Infusion Systems for Laboratory Animal Research VOLUME 14

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1 Infusion Systems for Laboratory Animal Research VOLUME 14

2 Species Key Watch for these icons to indicate species-specific products. As an attendee at the 1986 annual Society of Toxicology meeting, I presented the first ambulatory infusion system suitable for GLP canine toxicity studies. Nine years later, I founded SAI with the goal of helping other researchers implement reliable infusion techniques that are less stressful to laboratory animals, quickly and efficiently. SAI is staffed by Scientists and Surgeons who have performed complex infusion and sampling studies in laboratories of their own and have continued to refine the tools and procedures necessary to successfully support researchers in the field with difficult animal model challenges. Please accept this invitation to glance through our catalog or browse our website to see how we can help you overcome challenges and achieve success with your next research model. Don t hesitate to contact us to request copies of our informative white papers and publications or to speak directly with one of our experienced Specialists. We will show you exactly what tools and techniques to use to successfully reach your research endpoints. Don t adapt your research to fit the equipment; we will adapt the equipment to fit your research needs! Sincerely, Steven C. Denault, DABT President and Founder Mouse Rat Rabbit Pig Dog Primate When icons show as purple at the top of a page, the products on that page pertain to those animals. If the icons are green, the products on that page do not pertain to those animals. How to Order: SAI is the single source for all infusion products and services. Everything you see in this catalog can be purchased using the SAI Order Form on page 5. Fax or your purchase order to: F orders@sai-infusion.com Online Ordering also available at sai-infusion.com Same-day new account approval. Quantity discounts available. Minimum order of $75. CAUTION: SAI products are for investigational use in laboratory animals or other tests that do not involve human subjects. NOT FOR HUMAN USE. Limited Warranty: Seller warrants the original purchaser that the Product, including accessories, shall be free from defects in materials and workmanship under normal use, if used in accordance with any documentation accompanying the Product. Limitation of Remedies: The original purchaser s exclusive remedy shall be, at the Seller s sole option, the repair or replacement of the Product. THIS IS THE EXCLUSIVE REMEDY. IN NO EVENT WILL SELLER S LIABILITY ARISING OUT OF ANY CAUSE WHATSOEVER (WHETHER SUCH CAUSE IS BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY. TORT OR OTHERWISE) EXCEED THE PRICE OF THE PRODUCT AND IN NO EVENT SHALL SELLER BE RESPONSIBLE FOR CONSEQUENTIAL, INCIDENTAL OR SPECIAL DAMAGES OF ANY KIND OR NATURE WHATSOEVER, INCLUDING BUT NOT LIMITED TO, LOST BUSINESS, REVENUES OR PROFITS. Returned Goods: Product returned for any reason other than manufacturing defect will be subject to a 20% restocking charge. Custom items may not be returned. All prices are subject to change without notice. The Scientists, Surgeons, Engineers and entire staff of SAI would like to thank you for your past and present business. We look forward to working with you in the future and remain dedicated to providing the best products and services for all of your research needs.

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4 Order Information and Form 2-3, 5 Products 6-56 Systems 6-9 Rodent Infusion Systems Rabbit Infusion Systems Pig Infusion Systems Dog Infusion Systems Primate Infusion Systems Self-Administration Systems Insulin & Glucose Clamp System Pumps D Programmable Syringe Pump and Axios Software Harvard, F-Series & New Era Syringe Pumps Ambulatory Pumps Alzet & Sorenson Ambulatory Pumps EVA Drug Bags FluidSync Pump Catheters Mouse Catheters Rat Catheters Rodent Intrathecal & Lymph Catheters Rodent Catheters, Cather Connectors & Plugs Rabbit, Pig and Guinea Pig Catheters Dog Catheters Primate Catheters Large Animal Intrathecal & Lymph Catheters Large Animal Specialty Catheters Vascular Access Ports SAI CathPort Port Bard Vascular Access Port Rodent Infusion Equipment Quick Connect Infusion, Complete Kits Rat, Mouse and Guinea Pig Harnesses Omni Harness & Tethers Jackets and Jacket Adaptors Skin Buttons, Trocars, Vein Picks and Tail Cuffs Swivels Tethers Swivel Holders, Retainers and Mouse Restrainers Microdialysis Components 43 Large Animal Infusion Equipment Jackets Swivels & Tethers Prefilled Syringes and Vials 46 Needles, Vials & Syringes Needles on Syringes, Vials & Syringes Blunt Needles/Luer Stub Adaptors Huber/Non-Coring Needles Extension Lines 50 Bulk Tubing 51 Blood Collection Infusion and Sampling Accessories 55 Surgical Instruments 56 Services Reference & Conversion Tables tips: Look for me throughout the catalog to find great tips from the scientists at SAI! Index 4 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Today s Date: Company: Fax Number: Purchaser s Name & Phone: End User s Name & Phone: End User s E-Mail Address: PO Number: Need By Date: Qty ordered Item Number Price Ship to: Bill to:

5 Today s Date: Company: Fax Number: Purchaser s Name & Phone: End User s Name & Phone: End User s Address: PO Number: Need By Date: Qty ordered Item Number Price Ship to: Bill to: Credit Card Info (Mastercard or Visa only) Name on Card: CC Number: Exp. Date: CCV# (3 digits on back): Zip: Order Form ORDERS@SAI-INFUSION.COM P F

Rodent Infusion Systems Rodent Tethered Infusion Systems Tethered systems require an in-dwelling catheter, a harness or jacket, spring tether, swivel, swivel holder, extension lines and infusion pump.

flexible polymer tubing. New catheter and harness designs have made the entire process more reliable and less time-consuming.

locks. These fittings can be connected and disconnected quickly and cleanly allowing for intermittent infusion and sampling without continuous tethering or restraint.

Recent tapered catheter designs greatly increase success rates, allowing for smaller diameter distal ends that insert easily into vessels and thicker walled proximal ends that connect directly to the

6 Rodent Infusion Systems Rodent Tethered Infusion Systems Tethered systems require an in-dwelling catheter, a harness or jacket, spring tether, swivel, swivel holder, extension lines and infusion pump. In the past, the fluid-carrying components of these systems (the catheter, extension lines and swivel) were all connected by friction fitting a stainless steel cannula with the internal diameter of flexible polymer tubing. New catheter and harness designs have made the entire process more reliable and less time-consuming. Today, the most advanced system available, the patented Quick Connect system, eliminates all of the sizing issues inherent in older systems and replaces the friction connections with secure luer locks. These fittings can be connected and disconnected quickly and cleanly allowing for intermittent infusion and sampling without continuous tethering or restraint. Highquality polyurethane has become the preferred catheter material due to its pliability and thromboresistant nature. Recent tapered catheter designs greatly increase success rates, allowing for smaller diameter distal ends that insert easily into vessels and thicker walled proximal ends that connect directly to the harness or swivel. A. Catheters Mouse Catheter : MJC-01 Pg. 24 $8.25 Rat Catheter : RFV-01 Pg. 25 B. Harnesses *Rat Harness : QCH-21 Pg. 36 $30.00 Mouse Harness : SMH Pg. 36 C. Tethers *Rat Tether : QCT-12 Pg. 41 Tether : T-12 Pg. 41 D. Swivels *Single Swivel : QCS-S Pg. 40 *Dual Swivel : QCS-D Pg. 40 E. Swivel Mount SAI Swivel Mount Assembly : GMSHK Pg. 42 With Counter Balance : CBSHA Pg. 42 F. Pumps SAI 3D Syringe Pump : 3D Pg. 16 *All items covered under International and U.S. patent 7,665,424. Rat Mouse A. B. C. D. E. F. 6 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Rabbit Infusion Systems CPT CPT-AC M200 3D Micro 3D Mini BJ-02 Rabbit Ambulatory Infusion Systems Tethered Rabbit Infusion Systems Reduce animal stress by allowing unrestrained and untethered freedom

The basic ambulatory infusion system includes: infusion pump, pocketed jacket, extension line, and in-dwelling catheter.

All of the pumps are small enough to be carried by the animal and have a legacy of withstanding the rigors of onanimal applications.

For more information on selecting the right catheter and pump for your research contact us and we will assist you with assembling the right system for your specific research needs.

21 BJ-02 Rabbit Jacket, Pg. 44 TETHERED SYSTEM COMPONENTS CPT-RP Port, Pg. 33 WHIS-22 Winged Infusion Sets, Pg. 49 BJ-02 Rabbit Jacket, Pg. 44 EXT-36 Extension Lines, Pg.

7 Rabbit Infusion Systems CPT CPT-AC M200 3D Micro 3D Mini BJ-02 Rabbit Ambulatory Infusion Systems Tethered Rabbit Infusion Systems Reduce animal stress by allowing unrestrained and untethered freedom of movement at all times. New advancements in pump technology have made this system easier and less expensive for researchers to implement. The basic ambulatory infusion system includes: infusion pump, pocketed jacket, extension line, and in-dwelling catheter. We offer a number of highquality infusion pumps with a wide range of delivery options. All of the pumps are small enough to be carried by the animal and have a legacy of withstanding the rigors of onanimal applications. Above is a system we recommend for any continuous infusion study using large animals. For more information on selecting the right catheter and pump for your research contact us and we will assist you with assembling the right system for your specific research needs. AMBULATORY SYSTEM COMPONENTS CPT Port, Pg. 33 CPT-AC Introducer, Catheter, Female Luer, Pg. 34 M200 FluidSync Micro Pump, Pg. 23 3D Micro SAI 3D Micro Pump, Pg. 21 3D Mini SAI 3D Mini Pump, Pg. 21 BJ-02 Rabbit Jacket, Pg. 44 TETHERED SYSTEM COMPONENTS CPT-RP Port, Pg. 33 WHIS-22 Winged Infusion Sets, Pg. 49 BJ-02 Rabbit Jacket, Pg. 44 EXT-36 Extension Lines, Pg. 48 AS P Large Animal Swivel, Pg. 45 BT 02 Large Animal Tether, Pg. 45 3D SAI 3D Syringe Pump, Pg. 16 Tethered infusion systems are well suited for studies that require large dosing volumes for extended periods of time or when repeated interaction with the pump is necessary. With large dosing volumes, syringe pumps may not be optimal since the largest standard syringe only holds 60ml. Volumetric pumps can handle a wide range of flow rates and can accommodate reservoirs of 2 liters or larger. Reservoirs and delivery tubing sets are more expensive but the versatility and convenience are well worth it. The tethered system requires an in-dwelling catheter, either a tunneled exteriorized catheter or access port, jacket, metal tether, swivel, extension lines, and an infusion pump. CPT-RP WHIS-22 AS P BT 02 3D ORDERS@SAI-INFUSION.COM P F

8 Pig Ambulatory Systems Pig Ambulatory Infusion Systems Reduce stress by allowing animals unrestrained and untethered freedom of movement at all times. New advancements in pump technology, jacket design, catheter material, and surgical techniques have made this system easier and less expensive for researchers to implement. The basic ambulatory infusion system includes: infusion pump, pocketed jacket, extension line, and indwelling catheter. There are two catheter systems to choose from. One system is an exteriorized catheter that luer-locks to the extension line. The alternative system utilizes a vascular access port accessed by a Huber needle or catheter and extension line. We offer a number of high-quality infusion pumps with a wide range of delivery options. All of the pumps are small enough to be carried by the animal and have a legacy of withstanding the rigors of on-animal applications. AMBULATORY SYSTEM COMPONENTS CPT Port, Pg. 33 CPT-AC Introducer, Catheter, Female Luer, Pg. 34 CADD-6500 CADD Legacy Pump, Pg. 21 3D MicroBT SAI 3D MicroBT Pump, Pg. 20 3D MiniBT SAI 3D MiniBT Pump, Pg. 20 SS J1 Swine Jacket, Pg. 44 JP Jacket Pocket, Pg. 44 Below is a system we recommend for any continuous infusion study using large animals. For more information on selecting the right catheter and pump for your research give us a call or send us an and we will be happy to assist you with putting together the right system for your specific research needs. CPT CPT-AC CADD D MicroBT 3D MiniBT SS J1 8 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

9 Tethered Pig Systems Tethered Pig Infusion Systems The tethered infusion system is well suited for studies that require large dosing volumes for extended periods of time or when repeated interaction with the pump is necessary. With large dosing volumes, syringe pumps may not be optimal, since the largest standard syringe only holds 60ml. Volumetric pumps can handle a wide range of flow rates and can accommodate reservoirs of 2 liters or larger. Reservoirs and delivery tubing sets are more expensive, but the versatility and convenience are well worth it. TETHERED SYSTEM COMPONENTS CPT-RP Port, Pg. 33 SJVC-2LV Groshong Catheter, Pg. 34 LA T4 Large Animal Tether, Pg. 45 The tethered system requires an in-dwelling catheter1 either a tunneled exteriorized catheter or access port, pocketed jacket, metal tether, swivel, extension lines, and an infusion pump. AS P Large Animal Swivel, Pg. 45 WHIS-22 Winged Infusion Sets, Pg. 49 SS J1 Swine Jacket, Pg. 44 EXT-PM40 Extension Lines EXT-PF40 Extension Lines AT E1 Tether End Plate, Pg. 45 3D SAI 3D Syringe Pump, Pg. 16 Below is a system we recommend for any infusion study utilizing large animals. For more information on selecting the right catheter and pump for your research give us a call or send us an and we will be happy to assist you with putting together the right system for your specific research needs. CPT-RP LA T4 AS P SS J1 3D ORDERS@SAI-INFUSION.COM P F

Dog Ambulatory Infusion Systems Dog Ambulatory Infusion Systems Reduce stress by allowing animals unrestrained and untethered freedom of movement at all times.

10 Dog Ambulatory Infusion Systems Dog Ambulatory Infusion Systems Reduce stress by allowing animals unrestrained and untethered freedom of movement at all times. New advancements in pump technology, jacket design, catheter material, and surgical techniques have made this system easier and less expensive for researchers to implement. The basic ambulatory infusion system includes: infusion pump, pocketed jacket, extension line, and in-dwelling catheter. There are two catheter systems to choose from. One system is an exteriorized catheter that luer-locks to the extension line. The alternative system utilizes a vascular access port accessed by a Huber needle or catheter and extension line. We offer a number of high-quality infusion pumps with a wide range of delivery options. All of the pumps are small enough to be carried by the animal and have a legacy of withstanding the rigors of on-animal applications. Below is a system we recommend for any continuous infusion study using large animals. For more information on selecting the right catheter and pump for your research give us a call or send us an and we will be happy to assist you with putting together the right system for your specific research needs. AMBULATORY SYSTEM COMPONENTS CPT Port, Pg. 33 CPT-AC Introducer, Catheter, Female Luer, Pg. 34 CADD-6500 CADD Legacy Pump, Pg. 21, 3D MicroBT SAI 3D MicroBT Pump, Pg. 20 3D MiniBT SAI 3D MiniBT Pump, Pg. 20 DJ-02 Dog Jacket, Pg. 44 JP Jacket Pocket, Pg. 44 CPT CPT-AC CADD D MicroBT 3D MiniBT DJ INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Tethered Dog Infusion Systems Tethered Dog Infusion Systems The tethered infusion system is well suited for studies that require large dosing volumes for extended periods of time or when repeated

Volumetric pumps can handle a wide range of flow rates and can accommodate reservoirs of 2 liters or larger.

11 Tethered Dog Infusion Systems Tethered Dog Infusion Systems The tethered infusion system is well suited for studies that require large dosing volumes for extended periods of time or when repeated interaction with the pump is necessary. With large dosing volumes, syringe pumps may not be optimal, since the largest standard syringe only holds 60ml. Volumetric pumps can handle a wide range of flow rates and can accommodate reservoirs of 2 liters or larger. Reservoirs and delivery tubing sets are more expensive, but the versatility and convenience are well worth it. The tethered system requires an in-dwelling catheter1 either a tunneled exteriorized catheter or access port, pocketed jacket, metal tether, swivel, extension lines, and an infusion pump. TETHERED SYSTEM COMPONENTS CJVC-2LV Groshong Catheter, Pg. 32 AS P Large Animal Swivel, Pg. 45 LA T4 Large Animal Tether, Pg. 45 CPT-RP Port, Pg. 33 WHIS-22 Winged Infusion Sets, Pg. 49 DJ-02 Dog Jacket, Pg. 44 EXT-PM40 Extension Lines EXT-PF40 Extension Lines AT E1 Tether End Plate Pg. 45 3D SAI 3D Syringe Pump, Pg. 16 Below is a system we recommend for any infusion study utilizing large animals. For more information on selecting the right catheter and pump for your research give us a call or send us an and we will be happy to assist you with putting together the right system for your specific research needs. CPT-RP AS P LA T4 3D DJ-02 ORDERS@SAI-INFUSION.COM P F

Primate Ambulatory Infusion Systems Primate Ambulatory Infusion Systems Reduce stress by allowing animals unrestrained and untethered freedom of movement at all times.

The basic ambulatory infusion system includes: infusion pump, pocketed jacket, extension line, and in-dwelling catheter. There are two catheter systems to choose from.

12 Primate Ambulatory Infusion Systems Primate Ambulatory Infusion Systems Reduce stress by allowing animals unrestrained and untethered freedom of movement at all times. New advancements in pump technology, jacket design, catheter material, and surgical techniques have made this system easier and less expensive for researchers to implement. The basic ambulatory infusion system includes: infusion pump, pocketed jacket, extension line, and in-dwelling catheter. There are two catheter systems to choose from. One system is an exteriorized catheter that luer-locks to the extension line. The alternative system utilizes a vascular access port accessed by a Huber needle or catheter and extension line. We offer a number of high-quality infusion pumps with a wide range of delivery options. All of the pumps are small enough to be carried by the animal and have a legacy of withstanding the rigors of on-animal applications. Below is a system we recommend for any continuous infusion study using large animals. For more information on selecting the right catheter and pump for your research give us a call or send us an and we will be happy to assist you with putting together the right system for your specific research needs. AMBULATORY SYSTEM COMPONENTS CPT Port, Pg. 33 CPT-AC Introducer, Catheter, Female Luer, Pg. 34 CADD-6500 CADD Legacy Pump, Pg. 21, 3D MicroBT SAI 3D MicroBT Pump, Pg. 20 3D MiniBT SAI 3D MiniBT Pump, Pg. 20 PJ-01 Primate Jacket, Pg. 44 JP Jacket Pocket, Pg. 44 CPT CPT-AC CADD D MicroBT 3D MiniBT PJ INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Tethered Primate Infusion Systems Tethered Primate Infusion Systems The tethered infusion system is well suited for studies that require large dosing volumes for extended periods of time or when

13 Tethered Primate Infusion Systems Tethered Primate Infusion Systems The tethered infusion system is well suited for studies that require large dosing volumes for extended periods of time or when repeated interaction with the pump is necessary. With large dosing volumes, syringe pumps may not be optimal, since the largest standard syringe only holds 60ml. Volumetric pumps can handle a wide range of flow rates and can accommodate reservoirs of 2 liters or larger. Reservoirs and delivery tubing sets are more expensive, but the versatility and convenience are well worth it. The tethered system requires an in-dwelling catheter1 either a tunneled exteriorized catheter or access port, pocketed jacket, metal tether, swivel, extension lines, and an infusion pump. TETHERED SYSTEM COMPONENTS CPT-RP Port, Pg. 33 PJVC-2LV Groshong Catheter, Pg. 34 LA T4 Large Animal Tether, Pg. 45 AS P Large Animal Swivel, Pg. 45 WHIS-22 Winged Infusion Sets, Pg. 49 PJ-01 Primate Jacket, Pg. 44 EXT-PM40 Extension Lines EXT-PF40 Extension Lines AT E1 Tether End Plate Pg. 45 3D SAI 3D Syringe Pump, Pg. 16 Below is a system we recommend for any infusion study utilizing large animals. For more information on selecting the right catheter and pump for your research give us a call or send us an and we will be happy to assist you with putting together the right system for your specific research needs. CPT-RP LA T4 AS P 3D PJ-01 ORDERS@SAI-INFUSION.COM P F

Self-Administration Systems in Rodents Self-Administration Systems in Rodents Self-administration, a form of operant conditioning, often provides the reward as an intravenous dose of drug.

Standard self-administration systems use threaded connections and friction fittings at the junctions in the fluid path.

including harness or skin buttons, tethers, swivels and extension lines.

systems. Our self-administration components are designed for use with any standard operant self-administration system including but not limited to MED Associates or Panlab operant chambers.

