Improving the standard of care

Improving the standard of care Alan Hippe CFO Roche London, November 2015

This presentation contains certain forward-looking statements. These forward-looking statements may be identified by words such as believes, expects, anticipates, projects, intends, should, seeks, estimates, future or similar expressions or by discussion of, among other things, strategy, goals, plans or intentions. Various factors may cause actual results to differ materially in the future from those reflected in forward-looking statements contained in this presentation, among others: 1 pricing and product initiatives of competitors; 2 legislative and regulatory developments and economic conditions; 3 delay or inability in obtaining regulatory approvals or bringing products to market; 4 fluctuations in currency exchange rates and general financial market conditions; 5 uncertainties in the discovery, development or marketing of new products or new uses of existing products, including without limitation negative results of clinical trials or research projects, unexpected side-effects of pipeline or marketed products; 6 increased government pricing pressures; 7 interruptions in production; 8 loss of or inability to obtain adequate protection for intellectual property rights; 9 litigation; 10 loss of key executives or other employees; and 11 adverse publicity and news coverage. Any statements regarding earnings per share growth is not a profit forecast and should not be interpreted to mean that Roche s earnings or earnings per share for this year or any subsequent period will necessarily match or exceed the historical published earnings or earnings per share of Roche. For marketed products discussed in this presentation, please see full prescribing information on our website www.roche.com All mentioned trademarks are legally protected 2

Performance update Growth from existing and new products Productivity and efficiency Outlook 3

Q3 2015: Sales growth for fifth consecutive year 10% 8% 6% 6% 6% 6% 8% 7% 5% 5% 6% 7% 6% 4% 4% 4% 4% 4% 5% 2% 2% 0% 0% 0% 1% Q1 11 Q2 11 Q3 11 Q4 11 Q1 12 Q2 12 Q3 12 Q4 12 Q1 13 Q2 13 Q3 13 Q4 13 Q1 14 Q2 14 Q3 14 Q4 14 Q1 15 Q2 15 Q3 15 All growth rates at constant exchange rates (CER) 4

HY 2015: Strong underlying Group core operating profit & margin 40'7% 41'0% % of sales 38'1% 38'5% 39'2% (+0.4%p excl. filgrastim*) +2% at CER (+7%*) CHFbn 8'3 8'6 9'5 9'4 9'2 HY 2011 HY 2012 HY 2013 HY 2014 HY 2015 CER=Constant Exchange Rates * Excluding sale of filgrastim rights in 2014 at CER 5

2014: Dividend and payout ratio further increased CHF 10'00 9'00 8'00 7'00 6'00 5'00 4'00 2014 payout ratio: 56.0% 38'8 31'9 34'5 Dividend payout ratio (%) 51'6 48'6 44'8 55'3 54'5 54'7 56.0 8.00 3'00 2'00 1'00 0'00 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010 2012 2014 Payout ratio calculated as dividend per share divided by core earnings per share (diluted); Note: For 1995, a special dividend was paid 1 out compound to mark F. Hoffmann-La annual growth Roche s rate 100th anniversary in 1996 7

Performance update Growth from existing and new products Productivity and efficiency Outlook 8

Premium for innovation Roche strategy: Focused on medically differentiated therapies Pharma Dia Regulators: Optimised benefit / risk ratio Focus Payors: Optimised benefit / cost ratio MedTech Generics OTC Differentiation 9

HER2 franchise: Significant growth opportunities in current indications Patient shares Growth 100% 96% 93% 84% US EU5 EM Increased patient share Longer treatment duration Emerging markets 63% 58% 58% 51% 25% 0% <5% <5%. <5% <5% Herceptin Perjeta 1L Perjeta 2L Kadcyla Adjuvant Neoadjuvant mbc Sources: Market research tracking studies; Latest quarter Q315 in EU5 and US 10

Anti-CD20: Multiple approaches across the franchise 1L CLL Typical 5% 1L CLL Fit 6% CLL 17p-del 1% Gazyva (GREEN)- Extend chemo backbone Venetoclax Extend efficacy Rapidly and sustainably convert market to SC Gazyva (GALLIUM) (improve > SoC) inhl 49% 1L anhl 27% R/R CLL 5% Rapidly and sustainably convert market to SC R/R anhl 6% GAZYVA (GOYA) in anhl (improve > SoC) Broad development program for venetoclax as add on and in new tumour types SoC=standard of care; SC=subcutaneous; CLL=chronic lymphocytic leukemia; inhl=indolent non-hodgkin s lymphoma; anhl=aggressive NHL 11

