YOUR FIRST CHOICE FOR IN-OFFICE GENETIC TESTING

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1 YOUR FIRST CHOICE FOR IN-OFFICE GENETIC TESTING

2 THE NEW STANDARD OF CARE WHY GENETIC TESTING? Genetic testing makes it possible to know a priori how your patients will metabolize a specific drug. It is now extremely practical and cost effective to identify special biomarkers that affect how your individual patients will metabolize a broad array of prescribed drugs. Recent clinical studies reveal that approximately 50% of all people carry variant genes that will alter the rate they will metabolize or activate many commonly prescribed drugs used to treat cardiac disease (high blood pressure, chest pain/angina, irregular heart beats/arrhythmias, high cholesterol, blood clots/anticoagulants); manage pain (acute post-surgical or traumatic pain, chronic pain or generalized pain); treat neuropsychiatric disorders (anxiety, depression, seizures); treat gastric ulcers or reflux, and diabetes. Patients with gene variants are eight times more likely to experience an adverse drug reaction or lack of efficacy to their prescribed medication. IN-OFFICE GENETIC TESTING: SIMPLE, FAST AND ACCURATE Providing state-of-the-art genetic testing services in your office are simple to perform and easy to get started. All that is required is; 1) the physician orders the one-time study for the patient; 2) a nurse or PA obtains a patient specimen by taking a buccal swab from the inside of the patients cheek; and 3) the patient test sample is sent via PERSONALIZED MEDICINE: THE TIME IS NOW The use of modern pharmacogenomics enables clinicians to identify key genetic metabolic markers that determine their patient s metabolism and therapeutic response to a particular drug before prescribing a therapy. Molecular diagnostics are good for the patient, good for the practice and good for the healthcare system. Specific genes, chromosomes, enzymes and proteins determine drug response. MOLECULAR DIAGNOSTICS DEFINING TOOLS FOR A lab technologist prepares DNA sample for analysis. prepaid FEDX envelope to Genetisys s CLIA-accredited high complexity diagnostic laboratory (Bio Med Laboratory). A comprehensive genetics4you genotype panel evaluates a multitude of primary pharmacogenomic biomarkers and important inherited variants impacting metabolism or drug response using state-of-the-art microarray DNA analyzers. The patient s test results are provided electronically or via fax to the ordering physician in approximately one week. The ordering physician renders a professional interpretation of the patient s test results and defines a tailored or personalized treatment plan specific to an individual patient.

3 ARE THE MODERN MEDICINE. GENETIC TESTING REIMBURSMENT Genetic (molecular diagnostic and pharmacogenomic) tests are covered by Medicare, MediCAL and most major insurance carriers to evaluate a patient s ability to metabolize commonly used cardiovascular drugs. The FDA has issued a Black Box Warning on the Plavix label alerting patients that poor metabolizers are at greater risk for adverse cardiovascular events and informs them genetic testing can identify patients CYP2C19 metabolic function. Numerous clinical studies also demonstrate that CYP2C9, CYP2D6 or CYP3A4/3A5 variants can reduce metabolic function. Approximately 120 drugs now have the FDA Black Box Labeling. Molecular analysis reveals a patient s unique genetic signature.

4 YOUR PARTNER FOR PERSONALIZED MEDICINE GENETISYS THE QUALITY LEADER FOR IN-OFFICE GENETIC TESTING We are experts at bringing advanced molecular diagnostic testing services to physicians and their practices. Our focus is on delivering state-of-the-art diagnostic services with unequaled physician, staff and patient education; premier patient and referrer marketing materials; intuitive physician-friendly pharmacogenomic reports; and unmatched pharmacogenomic and interpretation support. With the growing body of literature supporting the use of genetic testing for a wide range inherited and pharmacogenomic applications its no surprise why everybody s talking about it. It s the reason many leading physicians are already embracing this technology and are distinguishing their practices today with the formal adoption of these new standards of care for their patients. WE MAKE IT EASY TO GET STARTED We provide the physician and their personnel all that is required to get started including comprehensive educational materials, genetic test requisition forms, patient informational materials, physician informational materials, informed patient consent forms, patient specimen collection kits, and prepaid test shipment kits. Genetisys oversee all start-up activities to ensure quality services are obtained consistently, right from the start. Premier Getting Starting Educational Programs In-Office Test Start-Up Procedures Patient DNA Specimen Collection & Shipment Kits Quality Patient and Referral Marketing Materials Comprehensive Genotype/Phenotype Test Results Intuitive Physician-Friendly Electronic Patient Reports Pharmacogenomic and Interpretation Support Responsive Local Support & Account Management WE PRIDE OURSELVES IN OUR ABILITY TO BRING LEADING EDGE CARE TO OUR PATIENTS YOUR EXPERT PARTNER IN GENETICS With more than 30 years of experience in molecular medicine and emerging technologies, Genetisys experts are uniquely qualified to get your practice set-up as a center of excellence for molecular diagnostic genetic testing. As your committed partner, we seek to keep our clients and their practices at the forefront in the use of the latest available in-office genetic tools and help to distinguish our client s clinical services by practicing Personalized Medicine The New Standards of Care. Pharmacogenomic testing make it possible to define the most effective drug therapy for an individual - the first time.