14 Self-Administration Systems in Rodents Self-Administration Systems in Rodents Self-administration, a form of operant conditioning, often provides the reward as an intravenous dose of drug. Both the test agent and the addictive drug can be administered remotely through chronically implanted intravenous catheters using swivel and tether systems. Standard self-administration systems use threaded connections and friction fittings at the junctions in the fluid path. Self-administration systems which provide luer lock fittings (Quick Connect) reduce the potential for contamination and provide a secure, locking fit between the components of the fluid path, including harness or skin buttons, tethers, swivels and extension lines. SAI s split-septum systems provide rapid needle-less connection and disconnection and eliminate the torque on the harness or skin button when connecting and disconnecting either threaded or luer-lock systems. Our self-administration components are designed for use with any standard operant self-administration system including but not limited to MED Associates or Panlab operant chambers. STANDARD SYSTEMS EXT-16 or EXT-36 Extension line (from syringe on infusion pump to swivel), 50/bx page 50 *QCS-S Single Luered Swivel (Connects extension line to tether) page 40 TT in. Tether with threaded end PU Extension line (from swivel through tether to skin button) SBD Skin button with nylon mesh and silicone catheter. Suture bead at 30 mm HSC20-1-B25 Pre-filled syringe w/ Heparin/saline & 25ga blunt needle for maintenance, 100/bx QUICK CONNECT/LUER LOCK EXT-16 or EXT-36 Extension line (from syringe on infusion pump to swivel), 50/bx page 50 *QCS-D Dual Luered Swivel (Connects extension line to tether) page 40 *QCT-12 Quick Connect Male-Male Tether page 41 *QCH-21 Quick Connect Harness with 21ga catheter connector page 36 SBD-CLI (Alternative to QCH-21) Quick Connect skin button page 36 HSC20-1-H25 Pre-filled syringe with Heparin/saline & 25ga Huber needle for flushing between sessions, 50/bx (Suggested catheters: RJVR-31, RFVR-8, See page 25 for additional catheters) SPLIT SEPTUM EXT-16 or EXT-36 Extension line (from syringe on infusion pump to Swivel), 50/bx page 50 *QCS-D Dual Luered Swivel (Connects extension line to tether) page 40 *QCT-12CL Quick Connect Male-Tether with Plastic Cannula *QCH-21CLI Self-Sealing Septum Skin Button with Jugular Vein Catheter SBD-CL1 (Alternative to QCH-21CLI) Self-Sealing Septum Skin Button page 39 HSC20-3-PN Pre-filled Syringe with Heparin/saline with plastic needle for flushing skin button between sessions, 50/bx (Suggested catheters: RJVR-31, RFVR-8, See Page 25 for additional catheters) *All items covered under International and U.S. patent 7,665,424. QCH-21 QCS-S QCT-12 QCS-D EXT-36 SBD-CL1 QCT-12CL 14 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Insulin & Glucose Clamp System Components for Insulin and Glucose Clamp System in Rodents RCA-06 Carotid Arterial Catheter RJVR-31 Jugular Venous RFV-17 Femoral

HGS-10 Catheter locking solution, page 46 *QCH-21 Harness, page 36 *QCDH-21 Dual Harness, page 36 *QCT-12 Tether, page 41 *QCDT-SS Tether GMSHK Swivel Mount

Prefilled Syringes, 100/bx, page 46 SC3LLHP Stopcocks, 10/bx, page 55 B22-50, B23-50 Blunt Needles, 25/bx, page 48 PE-50-25 Tubing, 25ft, page 51 PU-040-25

SAI carries a complete set of components for researchers using the Glucose, or Insulin Clamp Technique (sometimes called euglycemic or hyperinsulinemic clamp) in

These clamp methods are typically employed in research designed to measure the effects of test agents or other types of interventions on metabolic disease.

Dual infusion lines for glucose and insulin, as well as a separate sampling line for blood measurements are often used concurrently in these complex systems.

15 Insulin & Glucose Clamp System Components for Insulin and Glucose Clamp System in Rodents RCA-06 Carotid Arterial Catheter RJVR-31 Jugular Venous RFV-17 Femoral Venous RFA-08 Femoral Artery CP-21, CP-22, CP-23 Catheter Plugs, 100/bx, page 27 CC-21, CC-22, CC-23 Catheter Connectors, 100/bx, page 27 3-way-30 3-Way Connector HGS-10 Catheter locking solution, page 46 *QCH-21 Harness, page 36 *QCDH-21 Dual Harness, page 36 *QCT-12 Tether, page 41 *QCDT-SS Tether GMSHK Swivel Mount Assembly, page 42 *QCS-S, *QCS-D Swivels, page 40 EXT-36 Extension Line, 50/bx, page 50 F200T Infusion Pump, page 18 HSC Prefilled Syringes, 100/bx HSC500-1 Prefilled Syringes, 100/bx, page 46 SC3LLHP Stopcocks, 10/bx, page 55 B22-50, B23-50 Blunt Needles, 25/bx, page 48 PE Tubing, 25ft, page 51 PU Tubing, 25ft *All items covered under International and U.S. patent 7,665,424. SAI carries a complete set of components for researchers using the Glucose, or Insulin Clamp Technique (sometimes called euglycemic or hyperinsulinemic clamp) in rodents to assess Insulin Sensitivity. These clamp methods are typically employed in research designed to measure the effects of test agents or other types of interventions on metabolic disease. These systems require specialized infusion and sampling components to ensure meaningful data collection. Dual infusion lines for glucose and insulin, as well as a separate sampling line for blood measurements are often used concurrently in these complex systems. Accurate and easy-to-use syringe pumps are also essential in these studies, as the rate of infusion may be frequently adjusted throughout the Clamp procedure. When designing a clamp system for your research, please contact the experienced scientists at SAI to help select the appropriate components to meet your metabolic research needs. GMSHK QCH-21 F200T QCT-12 QCS-D ORDERS@SAI-INFUSION.COM P F

The 3D Programmable Pump Designed Specifically for Toxicology Infusion Studies The SAI model 3D infusion pump is the first state-of-the-art syringe driver built specifically for large-scale GLP

The SAI 3D provides the most versatile animal room power delivery configuration available. Power 1 48 pumps with one AC cord.

The SAI 3D has all of the features present in modern medical-purpose pumps but will never be discontinued or altered due to irrelevant software changes required in human-use pumps.

16 The 3D Programmable Pump Designed Specifically for Toxicology Infusion Studies The SAI model 3D infusion pump is the first state-of-the-art syringe driver built specifically for large-scale GLP Toxicology studies. Multiple communication options, wireless and/or Ethernet, provide unparalleled versatility for the end user when coupled with the Axios infusion management software system. The SAI 3D provides the most versatile animal room power delivery configuration available. Power 1 48 pumps with one AC cord. The small footprint and multiple mounting position features are designed specifically for space-challenged animal rooms. The SAI 3D has all of the features present in modern medical-purpose pumps but will never be discontinued or altered due to irrelevant software changes required in human-use pumps. SAI 3D SAI 3DE SAI 3D Programmable Syringe Pump SAI 3D Programmable Syringe Pump with Communication Unique Features Small footprint Up to 48 pumps powered by a single AC cord Multiple mounting positions Power over Ethernet; one cord for both power and Ethernet Ethernet and/or wireless communication Syringe recognition Modern medical pump features; no threat of discontinuation due to medical requirements Repair and Calibration Kits available for complete In-house support Built by SAI in the USA SAI onsite service available Unique Benefits More pumps per room Fewer cords per room Multiple mounting options Communication flexibility Reduces maintenance & repair downtime Designed by Toxicologists for Toxicologists Wired or Wireless Multi-Pump Network Configuration Pump Specifications Accuracy: +/- 3% Battery Capacity: 24 hours Flow Rates: 0.01 to 438 ml/hr Power: 110 or 220V, internal battery back-up Compatible Syringes: B-D, Terumo, Monoject Alarms/Alerts: Low Volume, Syringe Empty, Occlusion, Low Battery, Incorrect Syringe, Dose Due, Pump Idle, Syringe Mounted Improperly, Multiple Failsafe System Alerts 16 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Axios Infusion Study Software Improve Quality, Simplify Documentation & Reporting Axios Benefits Monitor and Control to improve quality & efficiency Modular Network with Centralized Database Import

studies Validation assistance available Specifications Windows-based GLP and 21 CFR Part 11-compliant Data Event Log Continuous or Intermittent Mode Monitor 600 pumps per room Multiple Study Status

and control 600 or more SAI 3D syringe or ambulatory pumps per room and access them from any computer on the Axios Network.

17 Axios Infusion Study Software Improve Quality, Simplify Documentation & Reporting Axios Benefits Monitor and Control to improve quality & efficiency Modular Network with Centralized Database Import Body Weights for automated dose changes Manage by Animal, Group, Study or Pump Simplifies Documentation and Reporting Improves GLP Compliance Developed by Toxicologists for large-scale Toxicology studies Validation assistance available Specifications Windows-based GLP and 21 CFR Part 11-compliant Data Event Log Continuous or Intermittent Mode Monitor 600 pumps per room Multiple Study Status Settings Comprehensive Reporting Options Calibration and Maintenance Module The Axios Infusion Management Software is a networked software platform that provides researchers the ability to monitor and control 600 or more SAI 3D syringe or ambulatory pumps per room and access them from any computer on the Axios Network. Axios is a CFR21 Part 11 compliant software platform that adds secure data collection, data safe redundancy and secure backups for all infusion studies. Axios tracks all user, pump and animal data including the importation of body and syringe weights allowing ready access to all Infusion related data. Any SAI 3D Syringe or ambulatory pump communicates with Axios via Wi-Fi, Ethernet, or Bluetooth connection. The 3D Syringe pump also has built-in fail over from Ethernet to Wi-Fi for 100% connectivity. Axios offers seamless integration, regardless of your IT infrastructure. Ethernet Wireless ORDERS@SAI-INFUSION.COM P F

Syringe Pumps Fusion Touch Pumps Our line of Fusion laboratory syringe pumps are designed for accuracy and ease of use and monitoring.

The new Fusion touch syringe pump has one of the newest ARM processors, allowing it to load/save methods, control motor force, and run an array of complex flow profiles.

Set any parameter through a familiar windows -like environment and change settings such as syringe ID, flow rate, volume, and delay time.

Both keypad and screen are coated with solvent-resistant PP coating for operational durability under laboratory environments. F100T 0.0001ul/min to 102 ml/min Infusion Only F200T 0.

00001ul/min to 10 ml/min Infusion Only The Nexus Series Syringe Pumps The Nexus series syringe pumps are high-end fluid delivery systems designed to tackle extremely tough applications with high rate

18 Syringe Pumps Fusion Touch Pumps Our line of Fusion laboratory syringe pumps are designed for accuracy and ease of use and monitoring. The Touch series features precise flow rates, combined with syringe recognition, and USB, RS232 and TTL for PC control. These pumps allow for Simple and Smart Advanced Flow Control. The new Fusion touch syringe pump has one of the newest ARM processors, allowing it to load/save methods, control motor force, and run an array of complex flow profiles. Users can program in (without a PC): Constant flow, Variable/Punctuated flow profiles, Gradient flows and Advanced loops. Fusion Touch features an overview hybrid touchscreen and keypad interface. Set any parameter through a familiar windows -like environment and change settings such as syringe ID, flow rate, volume, and delay time. Syringe dimensions can also be loaded from an internal syringe library stored on the pump. Dual entry modes allow users to wear gloves and still operate the system. Both keypad and screen are coated with solvent-resistant PP coating for operational durability under laboratory environments. F100T ul/min to 102 ml/min Infusion Only F200T ul/min to 65 ml/min Infusion/Withdraw F400T ul/min to 10 ml/min Infusion Only The Nexus Series Syringe Pumps The Nexus series syringe pumps are high-end fluid delivery systems designed to tackle extremely tough applications with high rate variation sensitivities due to high pressure and viscosity dosing. Standard Features: Color Graphic LCD interface RS232 port standard for computer control Infuse/withdraw rack Gradient/multistep pumping function Stall detection N ul/min to 300 ml/min, Infusion Withdraw 10 channel rack option. N ul/min to 200 ml/min Up to 550 lbs of force Infusion/Withdraw 4 channel rack options. NE-1000, NE-1600, NE-1800 Holds 1-8 Syringes up to 60cc (depending on model) Built-in Automation Network, control and monitor up to 100 pumps with one computer Infusion and withdrawal Infusion rates from 0.73 µl/hr (1cc syringe) to 2100 ml/hr (60cc syringe) Worldwide power supplies available Set a single pumping rate and/or dispensing volume Easy-to-use keypad interface Space Saving Chassis: Footprint size of only 5¾ x 8¾. Two-year warranty Operates stand-alone or from a computer Dispensing accuracy of +/-% Program up to 41 pumping phases that change pumping rates, set dispensing volumes, insert pauses, control and respond to external signals and sound the buzzer NE-1000 Single Syringe Pump NE-1600 Six Syringe Pump NE-1800 Eight Syringe Pump Standard Infusion-Only Pump 11 Elite Syringe Touch Pumps The Pump 11 Elite Series of syringe pumps expands its capabilities to satisfy your experimental requirements. These compact syringe pumps carry on the tradition as the premiere workhorse infusion pump, offering unparalleled ease of use with a high-resolution touch screen with intuitive icon interface. The Pump 11 Elite Series allows you to create, save and run simple to complex methods without a PC. These syringe pumps have a new mechanism that includes a tight gripping, more secure syringe clamp for syringes ranging from 0.5ul to 60ml (single syringe) and 0.5ul to 10 ml (dual syringe). The Pump 11 Elite Series offers enhanced flow performance with high accuracy and smooth flow from 1.28 pl/min to ml/min Pump 11 Elite Infusion-Only Single Syringe Pump 11 Elite Infusion-Only Dual Syringe Standard Infusion/Withdraw PHD Ultra Syringe Touch Pumps The PHD Ultra is the solution for your most demanding fluidics applications. This pump represents the latest technology in syringe pumps and was developed utilizing the feedback of the world s largest populations of syringe pump users. The PHD Ultra will change the way you think about syringe pumps PHD Ultra Syringe Pump Infuse-Only Standard A PHD Ultra 6x10 MultiRack - when purchased with Pump A PHD Ultra 4x140 MultiRack - when purchased with Pump PHD Ultra Syringe Pump Infuse/Withdraw Standard PHD Ultra Syringe Pump Infuse/Withdraw Programmable PHD Ultra Syringe Pump with Push/Pull Mechanism PHD Ultra Syringe Pump with Push/Pull Mechanism Programmable A PHD Ultra MicroDialysis MultiRack - when purchased with Pump 18 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Syringe Pumps 11 Pico Plus Syringe Pump It can accurately deliver volumes down to 3.3 picoliters/minute.

It has both infusion and withdrawal capabilities as well as RS-232 communications. # of Syringes: 2 Accuracy: +/-0.5% Average Linear Force: 16 lbs. Flow Rate Max: 0.

33 µm/step Syringe Size Maximum: 10 ml Syringe Size Minimum: 1 µl 702213 11 Pico Plus Pump 11 Plus Syringe Pump The Pump 11 Plus family of pumps is Harvard Apparatus more basic pumps, but provides

19 Syringe Pumps 11 Pico Plus Syringe Pump It can accurately deliver volumes down to 3.3 picoliters/minute. It is ideal for applications such as cellular injections or for providing the micro flow required for FIA or capillary LC. It has both infusion and withdrawal capabilities as well as RS-232 communications. # of Syringes: 2 Accuracy: +/-0.5% Average Linear Force: 16 lbs. Flow Rate Max: ml/min (using two 1ml syringes & combining the output ml/min) Flow Rate Min: µl/min Input Power: 12 VDC, 1.5 A, 18 W Pressure: low Pump Function: Infuse/Withdraw Step Resolution: 0.33 µm/step Syringe Size Maximum: 10 ml Syringe Size Minimum: 1 µl Pico Plus Pump 11 Plus Syringe Pump The Pump 11 Plus family of pumps is Harvard Apparatus more basic pumps, but provides the precision flow that Harvard Apparatus pumps are known for. Select from either 1 or 2 syringe models and from basic infusion-only or the more advanced infuse/withdraw models. The infuse/withdraw models also have RS-232 communications. # of Syringes: 1 or 2 Accuracy: +/-0.5% Average Linear Force: 16 lbs. Communications: Keypad only Display: Vacuum fluorescent, 2-line, 16 character Flow Rate Maximum: ml/min (single) ml/min (double) Flow Rate Minimum: µl/hr Infusion only: infusion - Infuse/withdraw (advanced) Syringe Rack Type: Standard Rack Syringe Size Maximum: 60 ml (single) 10 ml (double) Syringe Size Minimum: 0.5 µl Plus Single-Syringe Pump Plus Dual-Syringe Pump Plus Advanced Single-Syringe with Dual RS-232 Infuse/Withdraw Plus Advanced Dual-Syringe with Dual RS-232 Infuse/Withdraw 22 Multiple Syringe Pump The 22 Multiple Syringe Pump is Harvard Apparatus legendary syringe pump. It is the pioneer precision pump that is referenced the world over. Select from infusion only or infuse/withdraw models, all with RS-232 capabilities. It is available with a choice of syringe racks to accommodate 2, 4 or up to 10 syringes. A microliter syringe rack version is also available for microliter applications. # of Syringes: 2, 4, 6, 10 Accuracy: % Average Linear Force: 47 lbs. Communications: RS-232, TTL Display: LED, 3-1/2 digit, numeric Flow Rate Maximum: 55.1 ml/min Flow Rate Minimum: µl/hr Pump Function: Infusion, Infuse/withdraw Step Resolution: 0.33 µm/step Syringe Size Maximum: 140 ml Syringe Size Minimum: 0.5 µl Infusion-Only w/standard Syringe Holder Infusion-Only w/anti-siphon Standard Syringe Holder Infusion-Only with 4 x 140 Multi-Syringe Rack Infuse/Withdraw w/standard Syringe Holder Infuse/Withdraw w/microliter Syringe Holder Infuse/Withdraw w/ 4 x 140 Multi-Syringe Rack Infuse/Withdraw with 6/10 Multi-Syringe Rack ORDERS@SAI-INFUSION.COM P F

Ambulatory Pumps Bluetooth Ambulatory Pumps 3D MiniBT & 3D MicroBT Infusion Pumps with Wireless Communication The SAI 3D MiniBT and MicroBT Infusion Pumps are the first ambulatory pumps that can be

20 Ambulatory Pumps Bluetooth Ambulatory Pumps 3D MiniBT & 3D MicroBT Infusion Pumps with Wireless Communication The SAI 3D MiniBT and MicroBT Infusion Pumps are the first ambulatory pumps that can be controlled wirelessly from another room. The ultra-lightweight (141 grams) MiniBT and the MicroBT are research dedicated pumps, perfectly suited for ambulatory delivery in rodents, rabbits, dogs, pigs and primates. By combining the MiniBT or the MicroBT and the SAI 3D Syringe pump with the Axios Automated Infu sion Software researchers can manage all infusion for Safety Pharmacology and Toxicology with one universal system. The SAI 3D Mini & Micro are generally the same as the Crono PCA 50 with added, unique features. They are small enough to place two pumps on one animal for automated internal heat infusion. Unique Features: Bluetooth-Enabled Size: 84.5 x 55 x 42mm Weight with battery: 141 g Continuous or Bolus dosing Battery Life: 3-4 months Accuracy: +/- 2.0% Reservoir Volume: Up to 50 mls Flow Rate: ml/hr Depending on Model 3D MicroBT SAI 3D MicroBT Ambulatory Pump Flow Rate: ml/hr. Syringe Size: 10 or 20 ml 3D MiniBT SAI 3D MiniBT Ambulatory Pump Flow Rate: ml/hr. Syringe Size: 50 ml 3D MiniBT 3D MicroBT 3D Mini & Micro Software The 3D BT software coupled with the MiniBT or MicroBT pump, provides scientists 2-way, wireless communication from distances up to 300 feet. The wireless communication feature provides Start and Stop bolus or infusion and change flow rate, while not disturbing animal subjects. This pump and software combination also allows the researcher to monitor infusion rate, volume delivered, and volume remaining in reservoir, from an unobtrusive distance. SAI offers two distinct soft ware packages for remote monitoring and control of the 3D Mini and MicroBT pumps. The Cane software package offers basic remote monitoring and operation of the Mini and MicroBT pumps only. The Axios software package is a 21 CFR Part II validated server network that enables researchers to monitor, control, and track all infusion devices locally or worldwide. Specifications: Start/Stop an infusion for one or multiple pumps Assign a study animal number to each pump Export pump history Start/Stop a bolus dose Set Audible Alarm to either on or off Change dose rate Change volume of bolus dose View battery voltage Time Infusion completed Visual identification of alarms on the pump 3D Micro & Micro BT Reservoirs The 10 and 20 ml syringe reservoirs are only compatible with the pump models designated as Micro. Qty. CRN/10 10 ml Syringe 80/box CRN/20 20 ml Syringe 80/box 3D Mini & Mini BT Reservoirs The 50 ml syringe reservoirs are only compatible with the pump models designated as Mini. Qty. CRN/50 50 ml Syringe 60/box 20 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Ambulatory Pumps 3D Micro 3D Mini 3D Mini and 3D Micro Pumps Get the same ultra-lightweight (141 grams), durable, reliable, and accurate ambulatory infusion pump without the Bluetooth communication

