetic Waves Acoustic Communication Nano-mechanical Communication Molecular Communication IFA 09 BARCELONA 5

A Possible Solution: Molecular Communication Defined as the transmission and reception of information encoded in molecules A new and interdisciplinary field that spans nano, ece, cs, bio, physics, chemistry, medicine, and information technologies IFA 09 BARCELONA 6

EXAMPLE: NANO-NETWORK FOR INTRABODY IFA 09 BARCELONA 7

Nanonetworks vs Traditional Communication Networks Features Traditional Molecular Carrier: Electromagnetic waves Molecules Signal type: Electronic, optical, mechanical Chemical Propagation speed: Sound or light Extremely low Medium conditions: Noise: Wired: almost immune Wireless: affect communication Electromagnetic field and signals Affect communication Particles and molecules in medium Other features: High energy consumption Low energy consumption IFA 09 BARCELONA 8

Nanonetworks vs Traditional Communication Networks Traditional communication Molecular communication IFA 09 BARCELONA 9

Molecular Communication Molecular Communication Short Range (nm to µm) Medium Range (µm to mm) Long Range (mm to m) Wired Wireless Wireless Wired Wireless Molecular Motors Ion Signaling (e.g., calcium, sodium, potassium, chlorine) Flagellated Bacteria Catalytic Nanomotors Axons Capillaries Pheromones Light Transduction Pollen/Spores IFA 09 BARCELONA 10

Short-Range Communication Molecular Motors (Wired) Calcium Ions (Wireless) IFA 09 BARCELONA 11

Short-Range Communication using Molecular Motors Features: Communication Range Medium nm - mm Aqueous environment with necessary molecules at biologically appropriate conditions Carrier Molecular Motors IFA 09 BARCELONA 12

Short-Range Communication using Molecular Motors What is a Molecular Motor? Is a protein or a protein complex that transforms chemical energy into mechanical work at a molecular scale Has the ability to move molecules IFA 09 BARCELONA 13

Short-Range Communication using Molecular Motors Molecular Motors: * Found in eukaryotic cells in living organisms * Molecular motors travel or move along molecular rails called microtubules * Movement created by molecular motors can be used to transport information molecules IFA 09 BARCELONA 14

Short-Range Communication using Molecular Motors IFA 09 BARCELONA 15

Short-Range Communication using Molecular Motors Encapsulation of information: Information can be encapsulated in vesicles. A vesicle is a fluid or an air-filled cavity that can store or digest cell products. IFA 09 BARCELONA 16

Short-Range Communication using Molecular Motors Encoding Transmission Propagation Reception Decoding Select the right molecules that represent information Attach the information packet to the molecular motor Microtubules (molecular rails) restrict the movement to themselves Information molecules are detached from molecular motors Receiver nanosensor invokes the desired reaction according to the received information IFA 09 BARCELONA 17

Short-Range Communication using Ion Signaling Features: Communication Range Medium nm - mm Aqueous environment with necessary molecules at biologically appropriate conditions Carrier Calcium Ions (Ca 2+ ) IFA 09 BARCELONA 18

Short-Range Communication using Calcium Signaling Two different deployment scenarios Direct Access Indirect Access Exchange of information among cells located next to each other Cells deployed separately without any physical contact IFA 09 BARCELONA 19

Short-Range Communication using Calcium Signaling Direct Access: Ca 2+ signal travel through gates IFA 09 BARCELONA 20

Short-Range Communication using Calcium Signaling Gap Junctions: Biological gates that allow different molecules and ions to pass freely between cells (membranes). IFA 09 BARCELONA 21

Short-Range Communication using Calcium Signaling Indirect Access: Transmitter nano-machine release information molecules to the the medium. Generate a Ca 2+ at the receiver nano-machine. IFA 09 BARCELONA 22

Short-Range Communication using Calcium Signaling Encoding Transmission Signal Propagatio n Reception Decoding Information is encoded in Ca 2+ Involves the signaling initiation Propagation of the Ca 2+ waves Receiver perceives the Ca 2+ concentration Receiver nano-sensor reacts to the Ca 2+ concentration IFA 09 BARCELONA 23

Problems of Short Range Molecular Communication Molecular Motors: Molecular motors velocity is 500 nm/s They detach of the microtubule and diffuse away when they have moved distances in the order of 1 µm Development of a proper network infrastructure of microtubules is required Molecular motors move in a unidirectional way through the microtubules very long communication delays! IFA 09 BARCELONA 24

Problems of Short Range Molecular Communication Calcium Signaling Very high delays for longer (more than few µm) distances IFA 09 BARCELONA 25

Medium Range Molecular Communication M. Gregori and I. F. Akyildiz, "A New NanoNetwork Architecture using Flagellated Bacteria and Catalytic Nanomotors," submitted for journal publication, March 2009. Flagellated bacteria Pheromones Pheromones Light transduction Pollen & Spores Axons & capillaries Catalytic nanomotors Ion Signaling Molecular Motors IFA 09 BARCELONA 26

Medium Range Molecular Communication: Flagellated Bacteria Escherichia coli (E. coli) has between 4 and 10 flagella, which are moved by rotary motors, fuelled by chemical compounds. E. coli bacteria is approximately 2 µm long and 1 µm in diameter. IFA 09 BARCELONA 27