Franchise strategies for long term growth New indications and longer duration Growth opportunity HER2 Potential and new indications CD20 Potential and new indications Indication Perjeta adjuvant (APHINITY) Herceptin SC* Gazyva anhl (GOYA) Gazyva inhl (GALLIUM) MabThera SC* Venetoclax Global peak sales potential Small: up to CHF 0.5 bn medium= CHF 0.5 to CHF 1bn large > CHF1bn *Sales replacing current IV products; SC=subcutaneous; inhl=indolent non-hodgkin s lymphoma; anhl=aggressive NHL 12

Multiple major pivotal trials reading out near term Significant filing and launch activities ahead Year Molecule Indication 2015 2016 2017 2018 Market opportunity Incremental infrastructure Alectinib ALK+ NSCLC Low to medium Cotellic/Zelboraf Melanoma Low Venetoclax Hematology (CLL 17p del)* Low Ocrelizumab Multiple Scelerosis Medium Atezolizumab NSCLC, bladder (2/3L) Medium Lebrikizumab Asthma, AD, IPF, COPD Large APHINITY Adj HER2+ breast cancer Low GOYA NHL (aggressive) Low ACE 910 Hemophilia A Low to medium Lampalizumab Geographic atrophy Low to medium GALLIUM NHL (indolent) Low Atezolizumab+chemo NSCLC (1L) Low Taselisib (PI3Ki) HER2-/HR+ breast cancer Low to medium Idasanutlin (MDM2) Acute myeloid leukemia Low to medium Oncology Neuroscience Ophthalmology Immunology Small: up to CHF 0.5 bn medium= CHF 0.5 to CHF 1bn large > CHF1bn NSCLC=non-small cell lung cancer; CLL=chronic lymphocytic leukemia; AD=atopic dermatitis; IPF=idiopathic pulmonary fibrosis; COPD=chronic obstructive pulmonary disease; NHL=non-hodgkin s lymphoma; * first indication 13

Performance update Growth from existing and new products Productivity and efficiency Outlook 14

Value We are also driving operational efficiencies Select examples Technical Operations Network efficiencies Improve capacity planning across the network & align to future needs Complexity reduction Remove >40% of all presentations by streamlining the EP 1 portfolio (<0.1% sales impact 2 ) Continuous process improvement Implement lean principles, e.g. to decrease end-to-end cycle time by up to 50% 3 Need Optimize utilization & increase reliability Focus resources on key value driver Do the same with less Source: 1. Established Products 2. In 2016 3. For processes in scope 15

Resources shifted to new & strategic products while overall spend only increases slightly Product Marketing and Medical Costs (2012 2015) 60% 75% Recently launched + NME Strategic In-market Mature 2012 2013 2014 2015E 16

Achievements: Productivity Doubled number of projects at same costs Late stage development costs & number of projects +90% Filing 2010 2011 Ph3 Ph0-2 Pharma Development Spend 2012 2013 2014 Excludes Chugai, pred and gred, Medical Affairs and PTD Source: Roche internal development data 17

Performance update Growth from existing and new products Productivity and efficiency Outlook 18

2015 outlook: Guidance upgraded Group sales growth 1 Mid-single digit Core EPS growth 1 Ahead of sales growth 2 Dividend outlook Further increase dividend in Swiss francs 1 At constant exchange rates (CER) 2 Excluding sale of filgrastim rights in 2014 19

Positive outlook Strong pipeline mitigates biosimilar impact Sales NME launches Venetoclax, Alectinib, Cotellic, Ocrelizumab, Atezolizumab, Lebrikizumab, ACE910, Lampalizumab Pipeline Biosimilars MabThera, Herceptin, Avastin Marketed products 2014 2015E 2016E 2017E 2018E 2019E 2020E 2021E 2022E 2023E 20

Newsflow in H2 2015 Vienna, 25-29 Sep Barcelona, 7-10 Oct San Francisco, 18-21 Nov atezolizumab (+chemo) - NSCLC: POPLAR, BIRCH, P1b chemo combo update - Bladder: P2 (2L cohort) alectinib - ALK+ NSCLC: P2 update ocrelizumab - RMS: P3 OPERA I/II - PPMS: P3 ORATORIO atezolizumab + Zelboraf - mm: P1 Cotellic + Zelboraf - BRAF+mM: cobrim OS data CEA-IL2v FP; IDOi - solid tumors: P1 updates San Antonio, 19-22 Nov Orlando, 5-8 Dec San Antonio, 8-12 Dec atezolizumab - GBM: P1 Presentations planned venetoclax - R/R CLL 17p del: P2 venetoclax combinations - AML: P1 + chemo - NHL: P1 + Rituxan+benda - CLL: P1 + Gazyva Gazyva + chemo - NHL: P3 GADOLIN update - CLL: P3 GREEN update Atezolizumab + chemo - TNBC: P1b abraxane combo 21

Doing now what patients need next