21 Ambulatory Pumps 3D Micro 3D Mini 3D Mini and 3D Micro Pumps Get the same ultra-lightweight (141 grams), durable, reliable, and accurate ambulatory infusion pump without the Bluetooth communication features and save. The 3D Mini and 3D Micro pumps function exactly like the BT models (see opposite page) and use the same disposable reservoirs; the only thing missing is the communication feature. 3D Micro 3D Mini SAI 3D Micro Ambulatory Pump, Flow Rate: ml/hr. Syringe Size: 10 or 20 ml SAI 3D Mini Ambulatory Pump, Flow Rate: ml/hr. Syringe Size: 50 ml Ambulatory Infusion Pump CADD-Legacy PLUS Ambulatory Infusion Pump, Model 6500 Performance Runs in the Family The CADD-Legacy PLUS pump is the member of the new CADD-Legacy pump family of therapy-specific delivery systems you can rely on for continuous and intermittent therapies. The CADD line of pumps is the standard for ambulatory infusion in research. CADD pumps have an unparalleled track record of accuracy and durability dating back to the early 1980s. These pumps withstand the rigors of primate and canine ambulatory like no other. Infusion rates up to 125 ml/hr and dose volumes up to 1,000 ml can accommodate high-rate, high-volume therapies Longer delayed start time and expanded dosing parameters provide added flexibility in meeting complex therapy requirements Internal clock designed to keep dosing on schedule Features: Easy-to-read and understand display screen provides information for programming adjustments and troubleshooting Cassette detection sensor is designed to detect cassette attachment Upstream and downstream occlusion sensors are designed to alert the technician if interruption of fluid delivery occurs Air-in-line detector with Off, High and Low sensitivity settings. Pump weight: 395G ON/OFF key allows pump to be placed in low-power state and is designed to save battery life CADD pump reliability and durability can mean less down time and fewer interruptions Demand Dose:.000 or ml in.002 Mml increments Demand Dose Duration: 5-15 minutes in 1-minute increments, 15 minutes-24 hrs. in 5-minute increments Depleted Battery, Syringe Not Loaded CADD-6500 CADD-Legacy Plus Ambulatory Infusion Pump Medication Cassette Reservoirs 50 ml and 100 ml Medication Cassette reservoirs with female luer, clamp and non-vented stopper. For use with CADD-1, CADD-PLUS, CADD-PCA, CADD-Legacy, and CADD-Prizm pumps. All cassette models must be used with a Deltec Extension Set with anti-siphon valve. CADD administration set with bag spike, male luer, with integral anti-siphon valve, and clamp. CADD administration set with TOTM-plasticized blue-striped tubing with male luers upstream and downstream, add-on anti-siphon valve & clamp. Qty ml Medication Cassette Reservoirs 12/bx ml Medication Cassette Reservoirs 12/bx CADD Administration Set: Bag, Spike & Add-on Anti-Siphon Valve, Length: 60 12/bx CADD Administration Set: Male, Luers Upstream & Downstream, Length: 60 12/bx ORDERS@SAI-INFUSION.COM P F

Best of all it is extremely affordable at less than 25% the cost of similar ambulatory devices. AMBT-01 Sorenson Pump AMBT-01 Drug Bag AmbIT Medication Cassettes and Reservoirs Qty.

(Empty) Toxic plasticizers (DEHP) can leach from PVC bags and reservoirs into test formulations. The risk is especially high when using formulations that have a lipid component.

ER-1000 ER-500 ER-250 ER-100 1000ml EVA Drug Bag (Empty) 500ml EVA Drug Bag (Empty) 250ml EVA Drug Bag (Empty) 100ml EVA Drug Bag (Empty) ALZET Pumps Small Animal Pumps By attaching the proper

22 Ambit Ambulatory and Alzet Pumps AmbIT Continuous Pump The Sorenson Amibit Continuous ambulatory pump weighs only 4.7 oz, has a slender profile and can accommodate any size reservoir. It can deliver from 0.1 to 125 ml/hr, is accurate to +/- 6% and inserted in its durable hardshell is perfect for ambulatory infusion in small or large primates and dogs. Best of all it is extremely affordable at less than 25% the cost of similar ambulatory devices. AMBT-01 Sorenson Pump AMBT-01 Drug Bag AmbIT Medication Cassettes and Reservoirs Qty AmbIT Cassette with Filter and Male Luer 20/case AmbIT Cassette without Filter, with Male Luer 20/case AmbIT 250 ml MediBag 60/case AmbIT 420 ml MediBag 60/case Drug Bags (Empty) Toxic plasticizers (DEHP) can leach from PVC bags and reservoirs into test formulations. The risk is especially high when using formulations that have a lipid component. Use non-leaching, EVA reservoirs to remove this risk from your research equation. ER-1000 ER-500 ER-250 ER ml EVA Drug Bag (Empty) 500ml EVA Drug Bag (Empty) 250ml EVA Drug Bag (Empty) 100ml EVA Drug Bag (Empty) ALZET Pumps Small Animal Pumps By attaching the proper catheter, Alzet Osmotic Pumps can deliver substances into the venous or arterial circulation, into the brain, or into any organ, lumen or solid tissue. Alzet Corporation offers a range of specialized catheters, compatible with Alzet pumps, to enable targeted delivery to a variety of sites. Common routes of administration requiring use of a catheter: Articular cavity, blood vessels, bone, brain (solid tissue), brain (ventricles), ear, eye, muscle, nerves, spinal cord, stomach and tumors. Note: No catheter is necessary when systemic delivery is desired. This is accomplished by subcutaneous or intraperitoneal implantation of an Alzet Osmotic Pump without a catheter. Outer Membrane: Cellulose ester blend. Drug Reservoir: Thermoplastic hydrocarbon elastomer. Pack of 10. Note: All items are supplied sterile. Pumps cannot be reused. ALZET Flow Rates Qty D (1.0 µl/hr, 3 days) D (0.5 µl/hr, 1 week) (0.25 µl/hr, 2 weeks) (0.25 µl/hr, 2 weeks) D (8.0 µl/hr, 1 day) (1.0 µl/hr, 1 week) (0.5 µl/hr, 2 weeks) (0.25 µl/hr, 4 weeks) (0.25 µl/hr, 4 weeks) ML1 (10.0 µl/hr, 1 week) ML2 (5.0 µl/hr, 2 weeks) ML4 (2.5 µl/hr, 4 weeks) 10 tips: Pumps Catheters are available, perfectly adapted for Alzet Pumps: Rat Jugular Rat Femoral Rat Intrathecal Rat Femoral Tapered Mouse Jugular See Page INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

FluidSync Microinfusion System FluidSync micropump (200µL) FluidSync Microinfusion System consists of (1) implantable micropump, (2) wireless base station, and (3) programmable software.

The FluidSync software controls an array of base stations via wired USB connection or wireless Bluetooth connection.

23 FluidSync Microinfusion System FluidSync micropump (200µL) FluidSync Microinfusion System consists of (1) implantable micropump, (2) wireless base station, and (3) programmable software. Base Station B2MH FluidSync Microinfusion Components The FluidSync Microinfusion System enables precise localized delivery of drugs in rodents. It is the smallest wirelessly activated pump available and provides ultimate control over the delivery profile. The pump is implantable, refillable and compatible with a wide variety of formulations. The entire system is controlled via intuitive program software capable of handling multiple experiments at once. The FluidSync software controls an array of base stations via wired USB connection or wireless Bluetooth connection. The software offers the capability to program, execute, and document complex and customized dosing regimens. From one central location, the user has full access to all base stations and coupled micropumps. Specification: Flow rate: 1µl/hr - 100µl/hr Drug reservoir: 200µl Programmable dosing On-demand/event-triggered dosing Size: 19.1mm 13.8mm 8mm (L W H) Implantable Refillable Wireless Item Qty. Evaluation Kit EK-M200 Includes 2 - M200 (Micropump), B2MH (Base station), UH4 (USB Hub), UH4 (USB Hub), P18 (Power Supply), D6 (Digital Cable), S2013 (Control Software) 1 Detailed of Contents Micropump M µL Implantable Pump 1 Base Station B2MH Dosing Platform 1 USB Hub UH4 4-Channel Hub 1 DoseSync S2013 Control Software 1 Power Supply P18 9V, 18W 1 Digital Cable D6 6 ft Stereo Cord 1 System is also available for rental, please call for details. ORDERS@SAI-INFUSION.COM P F

Mouse Catheters Mouse Tail Vein Catheters Our biocompatible polyurethane and silicone catheters are designed to enhance patency and minimize vessel trauma during implantation.

Beads are also positioned to provide a secure tension loop to maximize continued patency during movement and growth.

24 Mouse Catheters Mouse Tail Vein Catheters Our biocompatible polyurethane and silicone catheters are designed to enhance patency and minimize vessel trauma during implantation. All these catheters have beads accurately positioned from the catheter tip for optimal implantation position within the vessel. Beads are also positioned to provide a secure tension loop to maximize continued patency during movement and growth. Mouse Jugular Vein Catheters Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Beads MJC-01 <25g 9 mm 1 F 14 cm 25 ga Polyurethane 2 MJC g 11 mm 1 F 14 cm 25 ga Polyurethane 2 MJC-05 >25g 11 mm 2.5 F 12 cm 23 ga Silicone 2 Mouse Femoral Vein Catheters Biocompatible polyurethane construction to minimize vessel trauma and increase patency. Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Beads MFV-02 <25g 20 mm 1 F 17 cm 25 ga Polyurethane 2 Mouse Arterial Catheters Our biocompatible catheters for the carotid artery of the mouse are designed for accurate placement to maximize patency. They are sized to fit into small mouse vessels, with suture beads located for optimal positioning. These catheters may be used for blood pressure measurement or infusion. Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Beads MAC-2B >25g 10 mm 1 F 15 cm 25 ga Polyurethane 2 MAC-05 >25g 30 mm 1 F 12 cm 25 ga Polyurethane 3 Mouse Tail Vein Catheters The SAI tail vein access system consists of a very small catheter and stylet that easily inserts into the tail vein of a restrained rodent. The size allows for quick, mistake-free access to the tail vein and once inserted, the flexibility keeps vessel trauma to a minimum. Unlike sharp, stiff needles this catheter moves freely up the vein to ensure the dose goes into the bloodstream, not into the surrounding tissue or back out through the insertion site. It bends naturally with the tail, reducing injury and allowing for continuous infusion or repeated bolus dosing with less chance of losing the tail. These catheters are often used for MRI, PET and CT applications and can easily be modified to eliminate all metallic components. Animal Size Intravascular Tip O.D. Stylet Total Length Connects to Needle Material Includes MTV-01 All Mice & Rats 1 F Yes 28 cm 23 ga Polyurethane Needle MTV-02 All Mice & Rats 1 F No 61 cm 23 ga Polyurethane Needle MTV-02S All Mice & Rats 1 F Yes 61cm 25 ga Polyurethane Needle MTV-03 All Mice & Rats 1 F No 91 cm 23 ga Polyurethane Needle MTV-05 All Mice & Rats 1 F No 162 cm 23 ga Polyurethane Needle MTV-BMS1 All Mice & Rats 1 F Yes 14 cm 25 ga Polyurethane Needle MTV-11 All Mice & Rats 32 ga No 28 cm 25 ga Polyurethane Needle Micro-Cannula Our Micro-Cannula simplifies vascular access for small vessels in rodents and other small species. A sharp stylet to aid insertion and a tapered tip make catheter placement fast and reliable. Features include suture beads positioned for secure placement and Teflon tubing for biocompatibility and resistance to organic vehicles. These catheters connect to standard syringes or any other luered fitting. MC OD x 0.008ID Tip with Sharpened Stylet and Female luer, total length 8 cm MC OD x 0.008ID Tip with Sharpened Stylet and Female luer, total length 10 cm BLF-24 BF BF Butterfly Needles These specialty needles (often called Winged Infusion Sets) offer a highly effective means of accessing a peripheral blood vessel for infusion or sampling in small and large animals. When compared to traditional straight needles, butterfly needles are often shorter, include wings on both sides of the needle for stability and have a tube attached to the end for easy connection to syringes or collection devices. The wings provide added grip and accuracy when handling the needle. These come in a wide variety of needle sizes and tubing lengths and can be customized. Often used to infuse in rodents via the tail vein, or in the cephalic or saphenous veins in larger animals they are biocompatible and resistant to organic vehicles. These catheters connect to standard syringes or any other luered fitting. 27G butterfly needle connected to 24 cm of polyurethane Mouse tail vein catheter 27G butterfly needle with 12 cm of polyurethane 27G butterfly needle winged infusion set 5 cm long 24 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

25 Rat Catheters Our tapered catheters combine features to give you the best of both worlds performance. They are thick-walled and heavy-duty where they exit the animal and soft and compliant in the vessel. Our catheters are available with rounded tips to decrease intravascular trauma. Rounded tips have been shown to increase patency, reduce histologic findings and offer less resistance while being inserted into the vessel. Rat Jugular Vein Catheters Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Suture Beads RJV g 3.5 cm 2.7 F 10 cm 22 ga Silicone Dacron RJV g 1.5 cm 3 F 18 cm 22 ga Tapered Polyurethane 2 RJV-04 All 2.8 cm 2.7 F 7 in 22 ga Polyurethane 2 RJVR g 3.5 cm 3 F 30 cm 22 ga Rounded Tip Polyurethane 2 Rat Femoral Vein Catheters Biocompatible polyurethane construction for low vessel trauma and increased patency. Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Suture Beads RFV g 4 cm 3 F 69 cm 22 ga Tapered Polyurethane 3 RFV g 4 cm 3 F 76 cm 23 ga Polyurethane 2 RFV g 4 cm 3 F 30 cm 23 ga Polyurethane 3 RFV g 4 cm 2.5 F 30 cm 25 ga Polyurethane 3 Rat Arterial Catheters Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Suture Beads RFA g 4 cm 2.3 F 79 cm 22 ga Tapered Polyurethane 3 RFA g 4 cm 3.7 F 79 cm 22 ga Polyurethane 3 RFA g 4 cm 2 F 46 cm 22 ga Rounded Tip Polyurethane 2 RCA g 4cm 3 F 14cm 22ga Polyurethane 2 beads RCA g 6cm 3 F 9cm 22ga Tri-Layer 3 beads Rat Gastric Catheter with Dacron Patch Our gastric catheter for intra-gastric administration has a Dacron patch and suture bead for secure anchoring at the site of implantation. Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Suture Beads RGC g 1.2 cm 3 F 20 cm 22 ga Polyurethane 4 Dacron Rat Intrathecal Catheters Our Intrathecal Catheters are designed for implantation from the cisterna magna to the lumbar region. A reinforced tubing junction minimizes kinking at the exit point from the intrathecal space. A PTFE-coated stylet slides smoothly out of the catheter once in place. All catheters are ETO exposed. Animal Size Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material Suture Beads RIT g 10 cm 1 F 13 cm 25 ga Polyurethane Yes RIT g 10 cm 3/4 F 13 cm 25 ga Polyurethane Yes Rat T-Tube The T-Tube is designed for non-occluded (flow-through) venous, arterial or bile duct sampling in rats and mice. Intravascular Tip Length Intravascular Tip O.D. Total Length Connects to Needle Material T-Tube mm/side 1.9 F 20 cm 25 ga Polyurethane T-Tube mm/side 2.3 F 20 cm 23 ga Polyurethane T-Tube mm/side 3 F 20 cm 22 ga Polyurethane ORDERS@SAI-INFUSION.COM P F

26 Rodent Intrathecal & Lymph Catheters Rodent Intrathecal Catheters Catheters for Intrathecal delivery or sampling in rodents. SAI offers a range of catheters and cannula for the collection of CSF or the administration of compounds to the intrathecal space in mice and rats. Our brand new Cisterna Magna cannula is made with non-reactive PEEK (instead of stainless steel) and utilizes a unique non-coring tip to guard against unnecessary trauma. Sample volumes of 50ul are easily collected and are repeatable for periods up to 12 weeks. For studies that require access to the CNS, look to SAI for the solution. RAT RCMC-01 RCMC-7.2 RIT-02 RIT-03 RIT-04 MOUSE MIT-01 MIT-02 Rodent Cisterna Magna Cannula. Constructed using PTFE and PEEK, 22G tip, 8.2 mm below pedistal. Rodent Cisterna Magna Cannula. Constructed using PTFE and PEEK, 22G cannula, 7.2 mm below pedistal and right angled outlet tube. Polyurethane catheter with 28G tip, 22 cm long, 22G Connection Polyurethane catheter with 32G tip, 22 cm long, 25G Connection Polyurethane catheter with 22G tip, 12 cm long, 22G Connection Mouse polyurethane catheter 28G tip, 6 ml long, 25G connection Mouse polyurethane catheter 32G tip adjustable length, 25G connection, outlet tube 60cm LYMT - Lymph Collection Catheters Lymph collection has long been considered a very difficult model for laboratory research. SAI has developed a new collection catheter for lymph that utilizes a unique catheter design. Lymph has the same clotting tendencies as blood. Coupled with its ultra-low production rate, catheter occlusion becomes a major limiting factor. SAI s new innovation allows a micro infusion of a low concentration heparin solution to accompany the lymph collection, great reducing or eliminating this limitation. RAT RLDC-TX25 Rodent lymph collection catheter with 3F tip and PE outlet tube 60cm long tips: Lymph Collection Lymph Collection Tip: To prevent occlusion and optimize lymph collection, infuse a slow concentration heparin solution at a very low rate and keep your catheters open. Contact our Research Scientists on staff for details. 26 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

27 Rodent Catheters, Catheter Connector & Plugs Rat Bile Catheters Animal Size RBD-01 Rat Double Tapered Bile Catheter: TecoFlex Polyurethane; 2 tapered catheters connected together, OD tapered from in. to in. with constant ID of 0.025in., length 35cm 150+g RBD-04 Rat Bile Collection or Portal Vein Catheter: TecoFlex Polyurethane; OD tapered from in. to in. ID tapered from in. to in., beads at 0.5 in., 7.62 cm. and cm. from the tip, length cm g Catheters for Alzet Pumps By attaching the proper catheter, Alzet Osmotic Pumps can deliver substances into the venous or arterial circulation, into the brain any organ, lumen or solid tissue. Alzet Corporation offers a range of specialized catheters, compatible with Alzet pumps, to enable targeted delivery to a variety of sites. Note: No catheter is necessary when subcutaneous or intraperitoneal delivery is desired. These can be accomplished by implantation of an Alzet pump without a catheter. Animal Size Total Length Material Mice 30+g 7.65cm Polyurethane Rats 250+g 15.24cm Silicone Rats 300+g 20.32cm Polyurethane Rats up to 300g 20.32cm Polyurethane Rats up to 300g 22.7cm Polyurethane Rodent Intra-Tracheal Catheters These tracheal catheters may be used for ventilation, sampling, or administration and come with a flexible cannula and y-adaptor for minimum dead space. Three standard sizes are available for use in mice, rats, and other small rodents and the catheters will readily connect to anesthesia systems. Our tracheal tubes may be trimmed to the appropriate size if necessary. Animal Size Gauge TRA-03 Mouse 24 TRA-04 Rat 16 TRA-05 Rat 20 TRA-06 Rat 14 Catheter Connectors Use SAI catheter plugs and connectors to ensure secure catheter access and maintenance. The quality manufactured stainless steel plugs and connectors are burr-free to prevent tearing of the catheter end during insertion and removal. There is no more need to hand make these critical fine components. Non-metallic PEEK connectors also available (call for pricing). Dimensions &Size SS 25G CC-25 SS 24G CC-24 SS 23G CC-23 SS 22G CC-22 SS 21G CC-21 SS 20G CC-20 Stainless Steel Plugs (See reference chart, pg. 48, for corresponding catheter sizes.) CP-20 CP-21 CP-22 CP-23 CP-24 CP-25 20G Stainless steel catheter plug 21G Stainless steel catheter plug 22G Stainless steel catheter plug 23G Stainless steel catheter plug 24G Stainless steel catheter plug 25G Stainless steel catheter plug ORDERS@SAI-INFUSION.COM P F

