Breeding and health management to improve sustainability and welfare in poultry production

The 2 businesses of Groupe Grimaud Genetic selection, production and sale of animal breeders, hatching eggs, semen: broiler and layer chickens, pigs, ducks, guinea fowl, rabbits, pigeons, shrimps. Biopharmacy serving human and animal health: vaccines, pharmaceutical proteins and sera, human antibodies, specific pathogen free animals, bacterial cultures. 2

What is a genetic progress? Number of animals Generation N Generation N+1 Performance m N m N+1 DG Genetic progress 4

Why Genetics matters? Pedigree 1 R&D (Pure lines) Grand Parents (GP) 50 OWN PRODUCTION GP CUSTOMERS Parent Stock (PS) 4000 PS CUSTOMERS HATCHERY Layers 400000 CS customers 5

A necessary improvement WORLD POPULATION GROWTH FAO World Poultry - 6

How can we improve sustainability and welfare? Sustainability Animal welfare / Robustness Competition for food Antibiotic resistance Impact of waste Biodiversity Injuries (agressivity) Physiological pathologies (wooden breast ) Adaptation to stress - biotic - abiotic 7

Biology at the heart of sustainable development 8

The 5 keys of the "Natural-Concept" 1. Favour robustness and feed efficiency traits in our breeding programs 9

1. Favour robustness and feed efficiency traits in our breeding programs Maintain genetic diversity through a large gene pool Maintaining different lines Considering the inbreeding in the selection programs 10

1. Favour robustness and feed efficiency traits in our breeding programs Adaptation to abiotic stress On top of the protected stations, run Selection under field conditions to develop animals vitality & robustness 11

1. Favour robustness and feed efficiency traits in our breeding programs Adaptation to biotic stress and reduction of antibiotic use Half-sib testing in Challenging conditions 12

under challenge 1. Favour robustness and feed efficiency traits in our breeding programs Adaptation to biotic stress and reduction of antibiotic use Mortality score breeding value correlation Under good sanitary conditions 13

1. Favour robustness and feed efficiency traits in our breeding programs Select animals for agressivity Selecting the animals in group conditions Studying the animal behavior (monitoring) 14

1. Favour robustness and feed efficiency traits in our breeding programs Reduction of pathologies and antibiotic use - Green muscle - Wooden Breast - White stripping - Poor cohesion Offer breeds with differentiated growth (slower growth, but more robust) to the livestock production industry 15

1. Favour robustness and feed efficiency traits in our breeding programs Reduction of pathologies and antibiotic use Example of the Dutch market: No wooden breast in chicken of tomorrow 16

1. Favour robustness and feed efficiency traits in our breeding programs Reduction of competition for food Keep focussing on feed efficiency 1,760 FCR genetic trend 1,740 1,720 1,700 gain of - 2 points / year 1,680 1,660 1,640 1,620 1,600 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 17

1. Favour robustness and feed efficiency traits in our breeding programs Reduction of competition for food Keep focussing on feed efficiency to produce more economically as well as to reduce the carbon footprint of the livestock production industry The feed efficiency improvement in the last 20 years represent 45 millions hectares / 112 millions acres of cultivated land (i.e. half of France) 18

1. Favour robustness and feed efficiency traits in our breeding programs Reduction of competition for food Adding the feeding behavior in the selection schemes 19

2. Better prevent disease risks through bacterial ecology management in breeding environment The competitive exclusion concept 21

2. Better prevent disease risks through bacterial ecology management in breeding environment Reduction of antibiotic use 22

3. Stimulate the immune system: - natural by competition FIELD TRIALS RESULTS : Decrease of colibacillosis mortality Ducks broilers; colibacillosis at 6 weeks of age FILACTIS distribution at day 0 and day+1 mortality 24

3. Stimulate the immune system: - acquired by vaccination Mortality 1/10 000 Control Vaccination Weeks of laying 25

The 5 keys of the "Natural-Concept" 1. Favour robustness and feed efficiency traits in our breeding programs 2. Better prevent infectious risks through bacterial ecology management in breeding environment 3. Stimulate the immune system of the animals : - natural by competition - acquired by vaccination 4. Because they are very valuable, use the chemical "super-molecules" only in case of proven pathology or as prevention in case of major stress 26

5. To give back to the earth the necessary nutrients by the composting of the organic by-products 28

The 5 keys of the "Natural-Concept" 1. Favour robustness and feed efficiency traits in our breeding programs 2. Better prevent disease risks through bacterial ecology management in breeding environment 3. Stimulate the immune system of the animals : - natural by competition - acquired by vaccination 4. Because they are very valuable, use the chemical "super-molecules" only in case of proven pathology or as prevention in case of major stress 5. To give back to the earth the necessary nutrients by the composting of the organic by-products The answer to sustainability challenge is a combination of different approaches 29

Thank you! Groupe Grimaud supports the United Nation Global Compact Groupe Grimaud is the founder of the Natural Concept Hubbard is certified code-efabar www.grimaud.com