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7 InCHIP Research Interest Groups Debbie Deborah.cornman@uconn.edu Debarchana.ghosh@uconn.edu HIV Research Interest Group - Chaired by Seth Seth.K@uconn.edu Amy.gorin@ucponn.edu kim.gans@chip.uconn.edu marlene.schwartz@uconn.edu Michelle Michelle.judge@uconn.edu Amy.gorin@ucponn.edu

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10 InCHIP Internal Seed Grant Competitions for InCHIP-Committee on Interprofessional Excellence in Healthcare Seed Grants ($5,000) Seed Grant Opportunity for InCHIP Junior Faculty Affiliates ($7,500)

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14 Grantsmanship L e a r n a b o u t N I H a n d f u n d i n g o p p o r t u n i t i e s

15 Become familiar with the mission of NIH

16 hoc) (do ad

17 Identify a Home Institute/Center

18 NIH Guide to Grants and Contracts

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24 Start writing several months (yes, months) before the due date.

25 Writing Your Specifics Aims NIH This is a critical section of your application.

26 SPECIFIC AIMS: One page that can make or break your chances of funding.

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29 Viruses are thought to be involved in 15% to 20% of human cancers worldwide, thus providing critical tools to reveal common mechanisms involved in human malignancies. As the etiologic agent of adult T cell leukemia/lymphoma (ATLL), human T cell leukemia virus type I (HTLV-1) is just such a virus. HTLV-1 encodes a potent oncoprotein, Tax, which regulates important cellular pathways including gene expression, proliferation, apoptosis, and polarity. Over the years, Tax has proven to be a valuable model system in which to interrogate cellular processes, revealing pathways and mechanisms that play important roles in cellular transformation. Although the Tax oncoprotein has been shown to transform cells in culture and to induce tumors in a variety of transgenic mouse models, the mechanism by which Tax transforms cells is not well understood. A large number of Tax mutants have been generated and their biological activities have been thoroughly characterized, primarily in cell culture systems. Currently, a major obstacle in the field is that the transforming activity of Tax mutants cannot be compared using available transgenic models due to random transgene integration sites, variable transgene copy number, and inconsistent transgene expression levels, making it difficult to link the biological activities of Tax mutants with their transforming potential. Hook Known Information Gap in Knowledge Critical Need

30 Hook Viruses are thought to be involved in 15% to 20% of human cancers worldwide, thus providing critical tools to reveal common mechanisms involved in human malignancies.

31 Known Information As the etiologic agent of adult T cell leukemia/lymphoma (ATLL), human T cell leukemia virus type I (HTLV-1) is just such a virus. HTLV-1 encodes a potent oncoprotein, Tax, which regulates important cellular pathways including gene expression, proliferation, apoptosis, and polarity. Over the years, Tax has proven to be a valuable model system in which to interrogate cellular processes, revealing pathways and mechanisms that play important roles in cellular transformation. A large number of Tax mutants have been generated and their biological activities have been thoroughly characterized, primarily in cell culture systems.

32 Gap in Knowledge Although the Tax oncoprotein has been shown to transform cells in culture and to induce tumors in a variety of transgenic mouse models, the mechanism by which Tax transforms cells is not well understood.

33 Critical Need A large number of Tax mutants have been generated and their biological activities have been thoroughly characterized, primarily in cell culture systems. Currently, a major obstacle in the field is that the transforming activity of Tax mutants cannot be compared using available transgenic models due to random transgene integration sites, variable transgene copy number, and inconsistent transgene expression levels, making it difficult to link the biological activities of Tax mutants with their transforming potential.

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35 Three Required (Summary?) Sections Project Summary/Abstract: Describe succinctly every major aspect of the proposed project Scientific Premise: Describe the scientific rationale for the project Project Narrative: Describe the relevance of your research to public health

36 Write the Project Summary and Project Narrative last Write the Scientific Premise early

37 NIH Description: The Project Summary/Abstract Brief background. Specific aims, objectives, or hypotheses. Significance of the proposed research. Unique features and innovation. Methodology to be used. Expected results. Description of how your results will affect other research areas and public health. All in 30 lines of text in the specified font and margins

38 How is the Project Summary Used: To direct the proposal to a review committee. As an abstract for the reviewers (primary, secondary, tertiary, and others). Refresher for reviewers. Once you get a good score: By agency staff to argue for funding. By upper level agency staff to decide whether to push for it. By the director of the agency to decide whether to fund it.

39 Project Summary/Abstract: Stress, Inflammation, and Metabolic Syndrome (MS)

40 In recent years, strong evidence has accrued indicating that inflammation (INF) and metabolic syndrome (MS) represent dysregulated biological systems that predict onset of chronic, age-related diseases such as cardiovascular disease, type 2 diabetes, rheumatoid arthritis, cancer, and dementia.