28 Rabbit, Pig & Guinea Pig Catheters Catheter diameter and length are optimized to meet the demanding requirements necessary to achieve success in these species. We use only the highest quality polyurethane or silicone and provide unlimited customization upon request. These catheters are provided with luer fittings to ensure secure connection. Rabbit Jugular Vein Catheters Size Material Length Suture Beads Female Luer RBJV-1LV 3 F Silicone 60 cm 5 & 7 cm Yes RBJV-2LV 5 F Silicone 60 cm 5 & 7 cm Yes RBJV-3LV 3 F Polyurethane 60 cm 5 & 7 cm Yes RBJV-4LV 5 F Polyurethane 60 cm 5 & 7 cm Yes Rabbit Femoral Vein Catheters: Rounded Tip or Standard Catheters Size Material Length Suture Beads Female Luer RBFV-5LV 3 F Silicone 60cm 7 & 9 cm Yes RBFV-6LV 5 F Silicone 60cm 7 & 9 cm Yes RBFV-1LV 3 F Polyurethane 60cm 7 & 9 cm Yes RBFV-2LV 5 F Polyurethane 60cm 7 & 9 cm Yes Rabbit Ear Vein Catheters Our Rabbit Ear Vein Catheter is designed for blood collection and dosing. The catheter is provided with a stylet and an introducer needle for simple implantation. With proper maintenance these catheters will remain patent up to 8 weeks. RBEV-1 RBEV-2 Material PE 10 Catheter with introducer needle and luer stub 1F PU 10 Catheter with introducer needle, luer stub and stylet Pig Jugular Vein Catheters Size Material Length Suture Beads Female Luer SJVC-1LV 7 F Silicone 60 cm 10 & 12 cm Yes SJVC-2LV 9 F Silicone 60 cm 10 & 12 cm Yes Guinea Pig Catheters SAI s hemocompatible guinea pig jugular vein and carotid artery catheters are designed to maximize potency and simplify insertion. Custom suture bead placement ensures catheters are secure and in the proper location for optimum performance. Combine with the QCH-GP harness to improve aseptic procedures, efficiency, and results! Size Material Length Suture Beads Features Connects GPVC-01 3 F Polyurethane 24 in 3, 6 cm For >350 g 22, 21 ga GPJV-04 3 F Silicone 19 in 9, 2.9 mm For <350 g 22, 21 ga GPJV F Polyurethane 7 in 2.5, 3.5 cm For <350 g 23 ga GPAC-02 3 F Polyurethane 7 in 3, 6 cm Rounded tip 22, 21 ga GPAC-04 3 F Polyurethane 7 in 3, 6 cm Smooth bevel tip 22, 21 ga tips: Catheterization Techniques Tip 1: Use catheters with suture beads to prevent them from pulling out. Tip 2: When catheterizing an animal, always place tension loops to allow for animal growth. Tip 3: Tapered catheters improve fluid dynamics which enhances catheter patency. 28 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

29 Dog Catheters Dog Jugular Vein Catheters: Rounded Tip or Standard Catheters Size Material Length Suture Beads Female Luer CJVC-1LV 3 F Silicone 60 cm 10 & 12 cm Yes CJVC-2LV 5 F Silicone 60 cm 10 & 12 cm Yes CJVC-3LV 7 F Silicone 60 cm 10 & 12 cm Yes CJVC-4LV 3 F Rounded Tip Polyurethane 60 cm 10 & 17 cm Yes CJVC-5LV 5 F Rounded Tip Polyurethane 60 cm 10 & 17 cm Yes CJVC-6LV 7 F Rounded Tip Polyurethane 60 cm 10 & 17 cm Yes Dog Femoral Vein Catheters: Rounded Tip or Standard Catheters Size Material Length Suture Beads Female Luer CFVC-1LV 3 F Silicone 60 cm 10 & 17 cm Yes CFVC-2LV 5 F Silicone 60 cm 10 & 17 cm Yes CFVC-3LV 7 F Silicone 60 cm 10 & 17 cm Yes CFVC-4LV 3 F Rounded Tip Polyurethane 60 cm 10 & 17 cm Yes CFVC-5LV 5 F Rounded Tip Polyurethane 60 cm 10 & 17 cm Yes CFVC-6LV 7 F Rounded Tip Polyurethane 60 cm 10 & 17 cm Yes Dog Duodenal Catheters These catheters are designed for duodenal or gastric delivery. The catheter is closed-ended, and has a slit-valve to prevent clogging of the catheter. These catheters can be with a 1/2 in. silicone patch or beads for a secure attachment. Size Material Length Suture Patch Suture Beads Female Luer CDCS-3LV 7 F Silicone 60 cm 6 cm 8 cm Yes CDCS-4LV 9 F Silicone 60 cm 6 cm 8 cm Yes Percutaneous Jugular Vein Catheters for the Dog: SAI s CPJC Catheters Central Blood Vessel Access without surgery is often called for in infusion and sampling studies in dogs. Our CPJC catheters offer the best alternative to performing a cut-down surgery when reliable vascular access in the dog is needed for short-term (day-long to week-long) studies. The catheters come with options including introducer needles, suture wings and injection sites. These catheters can be used for sampling or infusion. Infusion may be single bolus, repeated bolus, intermittent or continuous through these catheters. CPJC-02 CPJC-03 CPJC-04 CPJC-05 20cm Tip with suture wings and 4F introducer and luer valve 20cm Tip with suture bead and 4F introducer and luer valve 30cm Tip with suture bead and 4F introducer and luer valve 10cm Tip with suture wings and 4F introducer Ocular Catheters Our ocular catheters are designed for infusion into the aqueous humor, vitreous humor, or Tenon s space. They are bent at a 90 degree angle to make certain the catheter tips are positioned in the desired location. The catheters are complete with suture wings for corneal attachment to ensure they remain securely fixed during eye movement. These catheters can be connected to syringes or infusion pumps for continuous or intermittent delivery. Contact us for other intraoccular catheters. ROC-14 Ocular catheter designed for accessing Tenon s space Dog Gavage Tubes These biocompatible, firm but flexible tubes aid in consistent delivery to the stomach. The smooth bevel-cut tip and large internal diameter help to make their insertion easier and dosing more reliable. GVG-D26 GVG-D26L Dog Gavage tube 26 in. long with rounded bevel tip Dog Gavage tube 26 in. long with rounded bevel tip with luer ORDERS@SAI-INFUSION.COM P F

30 Primate Catheters Primate Jugular Vein Catheters Size Material Length Suture Beads Female Luer PJVC-1 3 F Silicone 60 cm 7 & 9 cm No PJVC-2 5 F Silicone 60 cm 7 & 9 cm No PJVC-3 7 F Silicone 60 cm 7 & 9 cm No PJVC-1LV 3 F Silicone 60 cm 7 & 9 cm Yes PJVC-2LV 5 F Silicone 60 cm 7 & 9 cm Yes PJVC-3LV 7 F Silicone 60 cm 7 & 9 cm Yes PJVC-4 3 F Rounded Tip Polyurethane 60 cm 7 & 9 cm No PJVC-5 5 F Rounded Tip Polyurethane 60 cm 7 & 9 cm No PJVC-6 7 F Rounded Tip Polyurethane 60 cm 7 & 9 cm No PJVC-4LV 3 F Rounded Tip Polyurethane 60 cm 7 & 9 cm Yes PJVC-5LV 5 F Rounded Tip Polyurethane 60 cm 7 & 9 cm Yes PJVC-6LV 7 F Rounded Tip Polyurethane 60 cm 7 & 9 cm Yes Primate Femoral Vein Catheters: Rounded Tip, Tapered, U Bend or Standard Catheters Size Material Length Suture Beads Female Luer PFVC-1 3 F Rounded Tip Polyurethane 60 cm 10 & 15 cm No PFVC-2 5 F Rounded Tip Polyurethane 60 cm 10 & 15 cm No PFVC-3 7 F Rounded Tip Polyurethane 60 cm 10 & 15 cm No PFVC-1LV 3 F Rounded Tip Polyurethane 60 cm 10 & 15 cm Yes PFVC-2LV 5 F Rounded Tip Polyurethane 60 cm 10 & 15 cm Yes PFVC-3LV 7 F Rounded Tip Polyurethane 60 cm 10 & 15 cm Yes PTFVC F Tapered Polyurethane 10 & 11 cm No PTFVC F Tapered Polyurethane 10 & 1 cm No This catheter is designed with a U Bend to allow for catheter placement in areas where movement is an issue. The catheter is attached to a U-shaped silicone patch to prevent the catheter from kinking at the bend. Size Material Length Suture Beads Female Luer PFVCU-1 3 F Silicone with U Bend 60 cm 10 & 15 cm No PFVCU-2 5 F Silicone with U Bend 60 cm 10 & 15 cm No PFVCU-3 7 F Silicone with U Bend 60 cm 10 & 15 cm No PFVCU-1LV 3 F Silicone with U Bend 60 cm 10 & 15 cm Yes PFVCU-2LV 5 F Silicone with U Bend 60 cm 10 & 15 cm Yes PFVCU-3LV 7 F Silicone with U Bend 60 cm 10 & 15 cm Yes Primate Duodenal Catheters These catheters are designed for duodenal or gastric delivery. The catheter is closed-ended, and has a slit-valve to prevent clogging of the catheter. These catheters can be with a 1/2 in. silicone patch or beads for a secure attachment. Size Material Length Suture Patch Suture Beads Female Luer PDC-1 3 F Silicone 60 cm 6 cm 8 cm No PDC-2 5 F Silicone 60 cm 6 cm 8 cm No PDC-3 7 F Silicone 60 cm 6 cm 8 cm No PDC-4 3 F Silicone 60 cm 3 & 4 cm No PDC-5 5 F Silicone 60 cm 3 & 4 cm No PDC-6 7 F Silicone 60 cm 3 & 4 cm No PDC-1LV 3 F Silicone 60 cm 6 cm 8 cm Yes PDC-2LV 5 F Silicone 60 cm 6 cm 8 cm Yes PDC-3LV 7 F Silicone 60 cm 6 cm 8 cm Yes PDC-4LV 3 F Silicone 60 cm 3 & 4 cm Yes PDC-5LV 5 F Silicone 60 cm 3 & 4 cm Yes PDC-6LV 7 F Silicone 60 cm 3 & 4 cm Yes Contact our in-house Large Animal Surgeon for procedures and recommendations. 30 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

31 Large Animal Intrathecal & Lymph Catheters Intrathecal System, Large Animal SAI has long been recognized as the leader in Intrathecal sampling and administration in rats, dogs, primates, and sheep. While this model can be very difficult to develop, SAI will help ensure your success. SAI has trained surgeons ready to assist you or make recommendations whatever your need. SAI offers catheters for the Cisterna Magna and lumbar intrathecal space for CSF collection or infusion. Our catheters are developed by surgeons at SAI so you are guaranteed that each catheter is made with the highest quality material and provide the longest patency possible. Dog, Primate, Sheep Cisterna Magna Catheter ITC-01 CMC-01 CMC-02 CM F tapered catheter with tapered bead for easy catheter insertion. Fenestrations at catheter tip for optimal CSF flow. Radio opaque polyurethane 3-4 F tapered catheter with suture bead for easy catheter insertion. Fenestrations at catheter tip for optimal CSF flow. Radio opaque polyurethane 5 F polyurethane catheter with dural suture patch and fenestrations for optimal CSF flow. 5-6 F tapered catheter with tapered bead for easy catheter insertion. Fenestrations at catheter tip for optimal CSF flow. Radio opaque polyurethane Dog, Primate, Sheep Lumbar Polyethylene (PE) lined polyurethane (PU) catheters provide researchers with the flexibility and biocompatibility of a PU exterior plus the chemical inertness of an interior coated with PE. The best of both worlds. IT-PU IT-PEPU-20 IT-PEPU-20/8 IT-PEPU-35 IT-PEPU-80 Polyurethane lumbar intrathecal catheter with 10cm IT portion. 35 cm long. Polyethylene-lined polyurethane lumbar intrathecal catheter. 10 cm long IT portion with a 9 cm sheathed part for extra strength. Fits 6 F access port Polyethylene-lined polyurethane lumbar Intrathecal catheter. 8 cm long IT portion with a 9 cm sheathed part for extra strength. Fits 6 F access port Polyethylene-lined polyurethane lumbar intrathecal catheter. 10 cm long IT portion with a 24 cm sheathed part for extra strength. Fits 6 F access port Polyethylene-lined polyurethane lumbar intrathecal catheter. 10 cm long IT portion with a 67 cm sheathed part for extra strength. Fits 6 F access port Lymph Collection Catheters Lymph collection has long been considered a very difficult model for laboratory research. SAI has developed a new collection catheter for lymph that utilizes a unique catheter design. Lymph has the same clotting tendencies as blood. Coupled with its ultra-low production rate, catheter occlusion becomes a major limiting factor. SAI s new innovation allows a micro infusion of a low concentration heparin solution to accompany the lymph collection, great reducing or eliminating this limitation. Large Animal Canine and Pig LYMT-1 5 F 10 cm Silicone with 7 F Silicon outlet tube 12 ft. long LYMT-2 4 F 10 cm Polyurethane with 4 F Polyurethane outlet tube 40 cm long LYMT F 10 cm Silicone with 7 F Silicon outlet tube 60 cm. LYMT-4 3 F 10 cm Silicone with 7 F Silicone outlet tube 60 cm long LYMT-5 6 F 11 cm Silicone with 7 F Silicone outlet tube 12 ft. long ORDERS@SAI-INFUSION.COM P F

Large Animal Specialty Catheters Femoral & Jugular Groshong Catheters The FDA-approved for human use Groshong line of central venous catheters by Bard offers the latest in technology.

32 Large Animal Specialty Catheters Femoral & Jugular Groshong Catheters The FDA-approved for human use Groshong line of central venous catheters by Bard offers the latest in technology. Unlike traditional open-ended catheters, the Groshong catheter has a rounded, closed tip and features the patented Groshong valve. The Groshong valve opens inward for blood aspiration and outward for infusion but remains closed when not in use. Because the valve remains closed when not in use, the inside of the catheter is sealed off preventing it from coming in contact with the animal s blood. Bard Access Systems offers catheters in a variety of French sizes as well as single, dual- and triple- lumen configurations. The Groshong valve technology is available on a variety of devices including implantable ports Groshong - 4F Single Lumen PICC 60cm Groshong - 3F Single Lumen Midline with flush-through stylet 20cm Femoral & Jugular Broviac/Hickman Catheters The Broviac/Hickman lines of chronic, tunneled central venous catheters by Bard offer the time-tested standard for proven performance and reliability. Bard Access Systems catheters offer single-, dual- and triple-lumen catheter configurations. In addition to the SureCuff tissue in-growth cuff, these catheters are also available with the VitaCuff Antimicrobial Cuff. The VitaCuff Antimicrobial Cuff is designed to help protect against infection and aid in catheter securement Broviac 4.2 French Single Lumen Pediatric Catheter w/surecuff Tissue In-growth Cuff - 2 VitaCuff Antimicrobial Cuff Broviac 6.6 French Single Lumen Pediatric Catheter w/surecuff Tissue In-growth Cuff - 4 VitaCuff Antimicrobial Cuff Bile Catheters This bile collection system by Research Technologies is by far our most popular. With this system the researcher has complete control to either collect bile, stop the bile flow to the duodenum, or infuse bile salts for metabolism studies. The system includes a catheter and three access ports. Additional access port options are available. BAD-Cath Features: The novel occluding diaphragm stays in open or closed position on its own, making it a low pressure system to operate The small (0.02cc) fluid volume needed to tightly seal the diaphragm closed protects the diaphragm from damage due to excess pressure accidentally infused into the system The ability to deliver compounds into the duodenum and selectively flush the diaphragm area or the bile duct proximal or distal to the T-Piece Available in a dual configuration for only bile occluding and sampling. The dual does not have the third port for delivering or flushing into the duoden. Specifications: Silicone construction Standard T-arm sizes range from 3F-9F Optional duodenal access/flush catheter Occluding diaphragms are available in large (dog) or small (nonhuman primate NHP) sizes Custom modifications available for different applications or use in different species. BAD-CATH-5 5F Arms with 7F Outlet Tubes BAD-CATH-5-P 5F Arms with 7F Outlet Tubes with 3 Bard Titanium Access Ports Bile Catheters BAD-CATH-5-B 5F Arms with 7F Outlet Tubes with Small Bulb BAD-CATH-5-PB 5F Arms with 7F Outlet Tubes with Small Bulb with 3 Bard Titanium Access Ports BAD-CATH-7 7F Arms with 7F Outlet Tubes BAD-CATH-7-P 7F Arms with 7F Outlet Tubes with 3 Bard Titanium Access Ports BAD-CATH-7-PB 7F Arms with 7F Outlet Tubes with Small Bulb with 3 Bard Titanium Access Ports BAD-CATH-5D 5F Arms with dual Outlet tubes for only bile occlusion or sampling BAD-CATH-5DP 5F Arms with dual Outlet tubes for only bile occlusion or sampling with 3 Bard Access Ports BAD-CATH-7D 7F Arms with dual Outlet tubes for only bile occlusion or sampling BAD-CATH-7DP 7F Arms with dual Outlet tubes for only bile occlusion or sampling with 3 Bard Access Ports Ferret Catheters Our Ferret catheters are built to match the size of the ferret. SAI makes a variety of catheters for Ferrets including catheters for the jugular vein, carotid artery and femoral vein. These can be externalized and protected under a jacket or may be implanted and secured subcutaneously to a vascular access device. FVC-01 Ferret Jugular vein catheter for percutaneous access includes: a rounded tip, incremented tip, suturing beads to secure the catheter and luer-fitting for simple connection. FVC in. Ferret Jugular Vein catheter with female luer and injection cap Customization Options GROSHONG WITH PATCH Negative pressure opens valve inward, permitting blood aspiration. Positive pressure opens valve outward, allowing infusion. At neutral pressure, valve remains closed, reducing risk of air embolism, blood reflux and clotting. Valued to prevent reflux. 32 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

33 CathPort TM CPT CPT-RP The future of access ports has arrived! SAI s new CathPort Twin combines an ultra-low volume top access port with a catheter-accessible side access CathPort resulting in a multi-dimensional, dual-septum port with a low profile design. The ultra low volume, top access port is designed to be accessed using a standard Huber or bullet point needle. This port is perfect for CSF or micro sampling (ultra low dead volume), to give a bolus injection, or just to simplify flushing and locking procedures. The side-access CathPort allows the researcher to insert a catheter into the port and advance it into the lumen of the main catheter for secure access. Using the sideaccess port researchers can perform long-term infusion or sampling studies without fear of needle pull-out or breakage as can occur with other needle gripping port designs. Both ports can be used in conjunction with one another to perform procedures which were virtually impossible prior to this revolutionary design. It is now possible to deliver around the side-access catheter for dual infusion or co-administer an intermittent bolus without disrupting the continuous infusion. For researchers searching for a low-cost side-access port, SAI offers our standard CathPort. The CathPort is a side-access port designed for long-term infusions or chronic sampling utilizing an innovative catheter and introducer for simplified access to the internal catheter. The updated side access CathPort catheter introducer is splittable for quicker, cleaner, access. The CathPort catheter and introdicer are compatable with all side-access port needles. Ports Dimensions CPT-RP CathPort Twin RP - ultra-low profile twin port reduces irritation and is perfectly 22mm x 15mm x 9mm suitable for rodents and small primates. Top Access Volume: 35ul Side Access Volume: 74ul CPT-PD CathPort Twin PD - innovative twin port designed to reduce 28mm x 18mm x 11mm subdermal irration in larger primates and dogs. Top Access Volume: 42ul Side Access Volume: 88ul CPT-DS CathPort Twin DS - larger twin port for easy location yet not too large 32mm x 21mm x 13mm to cause skin irritation for large dogs and swine Top Access Volume: 50.9ul Side Access Volume: 106ul CPT The CathPort side-access port allows for convenient side access and secure 22mm x 15mm x 9mm external catheter placement. The unique low profile shape allows for easier Side Access Volume: 74ul sucutaneous placement in animals as small as rats. It can be accessed by a standard Huber needle or the SAI side-access catheter introducer kit. Catheters CathPort Catheters are available in many different sizes to facilitate all species and exact vessel diameters. If you do not see the catheter you need, we can recommend other options or provide you with a custom catheter. SAI offers catheters for access sites or sampling requirements from IV to Intrathecal. Suture beads are movable unless specified and can be fixed at desired locations. CPC-36F Tapered polyurethane with rounded tip and beads at 6 and 8 cm from the tip. Sterile CPC-3FV 3 F polyurethane catheter with rounded tip and beads at 3 and 4 cm from the tip. Perfect for rodent femoral or jugular vein cannulations 8 in. long with 5 F connection. Sterile CPC-46F Tapered polyurethane with rounded tip and beads at 8 and 10 cm from the tip. Sterile CPC-6F Polyurethane catheter with rounded tip with beads at 10 and 12 cm from the tip. Sterile CPC-5FS Silicone with beads at 8 and 10 cm from the tip CPC-7FS Silicone with beads at 8 and 10 cm from the tip. Sterile ORDERS@SAI-INFUSION.COM P F

Vascular Access Ports CathPort TM Splittable Introducers The updated side access CathPortTM catheter introducer is splittable for quicker, cleaner, access.

Sterile 5/bx. 2.5 F nylon side-access catheter, 10/bx.

These are the highest quality human ports available at a price that is comparable to animal-only ports. Catheter Options: Tapered 3-6F & 4-6F= Polyurethane / Standard 5 F & 6 F = Polyurethane.1.

Journal of Parenteral and Enteral Nutrition 1984;8:399-406 69-2319 Kit Includes: Portal and Catheter - Call for Catheter Size 69-2319 P.A.S. Port Elite with Polyflow Polyurethane Catheters 69-2316 P.

