SUBSTANCE NAME CYTOP 340 organophosphine Tributylphosphine tributylphosphan Phosphine, tributyltrialkylphosphine GENERAL STATEMENT Tributylphosphine is a strong reducing agent. Direct contact may cause skin burns and eye irritation, may be harmful if swallowed. Contact with materials such as hair, clothing and paper may cause autoignition resulting in thermal burns. CHEMICAL IDENTITY EC Name: NA EC-No. : 213-651-2 CAS-No. : 998-40-3 REACH Registration No.: NA IUPAC name: tributyllphosphine Molecular formula: C 12H 27P Structural formula: USES AND APPLICATIONS CYTOP 340 organophosphine is used as a processing aide for a variety of common reactions used in the pharmaceutical and fine chemical industries. It is also used as a catalyst or intermediate in chemical reactions. PHYSICAL CHEMICAL PROPERTIES Appearance colorless to amber liquid Odor garlic Melting point -60 ⁰C Boiling point/boiling range: 240 ⁰C Vapor pressure: 50 mmhg at 150 ⁰C Molecular Weight: 202 Specific gravity: 0.81 g/ml at 20 ⁰C Flash point: >45 C Page 1
Flammability: LogPow: extremely flammable (catches fire if exposed to air) not available HEALTH EFFECTS Tributylphosphine is a pyrophoric material and overexposure by the oral and inhalation route is unlikely. The toxicological properties of this material have not been fully investigated. Based on the EU classification system (REGULATION (EC) No 1272/2008) tributylphosphine is classified as spontaneously flammable in air, causes severe skin burns, harmful if swallowed and toxic to aquatic organisms (may cause long-term adverse effects in the aquatic environment). Workers should be properly instructed and supervised in the handling of the substance. EFFECT ASSESSMENT Acute Toxicity (oral/dermal/inhalation) Irritation/Corrosivity (skin/eye/respiratory tract) Sensitization (skin/respiratory tract) Repeated Exposure Mutagenicity Carcinogenicity Reproductive Toxicity RESULT The oral LD 50 is 750 mg/kg and the dermal LD 50 is >2000 mg/kg. Based on the pyrophoric property of this material, overexposure by the oral and inhalation route may cause burns to the mouth, throat or respiratory tract. Tributylphosphine may skin burns and eye irritation. Tributylphosphine is not known to be a skin sensitizer. Not evaluated. Based on available data and/or professional judgment, the classification criteria are not met. Not mutagenic in an in vitro bacteria reverse mutation (Ames) test. Based on available data and/or professional judgment, the classification criteria are not met. Not evaluated. Based on available data and/or professional judgment, the classification criteria are not met. Not evaluated. Based on available data and/or professional judgment, the classification criteria are not met. ENVIRONMENTAL EFFECTS EFFECT ASSESSMENT Aquatic Toxicity FATE AND BEHAVIOR Biodegradation Bioaccumulation potential RESULT Tributylphosphine is toxic to aquatic animals. RESULT 30% biodegradation in a 28-day test. Based on professional judgment, tributylphosphine has a low Page 2
PBT/vPvB conclusion potential for bio-accumulation. Based on professional judgment, tributylphosphine is not considered to be persistent or bioaccumulating. This substance is not considered to be very persistent nor very bioaccumulating (vpvb). EXPOSURE Human Health Tributylphosphine is used solely in industrial facilities. When the recommended risk management measures and required operational conditions are observed, worker exposures are expected to be minimal during the manufacture and industrial use of tributylphosphine. There is no expected consumer exposure to tributylphosphine, including handling of finished products. Environment Due to physical/chemical characteristics and professional judgment tributylphosphine has a low potential for bioaccumulation or environmental persistence. No direct release of tributylphosphine to soil is expected during manufacturing or industrial use. If a release does occur it is important to use appropriate risk management procedures. RISK MANAGEMENT RECOMMENDATIONS Tributylphosphine is classified as spontaneously flammable in air, causes severe skin burns, harmful if swallowed and toxic to aquatic organisms (may cause long-term adverse effects in the aquatic environment). Working with this substance requires the use of appropriate chemical resistant gloves and protective clothing. Where inhalation exposure may occur, wear an approved, full-faced respirator. Industrial workers should receive task specific training on how to use the protective equipment. Food, beverages, and tobacco products should not be carried, stored, or consumed where this material is in use. Before eating, drinking, or smoking, wash face and hands thoroughly with soap and water. The most effective fire extinguishing agent is AFFF Foam. Dry chemical powder pressurized with nitrogen, sand or carbon dioxide are effective alternative extinguishing media, however, reignition of material is likely. Immediate action should be taken to confine the fire. If fire cannot be controlled with an