5 CARDIOLOGY CENTER OF EXCELLENCE MOLECULAR DIAGNOSTICS GENETIC TEST CENTER You have the opportunity to be at the forefront of this exciting medical revolution and distinguish your medical practice from your competitors. Genetisys makes it easy for your practice to be a quality provider for in-office genetic testing services simply and fast, with no capital investment. We will keep you informed of all the new opportunities to expand your in-office genetic testing portfolio as new tests become available. The time is now to differentiate your practice and start improving clinical outcomes for your patients by practicing the new standard of care afforded by genetic testing. As your partner, we make it effortless for you to Get Started. Patients are unique genetically and their care and treatment should be individualized.

6 YOUR CODE FOR PERSONALIZED MEDICINE genetics4you THE NEW STANDARD OF CARE The comprehensive genotyping test panel is typically performed on a person once in their lifetime to determine a patient s unique genetic blueprint, which can be used by the physician(s), over and over, as an important reference tool for choosing the most effective prescriptions or drug therapies, that produce the best clinical outcomes for individual patients. With the average Medicare patient seeing more than 6 physicians annually and those with chronic diseases over 10 physicians, choosing and managing a patient s drug therapies, and avoiding adverse drug-drug interactions is becoming increasingly important to optimizing overall patient care and outcomes. TYPES OF GENETIC TESTS There are two primary types of genetic tests available to patients, Molecular diagnostic testing, that identifies inherited genetic variants that predispose a patient to certain diseases; and pharmacogenomic testing which identifies a multitude of genetic biomarkers or variants that determine an individual s specific response to a broad array of drugs used to treat cardiac disease (Plavix, Coumadin, beta blockers, antiarrhythmics, CA channel blockers and statins), neuropsychiatric disorders (antidepressants, anti-seizure, migraines), gastric ulcers or reflux (PPI s), diabetes (sulfonylureas), and pain management (opioids, NSAIDs, benzodiazepines). More than 75% of the population have genetic variations that increase or decrease the availability of cytochrome enzymes that are heavily relied upon for drug metabolism and conversion. ONE-TIME TEST A LIFETIME OF BENEFITS The value of knowing your patient s genetic signature will enhance your ability to prescribe the most effective treatments for each patient; determine proper dosages of drugs based on predetermined patient-specific metabolic or inherited biomarkers; avoid serious drug-drug interactions and reduce the possibility of using drugs or dosages that could result in catastrophic adverse effects. A single genetics4you genotyping test, once in a lifetime that s all it takes to introduce personalized medicine to your patients and begin practicing a whole New Standard of Care. THE RIGHT DRUG, AT THE RIGHT PATIENT THAT S HIGH DIAGNOSTIC VALUE TODAY AND TOMORROW The genetics4you molecular diagnostic panel marks the start of a new era of personalized medicine for medical practices and patients. With hundreds of DNA tests under development that offer potential to identify a number of other inherited medical conditions, it is highly likely that diagnostic genetic tools will play an increasingly important role in optimizing patient care and outcomes. Genetic testing makes it possible to detect disease earlier, monitor a patient s response to therapy, and enables doctors to choose the right therapy for a patient the first time.

7 WHO DO I TEST? The genetics4you panel is extremely useful for assessing drug response in patients with cardiac disease; psychiatric disorders; acute, generalized or chronic pain; diabetes; gastric ulcers or reflux; as well as many other conditions. It s useful for determining the right drugs and dosage for every patient, prior to initiating drug therapy; for patients that have had adverse reactions to existing drugs or therapy; for patients you are having difficulty in obtaining the proper drug response, for patients with planned surgical or vascular inventions; and for patients who are on medications that have not been tested previously. One test benefits for a lifetime. RIGHT DOSE, FOR THE PERSONALIZED MEDICINE. A physician reviews the molecular diagnostic cardiac panel genotyping results with a patient and prescribes a tailored treatment plan based on their unique genetic signature.

8 THE NEW STANDARD OF CARE DISTINGUISH YOUR PRACTICE AND COMMITMENT TO YOUR PATIENTS We are proud to offer state-of-the-art genetic molecular diagnostic testing capabilities to all of our medical clients. Our conformance to the New Standards of Care afforded by what is called Personalized Medicine ensures that every patient receives the most effective treatment and care based on their individual genetic biomarkers that determine their inherent ability to respond to a particular drug or therapy. The First Choice For In-Office Genetic Testing Genetisys 149 W Lambert Road Brea, CA Phone: (858) Fax: (714) info@genetisysmdx.com Genetisys and genetics4you are trademarks of Genetisys Genetisys 03/13. Specifications or information subject to change at any time. Genetisys and Bio Med Laboratory are divisions of L&M Lab, Inc. REV201303