34 Vascular Access Ports CathPort TM Splittable Introducers The updated side access CathPortTM catheter introducer is splittable for quicker, cleaner, access. The CathPort TM catheter and introducer are compatable with all side access port needles. CPT-AC SAC-2.5 SPI-4 4 F splittable sheath introducer with a 2.5 F 12 in. nylon catheter and female luer. Sterile 5/bx. 2.5 F nylon side-access catheter, 10/bx. 4F splittable introducer for the side access catheter. 10/bx. CPT-AC Port-A-Cath Low Profile Titanium Ports with Polyflow Polyurethane Catheter The PORT-A-CATH access port is an FDA-approved port that is used by many laboratories for dogs and primates. It is designed to permit repeated access to the venous system for fluid delivery or for blood sampling. These are the highest quality human ports available at a price that is comparable to animal-only ports. Catheter Options: Tapered 3-6F & 4-6F= Polyurethane / Standard 5 F & 6 F = Polyurethane.1. Linder L, Curelaru I, Gustavsson B, et al. Material thrombogenicity in central venous catheterization: A comparison between soft, antebrachial catheters of silicone elastomer and polyurethane. Journal of Parenteral and Enteral Nutrition 1984;8: Kit Includes: Portal and Catheter - Call for Catheter Size P.A.S. Port Elite with Polyflow Polyurethane Catheters P.A.S. Port Elite Single-Lumen Unassembled System: 6F; 1.9mm O.D.; 1.0mm I.D. *With catheter accessory kit, includes: Portal, Catheter, Huber Needle and Vein Pick P.A.S. Port T2 Titanium with Polyflow Polyurethane Catheters: for Rabbits, Pigs, Dogs & Primates P.A.S. Port T2 Single-Lumen Unassembled System - Call for Catheter Size *With catheter accessory kit, includes: Portal, Catheter, Huber Needle and Vein Pick BardPorts for Pigs, Primates and Dogs Implantable vascular access ports (VAPs) were developed to help provide reliable vascular access for researchers who require long-term access to veins and arteries. VAPs are extremely useful for both infusion and blood sampling. VAP reservoirs are made from either titanium or plastic and come in many designs (arterial, peritoneal, single-lumen, dual-lumen, low profile and pre-connected or attachable catheter configurations). They are available with either the Groshong silicone catheter featuring the patented three-position valve, open-ended silicone catheter, or open-ended ChronoFlex Polyurethane catheter. Customized Catheter Options also available. NOTE: Complete line of BARD products is available with special Research pricing, please call for more information Titanium Low-Profile port, attachable open-ended chronoflex 6.0 French catheter, Height 9.4mm, Diameter 24.5mm BARD The FDA-approved P.A.S. PORT Elite access port is a human quality extremely low profile port with a large smooth septum. The ultra low profile design helps minimize the complication associated with animals that have very thin skin, such as primates and rabbits, and the large smooth septum aids in needle placement. The dual material construction of plastic on the outside and titanium on the inside gives you the benefits neither gives alone - light weight, low profile design and long-term durability. Many different catheter sizes are available from 3-9 French. Call for more details. 1.Linder L, Curelaru I, Gustavsson B, et al. Material thrombogenicity in central venous catheterization: A comparison between soft, antebrachial catheters of silicone elastomer and polyurethane. Journal of Parenteral and Enteral Nutrition 1984;8: INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Infusion Kits for Rats & Guinea Pigs Luered Connectors QCK-23 QCK-21 Tether QCK-23J QCK-21J Harness Complete Kits Quick Connect Infusion System SAI has taken years of hands-on research experience and

This small change can reduce your scheduling load 75% or more for infusion related procedures such as: blood draws, infusion set-up, intermittent infusions, body weights, cage changing, and general

All components work together to save time, reduce costs, and improve the integrity of your infusion and access systems. All systems and components are ETO exposed. US Patent No. 7,665,424.

35 Infusion Kits for Rats & Guinea Pigs Luered Connectors QCK-23 QCK-21 Tether QCK-23J QCK-21J Harness Complete Kits Quick Connect Infusion System SAI has taken years of hands-on research experience and translated that into technology that makes sense to the end-user. We have replaced the catheter, swivel and extension line friction/compression fittings with secure, easy-to-attach luer locks. This small change can reduce your scheduling load 75% or more for infusion related procedures such as: blood draws, infusion set-up, intermittent infusions, body weights, cage changing, and general catheter maintenance. The system includes the Quick Connect harness, tether and swivel. All components work together to save time, reduce costs, and improve the integrity of your infusion and access systems. All systems and components are ETO exposed. US Patent No. 7,665,424. Eliminate tubing & swivel matching Reduce leaks from friction-fit connections Decrease set-up time by ordering pre-cannulated, pre-harnessed animals COMPLETE KITS INCLUDE: QCK-23 23G Harness, 12 in. tether and dual luer swivel QCK-21 21G Harness, 12 in. tether and dual luer swivel QCK-23J 23G Jacket Adaptor, jacket, 12 in. tether and dual luer swivel Please specify size of Jacket. See page 38 for jacket sizes. QCK-21J 21G Jacket Adaptor, jacket, 12 in. tether and dual luer swivel Please specify size of Jacket. See page 25 for jacket sizes. GUINEA PIG INFUSION SYSTEMS QCK-21GP QCK-21JGP Harness Fits catheter w/an ID of Harness with a 21G catheter connector in. Harness with a 23G catheter connector in. Needle-less, Omni Harness Sterile Kits also Available! ORDERS@SAI-INFUSION.COM P F

Omni Harnesses and Tethers The OMNI Harness The word Omni is defined as all and that is exactly what the new Omni harness can do.

Gone are the days where researchers are tied to a high-cost, specific or hard-to-get needle used to access their current harnesses.

The Omni harnesses use a special sealed septum to allow for all the needles to be used. This new septum will not leak, produce cores or wear out over time with any of the needles used.

36 Omni Harnesses and Tethers The OMNI Harness The word Omni is defined as all and that is exactly what the new Omni harness can do. By all we mean this harness can accept all types of needles or cannulas. Gone are the days where researchers are tied to a high-cost, specific or hard-to-get needle used to access their current harnesses. The Omni harness can accept a blunt needle, Huber needle, hypodermic needle, pencil point, luer stub adaptor, or a plastic cannula. The Omni harnesses use a special sealed septum to allow for all the needles to be used. This new septum will not leak, produce cores or wear out over time with any of the needles used. SAI created the first Quick Connect harness and we have again re-invented the wheel. The Omni harness comes in two configurations, single septum and dual septum. This will allow researchers to use single and dual cannulated rodents for sampling, infusion or both. We have a bile re-circulation harness as well. Each septum is color-coded so you know exactly what you are connecting. SAI has also gone one step further in the rodent harness design. We have incorporated a selfsterilization feature in our harness caps. We have developed a cap to which the user can add a small amount of 70% isopropyl alcohol in order to keep the septum sterile between samples or use. SAI is the first and only company to offer this technology. OMNI Harnesses OMNI-22 OMNI-22JA OMNI-21D OMNI-22D OMNI Harness 22G OMNI 22G Jacket Adaptor OMNI Dual Harness 21G OMNI Dual Harness 22G OMNI Tethers with Male Luer OMNI-T12M OMNI-T14M OMNI-T18M OMNI 12 in. Tether with male luer OMNI 14 in. Tether with male luer OMNI 18 in. Tether with male luer OMNI Tethers with PU Tubing OMNI-T12 OMNI-T14 OMNI-T18 OMNI-TD12 OMNI-TD14 OMNI-TD18 OMNI 12 in. Tether with PU tubing OMNI 14 in. Tether with PU tubing OMNI 18 in. Tether with PU tubing OMNI 12 in. Dual Tether with PU tubing OMNI 14 in. Dual Tether with PU tubing OMNI 18 in. Dual Tether with PU tubing OMNI Replacable Tether Inserts - Green Option OMNI-G12 OMNI-G14 OMNI-G18 OMNI-GD12 OMNI-GD14 OMNI Kits OMNI 12 in. Tether insert for reusable tether spring OMNI 14 Tether insert for reusable tether spring OMNI 18 in. Tether insert for reusable tether spring OMNI 12 in. Dual Tether Insert for reusable tether spring OMNI 14 in. Dual Tether Insert for reusable tether spring KOMNI-22 Harness, 12 Tether, Dual Luered Swivel KOMNI-22JA Jacket Adaptor, Jacket, 12 Dual Tether, Dual Luered Swivel Please specify size of Jacket. See page 38 for jacket sizes. Spring Tethers - Green Option Standard, stainless steel spring tethers without luers or tubing. Used with SAI Standard Harness (SAH). A catheter fit will depend on wall thickness, material, and elasticity. Ask about our sizing kit to properly fit the harness with your catheter. T in. Stainless Steel Spring Tether T in. Stainless Steel Spring Tether T in. Stainless Steel Spring Tether OMNI Caps OMNI-SC OMNI Sterilizing Single Cap - box of 10 OMNI-DC OMNI Sterilizing Double Cap box of 10 OMNI-BRC OMNI Bile Recirculation Cap Also Available in Complete Sterile Kits OMNI-22 OMNI-22 OMNI-T12M OMNI-22D 36 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Rat, Mouse & Guinea Pig Harnesses Rat Harnesses The Quick Connect harness transforms all catheter connections to simple luer-lock fittings.

The harness connects directly to syringes and stopcocks. We can send the harness to your preferred animal supplier and you can receive your pre-cannulated animals ready to connect in seconds.

Eliminate stainless steel connectors and pins Complete kit (QCK) includes swivel, harness and tether Available with elastomeric belly bands or woven jacket Dual and triple channel models available

021 in. A proper fit will depend on the catheter s wall thickness, material, and properties. US Patent No. 7,665,424.

Samplers QCH-22CW Quick Connect 22G Harness with Luer Adaptor and Ring for use with Auto Samplers QCH-21CW Quick Connect 21G Harness with Luer Adaptor and Ring for use with Auto Samplers QCH-LIV23W

Belly Bands QCDH-23 Quick Connect 23G Dual Luered Harness QCDH-21 Quick Connect 21G Dual Luered Harness QCDH-23LIV Quick Connect Dual Harness 23G with 23G Luer Valve QCDH-21LIV Quick Connect Dual

Tether QCBH-21 Bile Harness with Infusion Port QCBDH-23 Quick Connect Dual Harness 23G for Bile Collection QCH-21CLI Quick Connect 21G Harness with needle-less Septum, see pg.

37 Rat, Mouse & Guinea Pig Harnesses Rat Harnesses The Quick Connect harness transforms all catheter connections to simple luer-lock fittings. No more matching catheter sizes with tether lines and swivel outlets. Use as you would a subcutaneous access port, but without the shaving, scrubbing, and best of all, no needles! The harness connects directly to syringes and stopcocks. We can send the harness to your preferred animal supplier and you can receive your pre-cannulated animals ready to connect in seconds. Add valves or injection caps to simplify dosing, sampling or flushing procedures. US Patent No. 7,665,424. Eliminate stainless steel connectors and pins Complete kit (QCK) includes swivel, harness and tether Available with elastomeric belly bands or woven jacket Dual and triple channel models available Perfect for auto-samplers ETO exposed Harness with a 21G catheter connector fits catheter with an ID of in. Harness with a 23G catheter connector fits catheter with an ID of in. A proper fit will depend on the catheter s wall thickness, material, and properties. US Patent No. 7,665,424. QCH-21 Quick Connect Luer Harness w/21g catheter connector QCH-23 Quick Connect Luer Harness w/23g catheter connector QCH-23CW Quick Connect 23G Harness with Luer Adaptor and Ring for use with Auto Samplers QCH-22CW Quick Connect 22G Harness with Luer Adaptor and Ring for use with Auto Samplers QCH-21CW Quick Connect 21G Harness with Luer Adaptor and Ring for use with Auto Samplers QCH-LIV23W Quick Connect 23G Harness with Luer Valve and Wire Belly Bands QCH-LIV22W Quick Connect 22G Harness with Luer Valve and Wire Belly Bands QCH-LIV21W Quick Connect 21G Harness with Luer Valve and Wire Belly Bands QCDH-23 Quick Connect 23G Dual Luered Harness QCDH-21 Quick Connect 21G Dual Luered Harness QCDH-23LIV Quick Connect Dual Harness 23G with 23G Luer Valve QCDH-21LIV Quick Connect Dual Harness 21G with 21G Luer Valve SAH-12 Standard Harness with 12 in. Tether SAH-14 Standard Harness with 14 in. Tether SAH-18 Standard Harness with 18 in. Tether QCBH-21 Bile Harness with Infusion Port QCBDH-23 Quick Connect Dual Harness 23G for Bile Collection QCH-21CLI Quick Connect 21G Harness with needle-less Septum, see pg. 41 for needle-less tether QCH-23CLI Quick Connect 23G Harness with needle-less Septum, see pg. 41 for needle-less tether Guinea Pig Harness US Patent No. 7,665,424. QCHGP-21CLI QCHGP-23PD QCHGP-23 QCHGP-21 QCDHGP-23 QCDHGP-21 Guinea Pig Harness connect to 21G catheters with needle-less Septum, see pg. 41 for needle-less tether Guinea Pig Harness connect to 23G catheters with Neutral Displacement Valve Quick Connect 23G Guinea Pig Harness with 300+ grams Quick Connect 21G Guinea Pig Harness with 300+ grams Quick Connect Dual Harness for Guinea Pig, 23G Quick Connect Dual Harness for Guinea Pig, 21G Mouse Harness SAI also has harnesses for mice, suitable for long or short-term infusion or sampling. US Patent No. 7,665,424. SMH SMH-MT SAI Mouse Harness Mouse Harness with 12 in. Tether Replacement Belly Bands When animals damage their Belly Bands, replace them by purchasing the bands separately and avoid purchasing an entire harness ensemble. Replace damaged or soiled bands inexpensively. Available with or without reinforcement (Image at right shown without wire reinforcement). Always have emergency replacements on hand. US Patent No. 7,665,424. QC-BB QC-BB-Wire Harness Belly Bands for Standard and Quick Connect Harness Harness Belly Bands Standard 12 in. Wire reinforcing Stainless Steel Wire Increase efficency by purchasing these components in complete lits, see pg. 35 QCH-21 QCH-23CW QCDH-23 QCDH-23LIV SAH-12 QCBH-21 QCHGP-23 SMH ORDERS@SAI-INFUSION.COM P F

Rodent Jackets & Jacket Adaptors Quick Connect Jacket Adaptor Designed for researchers who prefer woven rodent jacket over an elastomeric harness for continuous or intermittent infusion.

. The Jacket Adaptor comes in two sizes to fit a range of catheter sizes and types. Catheter material, wall thickness and elasticity all influence how well the catheter fits the harness.

QCJA-21 QCJA-23 QCJA-23-LIV QCJA-22-LIV QCJA-21-LIV QCJAD-23 QCJAD-22 QCJAD-21 QCDJA-23-LIV QCDJA-21-LIV Quick Connect Jacket Adaptor with 21G Catheter Connector Quick Connect Jacket Adaptor with 23G

Adaptor for use with Rodent Jacket Quick Connect Dual 22G Jacket Adaptor for use with Rodent Jacket Quick Connect Dual 21G Jacket Adaptor for use with Rodent Jacket Quick Connect Dual Jacket Adaptor

provides animal jackets that fulfill all the expectations today s researchers demand, down to the smallest detail.

38 Rodent Jackets & Jacket Adaptors Quick Connect Jacket Adaptor Designed for researchers who prefer woven rodent jacket over an elastomeric harness for continuous or intermittent infusion. The Jacket Adaptor utilizes the same luer design as the Quick Connect Harness but connects securely to a cloth jacket with Velcro and can be adjusted as the animal grows.. The Jacket Adaptor comes in two sizes to fit a range of catheter sizes and types. Catheter material, wall thickness and elasticity all influence how well the catheter fits the harness. Ask about our sizing kit to ensure a proper fit. Jackets come in a wide range of sizes to fit any size rodent. To be used with a Lomir Jacket. US Patent No. 7,665,424. QCJA-21 QCJA-23 QCJA-23-LIV QCJA-22-LIV QCJA-21-LIV QCJAD-23 QCJAD-22 QCJAD-21 QCDJA-23-LIV QCDJA-21-LIV Quick Connect Jacket Adaptor with 21G Catheter Connector Quick Connect Jacket Adaptor with 23G Catheter Connector Quick Connect Jacket Adaptor with 23G Luer Valve Quick Connect Jacket Adaptor with 22G Luer Valve Quick Connect Jacket Adaptor with 21G Luer Valve Quick Connect Dual 23G Jacket Adaptor for use with Rodent Jacket Quick Connect Dual 22G Jacket Adaptor for use with Rodent Jacket Quick Connect Dual 21G Jacket Adaptor for use with Rodent Jacket Quick Connect Dual Jacket Adaptor with 23G Luer port and 23G Luer Injection Valve Port Quick Connect Dual Jacket Adaptor with 21G Luer port and 23G Luer Injection Valve Port Rodent Jackets Working together with Lomir Biomedical, SAI provides animal jackets that fulfill all the expectations today s researchers demand, down to the smallest detail. A single jacket will typically incorporate many materials, special features and fabrication methods that combine to increase comfort for the subject, as well as ease of use for the handler. We work in close collaboration with investigators to develop custom jackets, specifically matched to the subject and procedure. Also available are anchoring patches for tethering systems and inserts for dermal procedures. Animal Size Grams MJ 01 Mouse Jacket Small < 25g MJ 02 Mouse Jacket Medium 25-30g MJ 03 Mouse Jacket Large 30+g RJ 00 Rat Jacket X-Small g RJ 00H Rat Jacket Spandex X-Small g RJ 01 Rat Jacket Small g RJ 01H Rat Jacket Spandex Small g RJ 02 Rat Jacket Medium g RJ 02H Rat Jacket Spandex Medium g RJ 03 Rat Jacket Large g RJ 04 Rat Jacket X-Large 500+g HJ 01 Hamster Jacket Small < 100g HJ 02 Hamster Jacket Medium g HJ 03 Hamster Jacket Large 175+g GP J1 Guinea Pig Jacket Small < 350g GP J2 Guinea Pig Jacket Medium g GP J3 Guinea Pig Jacket Large 600+g FF J1 Ferret Jacket Small < 750g FF J2 Ferret Jacket Medium g FF J3 Ferret Jacket Large 1000+g Rodent Dermal Applications Inserts & Jackets Designed for studies where test articles are applied by the dermal route, this system by Lomir provides a non-occlusive covering for the application site, reducing the possibility of oral ingestion, while allowing in-life investigations to be carried out with ease. Used in regulatory toxicology studies, these dermal inserts and jackets are suitable for many products that are administered by this route. Stock and custom dermal jackets are available for all subjects studied in dermal procedures. Lomir s animal jackets and inserts are manufactured for a range of species such as rabbits, guinea pigs and rodents, with custom models available for dogs and swine. Quality materials and construction ensure durability and efficiency over repeated usage. Adjustable-velcro connecting strip provides proper fit and ease of use. Animal Size Application RJ 00D Rat Jacket X-Small Dermal RJ 01D Rat Jacket Small Dermal RJ 02D Rat Jacket Medium Dermal RJ 03D Rat Jacket Large Dermal RJ 04D Rat Jacket X-Large Dermal RJ IND Rat Jacket Dermal Insert Insert MJ IND Mouse Jacket Dermal Insert Insert GP J1D Guinea Pig Jacket Small Dermal GP J2D Guinea Pig Jacket Medium Dermal GP J3D Guinea Pig Jacket Large Dermal GP IND Guinea Pig Jacket Dermal Insert Insert QCJA-21 QCJA-21-LIV QCJAD-21 MJ 01 RJ 01 RJ 00D 38 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Skin Buttons, Trocars, Vein Picks, & Tail Cuffs Skin Buttons Rodent Skin Buttons are used for externalizing a catheter and/or for attaching a spring tether to the animal as

The polyethylene button center has an inner diameter of 0.123 in. which makes a perfect friction fit with a standard stainless steel spring tether with an OD of 0.124 in.

Rodent Skin Buttons for use with auto samplers: With all the features of the standard skin button, the skin button for auto samplers has a wire hook for attachment to an

The auto sampler s arm connects to the wire hook to form a secure attachment.

Tether Rodent Skin Button with Dacron Patch for Auto Samplers Rodent Skin Button with Quick Release Septum Rodent Skin Button with Dacron Patch and silicone sleeve Dual Skin

skin. Our trocars are manufactured from thickwalled medical-grade stainless steel and have a semi-blunt 45-degree beveled tip or a stylet.

TRO-7-6 Semi-Blunt Tip, 7 gauge x 6 in./15 cm TRO-7-12 Semi-Blunt Tip, 7 gauge x 12 in./30 cm TRO-10-8 Semi-Blunt Tip, 10 gauge x 8 in.

