Practical Applications of Immunology (Ch 18) Zazzle.com
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1 Practical Applications of Immunology (Ch 18) Zazzle.com
2 Vaccine Overview
3 Practical Applications of Immunology (Ch 18) behance.net, CDC.gov
4 Variolation Lady Mary Wortley Montague ( ) Sacred to the Memory of the Right Honourable Lady Mary Wortley Montague. Who happily introduc d from Turkey, into this Country, The Salutary Art Of inoculating the Small Pox. Convinc d of its Efficacy She first tried it with Success On her own Children. And then recommended the practice of it To her fellow Citizens. Thus by her Example and Advice, We have soften d the Virulence And escap d the danger of this malignant Disease 1789
5 Measles cases in the United States, (CDC, 2010) , , ,000 Vaccine licensed Reported number of cases Reported number of cases 350, , , , Year 150, ,000 50, Year
6 Vaccines for bacteria
7 Vaccines for viruses
8 Immunization Schedule
9 Vaccine Types
10 Live Attenuated: Figure 18.1 Influenza viruses are grown in embryonated eggs.
11 Live Attenuated: Figure 13.7 Inoculation of an embryonated egg. Air sac Shell Amniotic cavity Chlorioallantoic membrane Chlorioallantoic membrane innoculation Amniotic innoculation Yolk sac Allantoic innoculation Shell membrane Albumin Allantoic cavity Yolk sac innoculation
12 Conjugated vaccines: Figure 17.6 T-independent antigen
13 West Nile DNA vaccine for horses nature.com
14 Adjuvants Thimerosal FAQ page from CDC CDC list of vaccine ingredients
15 Perception of Risk
16 Risk in United Kingdom
17
18 Risk
19 Let s not forget Mumps Measles Measles Rubella / German measles wikipedia.org
20 Let s not forget Diphtheria Diphtheria Diphtheria, skin lesion wikipedia.org
21 Let s not forget Polio un.org
22 Let s not forget Tetanus freeinfosociety.com wikipedia.org braindiseases.org
23 Diagnostic Immunology Two major problems to solve!
24 Figure The Production of Monoclonal Antibodies. 1 Mouse injected with antigen. Antibodies produced. Antigen 2 Mouse spleen removed. Contains B cells that produce antibodies. Spleen
25 3 Spleen cells mixed with myeloma cells. Some fuse into hybrid cells. Suspension of spleen cells Spleen cells Cultured myeloma cells (cancerous B cells) Suspension of myeloma cells Myeloma cells Hybrid cells Spleen cell 4 Mixture of cells placed in selective medium that allows only hybrid cells to grow.
26 Figure The Production of Monoclonal Antibodies. 5 Hybrid cells proliferate into clones called hybridomas. The hybridomas are screened for production of the desired antibody. Hybridomas Desired monoclonal antibodies 6 The selected hybridomas produce large quantities of monoclonal antibodies, for treating and diagnosing disease.
27 Naming Pharmacychoice.com, oncozine.com, novosurge.com, mims.com
28 Figure 18.11a Fluorescent-antibody (FA) techniques. Group A Fluorescent dye labeled Fluorescent Reactions in a positive direct fluorescent-antibody test streptococci from antibodies to group A streptococci patient s throat streptococci
29 Figure 18.11b Fluorescent-antibody (FA) techniques. Reactions in a positive indirect fluorescent-antibody test T. pallidum from laboratory stock Specific antibodies in serum of patient Antibodies binding to T. pallidum Fluorescent dye labeled anti-human immune Fluorescent spirochetes serum globulin (see Figure 3.6b) (will react with any immunoglobulin)
30 Figure 18.14: The ELISA method. Direct: detects antigens Indirect: detects antibodies
31 Figure The use of monoclonal antibodies in a home pregnancy test. Control windows Test windows 1 2 Free monoclonal antibody specific for hcg, a hormone produced during pregnancy. Capture monoclonal antibody bound to substrate. Sandwich formed by combination of capture antibody and free antibody when hcg is present, creating a color change. Not pregnant Pregnant hf/kuby/content/anm/kb07an01.htm
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Practical Applications of Immunology (Chapter 18) Lecture Materials for Amy Warenda Czura, Ph.D. Suffolk County Community College Eastern Campus
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