extinguishing agent, keep a safe distance, protect adjacent property and allow the product to burn until consumed. Human exposure should be prevented and nonessential personnel evacuated from the immediate area. Breathing vapors from this material or its combustion products should be avoided by using proper respiratory equipment. The following are first aid measures that should be taken if exposure should occur: Ingestion: If swallowed, call a physician immediately. Only induce vomiting at the instruction of a physician. Never give anything by mouth to an unconscious person. Skin Contact: Immediately take off all contaminated clothing. Wear impermeable gloves. Wash immediately with plenty of water and soap. Pay particular attention to skin crevices, nail folds, etc. Do not reuse contaminated clothing without laundering. Do not reuse contaminated leather footwear. Eye Contact: Rinse immediately with plenty of water for at least 15 minutes. Inhalation: Remove to fresh air. If breathing is difficult, give oxygen. Obtain medical advice if Page 3
symptoms persist. ENVIRONMENTAL PRECAUTIONS Exposure to air and other oxidizing material must be avoided. This material is a strong reducing agent and may react with combustible substances creating a fire or explosion hazard. Store tributylphosphine under an inert atmosphere such as nitrogen or carbon dioxide. Avoid contact with oxidizing agents. Block off source of spill, extinguish fire with appropriate extinguishing agent. Do not contact spill with paper cloth or vermiculite as spontaneous ignition will occur. Cover spill with an inert absorbent clay (such as cat litter or similar material) and place in a sealable container, sized such that free air volume is minimized. Seal under inert gas. Dispose of contents/container in accordance with local and national regulations. GOVERNMENT AGENCY REVIEW Tributylphosphine is listed on the following Chemical Inventories: United States (TSCA), Canada (DSL), Australia (AICS), Japan (ENCS), Philippines (PICCS) and China. REGULATORY INFORMATION/CLASSIFICATION AND LABELING Classification of the substance according to REGULATION (EC) No 1272/2008: R17 - Spontaneously flammable in air. R35 - Causes severe burns. R22 - Harmful if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. CONCLUSION Tributylphosphine is used as a catalyst or intermediate in chemical reactions and as a processing aide for a variety of common reactions used in the pharmaceutical and fine chemical industries. Before using this material, all workers should review the Material Safety Data Sheet and receive training on safety and handling procedures, and recommended personal protective equipment. Considering these precautions, the potential level of exposure to tributylphosphine, in normal use, is considered to be very low. CONTACT INFORMATION WITHIN COMPANY For further information on this substance or product safety summaries in general, please contact: Company: Address: Town/Country Postal code: E-mail: Cytec Industries 5 Garret Mountain Plaza Woodland Park, NJ 07424 (USA) custinfo@cytec.com Page 4
Worldwide Contact Info: www.cytec.com GLOSSARY Acute toxicity Biodegradation Bioaccumulation Carcinogenicity Chronic toxicity Flash point Genotoxicity Hydrolyze Mutagenicity PBT Persistence Reprotoxicity Sensitizing Sediment Vapor pressure vpvb Harmful effect resulting from a single or short term exposure to a substance. Decomposition or breakdown of a substance under natural conditions (actions of micro organisms etc). Progressive accumulation in living organisms of a chemical substance present in the environment. Substance effects causing cancer. Harmful effect after repeated exposures or long term exposure to a substance. The lowest temperature at which vapor of the substance may form an ignitable mixture with air. Substance effect that causes damage to genes, including mutagenicity and clastogenicity. Undergo hydrolysis; decompose by reacting with water. Substance effect that cause mutation on genes. Persistent, bioaccumulative, toxic chemical. Refers to the length of time a compound stays in the environment, once introduced. Including teratogenicity, embryotoxicity and harmful effects on fertility. Allergenic. Topsoil, sand and minerals washed from land into water forming in the end a layer at the bottom of rivers and sea. A measure of a substance s property to evaporate. Very persistent, very bioaccumulative. DATE OF ISSUE September 2012 REVISION Version 1.0 ADDITIONAL INFORMATION Further information can be found in the MSDS. DISCLAIMER Page 5
The information contained in this paper is intended as advice only and whilst the information is provided in utmost good faith and has been based on the best information currently available, is to be relied upon at the user s own risk. No representations or warranties are made with regards to its completeness or accuracy and no liability will be accepted by Cytec Industries for damages of any nature whatsoever resulting from the use of or reliance on the information. Page 6