The tapered tip of the vein pick is inserted into the incision of the vessel. The catheter slides under the grove on the underside of the vein pick directly into the vessel.

39 Skin Buttons, Trocars, Vein Picks, & Tail Cuffs Skin Buttons Rodent Skin Buttons are used for externalizing a catheter and/or for attaching a spring tether to the animal as an alternative to a harness or jacket. The polyethylene button is covered with a 1 in. Dacron patch for tissue ingrowth to provide a secure attachment. The polyethylene button center has an inner diameter of in. which makes a perfect friction fit with a standard stainless steel spring tether with an OD of in. All SAI tethers fit this skin button. Rodent Skin Buttons for use with auto samplers: With all the features of the standard skin button, the skin button for auto samplers has a wire hook for attachment to an auto sampler arm. The animal s catheter can exit the animal through the center of the button and be attached to the sampler. The auto sampler s arm connects to the wire hook to form a secure attachment. SBD-01 SBD-0112T SBD-AS SBD-CLI SBD-02 MRI-01 MRI-04 Rodent Skin Button with Dacron Patch Rodent Skin Button with Dacron Patch and 12 in. Tether Rodent Skin Button with Dacron Patch for Auto Samplers Rodent Skin Button with Quick Release Septum Rodent Skin Button with Dacron Patch and silicone sleeve Dual Skin Button without Dacon Patch 25 G Mouse Implant Trocars Subcutaneous tunneling needles (trocars) offer a quick and easy method for routing catheters and electrodes under the skin. Our trocars are manufactured from thickwalled medical-grade stainless steel and have a semi-blunt 45-degree beveled tip or a stylet. The 7G trocar is perfect for most large animal catheters while the 10G is suited for smaller animals and catheters. Call for custom lengths. TRO-7-6 Semi-Blunt Tip, 7 gauge x 6 in./15 cm TRO-7-12 Semi-Blunt Tip, 7 gauge x 12 in./30 cm TRO-10-8 Semi-Blunt Tip, 10 gauge x 8 in./20 cm TRO-7B-12 Semi-Blunt Tip, 7 gauge x 12 in. with Stylet TRO-14MS Mouse Trocar with Stylet Vein Pick Holds the vessel open during cut-down catheter insertion procedures. The tapered tip of the vein pick is inserted into the incision of the vessel. The catheter slides under the grove on the underside of the vein pick directly into the vessel. VP Tapered Tip Vein Pick, pack of 10 tips: Vein Picks Accessing small vessels for cannulation can be challenging. Try using a vein pick. RTC-1 RTC-2 Rodent Tail Cuffs Constructed of stainless steel or anodized aluminum with self-threading tether attachment point. Used as an alternative to the Rodent Jacket. MT T1 RTC-1 RTC-2 RTC-FS Mouse Tail Cuff Lightweight Rodent Tail Cuff. Anodized Aluminum Tapered Stainless Steel Rodent Tail Cuff 16mm O.D. to 14mm O.D. Stainless Steel Female Rodent Tail Cuff SBD-01 SBD-0112T SBD-AS SBD-02 TRO-7B-12 VP ORDERS@SAI-INFUSION.COM P F

Swivels Swivels Eliminate matching catheter and extension line diameters to swivel outlet tubing. The Quick Connect Swivel provides Luer-Lock fittings on both outlets to make connecting fast and easy.

Fits all standard luer fittings Double, single and no-luer models available Individually packaged ETO exposed QCS-D Quick Connect Swivel Dual-Luered QCS-S Quick Connect Swivel Single Luer - for use

pin swivel for use with 20 gauge tubing Stainless Steel Swivels Our stainless steel swivels are designed for both rats and mice.

These high quality dual swivels are offered with 22ga inlets and outlets, with custom sizes available.

The torque for rotation of our dual swivel is significantly lower than any other dual swivel on the market making it sutable for mice.

40 Swivels Swivels Eliminate matching catheter and extension line diameters to swivel outlet tubing. The Quick Connect Swivel provides Luer-Lock fittings on both outlets to make connecting fast and easy. Add injection caps, valves or stopcocks to simplify dosing or sampling procedures and limit animal interactions. US Patent No. 7,665,424. Fits all standard luer fittings Double, single and no-luer models available Individually packaged ETO exposed QCS-D Quick Connect Swivel Dual-Luered QCS-S Quick Connect Swivel Single Luer - for use with standard Harness with tether block QCS-D18 18G Dual Luer Swivel: Specially designed for high flow rate situations QCS-S-20 20G Single Luer Swivel SIV-20 20G Standard Luer Swivel: Standard, dual pin swivel for use with 20 gauge tubing Stainless Steel Swivels Our stainless steel swivels are designed for both rats and mice. They have two fluid channels that provide the flexibility to use for infusion, sampling, or monitoring two different vessels/sites with one swivel. These high quality dual swivels are offered with 22ga inlets and outlets, with custom sizes available. The 20 or 22G outlet tube is perfect for monitoring blood pressure and has a very low internal volume for blood samples or infusion. The torque for rotation of our dual swivel is significantly lower than any other dual swivel on the market making it sutable for mice. SAI provides rebuilding kits, refurbishing, and sterilization for all of our stainless steel swivels. SSD-20 SSD-22 20G Dual Stainless Steel Swivel 22G Dual Stainless Steel Swivel Lomir Swivels Swivels by Lomir are high-impact thermoplastic, precision stainless steel hypodermic tubing, and PTFE seals. Single or double fluid channels in a range of needle sizes. Material Needle Size Channels MS P4 Mouse Swivel High Impact Plastic 23G RS P1 Rodent Swivel High Impact Plastic 22G RS P4 Rodent Swivel High Impact Plastic 23G RS PF2 Rodent Swivel High Impact Plastic 22G 2 Fluid Channels RS P1 tips: Custom Infusion Kits Increase efficiency by ordering your swivels, tethers, harnesses and fluid lines, assembled and ETO exposed, ready to use, in complete custom kits. See pages 35 & 36 for details! QCS-D QCS-S QCS-D18 QCS-S-20 SIV-20 SSD INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

The male luered fittings connect to the Quick Connect Harness and Quick Connect Swivel to complete the system. Individually packaged and ETO exposed. US Patent No. 7,665,424.

41 Rodent Tethers Available with Quick Connect or Standard Velcro tab jacket or harness attachments. Dual Luer Spring Tethers The Dual Luer Spring Tether is a standard, stainless steel tether with a male luered polyurethane extension line built inside. The male luered fittings connect to the Quick Connect Harness and Quick Connect Swivel to complete the system. Individually packaged and ETO exposed. US Patent No. 7,665,424. QCT-12 QCT-14 QCT-18 QCT-12CL Quick Connect 12 in. Male to Male Dual Luered Spring Rat Tether Quick Connect 14 in. Male to Male Dual Luered Spring Rat Tether Quick Connect 18 in. Male to Male Dual Luered Spring Rat Tether Quick Connect Male Single Luer Spring Tether with needle-less Clip adapter, see pg.37 for needle-less harness. Dual Channel Luer Tethers QCDTL-12 QCDT QCDT-DS QCDT-SD QCDT-SS Quick Connect Dual Channel Luered Tether 12 in. low volume Quick Connect Dual Channel Luered Tether Quick Connect Dual Channel Luered Infusion Sampling Circuit Quick Connect Dual Channel Luered Tether, with 20G Swivel and Tether Block Quick Connect Dual Channel Luered Tether, with 22G Single Luer Swivel Single Luer Spring Tethers Single Luer Spring Tether: Researchers who wish to use a standard swivel or stainless steel swivel with the Quick Connect Harness can use a tether extension line with intregrated male end. Individually packaged and ETO exposed. M22T-12 M22T-14 M22T-18 M23T-12 M23T-14 M23T-18 M25T-12 M25T-14 M25T in. Male Single Luer Spring Tether with Tubing to fit 22G Swivel 14 in. Male Single Luer Spring Tether with Tubing to fit 22G Swivel 18 in. Male Single Luer Spring Tether with Tubing to fit 22G Swivel 12 in. Male Single Luer Spring Tether with Tubing to fit 23G Swivel 14 in. Male Single Luer Spring Tether with Tubing to fit 23G Swivel 18 in. Male Single Luer Spring Tether with Tubing to fit 23G Swivel 12 in. Male Single Luer Spring Tether with Tubing to fit 25G Swivel 14 in. Male Single Luer Spring Tether with Tubing to fit 25G Swivel 18 in. Male Single Luer Spring Tether with Tubing to fit 25G Swivel Reusable Spring Tethers - Green Option Standard, stainless steel spring tethers without luers or tubing. Used with SAI Standard Harness (SAH). A catheter fit will depend on wall thickness, material, and elasticity. Ask about our sizing kit to properly fit the harness with your catheter. T in. Stainless Steel Spring Rat Tether T in. Stainless Steel Spring Rat Tether T in. Stainless Steel Spring Rat Tether MT 12in. Mouse Tether MT-OP 12in. Mouse Tether - Open Spring Lomir Tethers Manufactured by Lomir from a strong but light stainless steel spring, in three standard lengths: 12 in. (30 cm), 18 in. (46 cm) and 24 in. (61 cm) for single or multiple channel use. The standard anchor is a molded button with a sewn Velcro tab for adjustable fit when using the jackets. MT 12S RT 12S RT 12D Mouse Tether 12 in., sewn for jacket Rodent Tether 12 in., sewn for jacket Rodent Tether 12 in., for double channel swivel QCT-12 QCT-12CL M23T-12 M23T-12 T-12 ORDERS@SAI-INFUSION.COM P F

Swivel Holders, Retainers & Restrainer SAI introduces a revolutionary, completely adjustable, multidirectional swivel mounting system.

The quick-release swivel holder allows for continuous infusion during body weights and cage changes. Anodized aluminum components are durable and the 8 inch post can be trimmed to any height.

GMSHK CBSHA SMSHK Complete Multidirectional Swivel Mount Assembly GMSHK SAI Quick Connect Swivel Mount Assembly - Adjustable ring with multi-directional swivel holder, two line retainers, 8 in.

42 Swivel Holders, Retainers & Restrainer SAI introduces a revolutionary, completely adjustable, multidirectional swivel mounting system. Reduce animal stress and tether tangles with unparalleled 4-axes of movement. Stainless steel base quickly attaches to any style caging and is cage washerresistant! The quick-release swivel holder allows for continuous infusion during body weights and cage changes. Anodized aluminum components are durable and the 8 inch post can be trimmed to any height. Interchangeable fittings allow use of the multi-directional swivel holder with or without the optional counter balance arm. GMSHK CBSHA SMSHK Complete Multidirectional Swivel Mount Assembly GMSHK SAI Quick Connect Swivel Mount Assembly - Adjustable ring with multi-directional swivel holder, two line retainers, 8 in. post with base and cage mount Complete Swivel Mount Assembly with Counter Balance Arm CBSHA SAI Quick Connect Counter Balance Swivel Assembly - Counter Balance Arm with multi-directional swivel holder, 8 in. post with post base and cage mount Quick Connect Stationary Mount Swivel Holder SMSHK A stationary-mount swivel holder designed for quick cage attachment using the same cage mount system found on our higher-end swivel holders. Comes with a 4 in. post, cage bracket/lid bracket, stationary or rotating arm and height adjusters. Swivel Retainers Made by LomirTM from stainless steel and high-impact plastic construction. Available in two designs selected by the type of cage in use. RS 01 RS 02 RS 03 RS 07 Rodent Swivel Retainer Rodent Swivel Retainer for Shoebox cage Rodent Swivel Retainer for Double Shoebox Mounting Clip Rodent Swivel Retainer for Double Swivel, Top-Mounting Shoebox The Cozy Mouse Restrainer The Cozy Mouse Restrainer by SAI is designed to comfortably restrain a mouse for tail vein injections or sampling. Features: Size = 2 in. x 4 in.; Weight = 2 lbs; Material = Brass. Benefits: Able to warm for animal comfort and vasodilation of the tail; Solid Brass maintains heat for extended periods; Weight provides a stable, secure placement on the lab bench; Can be sterilized via autoclave, ETO, liquid, VHP. MR-01 The Cozy Mouse Restrainer MR INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

5-300003 GUIDE NM - 030 - OUTSIDE 5-140005 PROBE NO - NM - PAN - 050-010 5-140022 PROBE NO - NM - PAN - 050-015 5-140039 PROBE NO - NM - PAN - 050-020 5-140056 PROBE NO - NM - PAN - 050-030 5-140073

NM - RC - 050-030 5-150073 PROBE NO - NM - RC - 050-040 5-300004 GUIDE NM - 040 - OUTSIDE 5-140006 PROBE NO - NM - PAN - 060-010 5-140023 PROBE NO - NM - PAN - 060-015 5-140040 PROBE NO - NM - PAN -

43 GUIDE NM OUTSIDE PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN GUIDE NM OUTSIDE PROBE NO - NM - RC PROBE NO - NM - RC PROBE NO - NM - RC PROBE NO - NM - RC PROBE NO - NM - RC GUIDE NM OUTSIDE PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN GUIDE NM OUTSIDE PROBE MQ - NM - RC PROBE MQ - NM - RC PROBE MQ - NM - RC PROBE MQ - NM - RC GUIDE NM OUTSIDE PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN GUIDE NM OUTSIDE PROBE MQ - NM - RC PROBE MQ - NM - RC PROBE MQ - NM - RC PROBE MQ - NM - RC microdialysis experiment without using a guide PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN PROBE NO - NM - PAN microdialysis experiment without using a guide PROBE NO - NM - RC PROBE NO - NM - RC PROBE NO - NM - RC PROBE NO - NM - RC PROBE NO - NM - RC Push-pull probe polyiamide GUIDE PP OUTSIDE PROBE NO - NM - PE GUIDE PP OUTSIDE PROBE NO - NM - PE Microdialysis Components Microdialysis Probes Brainlink is a manafacturer of high-quality components for microdialysis in aniaml research. A broad ranged of microdialysis probes and corresponding guide cannulas are offered, depending upon size, membrane type, probe materials and geometry. A number of standard membrane lengths are available: 1, 1.5, 2, 3, 4, and 5mm made from polyacrylonitrile and regenerated cellulose. Guide cannulas are available in sizes from 1 to 10 mm with corresponding dummy. GUIDE NM OUTSIDE shaft length guide = 3/0 mm PROBE NO - NM - PAN PAN = polyacrylonitrile membrane shaft length = 5.0 mm membrane length = 1.0 mm PROBE MQ - NM - RC MQ = MetaQuant RC = regenerated cellulose shaft length = 11.0 mm membrane length = 3.0 mm PROBE NO - NM - PE PE = polyethylene shaft length = 6.0 mm membrane length = 4.0 mm MetaQuant Probes The shaft is made from fused silica tubing with an outer diameter of 0.45mm and consists of two inlet tubings; one for slow flow (0.15ul/minute) the second for the carrier flow (0.8ul/minute) and the outlet tubing. ORDERS@SAI-INFUSION.COM P F

Large Animal Jackets Rabbit, Swine, Dog, Primate, Baboon & Squirrel Monkey Jackets & Jacket Pockets Working together with Lomir Biomedical, SAI provides animal jackets that fulfill all the

A single jacket will typically incorporate many materials, special features and fabrication methods that combine to increase comfort for the subject, as well as provide ease of use for the handler.

We work in close collaboration with investigators to develop custom jackets, specifically matched to the subject and procedure.

44 Large Animal Jackets Rabbit, Swine, Dog, Primate, Baboon & Squirrel Monkey Jackets & Jacket Pockets Working together with Lomir Biomedical, SAI provides animal jackets that fulfill all the expectations today s researchers demand, down to the smallest detail. A single jacket will typically incorporate many materials, special features and fabrication methods that combine to increase comfort for the subject, as well as provide ease of use for the handler. SAI s inventory of Large Animal Jackets has been designed and constructed to meet the requirements of a wide variety of subjects and activities. We work in close collaboration with investigators to develop custom jackets, specifically matched to the subject and procedure. For procedures requiring ambulatory equipment, we provide pouches in a range of materials and sizes for attachment to the jackets. Also available are anchoring patches for tethering systems and inserts for dermal procedures. SAI provides jackets suitable for all types of swine used in biomedical research. This may be for micro, mini, Yucatan and specific farm or market weight swine. All swine jackets are made to order. Please call for further information on how to order these jackets. Jacket Size Weight BJ 01 Rabbit Jacket X-Small < 2.7kg BJ 02 Rabbit Jacket Small kg BJ 03 Rabbit Jacket Medium kg BJ 04 Rabbit Jacket Large kg BJ 05 Rabbit Jacket X-Large 5.4+kg DJ 01 Dog Jacket X-Small 2.5-5kg DJ 02 Dog Jacket Small 5-7kg DJ 03 Dog Jacket Medium 8-12kg DJ 04 Dog Jacket Large 13-18kg DJ 05 Dog Jacket X-Large 18-25kg PJ 00 Primate Jacket X-Small < 2kg PJ 01 Primate Jacket Small 2-3kg PJ 02 Primate Jacket Medium 3.5-5kg PJ 03 Primate Jacket Large 5.5-7kg PJ 04 Primate Jacket X-Large 7-8kg PJ 05 Primate Jacket XX-Large 8-10kg PJ 06 Primate Jacket XXX-Large 10+kg JP 01 Jacket Pocket 3 in. x 7 in. x 2 in. JP 03 Jacket Pocket 11 in. Zipper 7 in. x 5.5 in. x 1.5 in. JP 04 Jacket Pocket 7 in. Zipper 6 in. x 4 in. x 2 in. JP 05 Jacket Pocket 5.25 in. x 3.5 in. x 1.5 in. Yucatan Swine Jackets 3/4 Length SS J1YU Yucatan Pig Jacket Small 20kg SS J2YU Yucatan Pig Jacket Medium 20-30kg SS J3YU Yucatan Pig Jacket Large 30-50kg Juvenile - Yorkshire Swine Jackets 3/4 Length SS J1YJ Yorkshire Swine Jacket Small, Juvenile 10-15kg SS J2YJ Yorkshire Swine Jacket Medium, Juvenile 20-30kg SS J3YJ Yorkshire Swine Jacket Large, Juvenile 35-40kg Adult - Yorkshire Swine Jackets 3/4 Length SS J1YA Yorkshire Swine Jacket Small, Adult 30-50kg SS J2YA Yorkshire Swine Jacket Medium, Adult 50-60kg SS J3YA Yorkshire Swine Jacket Large, Adult 60-70kg Ellegaard Göttingen Mini Pig Jackets 3/4 Length SS J1GEM Ellegaard Göttingen Mini Pig Jacket Small 10-15kg SS J2GEM Ellegaard Göttingen Mini Pig Jacket Medium 15-20kg SS J3GEM Ellegaard Göttingen Mini Pig Jacket Large 25-30kg SS J4GEM Ellegaard Göttingen Mini Pig Jacket X- Large 30kg + Juvenile - Hanford Swine Jackets 3/4 Length SS J1HMJ Hanford Swine Jacket Small, Juvenile 10-20kg SS J2HMJ Hanford Swine Jacket Medium, Juvenile 20-30kg SS J3HMJ Hanford Swine Jacket Large, Juvenile 35-45kg Adult - Hanford Swine Jackets 3/4 Length SS J1HMA Hanford Swine Jacket Small, Adult 50-75kg SS J2HMA Hanford Swine Jacket Medium, Adult kg SS J3HMA Hanford Swine Jacket Large, Adult kg Rabbit Swine Dog Primate 44 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Large Animal Swivels & Tethers Swivels Made by Lomir these single-fluid channel models are fabricated from high-impact plastic or stainless steel in standard gauges (16-20).

All large animal swivels are supplied with a C clamp and designed for repeated use.

45 Large Animal Swivels & Tethers Swivels Made by Lomir these single-fluid channel models are fabricated from high-impact plastic or stainless steel in standard gauges (16-20). Double and triple channel models for simultaneous applications are fabricated from high-impact plastic with 17 to 20 gauge channels. All large animal swivels are supplied with a C clamp and designed for repeated use. Material Needle Size ChannelsPrice AS P1 Large Animal Swivel High Impact Plastic 20G Single Fluid Channel AS P2 Large Animal Swivel High Impact Plastic 18G Single Fluid Channel AS P3 Large Animal Swivel High Impact Plastic 17G Single Fluid Channel AS P4 Large Animal Swivel High Impact Plastic 16G Single Fluid Channel Tethers Constructed by Lomir from flexible interlocking stainless steel. Machined aluminum end pieces are secured to swivels and end plates by two setscrews. Allows for ease of movement by the subject while eliminating interference and damage to the catheter. Tethers are available in three regular diameters. Standard lengths range from two to five feet, with other lengths available by special order. End Plates (Swivel Accessories): Machined by Lomir from a single piece of stainless steel for a durable and reliable connection to a reinforced anchor point on the jacket. BT 01 2 ft Rabbit Tether BT 02 3 ft Rabbit Tether LA T2 2 ft Large Animal Tether LA T3 3 ft Large Animal Tether LA T4 4 ft Large Animal Tether LA T5 5 ft Large Animal Tether End Plates (Swivel Accessories): Machined by Lomir from a single piece of stainless steel for a durable and reliable connection to a reinforced anchor point on the jacket. AT E1 Large Animal Tether End Plate Swivel Tether End Plate ORDERS@SAI-INFUSION.COM P F

Prefilled Syringes & Vials Prefilled Syringes SAI offers customized prefilled syringes for flushing, locking or sampling through any catheter or port system.