41 Although a wealth of findings has indicated that psychosocial stress is a major determinant of INF and MS, a number of crucial questions remain unanswered. First, we do not know whether sensitive period (early biological programming), stress accumulation, social schematic, or mismatch models best account for the development of INF and MS. Second, we have little information regarding the range of stressors within a developmental period that are most critical.

42 Studies of childhood stress usually simply assess low SES or exposure to harsh parenting, and these measurements typically entail retrospective reports. Research on the effect of adults stress sometimes includes community context but usually fails to consider the way that childhood stress may moderate reactions to adult stressors. And, whether the focus is childhood or adult adversity, there has been limited consideration of the way that race-related stress such as segregation, perceived racism, discrimination, and internalized racism impact biological dysregulation.

43 Third, we know little about the extent to which factors such as parental support, racial socialization, social support, or religiosity operate to reduce the deleterious impact of childhood, adolescent, or adult stressors on INF and MS.. In order to address these unanswered questions and limitations, this proposal seeks funding to add biomarkers of INF and MS, as well as telephone interview data regarding stress and health behaviors, to the 18 years of longitudinal data that have been collected on the Family and Community Health Study (FACHS) sample of roughly 700 African Americans (now 28 years of age). Specifically, we plan to pursue the following specific aims: 1). 2).3).

44 There are few, if any, efficacious interventions that address the cause of health disparities. The Institute of Medicine prescribes that such efforts be based on the results of longitudinal, epidemiological research with target populations. Currently, there are no prospective investigations that identify the protective factors that interrupt the translation of social determinants of stress onto biological vulnerabilities for African Americans. The results of the proposed research will identify protective processes and serve as the basis for empirically-based, health disparities preventative interventions.

45 NIH Definition: The Scientific Premise The scientific premise for an application is the research that is used to form the basis for the proposed research question(s). NIH expects applicants to describe the general strengths and weaknesses of the prior research include attention to the rigor of the previous designs, incorporation of relevant biological variables and authentication of key resources. Can be as long as you want it to be.

46 The Scientific Premise: Don t forget to include your own previous research Your research that supports your argument that your proposal is important and feasible. Description of the general strengths of your prior research. Description of the rigor of your previous experimental methods. New technology or methods (then and in proposal). New resources. Why your proposal will be an important advance.

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51 NIH Definition: Project Narrative (Public Health Relevance) describe the relevance of this research to public health plain language that can be understood by a general, lay audience

52 Narrative: Stress, Inflammation, and Metabolic Syndrome Improving the quality of longer lives requires information The present application tests competing models regarding the manner in which stress and protective factors combine to influence the development of inflammation and metabolic syndrome.

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61 Multiple PD/PIs

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67 NIH, 2016

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70 Importance NIH, Office of Extramural Research, 2014

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78 INSTITUTE SUCCESS RATE FY2016 PAYLINE (2016) FURTHER INFORMATION NCI (to 20) 12 for New & Early Stage- Investigators funding plan NHLBI for Early Stage Investigators/ FY 2016 Funding Strategy NIA **** FY 2016 Funding Strategy (under 500K: 19-new investigators; 21-early stage investigators)****significantl y higher paylines for applications focusing on Alzheimer's Disease. Follow link for details. NICHD FY 2016 Funding Strategy-new and ESI: 13 NIMH FY2016 Funding Strategy (anticipate a success rate of 20%)

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87 The investigators have been mostly responsive to previous critiques. There was a divergence of opinion among reviewers about the potential overall impact of this study.

88 While most reviewers indicate the application is likely to have an extraordinarily high impact on the field and larger social world, a minority of reviewers were unsure about the impact due to limitations of the methodology.

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92 Number of Investigators 25,000 20,000 Number and Percentage of First-Time* and Experienced Investigators on Competing and Noncompeting R01- Equivalent Grants** (Fiscal Years )*** Report Competing Experienced Investigators Competing First Time Investigators Noncompeting Only Investigators New as Percent of All Competing New as a Percent of All Competing and Noncompeting 45.0% 40.0% 35.0% 30.0% 15, % 10, % 15.0% 5, % 5.0% 0 0.0% Fiscal Year *The definition of first time investigator has changed over time, and the annual numbers in the chart reflect the first time investigator policies that were in place during those years. ** R01 Equivalents include activity codes R01, R23, R29, and R37, and beginning in 2008 included DP2 awards to first -time NIH investigators. Not all these activities are in use by NIH every year. *** Excludes American Reinvestment and Recovery Act Awards (ARRA).

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