Medium-Range Communication using Flagellated Bacteria Information is expressed as a set of DNA base pairs, the DNA packet, which is inserted in a plasmid. Encoding Transmission Propagation Reception Decoding DNA packet is introduced inside the bacteria s cytoplasm, using: Plasmids Bacteriophages Bacterial Artificial Chromosomes (BACs) Bacteria sense gradients of attractant particles. They move towards the direction and finds more attractants (chemotaxis). The receiver releases attractants so the bacteria can reach it. DNA packet is extracted from the plasmid using: Restriction endonucleases enzymes IFA 09 BARCELONA 28

Medium Range Molecular Communication: Catalytic Nanomotors (Nanorods) Au/Ni/Au/Ni/Pt striped nanorods are catalytic nanomotors 1.3 µm long and 400 nm on diameter Externally directed by applying magnetic fields. We propose to use them as a carrier to transport the DNA information among nano-sensors IFA 09 BARCELONA 29

Medium-Range Communication using Catalytic Nanomotors Information is expressed as a set of DNA base pairs, the DNA packet, which is inserted into a plasmid. Encoding Transmission Propagation Reception Decoding Nanorods are introduced in a solution of AEDP AEDP binds with the Nickel segments DNA packets (plasmids) are attached to nanorods CaCl 2 solution is used in order to compress and immobilize the plasmid Magnetic Fields guide the nanorod to the receiver DNA packet is extracted from the plasmid using: Restriction endonucleases enzymes IFA 09 BARCELONA 30

Long-Range Communication using Pheromones L. Parcerisa and I.F. Akyildiz, "Molecular Communication Options for Long Range Nanonetworks, submitted for publication, May 2009. Features: Communication Range Medium mm - m Wet and dry Carrier Pheromones Light Transduction Pollen & Spores Axons & Capillaries IFA 09 BARCELONA 31

Long-Range Communication using Pheromones Communication Features: IFA 09 BARCELONA 32

Long-Range Communication using Pheromones Encoding Transmission Signal Propagation Reception Decoding Selection of the Releasing the Pheremones Pheremones Interpretation specific pheromones are diffused bind to the of the pheromones to through into the Receptor information transmit the liquids or medium information and gases (Different produce the pheremones reaction at the trigger intended different receiver reactions) IFA 09 BARCELONA 33

Long Range Molecular Communication: Light Transduction the conversion between molecular and optical signals IFA 09 BARCELONA 34

Long Range Molecular Communication: Light Transduction: Conversion Molecular signal conversion to optical information Fluorescent proteins MOLED s (Molecular organic LED) Optical information conversion to molecular signal Molecular Switch Molecular Wire IFA 09 BARCELONA 35

Research Challenges in Nano-Sensor Networks Development of nano-machines (sensors), testbeds and simulation tools Information Theoretical Approach Architectures and Communication Protocols IFA 09 BARCELONA 36

MOLECULE DIFFUSION COMMUNICATION MODEL M. Pierobon, and I. F. Akyildiz, ``A Physical Communication Model for Molecular Communication in Nanonetworks, submitted for journal publication, March 2009. Molecule Diffusion Communication: Exchange of information encoded in the concentration variations of molecules. TN RN Emission Diffusion Reception process process process IFA 09 BARCELONA 37

OBJECTIVE OF THE PHYSICAL COMMUNICATION MODEL M. Pierobon, and I. F. Akyildiz, ``A Physical Communication Model for Molecular Communication in Nanonetworks, submitted for journal publication, March 2009. Derivation of DELAY and ATTENUATION as functions of the frequency and the transmission range Non-linear attenuation with respect to the frequency Distortion due to delay dispersion IFA 09 BARCELONA 38

HOW ABOUT Electro-Magnetics??? FUTURE INTERNET AFTER NEXT (FIAN) IFA 09 BARCELONA 39

Nano-Electromagnetic Communications J.M. Jornet and I.F. Akyildiz, A nano-patch antenna for electromagnetic nanocommunications in the terahertz band, submitted for publication, May 2009. J.M. Jornet and I.F. Akyildiz, A physical channel model for electromagnetic nanocommunications in the terahertz band, in preparation. Carbon Nanotubes and Graphene Nanoribbons can be used to build EM nano-transceivers: Nano-antennas can be developed using a single nanotube or nanoribbon (e.g., a nano-dipole). A single mechanically resonating nanotube can implement a fully operational radio (i.e., a nano-radio). Nano-Micro Interface 100 µm Nano-node IFA 09 BARCELONA 40

Nano-Electromagnetic Communications J.M. Jornet and I.F. Akyildiz, A nano-patch antenna for electromagnetic nanocommunications in the terahertz band, submitted for publication, May 2009. J.M. Jornet and I.F. Akyildiz, A physical channel model for electromagnetic nanocommunications in the terahertz band, in preparation. Frequency band, transmission range, energy constraints: everything needs to be determined. At this scale, novel information encoding techniques in light of quantum information theory can be further investigated. IFA 09 BARCELONA 41