Syringe sizes range from 1cc-60cc with volumes from a minimum of 0.2ml. Forget ordering and storing saline and other physiologic solutions in large, inconvenient containers.

46 Prefilled Syringes & Vials Prefilled Syringes SAI offers customized prefilled syringes for flushing, locking or sampling through any catheter or port system. We can fill any size syringe with your specified flush or lock solution and package them to suit your procedure. Order what you need when you need it, in convenient, ready-to-use packaging. Syringe sizes range from 1cc-60cc with volumes from a minimum of 0.2ml. Forget ordering and storing saline and other physiologic solutions in large, inconvenient containers. Forget wasting time unwrapping countless individually wrapped syringes for your daily procedures. Forget mixing sterile solutions, then filling syringes in an unsterile environment. Solutions may include: Saline, Heparin/saline, dextrose, Heparin/dextrose, and many others. For additional syringe sizes or solutions call SALINE (0.9%) FILLED SYRINGES Syringe Size Volume (cc) 1cc 1.0 SC1-1 3cc 3.0 SC3-3 5cc 5.0 SC5-5 10cc 10.0 SC cc 60.0 SC60-60 HEPARIN & SALINE FILLED SYRINGES Syringe Size Volume (cc) Heparin (U/ml) 1cc HSC50-1 3cc HSC50-3 1cc HSC cc HSC cc HSC cc HSC cc HSC cc HSC500-3 Prefilled Syringes HGS / HDS HGS: Heparin/Glycerol Catheter Lock Solution The antithrombic characteristics of Heparin plus the viscous nature of glycerol are combined in a solution to promote and extend the patency of vascular catheters. Proven as the solution of choice in studies in catheterized animals*, Cath-Loc HGS solution acts as a non-toxic anticoagulant lock solution for indwelling catheters. This formulation is the most widely used as a pre-clinical catheter lock. * Y.S. Luo, et. al. AALAS 2000 Comparison of Catheter Lock Solutions in Rats. HGS-10 HGS-50 10ml Vial - single use 50ml Vial HDS: Heparin/Dextrose Catheter Lock Solution Cath-Loc HDS acts as a non-toxic anticoagulant lock solution for in-dwelling catheters for pre-clinical research. This is one of the most common formulations used as a reliable pre-clinical lock solution to maintain catheter patency in vascular catheters. Used in both large and small animals, this solution combines the high viscosity of 50% dextrose with the anticoagulant activity of Heparin to promote and extend implanted catheter patency. The high osmolarity of dextrose prevents bacterial colonization and the high viscosity reduces washout from the catheter tip. Since both dextrose and Heparin are physiological constituents which occur naturally in the blood, any excess Cath-Loc HDS injected is quickly metabolized. HDS-10 HDS-50 10ml Vial - single use 50ml Vial KHS20-22B KHS100-23B KHS200-22H KHS500 Catheter Maintenance Kits Save time and money by using SAI s custom pre-filled syringes packaged with your selection of needles and accessories in ready-to-use kits. They simplify blood sampling and port or catheter flushing and locking procedures and allow for more efficient use of staff. Call us for a free sample and experience the difference Cath-Loc kits make. Contact us for information regarding additional kits, customized to fit your specific needs. Cath-Loc Kits 1 ml syringe with 20 U/ml Heparin in Sodium Chloride, 0.7 ml fill, 1 ml empty syringe (2) 22 G blunt needles 1 ml syringe with 100 U/ml Heparin in Sodium Chloride, 0.3 ml fill, 1 ml Sodium Chloride 0.5 ml fill, 2 empty 1 ml syringes (2) 23 G 0.5 in. blunt needles 1 ml syringe with 200 U/ml Heparin in Sodium Chloride, 3 ml syringe with 2.0 ml fill Saline, 3 ml empty syringe, 22 G 0.75 in. Huber needles 1 ml syringe with 500 U/ml Heparin in Sodium Chloride, 0.5 ml fill, 3 ml syringe filled with 0.9% Sodium Chloride, 1 ml empty syringe 46 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Vials and Syringes Blunt Needles with Minimal Dead Volume Syringes Blunt Needles attached to syringes not only save tremendous amounts of time but will also help lower costs.

1cc 20 B20-50-1cc B20-1-1cc 1cc 22 B22-50-1cc B22-1-1cc 1cc 23 B23-50-1cc B23-1-1cc 1cc 25 B25-50-1cc B25-1-1cc BN w/syringes Zero Dead Volume Zero and Minimal Dead Volume Syringes Zero dead volume

47 Vials and Syringes Blunt Needles with Minimal Dead Volume Syringes Blunt Needles attached to syringes not only save tremendous amounts of time but will also help lower costs. We can supply any size syringe with any size blunt needle. ALL syringes are caped and ETO exposed. Call for additional sizes. Syringe Size Gauge 0.5 in. 1.0 in. 1cc 20 B cc B20-1-1cc 1cc 22 B cc B22-1-1cc 1cc 23 B cc B23-1-1cc 1cc 25 B cc B25-1-1cc BN w/syringes Zero Dead Volume Zero and Minimal Dead Volume Syringes Zero dead volume syringes offer the researcher the ability to completely remove all the fluid from the syringe for zero test article loss when dosing and zero fluid loss when sampling. MDV Z1CC Z-1-22/25 Z-1-22 Minimal dead volume syringe sterilized 10/pack 1cc zero dead volume syringe - sterilized 10/pack Zero dead volume syringes with 22G catheter connector 25/pack 1cc zero dead volume syringes with 22G catheter connector 100/pack Contact us for alternative size connectors! Minimal Dead Volume Automated Sampling Vials SAI now offers Heparinized Borosilicate glass liquid chromatography and HPLC vials,which are typically used with automated blood sampling devices. Available with Heparin, EDTA, Citrate, or your choice of anticoagulant, all vials are prepared and capped in our clean room. Like our prefilled syringes, these vials come in a wide variety of shapes and sizes, and the amount of anticoagulant can be adjusted to your specific requirements. Contact us for alternatives! HV100 ECV2.5 HL100 V300 VCP 300µl Sodium Heparinized Vial 100U 300µl 2.5 Micromolar EDTA Vials 300µl Lithium Heparinized Vial 100U 300µl Borosilicate Glass Vial 6 x 32mm PE Snap Cap for Vial - price/1000 Vials Polycarbonate Syringes These polycarbonate syringes offer greater drug compatibility over standard syringes. Offered in sizes of 1, 3, 6, 10, 20, 30 and 60 ml and multiple color plungers. Contact us for more information. SPC-1ml SPC-3ml SPC-6ml SPC-10ml SPC-20ml SPC-30ml SPC-60ml 1 cc polycarbonate syringes 3 cc polycarbonate syringes 6 cc polycarbonate syringes 10 cc polycarbonate syringes 20 cc polycarbonate syringes 30 cc polycarbonate syringes 60 cc polycarbonate syringes SPC Syringe Caps SC Syringe caps for easy identification of different compounds within a syringe Specify color when ordering. Sterile 10/Pk (White, Purple, Blue, Green or Yellow) ORDERS@SAI-INFUSION.COM P F

48 Blunt Needles/Luer Stub Adaptors Blunt Needles / Luer Stub Adaptors Plastic Luer Hubs with Stainless Steel Cannula and Burr-free tips. Blunt tip needles have many uses around the laboratory including ensuring secure reliable connection to in-dwelling catheters. Unlike hand-made blunt needles fashioned from hypodermic needles, our manufactured blunt needles provide a smooth, burr-free needle edge to prevent inadvertent damage to the lumen of the catheter. When dosing, sampling, flushing or locking the catheter. These high-quality, low-cost blunt needles make blunting your own needles a thing of the past. Offered in ETO exposed or bulk non-sterile packages. Please contact us for other sizes. Blunt Needles: ETO-Exposed, Individually Packaged 25/Bx and Capped Lengths Gauge 0.5 in. 1.0 in. 1.5 in. 14 B14-50 B B B15-50 B B B16-50 B B B17-50 B B B18-50 B B B19-50 B B B20-50 B B B21-50 B B B22-50 B B B23-50 B B B24-50 B B B25-50 B B B26-50 B B B27-50 B B B30-50 B Blunt Needles: Bulk Non-Sterile Packaged per Bag Lengths Gauge 0.5 in. 1.0 in. 1.5 in. 14 B14-50 B B B15-50 B B B16-50 B B B17-50 B B B18-50 B B B19-50 B B B20-50 B B B21-50 B B B22-50* B22-100* B22-150* 23 B23-50* B23-100* B23-150* 24 B24-50 B B B25-50* B25-100* B25-150* 26 B26-50 B B B27-50* B27-100* B27-150* 30 B30-50* B30-100* *Capped unless otherwise specified. Luer Stub Adaptors fit this range of catheter sizes Luer Stub Gauge Catheter Material & Outer Diameter PE PU Silicone 20G (0.036 in.) G (0.032 in.) G (0.028 in.) G (0.025 in.) G (0.020 in.) G (0.016 in.) INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Huber/Non-Coring Needles Huber / Non-Coring Needles Huber needles are specially designed needles with deflected points.

A Huber needle must always be used to access any vascular access port to prolong the life and prohibit the catheter from being occluded by a piece of cored septum.

Great for dosing or sampling. Use with an access port or injection cap. Deflected point allows for greater septum life. Gauge 0.75 in. 1.0 in.

49 Huber/Non-Coring Needles Huber / Non-Coring Needles Huber needles are specially designed needles with deflected points. The point eliminates the potential to core a septum, in an injection cap or a vascular port. A Huber needle must always be used to access any vascular access port to prolong the life and prohibit the catheter from being occluded by a piece of cored septum. Needles are ETO exposed and available in various lengths. They can be purchased individually, multi-pack or in bulk. Straight Non-Coring Huber Needles Bulk 100 not sterile. Great for dosing or sampling. Use with an access port or injection cap. Deflected point allows for greater septum life. Gauge 0.75 in. 1.0 in. 20 H20-75 H H22-75 H Huber Needles with Injection Caps Huber needles with injection caps are great for intermittent access where you do not want to use a stopcock or luer valve. Gauge 0.75 in. 1.0 in. 20 H20-75-IC H IC 22 H22-75-IC H IC Straight With Injection Cap 90º Non-Coring Huber Needles Low-profile design. High quality. Great for running fluid lines parallel to the skin, dosing or sampling. Gauge 0.5 in in. 1.0 in. 19 HR19-50 HR19-75 HR HR20-50 HR20-75 HR HR22-50 HR22-75 HR º Huber Needles with Luer Lock Valve Huber needles with luer activated luer lock valve are great for needle-less access. Once the Huber needle is inserted, syringe changing can be done with a closed system. Connecting a syringe opens the valve, disconnecting the syringes closes the valve. Gauge 0.75 in. 1.0 in. 20 H20-75-LLV-S H LLV-S 22 H22-75-LLV-S H LLV-S With Luer Lock 90º Winged Infusion Sets Winged infusion sets are 90 Huber Needles with suture wings, connected to 10 inches of mirco-bore tubing with a luer lock fitting. The Huber Needles come in a variety of lengths and gauges, see below. Gauge 0.5 in in. 1.0 in. 1.5 in. 19 WHIS WHIS WHIS WHIS WHIS WHIS WHIS WHIS WHIS WHIS Winged Infusion ORDERS@SAI-INFUSION.COM P F

Luered Extension Lines EXT-36 Luered Extension Sets Luered Extension Lines SAI extension lines are medically approved non-dehp PVC tubing with luer adaptors, and available in a variety of standard

50 Luered Extension Lines EXT-36 Luered Extension Sets Luered Extension Lines SAI extension lines are medically approved non-dehp PVC tubing with luer adaptors, and available in a variety of standard lengths. Custom sizes are also available. Volume Per box EXT-12 Male-female, 12 in. Volume 0.15 ml 50 EXT-36 Male-female, 36 in. Volume 0.18 ml 50 EXT-60 Male-female, 60 in. Volume 1.40 ml 50 EXT-60HF Male-female, 60 in. High Flow Volume 2.40 ml 50 EXT-PF12-23 EXT-P24-25CC Swivel-to-Pump Extension Sets These fluid lines are perfectly sized to friction fit with any gauge swivel and terminate with a female luer to connect to any syringe. Per box EXT-PF12-23 Tubing to fit 23G swivel with Female Luer, 12 in. length 25 EXT-PF12-25 Tubing to fit 25G swivel with Female Luer, 12 in. Length 25 EXT-PF24-23 Tubing to fit 23G swivel with Female Luer, 24 in. Length 25 EXT-PF24-25 Tubing to fit 25G swivel with Female Luer, 24 in. Length 25 EXT-PF36-23 Tubing to fit 23G swivel with Female Luer, 36 in. Length 25 EXT-B36 Light-Shielding Black Opaque Extension Lines Polyurethane radio-opaque black extension lines eliminate the need to cover the extension line with tinfoil while dosing light-sensitive compounds. The standard configuration is male-to-female luers, but these can be changed to fit your needs. Custom sizes are available. Per box EXT-B12 Male - female 12 in. length 10 EXT-B24 Male - female 24 in. length 10 EXT-B36 Male - female 36 in. length 10 Swivel-Catheter, Tethered Extension Lines Polyurethane extension sets that can be run through a tether to connect swivels with indwelling catheters. These formulation resistant, biocompatible fluid lines are provided to fit any size catheter and swivel combination. Stainless steel connectors are included, custom sized for secure friction fit. Custom lengths, tubing sizes and connectors are all available upon request. Per box EXT-P24-25CC 25G catheter connector with 24 in. long PU extension line to fit 25G swivel 25 EXT-P24-23CC 23G catheter connector with 24 in. long PU extension line to fit 23G swivel 25 EXT-P36-25CC 25G catheter connector with 36 in. long PU extension line to fit 25G swivel 25 EXT-P36-23CC 23G catheter connector with 36 in. long PU extension line to fit 23G swivel 25 Co-Extruded Extension Lines Co-extruded polyethylene/pvc extension lines offer the best of both worlds. PE is naturally inert to most chemicals, and the flexibility and kink resistance of PVC makes these lines the ultimate choice. Our lines are offered in many standard sizes and luer configurations. For special applications contact us directly to assure you get the exact extension line you need. The ID of this material will fit an 18G luer stub adaptor or swivel. Bulk tubing available. Please call for details. Per box EXT-PE-12 Male-female luer, PE lined extension set, 12 in. 25 EXT-PE-24 Male-female luer, PE lined extension set, 24 in. 25 EXT-PE-36 Male-female luer, PE lined extension set, 36 in. 25 EXT-PE-24F Female luer/open end, PE lined extension set, 24 in. 25 EXT-PE-36F Female luer/open end, PE lined extension set, 36 in. 25 EXT-PE-60F Female luer/open end, PE lined extension set, 60 in. 25 Fluid Path Polyethylene Lining PVC Outer Layer 50 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

51 Bulk Tubing Polyurethane, Polyethylene, PTFE & Silicone & PEEK Tubing Intravascular Polyethylene (PE) Tubing Medical grade polyethylene micro tubing has excellent chemical and gas resistance. It is flexible, yet rigid enough for easy implantation into a vessel. Our PE tubing contains no leachable plasticizers or additives and meets FDA 21 CFR and USP class 6 requirements. PE (Polyethylene) Tubing Dimensions & Size Volume (ul/cm) PE in. OD x in. JD.32 PE-8-25 PE-8-50 PE in. OD x in. JD.61 PE PE PE in. OD x in. JD 1.1 PE PE PE in. OD x in. JD 2.7 PE PE PE in. OD x in. JD 5.9 PE PE PE in. OD x in. JD 4.6 PE PE PE in. OD x in. JD 10.2 PE PE PE in. OD x in. JD 11.2 PE PE Intravascular Polyurethane (PU) Tubing SAI s PU tubing is specially formulated for applications where intravascular thrombosis is a concern. It reduces platelet and other blood related deposits on the wall of the tubing. It is extremely blood compatible and its initial stiffness makes it easy to implant into a vessel but softens at body temperature. ETO sterilize only. PU (Polyurethane) Tubing Dimensions & Size Volume (ul/cm) PU in. ID x in. OD.13 PU PU PU in. ID x in. OD.73 PU PU PU in. ID x in. OD 1.0 PU PU PU in. ID x in. OD 2.9 PU PU PU in. ID x in. OD 8.1 PU PU PU in. ID x in. OD 4.6 PU PU Medical-Grade PTFE Tubing PTFE tubing has the lowest coefficient of friction of any polymer due to its extremely smooth internal and external surface. This allows the tubing to be inserted into a vessel or a trachea very easily. It s natural lubricious properties make this tubing the perfect choice for gavage tubes or simple catheters. PTFE is extremely resistant to most all chemicals and has a broad temperature working range. Medical Grade PTFE TubingDimensions & Size Volume (ul/cm) 32G in. ID x in. OD 0.5 PTFE PTFE G in. ID x in. OD 1.1 PTFE PTFE G in. ID x in. OD 1.8 PTFE PTFE G in. ID x in. OD 2.7 PTFE PTFE G in. ID x in. OD 4.0 PTFE PTFE G in. ID x in. OD 6.6 PTFE PTFE Intravascular Silicone Tubing Medical Grade Silicone tubing is biocompatible and resistant to chemicals. Our Platinum cured Silicone meets USDA Class VI standards and can be sterilized with Ethylene Oxide or autoclaving. Silicone Tubing Dimensions & Size Volume (ul/cm) 1F in. ID x in. OD 0.4 SIL F in. ID x in. OD 0.71 SIL-2-25 SIL F in. ID x in. OD 2.0 SIL-3-25 SIL F in. ID x in. OD 4.6 SIL-5-25 SIL F in. ID x in. OD 17.0 SIL-6-25 SIL F in. ID x in. OD 19.0 SIL-7-25 SIL F in. ID x in. OD 31.0 SIL-9-25 SIL-9-50 Custom Tubing Sets Available. PEEK Tubing PEEK tubing provides an alternative to the stainless steel tubing or where high chemical compatibility and strength is needed. PEEK is formulated from polyetheretherketone with a melting temperature of 500 degrees Fahrenheit. It is also non-metallic and contains no ferromagnetic materials that would interfere with MRI. Silicone Tubing Dimensions & Size 16G.025 ID x.062 OD PEEK-16-T 21G.018 ID x.032 OD PEEK-21-T 23G.016 ID x.022 OD PEEK-23-T 25G.010 ID x.020 OD PEEK-25-T 28G.003 ID x.013 OD PEEK-28-T ORDERS@SAI-INFUSION.COM P F

Blood Collection Microvette Blood Collection with Capillary Tubes The Microvette (from Sarstedt) capillary blood collection system is designed to offer practical solutions for individual requirements.

thorough sample mixing; colorcoded caps and print for easy identification of additive and nominal volumes; shelf life and batch number are printed on each tube. Packaged 100 /bx.

Sample Tube 100ul EDTA Sample Tube 200ul EDTA Sample Tube 200ul Fluoride Sample Tube Blood Collection with Collection Rim Microvette (from Sarstedt) tubes are ideal for the collection of blood using

Advantages include: Choice of different inner tube designs with 300 or 500ul volume capacity and corresponding graduation; easy open cap; optimized tube geometry ensures thorough sample mixing; cap

52 Blood Collection Microvette Blood Collection with Capillary Tubes The Microvette (from Sarstedt) capillary blood collection system is designed to offer practical solutions for individual requirements. Advantages of a modern capillary blood collection system: Preassembled end-to-end capillary; special cap design is easy to open and also minimizes aerosol effect; optimized tube geometry ensures thorough sample mixing; colorcoded caps and print for easy identification of additive and nominal volumes; shelf life and batch number are printed on each tube. Packaged 100 /bx. MVC-S-100 MVC-S-200 MVC-SG-200 MVC-H-100 MVC-H-200 MVC-E-100 MVC-E-200 MVC-F ul Serum Sample Tube 200ul Serum Sample Tube 200ul Serum-Gel Sample Tube 100ul Heparin Sample Tube 200ul Heparin Sample Tube 100ul EDTA Sample Tube 200ul EDTA Sample Tube 200ul Fluoride Sample Tube Blood Collection with Collection Rim Microvette (from Sarstedt) tubes are ideal for the collection of blood using the gravity-flow principal. Any part of the entire rim can be used. Advantages include: Choice of different inner tube designs with 300 or 500ul volume capacity and corresponding graduation; easy open cap; optimized tube geometry ensures thorough sample mixing; cap can be attached to the tube bottom to prevent mixup or loss; shelf life and batch number are printed on each tube. Packaged 100/bx. MV-S-300 MV-S-500 MV-SG-500 MV-H-300 MV-H-500 MV-HG-500 MV-E-500 MV-F ul Serum Sample Tube 500ul Serum Sample Tube 500ul Serum-Gel Sample Tube 300ul Heparin Sample Tube 500ul Heparin Sample Tube 500ul Heparin-Gel Sample Tube 500ul EDTA Sample Tube 300ul Fluoride Sample Tube Capillary and Venous Blood Collection in One System (capillary action with or without an attached needle) Made by Sarstedt for venous blood collection, a needle may be connected to the capillary tube of the Multivette. Self-filling of the inner tube is accomplished by normal venous pressure. Hygienic and safe capillary blood collection is performed using the end-to-end principle. The special capillary tube is designed to hold a volume of 600ul of capillary blood. Packaged 100/bx. MUL-S-600 MUL-SG-600 MUL-H-600 MUL-HG-600 MUL-E-600 MUL-F ul Serum Sample Tube 600ul Serum-Gel Sample Tube 600ul Heparin Sample Tube 600ul Heparin-Gel Sample Tube 600ul EDTA Sample Tube 600ul Fluoride Sample Tube Capillary Action Blood Collection Tube The Microvette CB 300 system (from Sarstedt) renders optimum serum/plasma recovery (capillary collection for 300ul volumes). The capillary tube with push cap is supplied complete with a carrier tube that is suitable for transport and centrifugation. After blood collection, the capillary tube is sealed with the attached push caps. The trumpet-shaped capillary tube ensures maximum serum/plasma recovery after centrifugation. For efficiency in the laboratory, the capillary tube, accommodated in its carrier tube, can be placed directly onto the analyzer. Packaged 100/bx. MVCB-S-300 Serum Microvette CB 300 MVCB-SA-300 Serum amber carrier Microvette CB 300 MVCB-H-300 Heparin Microvette CB 300 MVCB-HA-300 Heparin amber carrier Microvette CB 300 MVCB-E-300 EDTA Microvette CB INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Blood Collection Prepared Micro Tubes We offer a wide variety of 1.3ml sample tubes, each pre-treated with a different anticoagulant or additive.

Additionally, the push cap tubes have a transparent label, while the screw cap tubes have an integral O-ring in the cap and a paper label on the tube. Packaged 100/bx. PMTS-C-1.3 1.

1 1.1ml Serum-Gel Push Cap PMTP-H-1.3 1.3ml Heparin Push Cap PMTP-E-1.3 1.3ml EDTA Push Cap Safety-Lancet The easy handling Safety-Lancet is primed and ready for use.

A range of penetration depths and widths are available to accommodate various volume requirements and skin types, ensuring optimum blood flow.

53 Blood Collection Prepared Micro Tubes We offer a wide variety of 1.3ml sample tubes, each pre-treated with a different anticoagulant or additive. They are available in a skirted or conical base, and with a push cap closure or a screw cap closure. Additionally, the push cap tubes have a transparent label, while the screw cap tubes have an integral O-ring in the cap and a paper label on the tube. Packaged 100/bx. PMTS-C ml Citrate Screw Cap PMTS-S ml Serum Screw Cap PMTS-SG ml Serum-Gel Screw Cap PMTS-H ml Heparin Screw Cap PMTS-E ml EDTA Screw Cap PMTP-S ml Serum Push Cap PMTP-SG ml Serum-Gel Push Cap PMTP-H ml Heparin Push Cap PMTP-E ml EDTA Push Cap Safety-Lancet The easy handling Safety-Lancet is primed and ready for use. The needle point (or blade) is concealed both before and after use, reducing the risk of needle injury and cross contamination. A range of penetration depths and widths are available to accommodate various volume requirements and skin types, ensuring optimum blood flow. This sterile device is single-use only, and once used, can be safely discarded. Packaged 200/bx. - Size x Penetration depth SL-M-28 28G x 1.6 mm Mini (blue) SL-N-21 21G x 1.8 mm Normal (green) SL-E-18 18G x 1.8 mm Extra (yellow) SL-S mm x 1.6 mm Super (purple) SL-N mm x 1.2 mm Neonatal (pink) The optimally matched system components of the innovative S-Monovette blood collection system ensure Safety and Reliability when collecting blood from any of the accepted pre-clinical species. S-Monovette Accessories Syringes with additive and snap-off plungers become blood collection ubes for centrifugation or storage. Aspirate or Vacuum sample. Packaged 50/bx. SMV-SG-1.1 SMV-S-1.2 SMV-H-1.2 SMV-E-1.2 SMV-F-1.2 SMV-C-1.4 SMV-S-2.6 SMV-H-2.6 SMV-E-2.6 SMV-S-4.5 SMV-H-4.5 SMV-S-7.5 SMV-H-7.5 SMV-E ml Serum Gel 1.2 ml Serum 1.2 ml Heparin 1.2 ml EDTA 1.2 ml Fluoride 1.4 ml Citrate 2.6 ml Serum 2.6 ml Heparin 2.6 ml EDTA 4.5 ml Serum 4.5 ml Heparin 7.5 ml Serum 7.5 ml Heparin 7.5 ml EDTA S-Monovette Accessories (SMV-ASL or SMV-ALL adapter is necessary for attachment of blunts or other standard needles) Part# Units/PK SMV G 1 in. S-Monovette Needle 100 pieces SMVS G 1 in. S-Monovette Safety Needle 50 pieces SMV G 1.5 in. S-Monovette Needle 100 pieces SMV G 1 in. S-Monovette Needle 100 pieces SMVS G 1 in. S-Monovette Safety Needle 50 pieces SMV G 1.5 in. S-Monovette Needle 100 pieces SMV G 1 in. S-Monovette Needle 100 pieces SMVS G 1 in. S-Monovette Safety Needle 50 pieces SMV G 1.5 in. S-Monovette Needle 100 pieces SMV-21-MF 21G x 200 mm Tubing Multifly Needle 100 pieces SMV-23-MF 23G x 200 mm Tubing Multifly Needle 100 pieces SMV-ASL S-Monovette Adapter with Luer 100 pieces SMV-ALL S-Monovette Adapter with Luer Lock 100 pieces LMV-N-9 Luer Movovette 9 ml Neutral 100 pieces ORDERS@SAI-INFUSION.COM P F

Infusion & Sampling Accessories LY2FM LY3FM LTFFM LFC LMC SW4.5 SW4.

5K SW7B SW7P LCV LLV LLV-S LIV IC VP SC1LL SC2LL SC3LL SC1LLHP SC3LLHP MML FFL 3-Way-30 4-Way-25 Sampling Accessories Y connector with male rotating luer and two female luers; polycarbonate.

10/bx Non-vented, closed male luer cap, ABS. 10/bx Fixing wing; 4.5 french thru hole Pebax. 10/bx Y fixing wing; 4.5 french thru hole Kraton. 10/bx Fixing wing; 7 french thru hole Pebax.

10/bx Luer activated valve with female luer and male luer; ABS, polycarbonate - Makrolon, silicone. 10/bx Needle-less injection site with male luer lock, swabable; polycarbonate, silicone.

54 Infusion & Sampling Accessories LY2FM LY3FM LTFFM LFC LMC SW4.5 SW4.5K SW7B SW7P LCV LLV LLV-5 LIV VP SC1LL IC SC2LL SC3LL SC1LLHP SC3LLHP MML FFL All Parts Provided ETO-Exposed Call for Bulk Packaging LY2FM LY3FM LTFFM LFC LMC SW4.5 SW4.5K SW7B SW7P LCV LLV LLV-S LIV IC VP SC1LL SC2LL SC3LL SC1LLHP SC3LLHP MML FFL 3-Way-30 4-Way-25 Sampling Accessories Y connector with male rotating luer and two female luers; polycarbonate. 10/bx Infusion Y with swivel thread, 4 port polycarbonate, PVC. 10/bx T Connector with swivel male luer and two female luer locks; polycarbonate. 10/bx Non-vented female luer cap, polypropylene. 10/bx Non-vented, closed male luer cap, ABS. 10/bx Fixing wing; 4.5 french thru hole Pebax. 10/bx Y fixing wing; 4.5 french thru hole Kraton. 10/bx Fixing wing; 7 french thru hole Pebax. 10/bx Fixing wing; 7 french thru hole PVC. 10/bx 1-way valve with female inlet and male outlet, psi. 10/bx Needle-less injection site with male luer lock, swabable; polycarbonate, silicone. 10/bx Luer activated valve with female luer and male luer; ABS, polycarbonate - Makrolon, silicone. 10/bx Needle-less injection site with male luer lock, swabable; polycarbonate, silicone. 10/bx Male luer lock injection site, latex free polycarbonate, polyisoprene. 10/bx Vein pick: Holds the vessel open during the cut-down catheter insertion procedure. The tapered tip of the vein pick is inserted into the incision of the vessel. The catheter slides under the grove on the underside of the vein pick into the vessel. 10/pk 1-way stopcock with luer lock polycarbonate, polyethylene. 10/bx 2-way, 3-port luer lock, lipid-resistant, labeled handle feature, clear high-density polyethylene, polycarbonate. 10/bx 3-way stopcock with luer lock, polycarbonate, polyethylene. 10/bx 1-way stopcock with swivel nut; 200 psi. 10/bx 3-way stopcock with swivel nut; 200 psi. 10/bx Male-to-male luer connector; polycarbonate. 10/bx Female-to-female luer lock; ABS. 10/bx Stainless Steel Y-Connector 23G Stainless Steel Four Way 25G Connector Package Size TP-1 1 ml transfer pipette (30-45ul drop) 1000 pieces TP-2 2 ml transfer pipette (30-45ul drop) 1000 pieces TPF ml transfer pipette, graduated, Fine Tip (30-45ul Drop) 500 pieces PM-BLUE Blue permanent marker 10 pieces PM-BLACK Black permanent marker 10 pieces PM-GREEN Green permanent marker 10 pieces PM-RED Red permanent marker 10 pieces MC-CENT Mini centrifuge MC 6 1 piece LC-CENT Horizontal centrifuge LC 6 1 piece 54 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

Surgical Instruments 13160 13161 13164 16026 13169 13163 17539 17541 13166 13168 13167 Surgical Instruments SAI offers quality, low-cost, surgical instruments for the budget-minded surgeon.

(102 mm) 13161 Straight iris stainless steel scissors, mirror finish; 4.25 in. (114 mm) 13163 Webster stainless steel needle holder, mirror finish; 5 in.

(121 mm) 13167 Curved fine tip stainless steel forceps; satin finish; 4.75 in. (121 mm) 13168 Fine tip stainless steel forceps, mirror finish; 3.5 in. (89 mm) 13169 Straight Rochester stainless steel forceps, mirror finish; 6.

(127 mm) 17541 Curved locking stainless steel forceps, mirror finish; 5.5 in.

Answer the sterility question easily now with SAI s Sterilized Press n Seal in pre-packaged ETO-exposed rolls.

55 Surgical Instruments Surgical Instruments SAI offers quality, low-cost, surgical instruments for the budget-minded surgeon. These stainless steel surgical instruments are perfect to be used as disposable instruments, such as in necropsy or for light surgical use Straight stainless steel forceps, mirror finish; 4 in. (102 mm) Straight iris stainless steel scissors, mirror finish; 4.25 in. (114 mm) Webster stainless steel needle holder, mirror finish; 5 in. (127 mm) Straight may stainless steel scissors, mirror finish; 5.25 in. (140 mm) Adson stainless steel forceps; serrated, mirror finish; 4.75 in. (121 mm) Curved fine tip stainless steel forceps; satin finish; 4.75 in. (121 mm) Fine tip stainless steel forceps, mirror finish; 3.5 in. (89 mm) Straight Rochester stainless steel forceps, mirror finish; 6.25 in. (158 mm) Lister bandage stainless steel scissors, mirror finish; 5.5 in. (140 mm) Halstead mosquito stainless steel forceps, satin finish; 5 in. (127 mm) Curved locking stainless steel forceps, mirror finish; 5.5 in. (140 mm) Sterilized Glad Press n Seal Has your IACUC questioned the sterility of Glad Press n Seal when used as a sterile surgical wrap? Answer the sterility question easily now with SAI s Sterilized Press n Seal in pre-packaged ETO-exposed rolls. Many surgeons are faced with trying to prove that off-the-shelf Press n Seal is sterile and can be used in surgical settings. Although tests from multiple labs have shown that often nothing can be cultured from out-of-the-box Press n Seal, that doesn t prove sterility! Purchase your Press n Seal ETO-exposed, to help ensure the security of your sterile field. Offered in 70 and 140 square-foot single rolls labeled with expiration date. PSS-70 PSS sq feet ETO Exposed for Sterility 140 sq feet ETO Exposed for Sterility Rodent Surgical Drapes with an integral sterile field! SAI now has a drape kit designed for survival rodent surgery that has a combination of a sterile field and the proven application of Sterile Press n Seal. The drape system provides a sterile field drape to drop sterile instruments, and a pre-cut sterile animal drape of Press n Seal. Custom Drapes available, call or see our website for pricing. This kit: Provides a sterile yet transparent barrier for visual monitoring of the patient during surgery Retains additional body heat during surgery compared to an un-draped animal Can eliminate the need for towel clamps for accurate surgical site draping Enhances containment of any dander away from the surgical site compared to standard drapes that tend to move on the animal Can be cut to gain access to a prepared site. May be used to transport the animal to a recovery cage where it can be unwrapped upon completion of surgery Using these drape kits, along with sterile procedures and monitoring for surgery in rodents is in compliance with the precedents set in the Guide for the Care and Use of Laboratory Animals PSS-SD1 19 x 30 surgical drape with a 11 x 12 Press n Seal insert PSS-SD5 19 x 30 surgical drape with a 11 x 12 Press n Seal insert, 5/pk PSS-SD23 24 x 36 Surgical Drape with 11 x 12 Press n Seal insert PSS-SD x 36 Surgical Drape with 11 x 12 Press n Seal insert, 5/pk ORDERS@SAI-INFUSION.COM P F

SAI Services Surgical Services Regardless of species, continuous infusions lasting longer than two weeks require surgical procedures to insert and anchor

Frequent intermittent infusions of long duration or with test formulations that require central venous or arterial delivery also require cut-down

It is difficult, if not impossible, to maintain the skilled surgical staff necessary to perform these procedures without regular training or hands-on

SAI s experienced surgeons understand this and offer surgical consulting and practical training to ensure your animals are successfully instrumented and

General surgical overview and consultation are standard services provided with all of our infusion and access products.

56 SAI Services Surgical Services Regardless of species, continuous infusions lasting longer than two weeks require surgical procedures to insert and anchor in-dewelling catheters. Frequent intermittent infusions of long duration or with test formulations that require central venous or arterial delivery also require cut-down procedures for catheter or port implantation. It is difficult, if not impossible, to maintain the skilled surgical staff necessary to perform these procedures without regular training or hands-on practice. SAI s experienced surgeons understand this and offer surgical consulting and practical training to ensure your animals are successfully instrumented and maintained for the duration of the infusion. General surgical overview and consultation are standard services provided with all of our infusion and access products. In the event that a comprehensive review and in-depth, hands-on session is required, we will be happy to make arrangements to visit your facility Catheter Design Standard catheter designs may not always suit your specific research needs. Whether you are faced with an uncommon species, a difficult access site or you would just like to make improvements on an existing design, we can help. SAI custom designs and builds affordable, quality catheters that will improve the quality of your research. Our skilled engineers and experienced surgeons are ready to lend their expertise to produce unique catheters that are certain to perform to your expectations. 56 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

SAI Services Pump Rental Infusion pumps are usually the most expensive component of infusion systems with the possible exception of the Alzet pump.

In these situations, the best option may be to rent the pumps you need for the duration of the infusion.

sai offers a wide variety of infusion pumps from most medical manufacturers for rent or lease, with fully documented calibration, for your immediate use.

convenient solution. Let SAI s Biomedical Technicians provide you with fast, cost-effective and fully documented calibration and repair service.

57 SAI Services Pump Rental Infusion pumps are usually the most expensive component of infusion systems with the possible exception of the Alzet pump. Whether confronting a study with a large number of animals or running your first infusion study, it is not always possible or cost-effective to purchase new pumps. In these situations, the best option may be to rent the pumps you need for the duration of the infusion. Renting allows you to cover pump expenses from the operating budget and avoid making a long-term purchase to meet a shortterm shortfall.sai offers a wide variety of infusion pumps from most medical manufacturers for rent or lease, with fully documented calibration, for your immediate use. Pump Calibration & Repair If you already own several infusion pumps and are faced with regular calibration, internal battery replacement or repairs, we have a convenient solution. Let SAI s Biomedical Technicians provide you with fast, cost-effective and fully documented calibration and repair service. Even European manufactured pumps can be calibrated in our offsite facility. Avoid high fees, expensive shipping and long delays. Our technicians are fully qualified. Call for an estimate. Medfusion Smith s (Deltec) Harvard New Era ORDERS@SAI-INFUSION.COM P F

58 Reference Tables Compatibility Key Good: compatible for use with solvent; Poor: should not be used with solvent; Unknown: compatibility testing is suggested prior to use Compatibility of Catheter Materials Vehicle/Solvent Polyurethane Silicone Polyethylene Vinyl Acids, with ph greater than 1.8 Good Good Good Unknown Bases, with ph less than 14 Fair Good Unknown Unknown Cremophor EL, up to 25% in water Good Good Unknown Unknown Culture media (1% benzyl alcohol as bacteriostatic) Good Good Good Good Cyclodextrins Good Good Good Good Dextrose, up to 5%, in water or NaCl Good Good Good Good N, N-Dimethyl Formamide (DMF), up to 25% in water Poor Unknown Unknown Poor DMSO, up to 50% in water or polyethylene glycol Poor Good Good Poor DMSO, up to 50% in ethanol (< or = 15%) and water Poor Good Good Poor Ethanol, up to 15% in water Poor Good Good Poor Glycerol Good* Good* Good* Good* 1-Methyl-2-Pyrrolidone, up to 12.5% in water Unknown Unknown Unknown Unknown Phosphate buffer Good Good Good Good Polyethylene glycol 300 or 400, neat or in water Good* Good* Good* Good* Propylene glycol, neat or in water Good* Good* Good* Good* Ringer s solution Good Good Good Good Saline, 0.9% (aqueous salt solution) Good Good Good Good Serum (rat, mouse, etc.) Good Good Good Good Solutol, up to 30% in water Unknown Unknown Unknown Unknown Triacetin, up to 5% in water Unknown Unknown Unknown Unknown Tween 80, up to 2% Good Good Unknown Unknown Water, distilled Good Good Good Good Polyurethane catheters are made from Dow Pellethane 2363 material; Silicone catheters are made from Dow Silastic material *Be aware of the viscosity (viscosity may be a problem for catheters with very small inner diameter) Reference table provided by ALZET Corporation For luer stub adaptor catheter size, please see page 48. Imperial Unit Length Units Metric Equivalent Corresponding Metric Unit Inch 2.54 Centimeter Foot Meter Yard Meter Fathom Meter Chain Meter Furlong Kilometer Mile Kilometer Nautical Mile (UK) 1853 Meter Kg Pound Ounce Milliliter Pint 16 Ounce Quart 2 Pint Gallon 4 Quart Gallon Liter 58 INFUSION SYSTEMS FOR LABORATORY ANIMAL RESEARCH

59 Reference Tables French Catheter Scale *Sizes are outside diameter French Inches mm Conversions Convert From Multiply By To Get Celsius (1.8 x C) + 32 Fahrenheit Fahrenheit 5/9(F-32) Celcius cm Foot cm Inch cm Fl. Oz. Celcius (C) Fahrenheit (F) (C ) = K (5/9)(F ) = K (9/5C +32) = F (5/9)(F -32) = C Needle Gauge Chart Needle Nominal O.D. Nominal I.D. Volume Gauge mm Inches mm Inches (ul/cm) s Polyethlene (PE) Approx. O.D. I.D. Volume Inches mm Inches mm ul/cm PE PE PE PE PE PE PE PE PE PE PE PE PE PE PE PE ORDERS@SAI-INFUSION.COM P F

60 NEW Innovations from SAI Needle-less Access Harness Subcutaneous Access Ports CathPort Side Access, see pg. 33 Omni Harness, see pg. 36 CathPort Twin, see pg. 33 Subcutaneous Micro-Infusion System Self-Administration Systems in Rodents See pg. 23 See pg. 14 Call for all of your infusion and sampling needs! sai-infusion.com

Complete Solutions for Small Animal Infusion

Complete Solutions for Small Animal Infusion NEW! Full Line of Catheters Swivels and Infusion Cages Vascular Access Products and Tethers Tubing and Connectors Jackets Syringe Pumps Surgical Instruments